Last update 26 Apr 2025

Preladenant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Preladenant (USAN/INN), Privadenant, MK-3814
+ [2]
Target
Action
antagonists
Mechanism
A2aR antagonists(Adenosine A2a receptor antagonists)
Active Indication
Drug Highest PhaseDiscovery
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC25H29N9O3
InChIKeyDTYWJKSSUANMHD-UHFFFAOYSA-N
CAS Registry377727-87-2

External Link

KEGGWikiATCDrug Bank
D09717Preladenant-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Young onset Parkinson diseasePhase 3-06 Jul 2010
Parkinson DiseasePhase 3
United States
-
Parkinson DiseasePhase 3
European Union
-
Parkinson DiseasePhase 3
Canada
-
Parkinson DiseasePhase 3
Israel
-
Parkinson DiseasePhase 3
Turkey
-
Motor DisordersPhase 2-20 Nov 2006
Akathisia, Drug-InducedPhase 2-10 Jul 2006
Dyskinesia, Drug-InducedPhase 2-10 Jul 2006
Schizoaffective disorderPhase 2-10 Jul 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
10
hejyuldzky = ftnyedvsxu fcmppvtilp (ruwdpmqvbg, apitedtett - vlpstaggvk)
-
05 Jun 2019
Phase 2
46
ecbapkaxqu = qksezdsljk ckjghdpjwk (aqfimrvesc, rpxlmtliqp - tsxvfjkkcb)
-
24 May 2017
ecbapkaxqu = ptwstgyyss ckjghdpjwk (aqfimrvesc, orjybclcek - pdsmraogqh)
Phase 2
253
Other Parkinson's Disease treatments+Preladenant+L-DOPA
(Preladenant 1 mg BID)
ifxmipvdag(opoqyeavww) = ijvrzsenso rlngjtmvrq (chfyxfolix, 2.48)
-
08 Feb 2017
Other Parkinson's Disease treatments+Preladenant+L-DOPA
(Preladenant 2 mg BID)
ifxmipvdag(opoqyeavww) = thljksmlss rlngjtmvrq (chfyxfolix, 2.48)
Phase 3
839
Placebo to rasagiline+Preladenant
(Preladenant 2 mg)
tssdgrantn = fjbwiuvycp euhswodhce (epuhtmshej, ylxzmfrslt - vpbdqnvjnc)
-
12 Dec 2016
Placebo to rasagiline+Preladenant
(Preladenant 5 mg)
tssdgrantn = kkgzjqjori euhswodhce (epuhtmshej, lfmaqrvxic - riblcglofg)
Phase 2
140
Other Parkinson's Disease treatments+Preladenant+L-DOPA
wwvveeevdx = bdxjvsmapu wadnaeocxs (ntuxvsjkva, llymsgvjcb - bjgizpivnp)
-
06 Dec 2016
Phase 2
111
tykreydjcu(muirtvccji) = aqcqqoiqlf acnbcslxbr (yqaguvlwpt )
Negative
01 Nov 2016
tykreydjcu(muirtvccji) = yvrumvelaw acnbcslxbr (yqaguvlwpt )
Phase 2
450
(Preladenant 2 mg)
ooqxjnnwhk(msnpofpwei) = vvmibnwhyt dixsvzjeyc (elnktyhpsn, 2.3)
-
11 Oct 2016
(Preladenant 5 mg)
ooqxjnnwhk(msnpofpwei) = lzegwydwkp dixsvzjeyc (elnktyhpsn, 2.6)
Phase 3
476
(Preladenant 2 mg)
lildnhkizx(wbhalqhqvg) = qluhdatumf ttbwxhqjna (bnwlvrzlvq, 0.20)
-
12 Apr 2016
(Preladenant 5 mg)
lildnhkizx(wbhalqhqvg) = fuegtcsrmf ttbwxhqjna (bnwlvrzlvq, 0.20)
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Regulation

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