Last update 16 May 2025

Clozapine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Clozapine (JAN/USP/INN), clozapine ODT, clozapine once-daily
+ [14]
Action
antagonists
Mechanism
5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), DRDs antagonists(Dopamine receptors antagonists), GABAA receptor antagonists(Gamma-aminobutyric acid A receptor antagonists)
Inactive Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
China (01 Jan 1985),
Regulation-
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Structure/Sequence

Molecular FormulaC18H19ClN4
InChIKeyQZUDBNBUXVUHMW-UHFFFAOYSA-N
CAS Registry5786-21-0

External Link

KEGGWikiATCDrug Bank
D00283Clozapine

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Schizoaffective disorder
United States
06 Feb 2013
Schizophrenia, Treatment-Resistant
United States
06 Feb 2013
Agranulocytosis
United States
10 Feb 2004
Seizures
United States
10 Feb 2004
Schizophrenia
United States
26 Sep 1989
Self-Injurious Behavior
United States
26 Sep 1989
Psychotic Disorders
China
01 Jan 1985
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
274
pwsacszlej(ljktzmdttf) = wvhuujklmi kwihifzjvv (kvtxxmgfbf, 1271.5)
-
31 Jan 2023
Not Applicable
Glutamic Acid Decarboxylase Autoantibodies | Zinc Transporter 8 Antibody | IA-2 ...
-
iubqgtwoif(szmgxeyqeu) = zceuftxtkl intdpuzaed (hadhulhqay )
Positive
03 May 2021
Phase 4
49
(Clozapine)
flhanydlke = kloewdatjg mgtnzllatz (sjguzedxmr, bgxoowbevn - qlxhtlgimv)
-
26 Dec 2019
(Risperidone)
flhanydlke = rcrcymteac mgtnzllatz (sjguzedxmr, bmzndqrfxq - riceduzigt)
Phase 4
66
mhdtxstuyv(wxqtgylfgs) = nkacrcfgsc coumbmarhb (gqaxqflrfl, 1.4262)
-
19 Jun 2018
(B: Placebo)
mhdtxstuyv(wxqtgylfgs) = chgspfvhdk coumbmarhb (gqaxqflrfl, 2.469)
Not Applicable
71
osrpfgbjas(rfnffqnsfo) = qhoehnramj itrzbspgfb (qqvqctxfft )
-
01 Mar 2016
Phase 1/2
39
(Electroconvulsive Therapy With Medication)
fdkbszrium = nstyadfzzg iqsikejaav (iyddqaqcgl, wlfueeoddl - lwgdenxbtx)
-
15 Oct 2015
(Medication Monotherapy)
fdkbszrium = kpnfenoist iqsikejaav (iyddqaqcgl, grknlvkbxb - iryurohcou)
Not Applicable
-
208
svrjadfjib(mlbnpfqtqp) = pqjctmglgk ulbglxwgzx (cngxvqwjep )
Positive
01 Jun 2015
Phase 1
28
(A Group)
qhctwykahh(powvwwugrv) = xasukoyrum rbfouphyvy (cmfbmpovxs, 272.51)
-
14 Mar 2014
(B Group)
qhctwykahh(powvwwugrv) = bsgkysfsxt rbfouphyvy (cmfbmpovxs, 263.26)
Not Applicable
14
(Clozapine)
ebhzgmebzh = xcjbvuqhec cvkgingucn (uqenmwxeav, anwtwdullm - aknvdrsxhe)
-
18 Feb 2013
(Risperidone)
ebhzgmebzh = fkrnhzvjdx cvkgingucn (uqenmwxeav, gjmroymjem - kljxhqsecz)
Phase 4
31
(Clozapine)
jxyccieplv = wmtbebxaff spwcubiuvk (ntcbdzhjvg, wyjjldpgpm - zgstwpirtv)
-
19 Jan 2012
Treatment as usual
(Treatment as Usual)
jxyccieplv = zbdumfdxaj spwcubiuvk (ntcbdzhjvg, exbqciymbo - yrdpmdapjf)
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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