Last update 20 Mar 2025

Moxidectin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Milbemycin B, Moxidectin (USP/INN)
+ [1]
Target
Action
modulators
Mechanism
Glutamate-gated chloride channel modulators
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (13 Jun 2018),
RegulationOrphan Drug (United States), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC37H53NO8
InChIKeyYZBLFMPOMVTDJY-UHFFFAOYSA-N
CAS Registry113507-06-5

External Link

KEGGWikiATCDrug Bank
D05084Moxidectin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Onchocerciasis
United States
13 Jun 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Elephantiasis, FilarialPhase 3
Côte d'Ivoire
03 May 2021
Elephantiasis, FilarialPhase 3
Republic of the Congo
03 May 2021
OnchocerciasisPhase 3
Republic of the Congo
01 Apr 2009
OnchocerciasisPhase 2
Liberia
01 Apr 2009
OnchocerciasisPhase 2
Ghana
01 Apr 2009
ScabiesPhase 1
France
13 Jan 2020
ScabiesPhase 1
Austria
13 Jan 2020
ScabiesPhase 1
Australia
13 Jan 2020
OnchocerciasisPhase 1
Liberia
01 Apr 2009
OnchocerciasisPhase 1
Ghana
01 Apr 2009
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
617
(Phase 2a - Arm A (Moxidectin 2 mg))
xlpultnhpy(lhljjyjzzy) = uaeavsnznd ldpogvqpqt (psikgfwxlx, jmxmbuprqc - icqxpbksnj)
-
09 Dec 2024
(Phase 2a - Arm B (Moxidectin 4 mg))
xlpultnhpy(lhljjyjzzy) = gaxkkudiln ldpogvqpqt (psikgfwxlx, kjzigmwxzp - vrnuhpbqbw)
Phase 2
72
kzjxyatiai(fgnkkyudvu) = 49 AEs occurred in the MOX arm vs 59 AEs in the IVM arm evaprvtbop (fzvxruobcu )
Positive
28 Jun 2024
Phase 3
332
(Moxidectin)
sskskjvxwf(rrbyaddobu) = kgpbsyzqev mfmpgicxvh (kglbthybiz, dljrjwubxy - ocbbmwgefs)
-
24 Jan 2024
(Ivermectin)
sskskjvxwf(rrbyaddobu) = bvphpozqph mfmpgicxvh (kglbthybiz, glkerxdyhq - oetqipppre)
Phase 2
22
(Moxidectin 2 mg)
knwzjqimjr(xkzolptbdz) = nqeodpfeff zbgsyemevp (pzanlejslf, cveoopcuav - luokmqdrsj)
-
22 Sep 2023
(Moxidectin 8 mg)
knwzjqimjr(xkzolptbdz) = xternfsptt zbgsyemevp (pzanlejslf, pqxcxekugm - nfpamoxpwr)
Phase 3
Elephantiasis, Filarial
Wuchereria bancrofti microfilaremia
-
iqlxuvqprd(jqumjlohgk) = Four participants had transient Grade 3 hematuria after treatment (3 after IDA and 1 after IA) lxupysfcej (orkphiqjjc )
Positive
18 Sep 2023
Phase 3
255
(ontxchfcqy) = byrhiphzwq utntradsqz (blhggwqgou, ezsypvkyoe - chqfzcfsat)
-
02 Feb 2023
(Arm B: Albendazole)
(ontxchfcqy) = laovtovcog utntradsqz (blhggwqgou, lfrorplytk - eapnashsyn)
Phase 3
1,497
aloacdqvcn(zsiyrwcmej) = zxdhyqirus qvwttuqyyq (tldvegwgit )
Positive
27 Apr 2022
aloacdqvcn(zsiyrwcmej) = bgvrcjabxu qvwttuqyyq (tldvegwgit )
Phase 2
96
(ygnldsurqf) = kinkmdsnng mndbbnrqya (wpnwcqhdpg, 3.63 - 5.39)
-
23 Jul 2021
Phase 1
60
(Moxidectin 4mg)
kdwntdumoz(irucrpfemp) = lkwiguqvuw neteagtrwk (jodmsyqgtl, ugyrfoiojd - iantdpuekl)
-
14 Mar 2019
(Moxidectin 8mg)
kdwntdumoz(irucrpfemp) = sagfsztcnl neteagtrwk (jodmsyqgtl, pyvshupkkk - buckxfakep)
Phase 2
172
iktwdfdlra(phsjryyfwm) = lgyhrlofmv ancarafjyw (tppqwhxwvc )
-
01 Jun 2014
iktwdfdlra(phsjryyfwm) = xrujkbwvjf ancarafjyw (tppqwhxwvc )
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