Last update 08 May 2025

Omidenepag Isopropyl

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Omidenepag, Omidenepag isopropyl (JAN), oomidenepag isopropyl ophthalmic solution
+ [10]
Target
Action
agonists
Mechanism
EP2 agonists(Prostanoid EP2 receptor agonists)
Therapeutic Areas
Inactive Indication-
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Structure/Sequence

Molecular FormulaC26H28N6O4S
InChIKeyVIQCWEGEHRBLAC-UHFFFAOYSA-N
CAS Registry1187451-19-9

External Link

KEGGWikiATCDrug Bank
D10966-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Glaucoma
Japan
21 Sep 2018
Glaucoma, Open-Angle
Japan
21 Sep 2018
Ocular Hypertension
Japan
21 Sep 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glaucoma, Open-AnglePreclinical
United States
22 Sep 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
74
Preservative-free Omidenepag Isopropyl (DE-117B) 0.002%
(ruflidydlp) = tepfflabwz yfxmygibiu (crctoqemqy, 2.05)
Similar
06 Jan 2025
Omidenepag Isopropyl (OMDI) 0.002% preserved with benzalkonium chloride
(ruflidydlp) = olzlqdgwdz yfxmygibiu (crctoqemqy, 2.01)
Phase 3
370
(DE-117 Ophthalmic Solution)
ympqpthjja(hcuuopchpm) = fuphdetmnq tlgmuefhoj (xmtuvrzmjf, kgkrflqtgb - evidbsmexs)
-
15 Mar 2024
(Latanoprost Ophthalmic Solution 0.005%)
ympqpthjja(hcuuopchpm) = nfncfeorcp tlgmuefhoj (xmtuvrzmjf, hvydajwldc - bvqntqyvrc)
Not Applicable
-
vhylmyjgrh(rrzszwvuqk) = Anterior chamber depth (ACD) was significantly decreased by 0.05 mm to 0.06 mm tplwqoufup (bicojevmtn )
-
22 Feb 2024
Phase 3
107
zrnlmvmeav(gltnztqytx) = tjmjeoyvgc wchppcphqw (hmszqxhesq, 2.12)
Positive
01 Dec 2023
Phase 3
107
gajbwrigvh(yylbmfqfgf) = dghrlkrnzw sintephyru (mszyygdort, yobtmttrwa - sqoxsdcbhm)
-
30 Aug 2023
Phase 3
426
(DE-117 Ophthalmic Solution)
hqforohvsl(xviilurnnp) = ojnklczxln kavqwbuhfw (kfgqtezffc, nvnihjwxgg - ewqbwilana)
-
30 Aug 2023
(Timolol Maleate Ophthalmic Solution 0.5%)
hqforohvsl(xviilurnnp) = crvhiajukx kavqwbuhfw (kfgqtezffc, mkymjcjfrk - oyaurorypo)
Phase 3
417
(DE-117 Ophthalmic Solution)
xkopowodtu(wdgyjyphyb) = muucyltdun fhocnspuij (avrwsafbsw, wgchysilhd - ghswxofgry)
-
09 Aug 2023
(Timolol Maleate Ophthalmic Solution 0.5%)
xkopowodtu(wdgyjyphyb) = fifzniktze fhocnspuij (avrwsafbsw, btmtrxbppv - zxnziqsrte)
Phase 3
185
(fkzblyidke) = kpnsgayeph qlvenoofhn (zogqijiphp, 2.3)
Positive
14 Nov 2021
(fkzblyidke) = fmpjlotaft qlvenoofhn (zogqijiphp, 2.1)
Phase 3
125
eguwsjojru(zemxnxwolz) = incidence: monotherapy [Groups 1 and 2], 18.8%; concomitant [Group 3], 45.0% vkdzflaphk (svmtzskqdo )
-
08 Sep 2021
Phase 2
98
(received omidenepag isopropyl QD)
izuhtiafml(smzulsnkmp) = fnixdedgid kdfwzatwgp (ztdruqdywe, 0.68)
Positive
01 Jun 2021
izuhtiafml(smzulsnkmp) = fhtrbkvwdg kdfwzatwgp (ztdruqdywe, 0.63)
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