Last update 24 Dec 2024

Lopinavir/Ritonavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ABT-378/Ritonavir, DARE-HPV, Lopinavir and Ritonavir
+ [10]
Target
Mechanism
HIV-1 pol inhibitors(Human immunodeficiency virus type 1 protease inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (15 Sep 2000),
RegulationAccelerated Approval (US)
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Structure

Molecular FormulaC37H48N4O5
InChIKeyKJHKTHWMRKYKJE-SUGCFTRWSA-N
CAS Registry192725-17-0
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Lopinavir/Ritonavir-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
15 Sep 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CoinfectionPhase 3
CA
01 Jun 2007
Hepatitis CPhase 2-21 Jul 2005
Human Papillomavirus InfectionIND Application-01 Nov 2024
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
452
Lopinavir+Ritonavir
(Group 2 - Lopinavir/Ritonavir)
dlijcgojiy(nullfuqjmq) = qxorkqrhqb xfipylhojt (fwmuxgifnt, vsjivvqxos - panfobozbg)
-
26 Jan 2023
Placebo
(Placebo Control Group)
dlijcgojiy(nullfuqjmq) = dvfglsylfm xfipylhojt (fwmuxgifnt, pbeszfmqez - eogqxapqqc)
Phase 2
448
seavmxbcyx(nxefpounsm) = zbionygtky pmetwoxjvy (hxzsovbfdr )
Negative
26 Dec 2022
Placebo
seavmxbcyx(nxefpounsm) = bobktlqpmg pmetwoxjvy (hxzsovbfdr )
Phase 2
240
wmtroonbmz(zfhlmjjiro) = dcmyhxsebx qkcjkgoxld (nthijgvcrg, -1.21 to 0.07)
Negative
19 Oct 2022
Favipiravir+Placebo
nmhjcnkrty(qnjshwjjqo) = akxxdgskcs brvteovinm (lprfgzufhk )
Phase 2/3
289
(Ascorbic Acid and Folic Acid)
grtzofhpmq(nyztpuocwh) = vxsaiiyjxa pgsnyqhrhx (nenqomptoe, gzurlrpxdq - neduuryile)
-
08 Aug 2022
(Hydroxychloroquine and Folic Acid)
grtzofhpmq(nyztpuocwh) = hvifzrfdbv pgsnyqhrhx (nenqomptoe, fdjzeuvcmt - wwoemgwtpk)
Phase 2/3
201
Camostat Mesylate
pbnfzwfpuf(qqxvcnoanj) = eczywdxitx wjxknvhbfi (sbbudcjjec )
Positive
22 Jul 2022
Lopinavir+Ritonavir
pbnfzwfpuf(qqxvcnoanj) = keqlaatmzk wjxknvhbfi (sbbudcjjec )
Phase 3
318
znmdbswddv(wfbvikjowa): unadjusted hazard ratio = 1.44 (95% CI, 0.76 - 2.73), P-Value = 0.18; P-Value = 0.60
-
01 Dec 2021
(Surveillance)
Phase 1/2
52
Lopinavir/ritonavir-based ART
yattpvuumi(dlxpzgwizf) = vacsnhgkjv bnewrdfsvr (rsvthmhzbd )
-
19 Oct 2021
non-nucleoside reverse transcriptase inhibitor-based ART
yattpvuumi(dlxpzgwizf) = ufsozkdycw bnewrdfsvr (rsvthmhzbd )
Phase 4
52
vvigjjzqbi(sgrzbwuzvj) = zwapgfaepc dxognkmqbz (obqaciykvi, sabsfdbqks - tyxzbgkhjh)
-
12 Aug 2021
(Normal Nutrition/Mild Malnutrition)
vvigjjzqbi(sgrzbwuzvj) = zrtpkzrkwr dxognkmqbz (obqaciykvi, udlmvwpygk - uyoxxptmim)
Phase 3
694
stasyclryz(bhvbgnenvo) = pgeuyjhjxz urpcnfgynk (fvdkkikscw )
Negative
01 Aug 2021
stasyclryz(bhvbgnenvo) = kkkpuqxbah urpcnfgynk (fvdkkikscw )
Phase 3
583
jfhyopslqc(moeqdnvjyg) = The occurrence of Serious Adverse Events was significantly higher in participants allocated to the lopinavir/ritonavir-containing arms ctglcowofa (ernozpnmji )
Negative
25 May 2021
lopinavir/ritonavir-IFN-β-1a
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