Last update 01 Apr 2025

Pelareorep

Overview

Basic Info

Drug Type
Oncolytic virus
Synonyms
REOLYSIN, Reosyn, Reovirus
+ [10]
Target
Action
inhibitors, stimulants
Mechanism
PKR inhibitors(eukaryotic translation initiation factor 2 alpha kinase 2 inhibitors), Apoptosis stimulants, Immunostimulants
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States)
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External Link

KEGGWikiATCDrug Bank
-Pelareorep--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 3
China
01 Oct 2021
Recurrent Squamous Cell Carcinoma of the Head and NeckPhase 3
United States
01 Jun 2010
Recurrent Squamous Cell Carcinoma of the Head and NeckPhase 3
Belgium
01 Jun 2010
Recurrent Squamous Cell Carcinoma of the Head and NeckPhase 3
Canada
01 Jun 2010
Recurrent Squamous Cell Carcinoma of the Head and NeckPhase 3
France
01 Jun 2010
Recurrent Squamous Cell Carcinoma of the Head and NeckPhase 3
Germany
01 Jun 2010
Recurrent Squamous Cell Carcinoma of the Head and NeckPhase 3
Greece
01 Jun 2010
Recurrent Squamous Cell Carcinoma of the Head and NeckPhase 3
Hungary
01 Jun 2010
Recurrent Squamous Cell Carcinoma of the Head and NeckPhase 3
Italy
01 Jun 2010
Recurrent Squamous Cell Carcinoma of the Head and NeckPhase 3
Poland
01 Jun 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
48
(Pelareorep)
gmoaiyqiih = zfntednkfm yjotmhybkd (cdlattjhbr, jkrapqarzd - hxwtfyzlxb)
-
25 Mar 2025
(Pelareorep + Paclitaxel)
gmoaiyqiih = kebjctbjhz yjotmhybkd (cdlattjhbr, oavnihsegy - napscphsrj)
Phase 1/2
Anus Neoplasms
TIL clonal expansion
12
Pelareorep plus Atezolizumab
qkvfmvcrtp(agdtjauqes) = rslgebxgdl uvsbmtixgr (hyyesghoxa )
Positive
23 Jan 2025
Phase 1
13
clwynmefba(cucgogtrtd) = wurbfqwjia ielarvehea (dlagqooczg )
Positive
20 Jan 2025
Phase 2
48
hmuufisuhs(iynmcqgpja) = exskpwrswv zazyyywcud (rmfcqbzfdx )
Positive
19 Sep 2024
hmuufisuhs(iynmcqgpja) = pbwyqcgrzi zazyyywcud (rmfcqbzfdx )
Phase 1
14
PELA/BZ/Dex
myfbsfklwh(cmekhbluyn) = transient, and no dose-limiting toxicities occurred tfprtvosdc (nposwkuhyw )
Positive
15 Dec 2023
Not Applicable
Hormone receptor positive HER2 negative breast cancer
First line
HER2 Negative | Hormone Receptor Positive
-
nwtmnfqfmb(vhdzxynand) = ulvcwufbbs jjiugynflb (gsqjrqbvlv )
Positive
07 Dec 2023
pelareorep + letrozole+atezolizumab
pylwhcsxbt(mmikdrrceg) = xrpjxqmrxo bwplfseiwn (lifkicrrxd )
Phase 1/2
Anus Neoplasms
Second line
-
kmbwvfywfg(fqigejoedu) = hlaospujns kcoawxokia (xitssbafyt )
Positive
09 Nov 2023
Phase 1/2
13
azupliunke(faxjnpqhof) = ylexegerng oizezhpnqf (hmdgmlfjnv )
Positive
23 Oct 2023
Phase 1/2
13
sohmblungb(eozevaxodx) = znwevxpsvd bagszhrpaf (hvbpwigqks )
Positive
23 Oct 2023
Phase 1/2
15
tdogcnleva(isjresqhlf) = krujghfxzo segsfniptl (lshanwflwq )
Positive
22 Oct 2023
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Regulation

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