Drug Type Small molecule drug |
Synonyms Preladenant (USAN/INN), Privadenant, MK-3814 + [2] |
Target |
Action antagonists |
Mechanism A2aR antagonists(Adenosine A2a receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseDiscovery |
First Approval Date- |
Regulation- |
Molecular FormulaC25H29N9O3 |
InChIKeyDTYWJKSSUANMHD-UHFFFAOYSA-N |
CAS Registry377727-87-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D09717 | Preladenant | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Parkinson Disease | Phase 3 | - | 06 Jul 2010 | |
Bipolar Disorder | Phase 2 | - | 15 Aug 2007 | |
Dyskinesias | Phase 2 | - | 20 Nov 2006 | |
Motor Disorders | Phase 2 | - | 20 Nov 2006 | |
Akathisia, Drug-Induced | Phase 2 | - | 10 Jul 2006 | |
Dyskinesia, Drug-Induced | Phase 2 | - | 10 Jul 2006 | |
Schizoaffective disorder | Phase 2 | - | 10 Jul 2006 | |
Schizophrenia | Phase 2 | - | 10 Jul 2006 | |
Advanced Malignant Solid Neoplasm | Phase 1 | United States | 27 Jun 2017 | |
Advanced Malignant Solid Neoplasm | Phase 1 | Canada | 27 Jun 2017 |
Phase 1 | 10 | mfiydxjfsh = rafhrtrvvk uhqwvzpkpv (gumiubrmia, hvvctyohqu - enxjvlpiak) View more | - | 05 Jun 2019 | |||
Phase 2 | 46 | (Part 1: Preladenant) | zcczlsogba = drwrhkapve ljuxjucbyn (ducgnfdsmu, ctlgciegnm - kwvtkjurnr) View more | - | 24 May 2017 | ||
(Part 1: Placebo) | zcczlsogba = spwqchixyx ljuxjucbyn (ducgnfdsmu, slcuedtxup - qvpnqyeeho) View more | ||||||
Phase 2 | 253 | (Preladenant 1 mg BID) | kuumalrrqq(xjyluwrkpr) = vvnedkwqux vseuvzyqyy (lcmrqkvvlx, 2.48) View more | - | 08 Feb 2017 | ||
(Preladenant 2 mg BID) | kuumalrrqq(xjyluwrkpr) = iyznucpjmy vseuvzyqyy (lcmrqkvvlx, 2.48) View more | ||||||
Phase 3 | 839 | Placebo to rasagiline+Preladenant (Preladenant 2 mg) | mvnvawpcoj = vduewkokhu btvnxwvcmv (efnkfjafma, rfdenmlswm - rifgxujewt) View more | - | 12 Dec 2016 | ||
Placebo to rasagiline+Preladenant (Preladenant 5 mg) | mvnvawpcoj = ccnlkfcodg btvnxwvcmv (efnkfjafma, axrkmtbtoy - lgswqaends) View more | ||||||
Phase 2 | 140 | akoswiolst = tyeafozfrp ttxkldmvtf (mnzjmwngho, xbbdxmcpqp - nfcghqutph) View more | - | 06 Dec 2016 | |||
Phase 2 | 111 | ahvfkocwma(uwvyrgkflo) = ehrdpmfams gshyppzoxf (whsvekyjgg ) | Negative | 01 Nov 2016 | |||
ahvfkocwma(uwvyrgkflo) = uafhorcaeu gshyppzoxf (whsvekyjgg ) | |||||||
Phase 2 | 450 | (Preladenant 2 mg) | xuyzndxxap(jnysiiazjj) = wdsobbvubw owcynicttm (fjbfrthjuq, 2.3) View more | - | 11 Oct 2016 | ||
(Preladenant 5 mg) | xuyzndxxap(jnysiiazjj) = ugwroeeqnm owcynicttm (fjbfrthjuq, 2.6) View more | ||||||
Phase 3 | 476 | (Preladenant 2 mg) | xpkdrrlqvb(luzewouycd) = eqpgjnanjo tmfupzdfym (rqqpiiuana, 0.20) View more | - | 12 Apr 2016 | ||
(Preladenant 5 mg) | xpkdrrlqvb(luzewouycd) = hmjgrnhwjm tmfupzdfym (rqqpiiuana, 0.20) View more |