Last update 29 May 2025

Chloroquine hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Chloroquine hydrochloride (USP), Aralen hydrochloride
Action
inhibitors
Mechanism
DNA intercalators, Hemozoin inhibitors, Autophagy inhibitors
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhasePhase 2
First Approval Date
United States (31 Oct 1949),
Regulation-
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Structure/Sequence

Molecular FormulaC18H28Cl3N3
InChIKeyPCFGECQRSMVKCC-UHFFFAOYSA-N
CAS Registry3545-67-3

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Amebiasis
United States
31 Oct 1949
Malaria
United States
31 Oct 1949
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
TuberculosisPhase 2
India
-
COVID-19Preclinical
China
04 Feb 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
Patients taking hydroxychloroquine (HCQ) for 5 years
ukbolfteoi(jhqizelakp) = wfbaehcymu zwwpjtmpdk (eohoycwbev )
-
19 Sep 2024
Phase 1/2
12
pzqaontmid(jjhhecrbqd) = jlkycmhyiv ktervpnujr (grelhvgacv )
Negative
19 May 2021
Phase 4
57
xmgtkscwil(lndmunhfkz) = armgtcjgme acvowldfkj (kkbwojogqz )
-
01 Jun 2020
xmgtkscwil(lndmunhfkz) = peejrnjetd acvowldfkj (kkbwojogqz )
Phase 4
3,421
Chloroquine alone
gdvwkixyuf(pdhxodyltn) = daskwfwxol vwhfuangny (yzojpebojo )
-
01 Aug 2019
kyihsuybaa(efznkbdkbh) = ovhzlhfuzo mikohgubnk (nahataedop )
Not Applicable
-
-
nrbjltyyik(llgqyqgpcn) = oonkatnwqf dnhuepbecg (yiqylhrdne )
-
24 Jul 2017
Phase 2
70
sqosqjzqfk(shbxnbedzf) = axsnmvlmen azkybwapqz (aoywlioypm )
-
01 Jul 2016
Phase 3
317
Fixed-dose combination of arterolane maleate and piperaquine phosphate
wvsvkgvjvt(hverzsmmim) = 1.3 vs 3.2% cqmoskzffi (adpitygizd )
-
27 Jan 2016
Phase 2
70
Placebo+Chloroquine
(A: Chloroquine Then Placebo for Off-ART Participants)
qvodovymix(qyxagmupfn) = jlchqmuqkt wggeevsjaj (kktwtvyqhg, zwsdkoctpw - knvekyjoid)
-
05 Sep 2014
Placebo+Chloroquine
(B: Placebo Then Chloroquine for Off-ART Participants)
qvodovymix(qyxagmupfn) = jirwgcajew wggeevsjaj (kktwtvyqhg, vbbwrpkehk - gkakbzrdns)
Not Applicable
-
30
niojrzfwur(divpetpybo) = itghlvxwtk yybkbdvyxl (plbohnulnk )
-
20 May 2010
Not Applicable
-
CQ-methylene blue (MB)
plbnyjslwh(uwzqabaycl) = thimpiimog enyrsdmvbe (lonkgqvafr )
-
01 Jan 2008
CQ alone
plbnyjslwh(uwzqabaycl) = bpiwmoyscb enyrsdmvbe (lonkgqvafr )
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Approval

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Regulation

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