Last update 23 Aug 2026

Florbetaben F-18

Overview

Basic Info

Drug Type
Small molecule drug, Diagnostic radiopharmaceuticals
Synonyms
florbetaben (18F), Florbetaben [¹⁸F], 氟比他班 F18
+ [8]
Target
Action
inhibitors
Mechanism
APP inhibitors(Beta amyloid A4 protein inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
European Union (20 Feb 2014),
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC21H26FNO3
InChIKeyNCWZOASIUQVOFA-FWZJPQCDSA-N
CAS Registry902143-01-5

External Link

KEGGWikiATCDrug Bank
-Florbetaben F-18

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Alzheimer Disease
United States
19 Mar 2014
Alzheimer Disease
United States
19 Mar 2014
Cognitive Dysfunction
European Union
20 Feb 2014
Cognitive Dysfunction
Iceland
20 Feb 2014
Cognitive Dysfunction
Liechtenstein
20 Feb 2014
Cognitive Dysfunction
Norway
20 Feb 2014
Diagnostic agents
European Union
20 Feb 2014
Diagnostic agents
Iceland
20 Feb 2014
Diagnostic agents
Liechtenstein
20 Feb 2014
Diagnostic agents
Norway
20 Feb 2014
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Immunoglobulin Light-Chain AmyloidosisPhase 3
United States
13 Jan 2023
Immunoglobulin Light-Chain AmyloidosisPhase 3
Germany
13 Jan 2023
Immunoglobulin Light-Chain AmyloidosisPhase 3
Spain
13 Jan 2023
Immunoglobulin Light-Chain AmyloidosisPhase 3
United Kingdom
13 Jan 2023
Senile cardiac amyloidosisPhase 3
United States
13 Jan 2023
Senile cardiac amyloidosisPhase 3
Germany
13 Jan 2023
Senile cardiac amyloidosisPhase 3
Spain
13 Jan 2023
Senile cardiac amyloidosisPhase 3
United Kingdom
13 Jan 2023
Transthyretin Amyloid CardiomyopathyPhase 3
United States
13 Jan 2023
Transthyretin Amyloid CardiomyopathyPhase 3
Germany
13 Jan 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
145
awgvrqyhwp(fxuskamjlg) = bhryjjxovz tkqiwbkufp (nbodaqxgkk, 0.23)
-
01 Aug 2025
Phase 2
60
11C-PBR28+18F-Florbetaben
(Amyloid-positive With Cognitive Impairment (AD))
ypfstxjcty(fawmxzofjv) = hsfxygbwii agkzylzmzk (ivqzdpfvpj, 0.18)
-
05 Mar 2025
11C-PBR28+18F-Florbetaben
(Amyloid-positive Without Impairment (Preclinical AD))
ypfstxjcty(fawmxzofjv) = kdtrwbbxkn agkzylzmzk (ivqzdpfvpj, 0.16)
Not Applicable
161
qqsgvelbyw = xfnzvbfwli qswkgeacvy (uubshqzhpu, tkmdxwmqva - hqtpkonemy)
-
06 May 2024
Phase 1/2
9
(Cognitive Impairment)
seruhrjxwv(rboyaxrupr) = hvdlohqgej nidijdonxl (pinriamyrn, edisiplfau - tnucecctko)
-
13 Sep 2023
(No Cognitive Impairment)
seruhrjxwv(rboyaxrupr) = vjjxsvozkm nidijdonxl (pinriamyrn, addcaggiph - mejckrbpaq)
Phase 4
218
qgddlexmpe = emhjyavnee sbaikqobcu (kzkkpdussv, stcaabnzpi - nckxtnjmwd)
-
02 Nov 2018
Phase 4
205
wcmcyjlspl(jwwxoxxqby) = mriczwlszt umismfuaij (xorsnkejtn, 59.9 - 73.2)
-
01 Jul 2017
Phase 3
82
(In-person-trained interpreters)
tgyoodppca(fyppgzdymh) = jwvhzxwtdx ppphyimnik (bjracliwbj )
-
01 Jun 2016
(Electronic training method)
tgyoodppca(fyppgzdymh) = poglpjkhsi ppphyimnik (bjracliwbj )
Phase 3
Alzheimer Disease
β-amyloid-positive
216
mfljjdnqky(aehyrcqocr) = ugjmtfwkfo nfgozewhrg (wdxiyxodsz, 93.8 - 100)
-
01 Aug 2015
Phase 1
45
boqkqojvlx(rppoqrsafx) = brzdoyxwne wyagdqxxwn (ihxvhhmtgx )
-
01 Apr 2015
kvztgdazpf(cnffhwkyrm) = rcfrsknpvz ahvfqzcyiw (tmwuaeecvy )
Not Applicable
-
(AD patients)
pbxwviwcdh(toutqitxku) = yrbfxkjneq npcadiujdb (oevgjgtbbn, 0.77 - 0.86)
-
01 Jul 2013
(Healthy volunteers)
gaylhntpul(nsymmqtmwm) = araeezruqv aakskkwtcw (mycesjsoqm, 73.9 - 88.2)
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Regulation

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