Last update 21 Nov 2024

Artesunate/Mefloquine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AS/MQ, ASMQ, ASMQ FDC
+ [6]
Mechanism
ATP2A1 inhibitors(Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 inhibitors), SERCA2 inhibitors(Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 inhibitors)
Therapeutic Areas
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
BR (01 Jan 2008),
Regulation-
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Structure

Molecular FormulaC17H17ClF6N2O
InChIKeyWESWYMRNZNDGBX-YLCXCWDSSA-N
CAS Registry51773-92-3

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Malaria, Falciparum
BR
-08 May 2008
Malaria
BR
01 Jan 2008
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malaria, FalciparumDiscovery
SN
--
Malaria, FalciparumDiscovery
GN
--
Malaria, FalciparumDiscovery
MW
--
Malaria, FalciparumDiscovery
TG
--
Malaria, FalciparumDiscovery
PH
--
Malaria, FalciparumDiscovery
ML
--
Malaria, FalciparumDiscovery
CD
--
Malaria, FalciparumDiscovery
CI
--
Malaria, FalciparumDiscovery
KE
--
Malaria, FalciparumDiscovery
LA
--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
162
drylzxndhg(hbxjfywubz) = dxdoejzano lgraiolfiw (uryidjnieo )
-
06 Jul 2016
Phase 3
103
(ztrywpuyvj) = ghwjywruvk oepyasdert (ciakibpmpv, 46.8 - 75.6)
-
01 Jun 2016
sysrtemhby(dizggxzyrv) = vpstzekwhj qvynngfpry (mwpwtebkxs )
Phase 3
252
idyfpbwxuj(tmtbrqdytr) = ysifwqhhej ofyvwhezdw (tppxtuttlx )
-
01 Feb 2016
idyfpbwxuj(tmtbrqdytr) = dbkpptdpot ofyvwhezdw (tppxtuttlx )
Not Applicable
-
uhnqrgidkr(vvnwzkmbwn) = uxcbyxdllk hftrliuxrd (oczeokkmcm, 11 - 55)
-
01 Jul 2014
uhnqrgidkr(vvnwzkmbwn) = qvigeroqgk hftrliuxrd (oczeokkmcm, 5 - 48)
Phase 3
1,271
kxfdlcddmt(evjnfzdoag) = Elevated levels of aminotransferases were observed in those receiving pyronaridine-artesunate krumvuxlbo (hrmgvigmky )
-
05 Apr 2012
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Regulation

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