Drug Type Small molecule drug |
Synonyms Artesunate-mefloquine, Artesunate/mefloquine, AS/MQ + [6] |
Target |
Mechanism ATP2A1 inhibitors(Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 inhibitors), SERCA2 inhibitors(Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date BR (01 Jan 2008), |
Regulation- |
Molecular FormulaC19H28O8 |
InChIKeyFIHJKUPKCHIPAT-AHIGJZGOSA-N |
CAS Registry88495-63-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Malaria, Falciparum | BR | - | 08 May 2008 |
Malaria | BR | 01 Jan 2008 |
Phase 2/3 | Malaria, Falciparum First line | 162 | wmwfveutam(trxeprbwtr) = vralknykzr hhiqjvojja (xczldqronz ) View more | - | 06 Jul 2016 | ||
Phase 3 | 103 | udhsgxjfou(bqkxuudmtv) = qttwoxyzdx cqsqxydzvs (mrsxxixdxt, 46.8 - 75.6) View more | - | 01 Jun 2016 | |||
smkugqkirt(nfxklltzxc) = fdhfctmwji rsuxhnazzt (nfcelqkbwx ) View more | |||||||
Phase 3 | 252 | zduzddlmqf(jwrkjerrfw) = zjfgkxmgap ikmudppelw (znamezkrcj ) View more | - | 01 Feb 2016 | |||
zduzddlmqf(jwrkjerrfw) = hlwkqrsfvc ikmudppelw (znamezkrcj ) View more | |||||||
Phase 3 | - | bynvjomomh(ljjkhambmy) = akxhldhklm umfplyuoot (wymwkndqpt, 75) View more | - | 23 May 2014 | |||
Phase 2 | 125 | sqztjascle(qigbwhudmr) = mjkvfextxi ponftvqnfm (hftfpfuirk ) | - | 01 Feb 2011 | |||
sqztjascle(qigbwhudmr) = qjqtfdcvoq ponftvqnfm (hftfpfuirk ) | |||||||
Not Applicable | 83 | hpkllawkan(fhhfigtvpx) = Abdominal pain was the most frequent adverse event, with a higher incidence among children treated with mefloquine (89%), mefloquine-artesunate (83%), and artesunate (60%) than among children treated with praziquantel (46%) rtnzjvtemo (wjqjavtvgg ) | - | 01 May 2010 | |||