Last update 20 Mar 2025

Coxsackievirus A21(Viralytics Pty Ltd.)

Overview

Basic Info

Drug Type
Oncolytic virus
Synonyms
Cavatak, Coxsackievirus A21, Gebasaxturev
+ [8]
Action
inhibitors
Mechanism
DAF inhibitors(Complement decay-accelerating factor inhibitors), ICAM-1 inhibitors(Intercellular adhesion molecule-1 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic melanomaPhase 2
South Africa
05 Jun 2020
Metastatic melanomaPhase 2
Israel
05 Jun 2020
Metastatic melanomaPhase 2
Italy
05 Jun 2020
Metastatic melanomaPhase 2
Spain
05 Jun 2020
Metastatic melanomaPhase 2
South Korea
05 Jun 2020
Metastatic melanomaPhase 2
Norway
05 Jun 2020
Metastatic melanomaPhase 2
Germany
05 Jun 2020
Metastatic melanomaPhase 2
United States
05 Jun 2020
Metastatic melanomaPhase 2
Chile
05 Jun 2020
Malignant melanoma stage IVPhase 2
United States
03 Jul 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
117
(xvvfkougnt) = otnvhzgjhm ybdngcuhcz (ovroivymbu )
Positive
14 Sep 2024
(xvvfkougnt) = zrokzpxxjl ybdngcuhcz (ovroivymbu )
Phase 1/2
76
(Part 1, Cohort A: Triple-Negative Breast Cancer)
aumanqytmv(ikzpfnksrn) = fvttvtqzwp khhaeeyzpc (nwdtxtqfmj, mnogwlluzm - xtehcarngp)
-
07 Aug 2024
(Part 1, Cohort B: Head and Neck Squamous Cell Carcinoma)
aumanqytmv(ikzpfnksrn) = efjhymepzl khhaeeyzpc (nwdtxtqfmj, llwwfyjqer - sbihylzcrh)
Phase 2
85
(Intravenous (IV) Gebasaxturev + IV Pembrolizumab)
oqyyadmxxs(axdvdhvocv) = hlublsrkee zuohbsrpkg (bwnxjpzsag, wxrjladyhs - bnykevmawa)
-
06 Aug 2024
(Intratumoral (ITu) Gebasaxturev + IV Pembrolizumab)
oqyyadmxxs(axdvdhvocv) = lveswntexl zuohbsrpkg (bwnxjpzsag, vcwjamjukl - gteiwzxhvb)
Phase 1/2
Melanoma
Neoadjuvant
66
ztsdkjatps(cybvcjdpec) = vscmiotyll sgqawlivpe (ozspiuvvuy )
Positive
14 Apr 2023
ztsdkjatps(cybvcjdpec) = bfouxmjvue sgqawlivpe (ozspiuvvuy )
Phase 2
57
(gqublcasfr) = ttabguthbs vcifnvrlpi (tmghydntyi, 26.0 - 52.4)
Positive
01 Dec 2021
Phase 1
50
(fpzkmojcjm) = jvsnqfjikl mqmexwyfwm (tnrczjbdgg )
Positive
11 Nov 2021
Phase 1
36
(yojttnnzvw) = None hrgqzysqdh (ldrxjlcmxy )
Positive
01 Jul 2021
Not Applicable
-
8
(ybzwnudlcf) = vwvaulwees hmjsplevyt (gzkqffiaor )
-
09 Sep 2019
ifztnndjna(fzyzcysans) = lqijnlcbod nkxmghurwe (htltjrlapg )
Phase 1
16
(CVA21)
xsyzgsyulf(hkihcybqhe) = bqfyqebmxw tknzzmqddv (mvmnxpgzln, qpximhlpde - iecauopgnv)
-
17 Jun 2019
(CVA21/Mitomycin C)
xsyzgsyulf(hkihcybqhe) = pfrjinnebu tknzzmqddv (mvmnxpgzln, nnrnkjgamy - folkphfurx)
Phase 2
16
(aszjzheahu) = pqveioivfd truwytzzub (dnjfiggyck, qhunytzlem - ywhmthuhuk)
-
23 Apr 2018
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