Delving into the Latest Updates on Demeclocycline Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

6-demethyl-7-chlorotetracycline, 7-chloro-6-demethyltetracycline, DMCT

+ [15]

Target

30S subunit

Action

inhibitors

Mechanism

30S subunit inhibitors(30S ribosomal subunit inhibitors), Protein biosynthesis inhibitors

Therapeutic Areas

Infectious DiseasesEndocrinology and Metabolic DiseaseEye Diseases+ [7]

Active Indication

Bacterial InfectionsHyponatremiaAcute Bronchitis+ [26]

Inactive Indication-

Originator Organization

Lederle Laboratories

Active Organization

Sun Pharma Japan Ltd.Mercury Pharmaceuticals Ltd.

Inactive Organization

Lederle Cyanamid Canada Inc

Lederle Laboratories

Drug Highest PhaseApproved

First Approval Date

United States (14 Jan 1960),

Bacterial Infections

Regulation-

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Structure/Sequence

Molecular FormulaC21H21ClN2O8

InChIKeyFMTDIUIBLCQGJB-SEYHBJAFSA-N

CAS Registry127-33-3

View All Structures (2)

Heterogeneous Fenton-like system is a promising technique for wastewater treatment, while Fe2+ regeneration limits its degradation efficiency.Piezoelec. materials can produce free electrons under mech. stress.Based on this, a piezoelec. Fenton-like system coupling piezoelec. effect and Fenton-like reaction was proposed.Composite material BaTiO3/α-FeOOH was synthesized by sol-gel and hydrothermal method.Under ultrasonic vibration BaTiO3 continuously generated free electrons, which reduced Fe3+ to Fe2+ and realized Fe3+/Fe2+ cycle.The piezoelec. Fenton-like system based on BaTiO3/α-FeOOH was used to remove demethylchlortetracycline (DMCT) from water.The degradation ratio of DMCT can reach 100% within 5 min, and the coupled system exhibited excellent adaptability and stability.Free radical capture and quant. detection determined that .OH and .O-2 were the main active oxygen species.A comprehensive catalytic mechanism was proposed and supported by energy band structure anal., finite element method simulation, and D. Functional Theory (DFT) simulation calculationsThe piezoelec. electrons generated by BaTiO3 were transfered to α-FeOOH to improve the Fe3+/Fe2+ cycle.In addition, the possible degradation mechanism of DMCT was proposed through Ultra Pressure Liquid Chromatog.-Mass Spectrometry (UPLC-MS) measurement and DFT calculation, and the overall pollution toxicity of DMCT was assessed according to toxicity prediction.Overall, this work provided a new insight on coupling effect between piezoelec. effect and Fenton-like reaction.

01 Mar 2025·Water Research

Computational simulation of bioaccumulation and trophic transfer of antibiotics mechanisms in aquatic food chain

Article

Author: Ni, Hong-Gang ; Zhou, Jing-Xuan ; Peng, Zhao-Xing ; Zheng, Zi-Yi

Numerous antibiotics have been detected in aquatic ecosystems and induced severe toxic effects on aquatic organisms. However, mechanisms of bioaccumulation and trophic transfer of antibiotics are not adequately discussed, to the best of our knowledge. In this context, the bidirectional selective effect values (BSEV) and trophic transfer efficiency ratio (TTER) of 24 antibiotics in a simulated food chain (Chlorella sorokiniana-Daphnia magna-Danio rerio) were first calculated to mirror the bioaccumulation and biomagnification. Based on estimates above, the multi-output machine learning (ML) models, including K nearest neighbor (KNN), Support vector machine (SVM), Extremely randomized trees (ERT) and Extreme gradient boosting (XGBoost), were constructed, followed by molecular dynamics (MD) simulation and density functional theory (DFT) calculation to explore the bioaccumulation and biomagnification mechanism. According to our results, sulfonamide antibiotics had greater capacity biomagnification, while β-lactam and tetracycline antibiotics showed opposite results. Meanwhile Cytochromes P450 (CYP450) in Danio rerio played a key role in the food chain. The ERT model exhibited reliable prediction with indicators of R² = 0.816, MAE = 0.039, MSE = 0.003, RMSE = 0.053 and MAPE = 8.923. The AATS5s was identified as the most contributing descriptor. The differences in the atomic composition, structure and binding ability to enzymes of antibiotics lead to the differences in their bioaccumulation. Van der Waals interactions (ΔE_vdw) and non-polar interactions (ΔG_nonpolar) were the main driving energy for the biometabolism capability of antibiotics. Tetracyclines are the most readily biometabolized, whereas sulfonamides are more difficult to biometabolize due to their low binding capacity and low reactivity.

