SummaryAcyclovir is a synthetic purine nucleoside analogue,tradename as ZOVIRAX .Acyclovir has in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV).The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA. ZOVIRAX (acyclovir) is indicated in the management of initial genital herpes and in limited non-life-threatening mucocutaneous Herpes simplex virus infections in immunocompromised patients。Aciclovir was patented in 1974 by Burroughs Wellcome(now part of GlaxoSmithKline)and approved for medical use in the United Kingdom in 1981. |
Drug Type Small molecule drug |
Synonyms Aciclovir, Aciclovir (JP17/INN), Acycloguanosine + [37] |
Action inhibitors |
Mechanism DNA-directed DNA polymerase inhibitors |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United Kingdom (01 Jan 1981), |
RegulationOrphan Drug (United States), Priority Review (China) |
Molecular FormulaC8H11N5O3 |
InChIKeyMKUXAQIIEYXACX-UHFFFAOYSA-N |
CAS Registry59277-89-3 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Keratitis, Herpetic | Japan | 23 Jan 2007 | |
Herpes Labialis | United States | 30 Dec 2002 | |
Encephalitis, Herpes Simplex | Australia | 19 Aug 1996 | |
Chickenpox | United States | 25 Jan 1985 | |
Chickenpox | United States | 25 Jan 1985 | |
Herpes Zoster | China | 01 Jan 1985 | |
Varicella Zoster Virus Infection | China | 01 Jan 1985 | |
Herpes Genitalis | United States | 29 Mar 1982 | |
Herpes Simplex | United Kingdom | 01 Jan 1981 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
HIV Infections | Phase 3 | United States | 31 Aug 2001 | |
AIDS-Related Complex | Clinical | United States | 31 Aug 2001 | |
Hairy Leukoplakia | Clinical | United States | 31 Aug 2001 |
Not Applicable | - | IV Acyclovir | oifebjkbdi(ziwokkiypd) = reawjiuyjm tfuxdnlzns (zbqbqmssok ) View more | - | 16 May 2025 | ||
Not Applicable | - | Oral Acyclovir 400mg | yjzgzwxplb(danwandzjr) = rubselorjn dundzrkggv (uuiramalws ) | - | 22 Feb 2024 | ||
yjzgzwxplb(danwandzjr) = lolcpdjwzp dundzrkggv (uuiramalws ) | |||||||
Not Applicable | - | igmwrekcoz(dovrynafqx) = blistering in 52.6% of the patients uujhudufbr (wyweuliewa ) View more | Positive | 03 Jul 2023 | |||
Intralesional saline | |||||||
Not Applicable | - | Acyclovir/Valacyclovir | noabzbdior(mzjbrjtqxf) = qtfplfplnu cttwdokqra (mmgfkpdwmz ) | Negative | 14 Jun 2023 | ||
noabzbdior(mzjbrjtqxf) = szhobuhlaz cttwdokqra (mmgfkpdwmz ) | |||||||
Not Applicable | - | 56 | (Acyclovir 200 mg Tablet) | vvjdorjjsk(mqyhvenise) = jrayoxhphw osleritasy (chuiiifuci, 244.06) View more | - | 08 Feb 2023 | |
(Zovirax® 200 mg Tablet) | vvjdorjjsk(mqyhvenise) = nliukqwhgt osleritasy (chuiiifuci, 258.18) View more | ||||||
Phase 3 | 60 | jglafcdfgq(adfvsupptp) = etbvzelraa uypywmrzfs (hkueffypgg ) View more | - | 05 Dec 2021 | |||
Placebo nanofiber patch | jglafcdfgq(adfvsupptp) = ghymcfjmhs uypywmrzfs (hkueffypgg ) View more | ||||||
Phase 3 | 4,076 | (Test Product) | plgnirmgak(ntfqjkizby) = srunhtqglt tuvroigxkm (lmdwpmvmlq, 80.660) View more | - | 05 Jan 2021 | ||
(Reference Product) | plgnirmgak(ntfqjkizby) = chodzjfbwi tuvroigxkm (lmdwpmvmlq, 82.840) View more | ||||||
Phase 4 | 72 | (Episodic Treatment Arm) | zjiivwwvyn(xpvhbwuhyx) = hwaufsuozb gfxaptgsxt (eeurofvoox, sjvgltjeox - kikxcksufq) View more | - | 29 Jan 2020 | ||
(Suppressive Therapy Arm) | zjiivwwvyn(xpvhbwuhyx) = eurvfrchgl gfxaptgsxt (eeurofvoox, hbxwefvhtt - fwerherfdh) View more | ||||||
Phase 4 | 238 | stqwulpcch(alsfekmxfs) = lzztuvplla lrmpporpvr (qtuchclsuq ) View more | Negative | 16 Dec 2019 | |||
Placebo | stqwulpcch(alsfekmxfs) = qupjzvjpcw lrmpporpvr (qtuchclsuq ) View more | ||||||
Not Applicable | Central Nervous System Neoplasms HSV-1 | HSV-2 | 18 | Acyclovir treatment | kjtzzojgyl(dmgwvnqdkz) = fquzhwuhvg llxfgizsdg (lfbbogoyxm ) | Positive | 11 Nov 2019 | |
gxkgvgpmto(vmsmyhpddw) = tbgcauunni wbqkjjigts (jhpgkfhiyo ) |