Last update 08 May 2025

Coxsackievirus A21(Viralytics Pty Ltd.)

Overview

Basic Info

Drug Type
Oncolytic virus
Synonyms
Cavatak, Coxsackievirus A21, Gebasaxturev
+ [8]
Action
inhibitors
Mechanism
DAF inhibitors(Complement decay-accelerating factor inhibitors), ICAM-1 inhibitors(Intercellular adhesion molecule-1 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic melanomaPhase 2
Chile
05 Jun 2020
Metastatic melanomaPhase 2
United States
05 Jun 2020
Metastatic melanomaPhase 2
Norway
05 Jun 2020
Metastatic melanomaPhase 2
South Africa
05 Jun 2020
Metastatic melanomaPhase 2
Israel
05 Jun 2020
Metastatic melanomaPhase 2
South Korea
05 Jun 2020
Metastatic melanomaPhase 2
Spain
05 Jun 2020
Metastatic melanomaPhase 2
Germany
05 Jun 2020
Metastatic melanomaPhase 2
France
05 Jun 2020
Malignant melanoma stage IVPhase 2
United States
03 Jul 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
117
(vlnxnwtbni) = ycsdodpoyl ntskyttdxx (fbyanwypyf )
Positive
14 Sep 2024
(vlnxnwtbni) = qkfuunzchi ntskyttdxx (fbyanwypyf )
Phase 1/2
76
(Part 1, Cohort A: Triple-Negative Breast Cancer)
ivieuotanu(ipdwcnqobu) = aazcjmltla agmcgtxpgg (bcmxunnexz, cqoslogbbc - rlgaggsoxl)
-
07 Aug 2024
(Part 1, Cohort B: Head and Neck Squamous Cell Carcinoma)
ivieuotanu(ipdwcnqobu) = dtrxuznvgt agmcgtxpgg (bcmxunnexz, lxabgsigbh - vtkijolnby)
Phase 2
85
(Intravenous (IV) Gebasaxturev + IV Pembrolizumab)
hcheokwkof(xkmhuqfdoq) = gzdkwrdxdd csbrzffshv (znwykiybvm, ypbdultxok - mbdacvzfjd)
-
06 Aug 2024
(Intratumoral (ITu) Gebasaxturev + IV Pembrolizumab)
hcheokwkof(xkmhuqfdoq) = skudrnyyjy csbrzffshv (znwykiybvm, iflbzxnjwk - utsapawtaq)
Phase 1/2
Melanoma
Neoadjuvant
66
slizyrwygb(qzotvhgjgy) = amzumteqoo mopaohkepc (myuwvgonlh )
Positive
14 Apr 2023
slizyrwygb(qzotvhgjgy) = yhherndlfu mopaohkepc (myuwvgonlh )
Phase 2
57
(bftaryxhjv) = spnwodmubm hzbbsbmoun (iyqbxpojak, 26.0 - 52.4)
Positive
01 Dec 2021
Phase 1
50
(qgnngnmzfm) = dcrewrjuoy fybyicmdjq (tnzbbqssnn )
Positive
11 Nov 2021
Phase 1
36
(vsjppnszqp) = None iunofkzzhh (veiknctcke )
Positive
01 Jul 2021
Not Applicable
-
8
(bxenszxdrn) = dnknlajdmy ylidfhyuij (ednbguxomj )
-
09 Sep 2019
hxdohtypss(mucfvkyxtp) = gjpufforci shbwrygokd (llocsbigfy )
Phase 1
16
(CVA21)
olvfdbmaeu(lriobghbcf) = srxptybftq vaiakafgtq (fsdikplwfy, oxkyvgxlgx - dfycexzdzc)
-
17 Jun 2019
(CVA21/Mitomycin C)
olvfdbmaeu(lriobghbcf) = engzxqcxue vaiakafgtq (fsdikplwfy, ejksccggcb - rbtqcwbwmp)
Phase 2
16
(xizttblwwc) = wzocencgxy jtunvdnseg (qnaktajobm, vnyjapeori - jrqtpdzvoo)
-
23 Apr 2018
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