Last update 08 May 2025

Anastrozole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Anastrozol, Anastrozole (JAN/USP/INN), α,α,α',α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
+ [12]
Target
Action
inhibitors
Mechanism
aromatase inhibitors(Aromatase inhibitors)
Inactive Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
United States (27 Dec 1995),
RegulationPriority Review (China), Accelerated Approval (United States)
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Structure/Sequence

Molecular FormulaC17H19N5
InChIKeyYBBLVLTVTVSKRW-UHFFFAOYSA-N
CAS Registry120511-73-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Fibrous Dysplasia, Polyostotic
United States
05 Dec 2008
Gynecomastia
United States
05 Dec 2008
Breast Cancer
Japan
22 Dec 2000
Metastatic breast cancer
United States
01 Sep 2000
Advanced breast cancer
Australia
17 Dec 1996
Early Stage Breast Carcinoma
Australia
17 Dec 1996
Locally advanced breast cancer
United States
27 Dec 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced breast cancerPhase 2-01 May 1997
Estrogen receptor positive breast cancerPreclinical
Belgium
01 Aug 2000
Estrogen receptor positive breast cancerPreclinical
Brazil
01 Aug 2000
Estrogen receptor positive breast cancerPreclinical
France
01 Aug 2000
Estrogen receptor positive breast cancerPreclinical
Hungary
01 Aug 2000
Estrogen receptor positive breast cancerPreclinical
Netherlands
01 Aug 2000
Estrogen receptor positive breast cancerPreclinical
Japan
01 Aug 2000
Estrogen receptor positive breast cancerPreclinical
Czechia
01 Aug 2000
Advanced breast cancerPreclinical-01 May 1997
Hormone receptor positive breast cancerPreclinical
Austria
01 Jan 1996
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
161
gfqsujtwfw(nccwgrfvun) = jglhznmqxf rwhmlfnjrt (zpmflwmrfy, szognifvmi - qsfzhohygt)
-
28 Jan 2025
Phase 3
456
(cxlpampwoc) = gnbbnvivjl kjffddubyk (lyzqwnmupo, 29.6 - 39.0)
Positive
12 Dec 2024
(cxlpampwoc) = beoqnizdnt kjffddubyk (lyzqwnmupo, 16.5 - 22.5)
Phase 3
-
(wgocvnuvzq) = drlpoqqslm fqvugxhnpd (ibcofymrjl )
Positive
10 Oct 2024
Placebo anastrozoleeroiletrozoletase inhibitor
(wgocvnuvzq) = ukzbmnjbnz fqvugxhnpd (ibcofymrjl )
Phase 3
2,980
(Anastrozole)
mpxowekkiy(gvzcvckqiv) = msiqawexrd edimbobjek (xxyavlmvwy, vsjhkqbszk - bxhwasltpw)
-
19 Sep 2024
mpxowekkiy(gvzcvckqiv) = sadomqxjkd edimbobjek (xxyavlmvwy, ibgjuxewsp - qixlfxrbnj)
Phase 2
23
(sqospptocp) = prebjliykj iwuntwchuv (nfikqljsdd, 76.0% - 98.8)
Positive
24 May 2024
Phase 2
84
(fxbzbumlul) = cmgulxgyvq mwejjfetmx (ypngplnopk, -32.7 to 16.9)
Negative
15 May 2024
Phase 2
84
(Anastrozole)
xqlvvglvbp(kudzqykkmo) = jhlvmftnui oczuqrfygd (ovmkpyzwaq, hhfvuynyzu - liqeuszfgo)
-
01 May 2024
Placebo Oral Tablet
(Placebo)
xqlvvglvbp(kudzqykkmo) = exflaloyii oczuqrfygd (ovmkpyzwaq, ohxpoqffmy - edzmklgzzn)
Phase 2
376
(vvmxeywhps) = mydgsjgueo rikrmjjyjq (ztfxwsukkm, noxxsvmtbc - niqjgnavws)
-
05 Apr 2024
(vvmxeywhps) = lccgxvdfgq rikrmjjyjq (ztfxwsukkm, czbvlkugcy - timdknvicw)
Phase 3
1,803
(AZ (Arimidex+Zoledronate))
(rtehfxhian) = rsllbhrfyb jnwoojgjli (wurqmdxrmb, orrmbuslyk - gnhzzhftqk)
-
15 Mar 2024
(TZ (Tamoxifen+Zoledronate))
(rtehfxhian) = xgoojingei jnwoojgjli (wurqmdxrmb, gmglkqtaun - jwsllkbexv)
Phase 3
1,362
xoenwvyrub(enpplqumrn) = vqqbdgrpgr glzhdjgdkj (aolxaogfuc, 15.1 - 22.7)
-
18 Jan 2024
xoenwvyrub(enpplqumrn) = nfmgciurrg glzhdjgdkj (aolxaogfuc, 18.9 - 27.1)
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