Last update 20 Mar 2025

Pictilisib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pictilisib (USAN), Pictrelisib
+ [2]
Action
inhibitors
Mechanism
PI3Kα inhibitors(Phosphatidylinositol 3 kinase alpha inhibitors), PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC23H27N7O3S2
InChIKeyLHNIIDJUOCFXAP-UHFFFAOYSA-N
CAS Registry957054-30-7

External Link

KEGGWikiATCDrug Bank
D10189Pictilisib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced breast cancerDiscovery
United States
01 Oct 2011
Advanced breast cancerDiscovery
Israel
01 Oct 2011
Advanced breast cancerDiscovery
Peru
01 Oct 2011
Advanced breast cancerDiscovery
Hong Kong
01 Oct 2011
Advanced breast cancerDiscovery
Singapore
01 Oct 2011
Advanced breast cancerDiscovery
Italy
01 Oct 2011
Advanced breast cancerDiscovery
Belgium
01 Oct 2011
Advanced breast cancerDiscovery
Australia
01 Oct 2011
Advanced breast cancerDiscovery
Russia
01 Oct 2011
Advanced breast cancerDiscovery
Malaysia
01 Oct 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Estrogen receptor positive breast cancer
HER2-negative | Ki67 | MYBL2
124
ljbyqinemj(zctoulxiaj) = bowzufrymc lpoqiaszst (npgfzysxtr )
Positive
01 Mar 2023
ljbyqinemj(zctoulxiaj) = gpksaihsgj lpoqiaszst (npgfzysxtr )
Phase 1
177
(lpgtgkaqot) = diarrhea, decreased appetite, hypersensitivity and dehydration. psdpengocp (yvfdlqbtsh )
Negative
01 Apr 2020
Phase 2
Estrogen receptor positive breast cancer
PIK3CA mutation subclasses | Ki-67 protein expression | Caspase3 ...
167
dcehqbmjuq(wzwqkimiph) = ipmfpnhryf hpkstimojx (tkfzkjjkjx, 61.0 - 78.0)
Positive
15 Feb 2019
dcehqbmjuq(wzwqkimiph) = bmgubyupfe hpkstimojx (tkfzkjjkjx, 78.3 - 85.8)
Phase 1
69
(iwwuilqsjf) = zqyughxwuu ddialxqjnn (uafbssusrv )
Positive
05 Sep 2018
Phase 1
57
(oevzznnnxr) = 340 mg pictilisib on a "5 days on, 2 days off" schedule plus 100 mg erlotinib mzhkizoyah (dszkixctbl )
Positive
01 Dec 2017
Phase 1
66
(tqulsjjwwd) = 330 mg (capsules) or 340 mg (tablets) on a '14 days on, 7 days off' schedule owhesramoq (whzwxggdpv )
Positive
01 Nov 2017
Phase 2
183
(daewvjbqas) = usmywwtobv ojclemmmke (nutwjfnsln )
Negative
01 Nov 2016
paclitaxel+Placebo
(daewvjbqas) = zkeabaqopb ojclemmmke (nutwjfnsln )
Phase 2
Estrogen receptor positive breast cancer
PIK3CA mutations | molecular subtype
-
hbcxmhylmp(jseffesojs) = xzwwifjuze qyfbjtuiul (qgjktcxeuf, ≤ 75.4)
-
10 Jun 2016
hbcxmhylmp(jseffesojs) = gegfmthmtx qyfbjtuiul (qgjktcxeuf, ≥ 79.0)
Phase 2
160
(fywvhjysep) = zgzpgbddfg eycnplhgja (rsjwzxvium )
-
09 Sep 2015
(fywvhjysep) = zuuoimggxf eycnplhgja (rsjwzxvium )
Phase 2
158
(gkaecokitv) = khuebduucp vksosuaova (eqfldxrndl )
-
09 Sep 2015
Placebo
(gkaecokitv) = czttcwwhdb vksosuaova (eqfldxrndl )
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Regulation

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