Delving into the Latest Updates on Ethyl chloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Ethyl chloride (USP), chloroethane, monochloroethane

Target-

Action-

Mechanism-

Therapeutic Areas

Nervous System DiseasesOther Diseases

Active Indication

Pain

Inactive Indication-

Originator Organization-

Active Organization

Gebauer Co.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC2H5Cl

InChIKeyHRYZWHHZPQKTII-UHFFFAOYSA-N

CAS Registry75-00-3

Fear of needles is a well-documented issue that affects many patients. This fear may cause significant anxiety in various medical situations, including in the dermatology office 1. If not properly managed, needle phobia can persist, affecting a patient's experience during each visit. This effect may compound and lead to avoidance behaviors that can delay necessary treatments 2. This issue is particularly relevant in a Mohs micrographic surgery (MMS) clinic where each patient experiences several painful needle injections before the day is over.
Ethyl chloride is gaining popularity among dermatologists for its routine use in clinical practice due to its anesthetic and antiseptic properties, especially as a pre-injection agent. Research indicates that cryotherapy or pre-cooling the skin before administering a local anesthetic may offer benefits over topical anesthetics, such as enhanced pain relief, quicker onset, and better patient compliance 3,4. However, to our knowledge, no studies have specifically examined the effectiveness of pre-cooling with ethyl chloride prior to Mohs micrographic surgery. To address this gap, we're conducting a trial aimed at evaluating the impact of pre-cooling with ethyl chloride on pain perception in adult patients undergoing Mohs micrographic surgery with local anesthetic injections.
The trial is a single-center, split-body study. The split-body design will involve dividing the surgical site into two equal halves, with one half (right side relative to patient) designated as the treatment side (receiving ethyl chloride spray prior to lidocaine injection) and the other as the control side (no ethyl chloride spray prior to injection). During the procedure, the participant will be asked to rate the pain associated with the needle injection AND the pain from infiltration of anesthetic from each side of the wound using the visual analog scale (VAS) scoring system (1 = no pain, 10 = most amount of pain possible). The results of the study will help us better understand how to mitigate pain and anxiety for patients requiring MMS.

Start Date01 Jun 2025

Sponsor / Collaborator

University of California, Davis

NCT06651788

/ Not yet recruitingNot ApplicableIIT

Does "Freeze Spray" Work? Evaluating the Efficacy of Ethyl Chloride Usage Prior to Orthopaedic Injections

A procedure frequently performed by orthopaedic providers is the administration of corticosteroid injections for the management of various soft tissues and joint-related conditions, such as osteoarthritis, tendinitis, carpal tunnel syndrome, trigger finger, and de Quervain's tenosynovitis. While these injections have demonstrated effectiveness in alleviating symptoms, the discomfort associated with the procedure can be a source of anxiety and apprehension for patients. This discomfort arises from the sensation of the needle entering the affected area and the burning sensation induced by the corticosteroid solution.

Start Date01 Jun 2025

Sponsor / Collaborator

The University of Chicago

NCT06596486

/ RecruitingNot ApplicableIIT

A Comparison of CoolStick and Ethyl Chloride Spray for the Assessment of Sensory Block to Light Touch and Cold Before Caesarean Section Under Spinal or Combined Spinal-epidural Anaesthesia

The main aim of this study is to compare CoolStick to ethyl chloride spray for the assessment of light touch following neuraxial anaesthesia for caesarean delivery.
Coolstick and ethyl chloride will also be compared for the assessment of cold sensation.
Participants will also be asked whether they experienced any intraoperative pain.

Start Date01 Nov 2024

Sponsor / Collaborator

Barts & The London NHS Trust

100 Clinical Results associated with Ethyl chloride

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100 Translational Medicine associated with Ethyl chloride

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100 Patents (Medical) associated with Ethyl chloride

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5,287

Literatures (Medical) associated with Ethyl chloride

01 Jul 2025·Journal of Pharmaceutical and Biomedical Analysis

Effect of Astragalus polysaccharide combined with cisplatin on exhaled volatile organic compounds as biomarkers for lung cancer and its anticancer mechanism

Article

Author: Zhang, Zhijuan ; Zhang, Huanqing ; Shi, Wenmin ; Feng, Weisheng ; Tang, Hanxiao

Cisplatin (DDP) is widely used to fight lung cancer, but there is a risk of immune damage. Astragalus polysaccharides (APS) is the main active component of Astragalus membranaceus Bunge. It has demonstrated anticancer properties across a range of cancer types as well as to be effective against cisplatin induced immune damage. However, its therapeutic mechanism has not been fully explored. This study aimed to explore the antitumor mechanisms of APS and elucidate the relationship between APS and volatile organic compounds (VOCs) in exhaled breath of Lewis lung cancer (LLC) mice. Gas chromatography-mass spectrometry (GC-MS) was utilized to analyze the exhaled VOCs in LLC mice. A specific group of VOCs was identified as potential biomarkers for monitoring tumor progression. Furthermore, the effects of combined treatment with APS and DDP on the concentration of exhaled VOCs in LLC mice was evaluated. Stoichiometric analysis revealed that the levels of 12 VOCs exhibited substantial recovery following APS treatment. And a high concentration of APS (400 mg/kg), when combined with DDP, exhibited enhanced antitumor efficacy. The metabolic pathways involved in the action of APS include 12 pathways. Our methodology elucidated both the effects and mechanisms of APS on lung cancer, as well as the pharmacological enhancement of cisplatin by APS. These findings facilitate real-time monitoring of lung cancer treatments and contribute to the future development of anticancer therapies.

