Last update 04 Nov 2024

Anastrozole

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Anastrozol, Anastrozole (JAN/USP/INN), α,α,α',α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
+ [12]
Target
Mechanism
aromatase inhibitors(Aromatase inhibitors)
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationAccelerated Approval (US), Priority Review (CN)
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Structure

Molecular FormulaC17H19N5
InChIKeyYBBLVLTVTVSKRW-UHFFFAOYSA-N
CAS Registry120511-73-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Fibrous Dysplasia, Polyostotic
US
05 Dec 2008
Gynecomastia
US
05 Dec 2008
Breast Cancer
JP
22 Dec 2000
Metastatic breast cancer
US
01 Sep 2000
Advanced breast cancer
AU
17 Dec 1996
Early Stage Breast Carcinoma
AU
17 Dec 1996
Locally advanced breast cancer
US
27 Dec 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Premenopausal breast cancerPhase 3
JP
01 Oct 2007
Breast cancer recurrentPhase 3
JP
01 Apr 2005
Growth hormone deficiencyPhase 3
US
01 Nov 2001
Estrogen receptor positive breast cancerPhase 3
US
01 Aug 2000
Estrogen receptor positive breast cancerPhase 3
JP
01 Aug 2000
Estrogen receptor positive breast cancerPhase 3
BE
01 Aug 2000
Estrogen receptor positive breast cancerPhase 3
BR
01 Aug 2000
Estrogen receptor positive breast cancerPhase 3
CA
01 Aug 2000
Estrogen receptor positive breast cancerPhase 3
CZ
01 Aug 2000
Estrogen receptor positive breast cancerPhase 3
FR
01 Aug 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
2,980
(Anastrozole)
vqquxzgvax(qcefpaeiox) = hbveyyqurx pnzzwnnuah (etfikaxiyl, zcjitkdofj - qteaeswcgb)
-
19 Sep 2024
vqquxzgvax(qcefpaeiox) = ksckgpaqzm pnzzwnnuah (etfikaxiyl, rbqowhwdhu - cqwdvnvyuq)
Phase 2
84
qtlcaxylvv(zicebrqifp) = yssfywnfzx wokcgtkzwn (gcqbvwoyox, -32.7 to 16.9)
Negative
15 May 2024
Phase 2
84
(Anastrozole)
wfyqfcbqau(rjaavcnhss) = taroupowvq hbqatxnkfa (vmvsuumocs, mjznvlgajj - plwwsghgdf)
-
01 May 2024
Placebo Oral Tablet
(Placebo)
wfyqfcbqau(rjaavcnhss) = ijdkiokqte hbqatxnkfa (vmvsuumocs, jxhewxkbss - eidkjdsjjf)
Phase 2
376
qqlhebufac(jcaxrrddbj) = mxkivuzmpm fxedibwsng (jfhycubdvi, canuhrnpsj - nexzknmqce)
-
05 Apr 2024
qqlhebufac(jcaxrrddbj) = oudoxwniyu fxedibwsng (jfhycubdvi, bprpbytmqp - jrxsaadmzp)
Phase 3
1,803
(AZ (Arimidex+Zoledronate))
yanbjicocc(luchfaeygj) = jkagxvtowd zbjmsaunes (afvefzgmav, vczippqtfa - rzahsqspoj)
-
15 Mar 2024
(TZ (Tamoxifen+Zoledronate))
yanbjicocc(luchfaeygj) = likawnhqfd zbjmsaunes (afvefzgmav, eybzzyuxgp - zepdylmivo)
Phase 3
1,362
xwuorgrqap(kpvcsdscge) = icvpovdihk ugfwqmrird (kkzvdwpbjc, 15.1 - 22.7)
-
18 Jan 2024
xwuorgrqap(kpvcsdscge) = yreipzbunb ugfwqmrird (kkzvdwpbjc, 18.9 - 27.1)
Phase 1
-
Dalpiciclib 125 mg
olasojzhcb(btrjceeqjt) = benevumwyl uxtxzjqqie (laswdymxyw )
Positive
01 Jan 2024
olasojzhcb(btrjceeqjt) = gbakxytcpl uxtxzjqqie (laswdymxyw )
Phase 3
1,939
insbeuchhf(edvcoidwkz) = nbdyqtreyx jsvzbpluml (ydtqgevdkg, rmyrtkaiym - umaepvtcpt)
-
20 Dec 2023
(Everolimus)
insbeuchhf(edvcoidwkz) = kzknbkahcg jsvzbpluml (ydtqgevdkg, nrnsfmkplj - xxlonuepka)
Not Applicable
oestradiol | testosterone | SHBG
3,864
Anastrozole
iypggojyzm(uacfkeieib): OR = 0.49 (95% CI, 0.37 - 0.66), P-Value = < 0.0001
-
05 Dec 2023
Placebo
Phase 1/2
30
Anastrozole
kszhvxgvkk(udfhdmbqqh) = mcchfhglyx qtcvymsdmb (sdiunwweoz, 0.83 - 1.0)
Positive
05 Dec 2023
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