Herombopag Olamine

Hetrombopag is a novel thrombopoietin receptor agonist that has shown an additive effect in stimulating platelet production when combined with recombinant human thrombopoietin (rhTPO). But it remains unclear whether this combination can promote hematopoietic reconstruction after autologous stem cell transplant (ASCT).

To compare the effect of recombinant human thrombopoietin (rhTPO) plus thrombopoietin receptor agonists (TPO-RA) versus rhTPO alone on hematopoietic recovery, adverse events, post-operative complications, and cost effectiveness in patients with newly diagnosed multiple myeloma (NDMM) undergoing autologous stem cell transplant (ASCT).

Sixty-seven NDMM consecutive patients who underwent ASCT at our hospital from January 2021 to May 2024 were included. Thirty-five patients received a combination of rhTPO and the TPO-RA hetrombopag after stem cell reinfusion (observation group), while 32 patients received rhTPO alone (control group). Hematopoietic reconstitution between the two groups was compared.

Baseline clinical characteristics were similar between both groups. In the observation group, the median time to platelet recovery was the 9 days after stem cell reinfusion, which significantly shorter than that in the control group (p=0.003). The mean number of platelet transfusion in the observation group was significantly lower than that in the control group (1.0 vs 2.0 units, p=0.034). All the patients tolerated rhTPO and TPO-RA well, with no thrombotic events observed. Survival analysis showed no reduction in time to progression (TTP) and overall survival (OS) with the addition of TPO-RA. There were no statistical differences in the incidence of adverse events, drug expenses and hospital stay between two groups (p > 0.05).

Although sample size and study design limit the data from this study, our findings suggest the combination of TPO-RA (hetrombopag) with rhTPO enhance platelet recovery in comparison to rhTPO alone, without increasing adverse effects.

This study aimed to investigate the effect of hetrombopag combined with conventional treatment on immune function in patients with severe aplastic anemia (SAA). Patients were categorized into the control group (n = 50, receiving conventional treatment only) and experimental group (n = 50, receiving hetrombopag combined with conventional treatment). Before treatment and at weeks 18, 24, and 52 after treatment, the two groups were compared in routine blood test indicators, natural killer (NK) cell activity, and peripheral blood inflammatory factor levels. The overall remission rate and incidence of adverse events were also compared between the two groups. Outpatient or telephone follow-up was performed before treatment and at weeks 18, 24, and 52 after treatment to observe patients' immune function, treatment outcome, quality of life, and adverse events. Hemoglobin (Hb), and platelet count (PLT) (P < 0.05), and a rise in NK cell activity (P < 0.05). Interleukin (IL-10) levels were significantly higher, while IL-6 levels were significantly lower in the experimental group compared to the control group (P < 0.05). After receiving the treatment, all scores of SF-36 domains in both groups were higher than before treatment, particularly with higher scores in the experimental group (P < 0.05). Hetrombopag combined with conventional treatment improved the immune function and hematopoiesis of patients with SAA.