01 Jun 2025·Food Chemistry

Antioxidant and chemosensory properties of rice (Oryza sativa L.) bran under different oven-roasting conditions

Article

Author: Yoon, Sojeong ; Moon, Hee Sung ; Park, Hyeonjin ; Yu, Se Young ; Hong, Seong Jun ; Ban, Younglan ; Shin, Eui-Cheol

In this study, the antioxidant and chemosensory properties of rice bran were evaluated under different oven-roasting temperatures (160 °C, 180 °C, and 200 °C) and durations (5 min, 10 min, and 15 min). The γ-oryzanol and total phenolic contents initially increased in raw rice bran but decreased with increasing roasting levels, whereas total flavonoid content initially decreased and then increased. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity exhibited a decreasing trend. Electronic tongue (E-tongue) analysis revealed that sweetness was decreased and bitterness was increased as accelerated roasting times and temperatures. Electronic nose (E-nose) analysis confirmed that the generation of vanillin was identified during roasting, which contributed to a vanilla-like odor. The roasting conditions enhanced γ-oryzanol contents while improving flavor were 200 °C for 5 min, 180 °C for 5 min or 10 min, and 160 °C for 5 min or 10 min. These findings provide fundamental insights into the potential use of rice bran by-products as food ingredients.

01 Jun 2025·Food Chemistry

Sensomics and chemometrics approaches of differential brewed and roasted coffee (Coffea arabica) from Ethiopia using biomimetic sensory-based machine perception techniques: Effects of caffeine on bitter taste and the generation of volatiles

Article

Author: Yu, Se Young ; Moon, Hee Sung ; Ban, Younglan ; Shin, Eui-Cheol ; Park, Hyeonjin ; Hong, Seong Jun

This study investigated the effects of caffeine in coffee extract (CE) prepared under various roasting and brewing conditions on non-volatile characteristics (antioxidant activity, caffeine contents, chlorogenic acid contents, and taste patterns) and volatile compounds. The representative taste of coffee is bitter taste, and it was mainly influenced by roasting processes compared with the contents of caffeine. Non-volatile compounds were influenced by the bean types (regular and decaffeinated beans) and brewing methods, whereas volatile compounds were mainly affected by the brewing methods and roasting processes. In chemometrics approaches, the correlation between caffeine and bitterness (-0.003) and sourness (0.549) was identified. The correlation between chlorogenic acid and bitterness (0.399) and sourness (0.693) was identified. This study is expected to serve as a basis for understanding changes in bitterness and the generation of volatile compounds according to the contents of caffeine.

100 Deals associated with Ethyl chloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D04088	-	-	DB13259

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Pain	United States	Gebauer Co.	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04207710 (CTgov)	Phase 4	Pain	72	Ethyl Chloride (Microbial Growth on Wrist After Application of Gebauer's Ethyl Chloride)	ttaqikgaav(qnexgqizeo) = xtmwiiuvjp pzewttsdwr (zychovpnff, sutgvdfpbf - punnyghkdj) View more	-	04 Mar 2024
				Ethyl Chloride (Microbial Growth on Lower Back After Application of Gebauer's Ethyl Chloride)	ttaqikgaav(qnexgqizeo) = aluxvzbniz pzewttsdwr (zychovpnff, vixlnimbyw - tjyvuwqylc) View more
NCT02587143 (CTgov)	Not Applicable	Pain \| Anesthesia	126	Alcohol (Control)	utbppxrylh(nlvetxghuw) = oxjlpqejaz gdediuzcww (pyglvnvphm, sugzptlsrb - uubmgkdvwt) View more	-	22 Jan 2020
				Ethyl chloride (Ethyl Chloride)	utbppxrylh(nlvetxghuw) = xppjjvyovc gdediuzcww (pyglvnvphm, cxadwxyjhq - faivlhikav) View more
NCT03054740 (CTgov)	Phase 4	Pain	30	Gebauer Ethyl Chloride (Gebauer Ethyl Chloride)	etwacmiqcz(zktwiwyjbo) = lvfjkohvyw grarjdfvrz (wpzelwcfdl, vbgcpuuciv - vaepycurhm) View more	-	03 Oct 2018
				Nature's Tears (Nature's Tears)	etwacmiqcz(zktwiwyjbo) = ioxzvudysp grarjdfvrz (wpzelwcfdl, nvgkahvybl - kosybpauez) View more
NCT02592629 (CTgov)	Phase 4	Shoulder Pain	19	lidocaine+Kenalog (no Topical or Subcutaneous Anesthetic)	hdxznlhqqj(hjeixxlzqc) = dqpidhdnle pdnzbzwgkf (hkurhklbsq, pqzjsgxyhq - vonqnppwst) View more	-	10 Sep 2018
				lidocaine+Kenalog (Subcutaneous Lidocaine)	hdxznlhqqj(hjeixxlzqc) = tspgjjpizs pdnzbzwgkf (hkurhklbsq, sfzjrqenjm - fnxmidecut) View more