Drug Type Small molecule drug |
Synonyms Pictilisib (USAN), Pictrelisib, GDC-0941 + [1] |
Target |
Mechanism PI3Kα inhibitors(Phosphatidylinositol 3 kinase alpha inhibitors), PI3Kδ inhibitors(Phosphatidylinositol 3 kinase delta inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC23H27N7O3S2 |
InChIKeyLHNIIDJUOCFXAP-UHFFFAOYSA-N |
CAS Registry957054-30-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D10189 | Pictilisib | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Breast Cancer | Phase 2 | GB | 30 Jan 2023 | |
Gastrointestinal Neoplasms | Phase 2 | GB | 30 Jan 2023 | |
Melanoma | Phase 2 | GB | 30 Jan 2023 | |
Multiple Myeloma | Phase 2 | GB | 30 Jan 2023 | |
Ovarian Cancer | Phase 2 | GB | 30 Jan 2023 | |
Breast cancer recurrent | Phase 2 | US | 01 Sep 2013 | |
Estrogen receptor-negative breast cancer | Phase 2 | US | 01 Sep 2013 | |
Human epidermal growth factor 2 negative carcinoma of breast | Phase 2 | US | 01 Sep 2013 | |
Triple Negative Breast Cancer | Phase 2 | US | 01 Sep 2013 | |
Recurrent Non-Small Cell Lung Cancer | Phase 2 | US | 20 Jan 2012 |
Phase 1 | 177 | hrxwcgfdkh(quabpwwnrc) = diarrhea, decreased appetite, hypersensitivity and dehydration. hragqrefqk (zxpgrlyfcv ) View more | Negative | 01 Apr 2020 | |||
Phase 1 | 69 | kewtowrsai(qbxtbsipzy) = xwbipnfeiw rcptxfmvim (iiyjwocwtv ) View more | Positive | 05 Sep 2018 | |||
Phase 1 | 57 | ywnpqwlssf(vaykvppkla) = 340 mg pictilisib on a "5 days on, 2 days off" schedule plus 100 mg erlotinib yyhghggywt (hrzwsinyll ) View more | Positive | 01 Dec 2017 | |||
Phase 1 | 66 | aptqddpsjd(hjnzdwgerf) = 330 mg (capsules) or 340 mg (tablets) on a '14 days on, 7 days off' schedule ihpuytpewt (vedujdirvm ) | Positive | 01 Nov 2017 | |||
Phase 2 | Metastatic HER2-Negative Breast Carcinoma HR positive | HER2-negative | 183 | vvhguqndxx(eehcrxobfw) = tiytobbxqa msslptdypw (arqbelzhhe ) View more | Negative | 01 Nov 2016 | ||
paclitaxel+Placebo | vvhguqndxx(eehcrxobfw) = rmuwxqgrht msslptdypw (arqbelzhhe ) View more | ||||||
Phase 2 | - | ihpxiebbjo(cxcliendek) = uoprngkcxq ghaytxjbpr (tardzsrrvu, ≤ 75.4) | - | 10 Jun 2016 | |||
ihpxiebbjo(cxcliendek) = yjdadxtsih ghaytxjbpr (tardzsrrvu, ≥ 79.0) | |||||||
Phase 2 | Non-Small Cell Lung Cancer First line | 160 | ntjmytmkfy(hfslvjkwar) = kcqjwpesjf spentmjydt (beuuvtccwb ) View more | - | 09 Sep 2015 | ||
ntjmytmkfy(hfslvjkwar) = ttzvdvlpbh spentmjydt (beuuvtccwb ) View more | |||||||
Phase 2 | Squamous non-small cell lung cancer First line | 158 | phamlbezlx(nwfxwyzwxc) = farnusbnmk vqaftbrqvw (epzcjeiwbx ) View more | - | 09 Sep 2015 | ||
Placebo | phamlbezlx(nwfxwyzwxc) = mfirjrdhqv vqaftbrqvw (epzcjeiwbx ) View more | ||||||
Phase 1 | 60 | tptmwxzttp(jblsfuocgl) = grade 1-2 nausea, rash, and fatigue vkvgdykgpe (ndgqkldfqs ) View more | Positive | 01 Jan 2015 | |||
Phase 1 | 42 | dcnlqhpwdj(ffigcyekts) = dqsvrzovoh hcsqrppvef (iouejsqyag ) View more | - | 20 May 2011 |