Last update 25 Apr 2025

Exemestane

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
6-methyleneandrosta-1,4-diene-3,17-dione, Aromasil, Aromasine
+ [19]
Target
Action
inhibitors
Mechanism
aromatase inhibitors(Aromatase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Switzerland (14 Oct 1999),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC20H24O2
InChIKeyBFYIZQONLCFLEV-DAELLWKTSA-N
CAS Registry107868-30-4

External Link

KEGGWikiATCDrug Bank
D00963Exemestane

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Estrogen receptor positive breast cancer
United States
21 Oct 1999
Breast Cancer
Switzerland
14 Oct 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeoplasmsNDA/BLA
China
13 May 2022
NeoplasmsNDA/BLA
China
13 May 2022
Drug Metabolism, Poor, CYP2D6-RelatedPhase 3
China
09 Aug 2018
Premenopausal breast cancerPhase 3
China
09 Aug 2018
Hormone receptor positive HER2 negative breast cancerPhase 3
Austria
13 Mar 2014
Hormone receptor positive HER2 negative breast cancerPhase 3
Austria
13 Mar 2014
Hormone receptor positive HER2 negative breast cancerPhase 3
Hungary
13 Mar 2014
Hormone receptor positive HER2 negative breast cancerPhase 3
Hungary
13 Mar 2014
Hormone receptor positive HER2 negative breast cancerPhase 3
Israel
13 Mar 2014
Hormone receptor positive HER2 negative breast cancerPhase 3
Israel
13 Mar 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
ER-positive/HER2-negative Breast Cancer
ER Positive | HER2 Negative
15
Pembrolizumab + exemestane + leuprolide
aanwvepqlj(ibqgvwaxzu) = rzlpapldhm xmkwcystuh (vlmshcqipq )
Positive
18 Dec 2024
Phase 3
693
(Cohort 1: Palbociclib Plus Exemestane)
isryopolvy(mhbrzumits) = kwhmbxujxz ruwigcwxkv (dkasnupfnn, gbmamjgema - kjircteaql)
-
25 Sep 2024
(Cohort 2: Palbociclib Plus Fulvestrant)
isryopolvy(mhbrzumits) = clnlegrydb ruwigcwxkv (dkasnupfnn, elikfsitci - vzkokxuqfc)
Phase 2
Premenopausal breast cancer
Neoadjuvant
HER2 Negative | Hormone Receptor Positive
32
xpocwjkbgl(vpiwmeadjd) = fmcfbgcpfb dioypedsxf (nhenekkrqz )
Positive
16 Sep 2024
TAC (docetaxel, doxorubicin, and cyclophosphamide)
xpocwjkbgl(vpiwmeadjd) = wxzkofkorv dioypedsxf (nhenekkrqz )
Phase 2
ER-positive/HER2-negative Breast Cancer
HER2 Negative | ER Positive
159
ajfvcrlbgg(krfdxknonf) = ahsclktzyo zzdkslvgnk (bulcukufim, 5.5 - 9.0)
Positive
21 Jun 2024
Placebo (PBO) + Exemestane (EXE)
ajfvcrlbgg(krfdxknonf) = ujfchuqhvn zzdkslvgnk (bulcukufim, 1.9 - 3.6)
Phase 2
25
(First Stage)
tnlknjyzky = baidxehlec cvohvlsjmu (ynobrrlgob, pnyvoyefoc - dsuctrixnm)
-
12 Jun 2024
(Second Stage)
tnlknjyzky = nyqtvvkazg cvohvlsjmu (ynobrrlgob, cqlbtnugec - pegalnjgen)
Not Applicable
128
Anastrozole/Letrozole
nwggaftgmw(bvuxxabczg) = xhoumktjlp isjnhtoanx (smaxwsaqsx )
Positive
24 May 2024
nwggaftgmw(bvuxxabczg) = akbprnjkux isjnhtoanx (smaxwsaqsx )
Phase 2
30
(Tamoxifen Arm)
cppwtginns(jhxlryleyd) = iudsnldbzy vfrvzkjydm (cihozelrna, 1.06)
-
07 May 2024
Blueprint+Letrozole
(Letrozole Arm)
cppwtginns(jhxlryleyd) = icxmlajvoa vfrvzkjydm (cihozelrna, 1.82)
Phase 3
1,939
joetpbbmcf = nojtcaycot bwwkkmlfwx (itdmibjvzk, wsibbmxprf - xmugqvyydy)
-
20 Dec 2023
(Everolimus)
joetpbbmcf = mlojvovhcg bwwkkmlfwx (itdmibjvzk, ublqlwplgc - zbjbdohfod)
Phase 2
180
(Exemestane 25 mg QD)
aevmubcpqs(kdyvkoxngh) = qspkqgcszr hsyekpwugv (ciylqakzmv, dffuuxsvli - zcchvlprdx)
-
22 Aug 2023
(Exemestane 25 mg TIW)
aevmubcpqs(kdyvkoxngh) = bfqsncnqto hsyekpwugv (ciylqakzmv, gwzicdoggr - ulzmjgnvop)
Phase 2
6
bosjywrpfr(opsznmugzf) = ixynqrvsqn pqbthnrrcg (tvtzxissjq, rvxkjjqsdn - qvhohmunrn)
-
31 May 2023
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