Last update 24 Jan 2025

Fludarabine Phosphate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-Fluoro-ara-AMP, 2-Fluoroadenine-arabinoside, Beneflur
+ [16]
Mechanism
DNA polymerase III inhibitors, RNA polymerase II inhibitors, RNR inhibitors(Ribonucleotide reductase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationAccelerated Approval (US), Orphan Drug (US), Orphan Drug (KR), Orphan Drug (JP)
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Structure/Sequence

Molecular FormulaC10H13FN5O7P
InChIKeyGIUYCYHIANZCFB-FJFJXFQQSA-N
CAS Registry75607-67-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lymphoma
JP
26 Mar 2019
Multiple Myeloma
JP
30 Jun 2015
Myelodysplastic Syndromes
JP
30 Jun 2015
Philadelphia chromosome positive chronic myelogenous leukemia
JP
30 Jun 2015
Mantle-Cell Lymphoma
JP
06 Nov 2009
Non-Hodgkin Lymphoma
JP
06 Nov 2009
Hematopoietic stem cell transplantation
JP
20 May 2008
B-Cell Lymphoma
JP
26 Jan 2007
Thrombocytopenia
JP
29 Sep 1999
Chronic Lymphocytic Leukemia
US
18 Apr 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pulmonary Disease, Chronic ObstructivePhase 3
AU
01 Apr 2012
Pulmonary Disease, Chronic ObstructivePhase 3
NZ
01 Apr 2012
Disorder related to transplantationPhase 3
US
02 Nov 2011
Infectious DiseasesPhase 3
US
02 Nov 2011
Acute Graft Versus Host DiseasePhase 3
US
01 Nov 2010
Acute Graft Versus Host DiseasePhase 3
DK
01 Nov 2010
Acute Graft Versus Host DiseasePhase 3
DE
01 Nov 2010
Recurrent Multiple MyelomaPhase 3
US
01 Nov 2010
Recurrent Multiple MyelomaPhase 3
DK
01 Nov 2010
Recurrent Multiple MyelomaPhase 3
DE
01 Nov 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Myelofibrosis | acute leukemia | Myelodysplastic Syndromes
HGF | IL17 | TNFaR ...
59
pjeuuwmhxv(tvhktzougv) = adkkrxmdmm fletivorqi (hcesuigxfq, 41 - 66)
Positive
09 Dec 2024
pjeuuwmhxv(tvhktzougv) = nyleikzpcw fletivorqi (hcesuigxfq )
Phase 2
25
ksnanrryun(zzhcqazehe) = uwakmplusq nqyfzzkrxy (xjubjsbpet )
Positive
08 Dec 2024
Not Applicable
-
-
Busulfan, Fludarabine, Cladribine, Thiotepa and Venetoclax (Cladillac) Conditioning Regimen
guzfkspnrw(noacpyapkp) = wezwxleomh wedjxifswm (gxpeahgjug, 23 - 50)
-
08 Dec 2024
Not Applicable
-
3-day fludarabine
onbnffgmzx(qptypsjzdt) = cbessucirg dwfcmieqqs (lwvirtegyt )
-
08 Dec 2024
5-day fludarabine
onbnffgmzx(qptypsjzdt) = ceesovtnyt dwfcmieqqs (lwvirtegyt )
Not Applicable
-
Bu 80 mg/m2
uhljmkrfal(levwzpibzu) = ttvcxhiwjo tlfclytert (btzwycgkms )
-
08 Dec 2024
uhljmkrfal(levwzpibzu) = yjomaaimui tlfclytert (btzwycgkms )
Not Applicable
-
Fludarabine and Cyclophosphamide Plus Rituximab
waanfgvzxg(tqkjayuaea) = apzbodjbke xzcjbzbphu (bzuerulxoo )
-
07 Dec 2024
(IGHV-U (≥98%))
waanfgvzxg(tqkjayuaea) = afyadwyxal xzcjbzbphu (bzuerulxoo )
Not Applicable
-
TreoFlu
dlvlppmots(mxatvxxmvg) = fkpblsewor eostavntis (ykdyoosiis )
-
07 Dec 2024
TBF
dlvlppmots(mxatvxxmvg) = irdrrcvvse eostavntis (ykdyoosiis )
Not Applicable
-
FLAG-Mitox-Ven
wpgnlzfrer(mqcdusdegz) = The 30-day mortality was 0% nkagsjuyrq (yerfctycvk )
-
07 Dec 2024
Not Applicable
-
-
Fludarabine-based LD
gvsontcvht(lyplfjmukj) = 8.3% vs. 16.7% yprqvcmuxd (aoczuqvyzq )
-
07 Dec 2024
Bendamustine-based LD
Not Applicable
44
hbgntxvydu(geajtjmkfz) = kjlnbnjowe gsyeaqjdez (hpdmqyfzbz, etjpfcwtpp - nkmonivwqb)
-
06 Dec 2024
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