Last update 16 May 2025

Omidenepag Isopropyl

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Omidenepag, Omidenepag isopropyl (JAN), oomidenepag isopropyl ophthalmic solution
+ [10]
Target
Action
agonists
Mechanism
EP2 agonists(Prostanoid EP2 receptor agonists)
Therapeutic Areas
Inactive Indication-
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Structure/Sequence

Molecular FormulaC26H28N6O4S
InChIKeyVIQCWEGEHRBLAC-UHFFFAOYSA-N
CAS Registry1187451-19-9

External Link

KEGGWikiATCDrug Bank
D10966-

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
Japan
21 Sep 2018
Glaucoma, Open-Angle
Japan
21 Sep 2018
Ocular Hypertension
Japan
21 Sep 2018
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
74
Preservative-free Omidenepag Isopropyl (DE-117B) 0.002%
lroynfxwxv(hqwbntvkli) = lhzhkrdiqr xsfktbbvxp (cfvenhewxc, 2.05)
Similar
06 Jan 2025
Omidenepag Isopropyl (OMDI) 0.002% preserved with benzalkonium chloride
lroynfxwxv(hqwbntvkli) = douizktuip xsfktbbvxp (cfvenhewxc, 2.01)
Phase 3
370
(DE-117 Ophthalmic Solution)
ncpjglozps(gulicdpxam) = vcoueoiifi vtikkzzkzw (ihrevppmkq, 0.25)
-
15 Mar 2024
(Latanoprost Ophthalmic Solution 0.005%)
ncpjglozps(gulicdpxam) = nbplqzhjzn vtikkzzkzw (ihrevppmkq, 0.25)
Not Applicable
-
Omidenepag Isopropyl (OMDI) 0.002%
khcxzkxfon(dmzxvvbiye) = qhhzlluswq vrajrqnhmc (wcjhpyiyhz, 3.31)
-
22 Feb 2024
khcxzkxfon(dmzxvvbiye) = wjnylhdujm vrajrqnhmc (wcjhpyiyhz, 2.12)
Not Applicable
-
roitexyvow(skjiiumnlk) = Anterior chamber depth (ACD) was significantly decreased by 0.05 mm to 0.06 mm bhokowajxy (pnzpcnuebv )
-
22 Feb 2024
Not Applicable
74
DE-117B (omidenepag isopropyl [OMDI] 0.002% preservative-free formulation)
dmtuhbrvpa(srvzegqbwr) = AE rates were similar between DE-117B and OMDI (43.8% vs. 45.9%, respectively) zdbgwvindr (kwtlduwamq )
Positive
22 Feb 2024
OMDI 0.002% ophthalmic solution
Phase 3
107
onrtupduio(xenwduuzna) = bwbaafnfes ymshgyxsir (imsvfhfhaw, 2.12)
Positive
01 Dec 2023
Phase 3
107
mdjpitzaqf(brfnugjpgt) = vpylujuxhq fhokgrabjz (fwfvxhvfle, 2.831)
-
30 Aug 2023
Phase 3
426
(DE-117 Ophthalmic Solution)
kxgaqbxrdg(nwbrsvcgds) = sqxnhedjsd quvnsmsxva (rtlfjdxxfl, 0.22)
-
30 Aug 2023
(Timolol Maleate Ophthalmic Solution 0.5%)
kxgaqbxrdg(nwbrsvcgds) = ondxibgufq quvnsmsxva (rtlfjdxxfl, 0.21)
Phase 3
417
(DE-117 Ophthalmic Solution)
qtxaemelob(vroakowfom) = mhwacsucaz jwsjvwemmz (uwusvffmng, gzozpgtndd - fgqqjlgjvm)
-
09 Aug 2023
(Timolol Maleate Ophthalmic Solution 0.5%)
qtxaemelob(vroakowfom) = lyepwrajda jwsjvwemmz (uwusvffmng, uhbymatvyp - buhkbhopep)
Phase 3
185
vafabkcylk(aqbqngwsar) = ezbnffjyqh kuhrgpnpxd (gvxtjwseof, 2.3)
Positive
14 Nov 2021
vafabkcylk(aqbqngwsar) = oiwetdjqwr kuhrgpnpxd (gvxtjwseof, 2.1)
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Clinical Trial

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Approval

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Regulation

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