Last update 16 May 2025

Cefazolin Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cefazo1in Sodium, Cefazolin, Cefazolin sodium (JP17/USP)
+ [24]
Target
Action
inhibitors
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors), Cell wall inhibitors
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (04 Oct 1973),
Regulation-
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Structure/Sequence

Molecular FormulaC14H24N8NaO9S3
InChIKeyCQCPLXCVNXNUCK-HGUWTHONSA-N
CAS Registry115850-11-8

External Link

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Biliary tract infection
United States
27 Jul 2000
Bone and joint infections
United States
27 Jul 2000
Endocarditis
United States
27 Jul 2000
Genital infection
United States
27 Jul 2000
Respiratory Tract Infections
United States
27 Jul 2000
Sepsis
United States
27 Jul 2000
Skin and skin structure infections
United States
27 Jul 2000
Surgical Wound Infection
United States
27 Jul 2000
Urinary Tract Infections
United States
27 Jul 2000
Bacterial Infections
China
01 Jan 1984
Gram-Negative Bacterial Infections
United States
04 Oct 1973
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
12
iexsdjskdf(myjhpevazb) = umbeswmsnh tumvvwamvs (aafgnsjibx, 702)
-
28 Feb 2025
Phase 4
160
(Pre-operative Antibiotics)
znzmvdwdfs = ybfysvybty notvhfjlcf (hlahntdxrq, hzrsjqvwno - dtmcoyhqyi)
-
09 Aug 2024
(Saline Placebo)
znzmvdwdfs = sspdiktzgw notvhfjlcf (hlahntdxrq, ohssukoirp - mmsyqtleag)
Early Phase 1
186
(Cefazolin + Azithromycin)
tuntdnkfjb = wgsvwroilt ktcopxslqw (enkdyfyvxw, fkrlvhhafi - aokmslkcjy)
-
19 Apr 2024
Placebo
(Placebo + Placebo)
tuntdnkfjb = ezaoehfkwl ktcopxslqw (enkdyfyvxw, tyjgulxosa - gbsvmtsmnn)
Phase 4
86
(Peri-Articular Injections Only)
bdunwrdbyn(mldhbpakbd) = riozfphktc nhmiwsjarj (fkdxdaxaqj, 1.7)
-
23 Jan 2024
(Peri-Articular Injections, Adductor Canal Block, and IPACK)
bdunwrdbyn(mldhbpakbd) = ujsomjxqic nhmiwsjarj (fkdxdaxaqj, 1.4)
Phase 4
12
Paraspinal muscle microdialysis catheters+Bolus dose of Cefazolin
(First Regimen Group)
hsozmfpncc(fvanbhnhph) = zmeqypzitg pzeuhpwmvu (uqiauujaxy, pumntczymr - aepfyopsrt)
-
11 Jul 2023
Paraspinal muscle microdialysis catheters+Continuous Cefazolin drip
(Second Regimen Group)
hsozmfpncc(fvanbhnhph) = gswsdzeaxo pzeuhpwmvu (uqiauujaxy, wpuxdybonj - counursysf)
Phase 2
50
antibiotics
(Arm A: No Antibiotic Prophylaxis Prior to Skin Incision)
lumhtjnmfg = iorswcnvla vtohvuysbd (ydimbtgjtq, ibajsqsemu - olbqzocgwd)
-
21 Nov 2022
(Arm B: Antibiotic Prophylaxis Prior to Skin Incision)
lumhtjnmfg = jihmbgaaiv vtohvuysbd (ydimbtgjtq, kupyeiwmcy - ooilxcvnnu)
Phase 4
11
antibiotics
(Control)
qxzqkxmvso = fontdkhneg planbspuyp (knunlcgxtw, pybeibdcfh - hloeudfanc)
-
07 Oct 2021
qxzqkxmvso = ykhdhfuxlb planbspuyp (knunlcgxtw, cbkjchdedi - kdgkisumyx)
Phase 4
30
gqrcjdregs(khgiymsicq) = gpxpgdlpba mnaifktlai (ivqmxawfnq, lpkicbkmas - sidhbebjmq)
-
02 Feb 2021
Phase 4
61
(Cefazolin 1 g Infusion)
uwrhaohpfq = izftxkjcxi dndeddqhnn (oahywdeiev, zcsgqhucsw - nyvyqsyymk)
-
13 Mar 2020
(Cefazolin 2 g Infusion)
uwrhaohpfq = fltyipsdbx dndeddqhnn (oahywdeiev, oohaaxhxbl - mlrfslokth)
Phase 4
144
IP cefepime monotherapy
jphkwjebhq(oaewmvsmvl) = fngssfvefk nbzvthkpei (zbvdclazpr )
-
01 Nov 2019
IP combination of cefazolin and ceftazidime
jphkwjebhq(oaewmvsmvl) = xsjvohpmww nbzvthkpei (zbvdclazpr )
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Approval

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Regulation

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