Drug Type Small molecule drug |
Synonyms JQ-2, RG 6146, RG6146 + [4] |
Target |
Mechanism BET inhibitors(Bromodomain and extra terminal domain protein inhibitors), BRD2 inhibitors(Bromodomain-containing protein 2 inhibitors), BRD3 inhibitors(Bromodomain-containing protein 3 inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 1 |
First Approval Date- |
Regulation- |
Molecular FormulaC27H34ClN7OS |
InChIKeyPKQXLRYFPSZKDU-QFIPXVFZSA-N |
CAS Registry1349719-98-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Ovarian Cancer | Phase 1 | US | 08 Nov 2017 | |
Ovarian Cancer | Phase 1 | AU | 08 Nov 2017 | |
Ovarian Cancer | Phase 1 | CA | 08 Nov 2017 | |
Ovarian Cancer | Phase 1 | DK | 08 Nov 2017 | |
Ovarian Cancer | Phase 1 | GB | 08 Nov 2017 | |
Triple Negative Breast Cancer | Phase 1 | US | 08 Nov 2017 | |
Triple Negative Breast Cancer | Phase 1 | AU | 08 Nov 2017 | |
Triple Negative Breast Cancer | Phase 1 | CA | 08 Nov 2017 | |
Triple Negative Breast Cancer | Phase 1 | DK | 08 Nov 2017 | |
Triple Negative Breast Cancer | Phase 1 | GB | 08 Nov 2017 |
Phase 1 | 39 | tfthjtjfmk(itufuprcqv) = neutropenia (28%) and anemia and thrombocytopenia (23% each) xdobfwwuwe (yvkcguqqun ) View more | Positive | 23 Nov 2021 | |||
Phase 1 | 32 | vojvtkuscd(kkmuzgdoit) = fatigue, injection site reactions, diarrhea, decreased appetite and nausea ataphwzllp (chbshnhdwy ) View more | Negative | 01 Jul 2021 | |||
Phase 1 | - | rjyxucegmk(dfhhwxkuhv) = fhvulcmtny wfxzkyvjbn (nbcfhdjpog ) View more | Positive | 01 Feb 2021 | |||
NCT03068351 (ASH2020) Manual | Phase 1 | 24 | xtgjrimlge(metnxyvqbg) = 1 pt in the 0.65 mg/kg cohort (thrombocytopenia grade 4, angina pectoris grade 3) ydlasykzcy (uhctoutipi ) View more | Negative | 05 Nov 2020 |