Delving into the Latest Updates on Ethyl chloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Ethyl chloride (USP), chloroethane, monochloroethane

Target-

Action-

Mechanism-

Therapeutic Areas

Nervous System DiseasesOther Diseases

Active Indication

Pain

Inactive Indication-

Originator Organization-

Active Organization

Gebauer Co.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC2H5Cl

InChIKeyHRYZWHHZPQKTII-UHFFFAOYSA-N

CAS Registry75-00-3

A procedure frequently performed by orthopaedic providers is the administration of corticosteroid injections for the management of various soft tissues and joint-related conditions, such as osteoarthritis, tendinitis, carpal tunnel syndrome, trigger finger, and de Quervain's tenosynovitis. While these injections have demonstrated effectiveness in alleviating symptoms, the discomfort associated with the procedure can be a source of anxiety and apprehension for patients. This discomfort arises from the sensation of the needle entering the affected area and the burning sensation induced by the corticosteroid solution.

Start Date01 Feb 2025

Sponsor / Collaborator

The University of Chicago

NCT06596486

/ RecruitingNot ApplicableIIT

A Comparison of CoolStick and Ethyl Chloride Spray for the Assessment of Sensory Block to Light Touch and Cold Before Caesarean Section Under Spinal or Combined Spinal-epidural Anaesthesia

The main aim of this study is to compare CoolStick to ethyl chloride spray for the assessment of light touch following neuraxial anaesthesia for caesarean delivery.
Coolstick and ethyl chloride will also be compared for the assessment of cold sensation.
Participants will also be asked whether they experienced any intraoperative pain.

Start Date01 Nov 2024

Sponsor / Collaborator

Barts & The London NHS Trust

CTRI/2024/07/070481

/ Not yet recruitingPhase 2/3IIT

A Randomised Study to Compare the Effectiveness of One Spray versus Two Sprays of Ethyl Chloride of Reducing Venepuncture Induced Pain in Patients requiring IV Cannulation Before Surgery under Anaesthesia at SMS Medical College, Jaipur - Nil

Start Date31 Jul 2024

Sponsor / Collaborator-

100 Clinical Results associated with Ethyl chloride

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100 Translational Medicine associated with Ethyl chloride

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100 Patents (Medical) associated with Ethyl chloride

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5,274

Literatures (Medical) associated with Ethyl chloride

05 Mar 2025·Journal of the American Chemical Society

C₁-Based Route for Vinyl Chloride Synthesis with Environmental and Economic Benefits

Article

Author: Liu, Chengyuan ; Pérez-Ramírez, Javier ; Guillén-Gosálbez, Gonzalo ; Nabera, Abhinandan ; Zhao, Yilin ; Zou, Shihui ; Ren, Yutao ; Wei, Kunkun ; Pan, Yang ; Hu, Jingbo ; Liu, Juanjuan ; Bao, Yunxin ; Wang, Yong ; Wang, Yue ; Chen, Xutao ; Fan, Jie

Selective coupling of C₁ platform molecules to C₂ olefins is a cornerstone for establishing a sustainable chemical industry based on nonpetroleum sources. Vinyl chloride (C₂H₃Cl), one of the top commodity petrochemicals, is commercially produced from coal- or oil-derived C₂ hydrocarbon (acetylene and ethylene) feedstocks with a high carbon footprint. Here, we report a C₁-based route for vinyl chloride synthesis via the selective oxidative coupling of methyl chloride. This is enabled by a solid catalyst, featuring tungstate nanoclusters embedded in a zirconia matrix, which effectively captures ·CH₂Cl radicals homogeneously generated in CH₃Cl oxy-pyrolysis and selectively couples them into C₂H₃Cl. In situ synchrotron-based vacuum ultraviolet photoionization mass spectrometry provides direct experimental evidence of the homogeneous-heterogeneous reaction mechanism. The process achieves methyl chloride conversion of 10-65% with a high vinyl chloride selectivity (60-75%) at a reaction temperature of 650-750 °C, which is much lower than the traditional pyrolysis (>850 °C). The catalyst delivers stable performance (at a vinyl chloride yield of ca. 30%) with no deactivation observed during a 50 h test. Furthermore, combining with reaction of methanol and HCl to produce methyl chloride, we establish a methanol-to-vinyl chloride (MTV) route with the potential for significant reductions in climate change impact (24%) and cost (38%) compared to the state-of-the-art ethylene-based balanced process. A more remarkable 237% reduction in climate change impacts can be anticipated in the future-oriented green scenario for the MTV process primarily attributed to the utilization of renewable C₁ feedstocks that results in negative net contributions to the overall impacts.

