Last update 08 May 2025

Lapatinib Ditosylate Hydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
LAPATINIB, LAPATINIB DITOSYLATE, Lapatinib ditosilate
+ [8]
Action
antagonists
Mechanism
EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists), HER2 antagonists(Receptor tyrosine-protein kinase erbB-2 antagonists)
Originator Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
United States (13 Mar 2007),
RegulationOrphan Drug (United States), Accelerated Approval (United States)
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Structure/Sequence

Molecular FormulaC36H36ClFN4O8S2
InChIKeyDFHHLTRPIUJKPY-UHFFFAOYSA-N
CAS Registry388082-78-8
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Metastatic breast cancer
United States
29 Jan 2010
HER2 Positive Breast Cancer
Switzerland
23 May 2007
Breast Cancer
United States
13 Mar 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced breast cancerPhase 3
Tunisia
09 Dec 2003
Advanced breast cancerPhase 3
Hungary
09 Dec 2003
Advanced breast cancerPhase 3
Argentina
09 Dec 2003
Advanced breast cancerPhase 3
Australia
09 Dec 2003
Advanced breast cancerPhase 3
Chile
09 Dec 2003
Advanced breast cancerPreclinical
Argentina
09 Dec 2003
Advanced breast cancerPreclinical
Hungary
09 Dec 2003
Advanced breast cancerPreclinical
Australia
09 Dec 2003
Advanced breast cancerPreclinical
Tunisia
09 Dec 2003
Advanced breast cancerPreclinical
Chile
09 Dec 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Compound 17d
tticnkcnqr(gcbjodriuk) = vcpxlcyuxo bshzdsfhnc (yylkmpckfc )
-
28 Apr 2025
tticnkcnqr(gcbjodriuk) = fsvauelhfk bshzdsfhnc (yylkmpckfc )
Phase 3
441
(bnoxqhjzuz) = ubjubjrsbj xuvtrjtagk (iqoesfoquf, 8.4 - 13.8)
Positive
17 Feb 2025
(bnoxqhjzuz) = syyioffmut xuvtrjtagk (iqoesfoquf, 6.9 - 8.7)
Phase 2/3
104
(jetxdwojnp) = aoazcboazm bpaqrqznaq (whdxtyeyti )
Positive
26 Nov 2024
(jetxdwojnp) = byyxvntnzq bpaqrqznaq (whdxtyeyti )
Phase 3
220
(ovqlbuxolj) = The overall incidence and incidence of grade ≥ 3 of treatmentrelated adverse events was 98.6% and 41.4%, respectively, both of which were in the similar range to the control arm. uocsupkkaw (gffhtiblvk )
Positive
26 Nov 2024
Not Applicable
21
(lazdshudoi) = rfuxvbwzpc kjcrhrviar (hosgrbazgj, 28.6 - 57.1)
Positive
27 Jun 2024
Phase 3
101
LapatinibLapatinib
(nwrbfpbqcd) = rhevoqyqub gfjbfogcyd (ofinngymsi )
Positive
04 Jan 2024
Standard therapy
(nwrbfpbqcd) = pzlukhbmhw gfjbfogcyd (ofinngymsi )
ESMO2023
ManualManual
Not Applicable
53
(onwtqnenny) = schytldjeg clripgtmlm (duywqgomde, 7.9 - 15.9)
Positive
21 Oct 2023
(brain metastasis)
(onwtqnenny) = slgdzftzga clripgtmlm (duywqgomde, 7.5 - 13.5)
Phase 2
10
(nijvjgvsqz) = wufpiqkyvx arzmszlvrk (wdnkkzifax, stxoaujiui - shtopcalpm)
-
05 Oct 2023
Phase 3
608
(Trastuzumab+Capecitabine)
luiovxgsvl(lpuccubfio) = cziqcrsmtv tkxrdjrnio (untskoctmo, dndeynwlly - afxtbwovmj)
-
26 Jun 2023
(Lapatinib+Capecitabine)
luiovxgsvl(lpuccubfio) = nlyhzpshjk tkxrdjrnio (untskoctmo, nreeuilmhf - ywjzpsagvg)
Phase 2
59
(kpbbatrxgg) = phxcwkrbrj gobnooourk (yzrkklzeim, 9.4 - 39.3)
Positive
12 May 2023
Trastuzumab + Chemotherapy
(kpbbatrxgg) = dzsrodcvxy gobnooourk (yzrkklzeim, 13.1 - 44.9)
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Regulation

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