01 Dec 2024·Journal of Hazardous Materials

Occurrence, removal and environmental risk assessment of pharmaceutical active compounds (PhACs) and metabolites in hospital wastewater

Article

Author: Ma, Chunmeng ; Niu, Jiangqi ; Wang, Hui ; Lu, Yanna ; Qiao, Xiaocui ; Liu, Yan ; Wang, Haiyan

In recent years, the widespread detection of pharmaceuticals and personal care products (PPCPs) in aquatic environments has become a global concern, and wastewater discharged from hospitals is an important source. This study investigated the occurrence, removal efficiency and risk assessment of 74 commonly used pharmaceutical active compounds (PhACs), including 58 antibiotics, seven psychiatric drugs, four nonsteroidal anti-inflammatory drugs, three β-blockers and two lipid regulators, at wastewater treatment plants (WWTPs) in 11 hospitals. A total of 51 PhACs were detected in the wastewater effluents of 11 hospitals, with concentrations of 0.00089 (alprenolol) ∼ 69 µg/L (acetaminophen) in the influent samples and 0.00057 (alprenolol) ∼ 5.7 µg/L (theophylline) in the effluent samples. Under the same scales, the concentrations of PhACs in the influent of psychiatric hospital WWTP were 1.16 times and 2.28 times greater than those of general hospital and infectious disease hospital, respectively, and the concentrations in small and large hospitals were comparable and were approximately 1.73 times greater than those in medium hospitals, suggesting the influence of the hospital type and scale on the discharge characteristics of PhACs. The removal efficiency of PhACs ranged from negative to 100 %. The removal efficiency of the membrane bioreactor (MBR) was 53.98 %, which was better than that of the biological contact oxidation (BCO). An environmental risk assessment revealed that the PhACs detected in hospital wastewater might pose potential risks to the aquatic environment. In addition, attention should be paid to the management of wastewater discharge in special hospitals and small and medium hospitals. This study provides a basis for the management and control of PhACs in hospitals in China.

100 Deals associated with Demeclocycline Hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D00290	Demeclocycline Hydrochloride	J01AA01 D06AA01	DB00618

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Acute Bronchitis	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Cystitis	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Dacryocystitis	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Gas Gangrene	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Gonorrhea	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Intrauterine infection	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Laryngitis	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Lymphogranuloma Venereum	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Mastitis	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Osteomyelitis	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Otitis Externa	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Otitis Media	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Pharyngitis	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Pneumonia	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Scarlet Fever	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Secondary infection	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Sinusitis	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Tonsillitis	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Tularemia	Japan	Sun Pharma Japan Ltd.	01 Nov 1965
Urethritis	Japan	Sun Pharma Japan Ltd.	01 Nov 1965

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


WCLC2015	Not Applicable	Small Cell Lung Cancer	132	Chemotherapy alone	(yzkyvlykjs) = nmdznblgvd tlfwyrvedh (vtqakxstep )	-	08 Sep 2015
				Chemotherapy plus Demeclocycline	(yzkyvlykjs) = oaqbgmuwii tlfwyrvedh (vtqakxstep )