01 Mar 2025·Phytochemical Analysis

Discrimination between raw and ginger juice processed Fructus Gardeniae based on UHPLC‐Q‐TOF‐MS and Heracles NEO ultra‐fast gas phase electronic nose

Article

Author: Lu, Tulin ; Fan, Xingchen ; Wang, Sichen ; Zhang, Kewei ; Dai, Guiyu ; Mao, Chunqin ; Qi, Yufang

AbstractIntroductionFructus Gardeniae (ZZ), a traditional Chinese herb, has been used in treating patients with jaundice, inflammation, etc. When mixed with ginger juice and stir‐baked, ginger juice‐processed Fructus Gardeniae (JZZ) is produced, and the chemical compositions in ZZ would be changed by adding the ginger juice.ObjectiveTo illuminate the differential components between ZZ and JZZ.MethodsHPLC, UHPLC‐Q‐TOF‐MS, and Heracles NEO ultra‐fast gas phase electronic nose were applied to identify the differential components between ZZ and JZZ.ResultsHPLC fingerprints of ZZ and JZZ were established, and 24 common peaks were found. The content determination results showed that the contents of shanzhiside, geniposidic acid, genipin‐1‐β‐D‐gentiobioside and geniposide increased, while the contents of crocin I and crocin II decreased in JZZ. By UHPLC‐Q‐TOF‐MS, twenty‐six possible common components were inferred, among which 11 components were different. In further investigation, eight components were identified as the possible distinctive non‐volatile compounds between ZZ and JZZ. By Heracles NEO ultra‐fast gas phase electronic nose, four substances were inferred as the possible distinctive volatile compounds in JZZ.ConclusionShanzhiside, caffeic acid, genipin‐1‐β‐D‐gentiobioside, geniposide, rutin, crocin I, crocin II, and 4‐Sinapoyl‐5‐caffeoylquinic acid were identified as the possible differential non‐volatile components between ZZ and JZZ. Aniline, 3‐methyl‐3‐sulfanylbutanol‐1‐ol, E‐3‐octen‐2‐one, and decyl propaonate were inferred as the possible distinctive volatile compounds in JZZ. This experiment explored a simple approach with objective and stable results, which would provide new ideas for studying decoction pieces with similar morphological appearance, especially those with different odors.

20 Feb 2025·The Journal of Physical Chemistry A

What Dictates the α-Effect in Gas-Phase S_N2 Reactions? A Density Functional Theory Study

Author: Poddar, Arpita ; Ayers, Paul W. ; Liu, Shubin ; Zhao, Dongbo ; Chattaraj, Pratim K.

The α-effect is an important concept in chem. and biochem., namely that for a bimol. nucleophilic substitution (S_N2) reaction, the nucleophilicity of an atom is increased if its adjacent (α) atom has a lone pair of electrons, lowering the reaction barrier height and increasing the reaction rate.However, exceptions exist, even for very similar structural motifs.We investigate what underlies the α-effect in gas-phase S_N2 reactions using two total energy decomposition schemes based on d. functional theory (DFT) and find that steric effects play an important role, but that there exists a strong linear correlation between the α-effect and electrostatic contribution, suggesting that it is the electrostatic interaction that stabilizes the transition state and leads to the α-effect in gas-phase S_N2 reactions.This multifaceted explanation resolves the long-standing uncertainty about the α-effect.We show that the α-effect increases with the branching of the central carbon atom.

100 Deals associated with Ethyl chloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D04088	-	-	DB13259

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Pain	United States	Gebauer Co.	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02587143 (CTgov)	Not Applicable	Pain \| Anesthesia	126	Alcohol (Control)	mgceimgmsq(azegwvqfjv) = phbuiwploa ysqfsxyxqy (qewvghfiyx, givntsgiml - eesrpfiwnh) View more	-	22 Jan 2020
				Ethyl chloride (Ethyl Chloride)	mgceimgmsq(azegwvqfjv) = iyvocygqye ysqfsxyxqy (qewvghfiyx, lgbbhngpcl - bufdqqzmjl) View more
NCT03054740 (CTgov)	Phase 4	Pain	30	Gebauer Ethyl Chloride (Gebauer Ethyl Chloride)	skbgyirseb(iwpslonjgb) = tqfdremkjh azigfeyvwo (mepwhcfxvu, wbgdfcxgnw - nbavsnbipa) View more	-	03 Oct 2018
				Nature's Tears (Nature's Tears)	skbgyirseb(iwpslonjgb) = xktcqaqonx azigfeyvwo (mepwhcfxvu, xjvzdboleh - sexxfvwafe) View more
NCT02592629 (CTgov)	Phase 4	Shoulder Pain	19	lidocaine+Kenalog (no Topical or Subcutaneous Anesthetic)	zdlqaqbjdz(lnyscsfggo) = ypunggotll sitppjdfab (irvsszfobo, rvtjwqnffi - urtogukiam) View more	-	10 Sep 2018
				lidocaine+Kenalog (Subcutaneous Lidocaine)	zdlqaqbjdz(lnyscsfggo) = xrrjziowcb sitppjdfab (irvsszfobo, ikickfallp - bnzonztded) View more