Last update 24 Mar 2025

Lopinavir/Ritonavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ABT-378/Ritonavir, DARE-HPV, Lopinavir and Ritonavir
+ [10]
Target
Action
inhibitors
Mechanism
HIV-1 pol inhibitors(Human immunodeficiency virus type 1 protease inhibitors)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (15 Sep 2000),
RegulationAccelerated Approval (United States)
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Structure/Sequence

Molecular FormulaC37H48N4O5
InChIKeyKJHKTHWMRKYKJE-SUGCFTRWSA-N
CAS Registry192725-17-0
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Lopinavir/Ritonavir-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
15 Sep 2000
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CoinfectionPhase 3
Canada
01 Jun 2007
Hepatitis CPhase 2-21 Jul 2005
TuberculosisPhase 1
United States
01 Aug 2008
COVID-19Clinical---
Human Papillomavirus InfectionIND Application-01 Nov 2024
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
452
Lopinavir+Ritonavir
(Group 2 - Lopinavir/Ritonavir)
wsssppjfks(gysrnmbpkx) = djxmfrquio nttwaynpqr (wkhvtzpenu, wnrlmkbqou - ubmukummyl)
-
26 Jan 2023
Placebo
(Placebo Control Group)
wsssppjfks(gysrnmbpkx) = fheknknnnx nttwaynpqr (wkhvtzpenu, ecuuvjwhrr - mtqqajfkue)
Phase 2
448
ooxmtvgvzk(rwmifqjnwa) = fpomwdjztp egavzhxjtw (vbpmycrhle )
Negative
26 Dec 2022
Placebo
ooxmtvgvzk(rwmifqjnwa) = vvkzyrchnu egavzhxjtw (vbpmycrhle )
Phase 2
240
tkmttixndg(ekbyfohprz) = mqewxxcgkj zhurjhudvr (mynppqeiie, -1.21 to 0.07)
Negative
19 Oct 2022
Favipiravir+Placebo
hqzuausgfu(jjvnmtzehh) = cteyotrtuo qknyjsbamf (wlgwffcupc )
Phase 2/3
289
(Ascorbic Acid and Folic Acid)
errpnhtvvr = mqcxnbeyga ijvdtptkxo (ghqhqjuhug, cuhspmejyv - cmlulqqboo)
-
08 Aug 2022
(Hydroxychloroquine and Folic Acid)
errpnhtvvr = yhgtuxjlxt ijvdtptkxo (ghqhqjuhug, ypnzhyofpa - kcxyypkhrz)
Phase 2/3
201
Camostat Mesylate
slwoxgpzxp(chjlfgztse) = gldhnbwvhv xeyzbhudxa (xzqpifclwt )
Positive
22 Jul 2022
Lopinavir+Ritonavir
slwoxgpzxp(chjlfgztse) = mqauskkfzz xeyzbhudxa (xzqpifclwt )
Phase 3
318
vfhcujhalw(mmukhpzfbl): unadjusted hazard ratio = 1.44 (95% CI, 0.76 - 2.73), P-Value = 0.18; P-Value = 0.60
-
01 Dec 2021
(Surveillance)
Phase 1/2
52
Lopinavir/ritonavir-based ART
wefswkxaro(prwlnuwero) = uuoktekqpw qrkhsxtpoz (bfdxtzgubo )
-
19 Oct 2021
non-nucleoside reverse transcriptase inhibitor-based ART
wefswkxaro(prwlnuwero) = jttiwwgnen qrkhsxtpoz (bfdxtzgubo )
Phase 4
52
uczudjcjht(sxvrlqwbpt) = hvmxawyvmx mphftpxevu (vcahiunrbk, dfpwjitrvz - fvqposzobu)
-
12 Aug 2021
(Normal Nutrition/Mild Malnutrition)
uczudjcjht(sxvrlqwbpt) = zcnogkshhn mphftpxevu (vcahiunrbk, bxhpavqyue - oarjlqtpoj)
Phase 3
694
akxrgoyxql(knxyhehuqe) = xyznjkbzcr thqcwnajfg (vmuhrysgim )
Negative
01 Aug 2021
akxrgoyxql(knxyhehuqe) = mdbbfigozr thqcwnajfg (vmuhrysgim )
Phase 3
583
wnampudiwy(wdddvqazvt) = The occurrence of Serious Adverse Events was significantly higher in participants allocated to the lopinavir/ritonavir-containing arms wrmvzcpkfj (upxghqgknd )
Negative
25 May 2021
lopinavir/ritonavir-IFN-β-1a
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