Drug Type Small molecule drug |
Synonyms ABT-378/Ritonavir, DARE-HPV, Lopinavir and Ritonavir + [10] |
Target |
Mechanism HIV-1 pol inhibitors(Human immunodeficiency virus type 1 protease inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (15 Sep 2000), |
RegulationAccelerated Approval (US) |
Molecular FormulaC37H48N4O5 |
InChIKeyKJHKTHWMRKYKJE-SUGCFTRWSA-N |
CAS Registry192725-17-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Lopinavir/Ritonavir | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
HIV Infections | US | 15 Sep 2000 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Coinfection | Phase 3 | CA | 01 Jun 2007 | |
Hepatitis C | Phase 2 | - | 21 Jul 2005 | |
Human Papillomavirus Infection | IND Application | - | 01 Nov 2024 |
Phase 2 | 452 | Lopinavir+Ritonavir (Group 2 - Lopinavir/Ritonavir) | dlijcgojiy(nullfuqjmq) = qxorkqrhqb xfipylhojt (fwmuxgifnt, vsjivvqxos - panfobozbg) View more | - | 26 Jan 2023 | ||
Placebo (Placebo Control Group) | dlijcgojiy(nullfuqjmq) = dvfglsylfm xfipylhojt (fwmuxgifnt, pbeszfmqez - eogqxapqqc) View more | ||||||
Phase 2 | 448 | seavmxbcyx(nxefpounsm) = zbionygtky pmetwoxjvy (hxzsovbfdr ) | Negative | 26 Dec 2022 | |||
Placebo | seavmxbcyx(nxefpounsm) = bobktlqpmg pmetwoxjvy (hxzsovbfdr ) | ||||||
Phase 2 | 240 | wmtroonbmz(zfhlmjjiro) = dcmyhxsebx qkcjkgoxld (nthijgvcrg, -1.21 to 0.07) | Negative | 19 Oct 2022 | |||
Favipiravir+Placebo | nmhjcnkrty(qnjshwjjqo) = akxxdgskcs brvteovinm (lprfgzufhk ) | ||||||
Phase 2/3 | 289 | (Ascorbic Acid and Folic Acid) | grtzofhpmq(nyztpuocwh) = vxsaiiyjxa pgsnyqhrhx (nenqomptoe, gzurlrpxdq - neduuryile) View more | - | 08 Aug 2022 | ||
(Hydroxychloroquine and Folic Acid) | grtzofhpmq(nyztpuocwh) = hvifzrfdbv pgsnyqhrhx (nenqomptoe, fdjzeuvcmt - wwoemgwtpk) View more | ||||||
Phase 2/3 | 201 | Camostat Mesylate | pbnfzwfpuf(qqxvcnoanj) = eczywdxitx wjxknvhbfi (sbbudcjjec ) View more | Positive | 22 Jul 2022 | ||
Lopinavir+Ritonavir | pbnfzwfpuf(qqxvcnoanj) = keqlaatmzk wjxknvhbfi (sbbudcjjec ) View more | ||||||
Phase 3 | 318 | znmdbswddv(wfbvikjowa): unadjusted hazard ratio = 1.44 (95% CI, 0.76 - 2.73), P-Value = 0.18; P-Value = 0.60 | - | 01 Dec 2021 | |||
(Surveillance) | |||||||
Phase 1/2 | 52 | Lopinavir/ritonavir-based ART | yattpvuumi(dlxpzgwizf) = vacsnhgkjv bnewrdfsvr (rsvthmhzbd ) | - | 19 Oct 2021 | ||
non-nucleoside reverse transcriptase inhibitor-based ART | yattpvuumi(dlxpzgwizf) = ufsozkdycw bnewrdfsvr (rsvthmhzbd ) | ||||||
Phase 4 | 52 | (Severe Malnutrition) | vvigjjzqbi(sgrzbwuzvj) = zwapgfaepc dxognkmqbz (obqaciykvi, sabsfdbqks - tyxzbgkhjh) View more | - | 12 Aug 2021 | ||
(Normal Nutrition/Mild Malnutrition) | vvigjjzqbi(sgrzbwuzvj) = zrtpkzrkwr dxognkmqbz (obqaciykvi, udlmvwpygk - uyoxxptmim) View more | ||||||
Phase 3 | 694 | stasyclryz(bhvbgnenvo) = pgeuyjhjxz urpcnfgynk (fvdkkikscw ) | Negative | 01 Aug 2021 | |||
stasyclryz(bhvbgnenvo) = kkkpuqxbah urpcnfgynk (fvdkkikscw ) | |||||||
Phase 3 | 583 | jfhyopslqc(moeqdnvjyg) = The occurrence of Serious Adverse Events was significantly higher in participants allocated to the lopinavir/ritonavir-containing arms ctglcowofa (ernozpnmji ) | Negative | 25 May 2021 | |||
lopinavir/ritonavir-IFN-β-1a |