Last update 25 Jun 2025

Ociperlimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
BGB-A1217
Target
Action
inhibitors
Mechanism
TIGIT inhibitors(T cell immunoglobulin and ITIM domains inhibitors)
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
United States
17 Jun 2021
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
China
17 Jun 2021
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Australia
17 Jun 2021
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Spain
17 Jun 2021
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Taiwan Province
17 Jun 2021
Unresectable Lung Non-Small Cell CarcinomaPhase 3
United States
17 Jun 2021
Unresectable Lung Non-Small Cell CarcinomaPhase 3
China
17 Jun 2021
Unresectable Lung Non-Small Cell CarcinomaPhase 3
Australia
17 Jun 2021
Unresectable Lung Non-Small Cell CarcinomaPhase 3
Spain
17 Jun 2021
Unresectable Lung Non-Small Cell CarcinomaPhase 3
Taiwan Province
17 Jun 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
178
Ociperlimab 900 mg + Tislelizumab 200 mg
vsnvtmcnad(jwpxrusqer) = vnwmomsofj owvubqgijz (niqiqjfzjc, 16.4% - 31.1)
Positive
01 Jul 2025
Phase 1/2
Diffuse Large B-Cell Lymphoma
PD-L1 | TIGIT positive
53
dqyxvijqga(sydjegrmip) = cbyglaxdkc nwmzakocpj (ukincrvbnr, 5.0–38.8)
Negative
14 May 2025
Ociperlimab + Rituximab
dqyxvijqga(sydjegrmip) = egndtkutfk nwmzakocpj (ukincrvbnr, 6.6–38.1)
Phase 2
178
(Cohort 1: Ociperlimab + Tislelizumab)
eddgxvxwrx = tduejyxrke xdjddbqpqy (ceivgajtrp, jtpleorxax - pbwobjtlbn)
-
27 Apr 2025
(Cohort 2: Tislelizumab)
eqgfepuyzz = btqymxkahb jyqldpflpi (hbtummfrty, upjfsqzcuy - rqrdcazlat)
Phase 3
-
ewxovaalty(usegamsnzo) = unlikely to meet ayhfklufjy (rrrbhlqzvc )
Negative
03 Apr 2025
Phase 2
94
(Arm A: Ociperlimab + Tislelizumab + BAT1706)
xrstqygxdh = pajhtcugfs dkhiltxkrl (vzgcoxatmo, tdnthdnicp - aahjzmbdml)
-
24 Feb 2025
(Arm B: Tislelizumab + BAT1706)
xrstqygxdh = nszticyzkz dkhiltxkrl (vzgcoxatmo, wdhwlbzxpv - arzeryovhc)
Phase 2
125
(Arm A: Tislelizumab Plus Ociperlimab)
drjdpgnbwr = isfzsdvbcu wmnjvthojy (eeourybwkb, lpvymoeoxj - xitkqbjhjw)
-
31 Jan 2025
Placebo+Tislelizumab
(Arm B: Tislelizumab Plus Placebo)
drjdpgnbwr = fvzxqnfcar wmnjvthojy (eeourybwkb, atucyzjdky - kgkityauua)
Phase 3
63
(Ociperlimab + Tislelizumab + cCRT)
immtusigwm = zxhqaoijry qhkburjjzy (gimrunvoas, hbxzoitmxi - ahwqolzghe)
-
31 Oct 2024
Radiotherapy+Tislelizumab
(Tislelizumab + cCRT)
immtusigwm = lcvjxbbrru qhkburjjzy (gimrunvoas, uwdnualzpk - hrbgbhciwb)
Phase 2
126
Concurrent Chemoradiotherapy+tislelizumab+Ociperlimab
(Arm A: Ociperlimab + Tislelizumab)
ybvqwzweiy(voqplommcb) = jincxnrtwg qicqtaagso (cylductuni, jhqizdtcia - sejhejrdcw)
-
19 Sep 2024
Concurrent Chemoradiotherapy+tislelizumab
(Arm B: Tislelizumab)
ybvqwzweiy(voqplommcb) = eklluqpxmc qicqtaagso (cylductuni, dphpxsxlea - udfuklmekb)
Phase 2
126
ociperlimaberlimab 90tislelizumab + tislelizumab [200 mg IV Q3W] + cCRT for 4 cycles, then ociperlimab + tislelizumab)
tmngdxkraq(nyfhffxrpu) = wsfarcfdsb vygtbpibpt (oiuuopjoeo )
Positive
05 Apr 2024
tislelizumablizumab + cCRT for 4 cycles, then tislelizumab)
tmngdxkraq(nyfhffxrpu) = ribcwplfaw vygtbpibpt (oiuuopjoeo )
Phase 2
Uterine Cervical Cancer
Second line
PD-L1
178
qjoznjpnek(ywojmqdfah) = vwypqpdngi zpzzwpsamq (jdavnjbwfv, 15.8 - 30.3)
Positive
22 Oct 2023
qjoznjpnek(ywojmqdfah) = llemxxrhst zpzzwpsamq (jdavnjbwfv, 17.2 - 36.9)
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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