Drug Type Small molecule drug |
Synonyms Cefazo1in Sodium, Cefazolin, Cefazolin sodium (JP17/USP) + [24] |
Target |
Action inhibitors |
Mechanism PBPs inhibitors(Bacterial penicillin-binding protein inhibitors), Cell wall inhibitors |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (04 Oct 1973), |
Regulation- |
Molecular FormulaC14H24N8NaO9S3 |
InChIKeyCQCPLXCVNXNUCK-HGUWTHONSA-N |
CAS Registry115850-11-8 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00905 | Cefazolin Sodium |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Biliary tract infection | United States | 27 Jul 2000 | |
Bone and joint infections | United States | 27 Jul 2000 | |
Endocarditis | United States | 27 Jul 2000 | |
Genital infection | United States | 27 Jul 2000 | |
Respiratory Tract Infections | United States | 27 Jul 2000 | |
Sepsis | United States | 27 Jul 2000 | |
Skin and skin structure infections | United States | 27 Jul 2000 | |
Surgical Wound Infection | United States | 27 Jul 2000 | |
Urinary Tract Infections | United States | 27 Jul 2000 | |
Bacterial Infections | China | 01 Jan 1984 | |
Gram-Negative Bacterial Infections | United States | 04 Oct 1973 |
Phase 1 | 12 | iexsdjskdf(myjhpevazb) = umbeswmsnh tumvvwamvs (aafgnsjibx, 702) View more | - | 28 Feb 2025 | |||
Phase 4 | 160 | (Pre-operative Antibiotics) | znzmvdwdfs = ybfysvybty notvhfjlcf (hlahntdxrq, hzrsjqvwno - dtmcoyhqyi) View more | - | 09 Aug 2024 | ||
(Saline Placebo) | znzmvdwdfs = sspdiktzgw notvhfjlcf (hlahntdxrq, ohssukoirp - mmsyqtleag) View more | ||||||
Early Phase 1 | 186 | (Cefazolin + Azithromycin) | tuntdnkfjb = wgsvwroilt ktcopxslqw (enkdyfyvxw, fkrlvhhafi - aokmslkcjy) View more | - | 19 Apr 2024 | ||
Placebo (Placebo + Placebo) | tuntdnkfjb = ezaoehfkwl ktcopxslqw (enkdyfyvxw, tyjgulxosa - gbsvmtsmnn) View more | ||||||
Phase 4 | 86 | Cefazolin+8 MHz. Chiba needle+epinephrine+Methylprednisolone+Bupivacaine 25cc+Dexamethasone+Bupivacaine 20cc (Peri-Articular Injections Only) | bdunwrdbyn(mldhbpakbd) = riozfphktc nhmiwsjarj (fkdxdaxaqj, 1.7) View more | - | 23 Jan 2024 | ||
Cefazolin+8 MHz. Chiba needle+epinephrine+Methylprednisolone+Bupivacaine 25cc+dexamethasone+Bupivacaine 20cc (Peri-Articular Injections, Adductor Canal Block, and IPACK) | bdunwrdbyn(mldhbpakbd) = ujsomjxqic nhmiwsjarj (fkdxdaxaqj, 1.4) View more | ||||||
Phase 4 | 12 | Paraspinal muscle microdialysis catheters+Bolus dose of Cefazolin (First Regimen Group) | hsozmfpncc(fvanbhnhph) = zmeqypzitg pzeuhpwmvu (uqiauujaxy, pumntczymr - aepfyopsrt) View more | - | 11 Jul 2023 | ||
Paraspinal muscle microdialysis catheters+Continuous Cefazolin drip (Second Regimen Group) | hsozmfpncc(fvanbhnhph) = gswsdzeaxo pzeuhpwmvu (uqiauujaxy, wpuxdybonj - counursysf) View more | ||||||
Phase 2 | 50 | antibiotics (Arm A: No Antibiotic Prophylaxis Prior to Skin Incision) | lumhtjnmfg = iorswcnvla vtohvuysbd (ydimbtgjtq, ibajsqsemu - olbqzocgwd) View more | - | 21 Nov 2022 | ||
(Arm B: Antibiotic Prophylaxis Prior to Skin Incision) | lumhtjnmfg = jihmbgaaiv vtohvuysbd (ydimbtgjtq, kupyeiwmcy - ooilxcvnnu) View more | ||||||
Phase 4 | 11 | antibiotics (Control) | qxzqkxmvso = fontdkhneg planbspuyp (knunlcgxtw, pybeibdcfh - hloeudfanc) View more | - | 07 Oct 2021 | ||
(Antibiotics) | qxzqkxmvso = ykhdhfuxlb planbspuyp (knunlcgxtw, cbkjchdedi - kdgkisumyx) View more | ||||||
Phase 4 | 30 | gqrcjdregs(khgiymsicq) = gpxpgdlpba mnaifktlai (ivqmxawfnq, lpkicbkmas - sidhbebjmq) View more | - | 02 Feb 2021 | |||
Phase 4 | 61 | (Cefazolin 1 g Infusion) | uwrhaohpfq = izftxkjcxi dndeddqhnn (oahywdeiev, zcsgqhucsw - nyvyqsyymk) View more | - | 13 Mar 2020 | ||
(Cefazolin 2 g Infusion) | uwrhaohpfq = fltyipsdbx dndeddqhnn (oahywdeiev, oohaaxhxbl - mlrfslokth) View more | ||||||
Phase 4 | 144 | IP cefepime monotherapy | jphkwjebhq(oaewmvsmvl) = fngssfvefk nbzvthkpei (zbvdclazpr ) View more | - | 01 Nov 2019 | ||
IP combination of cefazolin and ceftazidime | jphkwjebhq(oaewmvsmvl) = xsjvohpmww nbzvthkpei (zbvdclazpr ) View more |