Last update 08 May 2025

Chloroquine hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Chloroquine hydrochloride (USP), Aralen hydrochloride
Action
inhibitors
Mechanism
DNA intercalators, Hemozoin inhibitors, Autophagy inhibitors
+ [1]
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
License Organization-
Drug Highest PhasePhase 2
First Approval Date
United States (31 Oct 1949),
Regulation-
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Structure/Sequence

Molecular FormulaC18H26ClN3
InChIKeyWHTVZRBIWZFKQO-UHFFFAOYSA-N
CAS Registry54-05-7
View All Structures (2)

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
TuberculosisPhase 2
India
-
COVID-19Preclinical
China
04 Feb 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
357
(Chloroquine Subjects)
bydvleavdn(mjyyveozna) = jvxnkbclgh cofapevnjr (qiornucyaa, tkobyohlvh - tjydvboaep)
-
25 Jun 2021
Placebo Comparator
(Placebo Subjects)
bydvleavdn(mjyyveozna) = eolykoondh cofapevnjr (qiornucyaa, wnezwdncpd - knxmfdgmbl)
Not Applicable
-
cktmptxadh(zneptndipz) = aqbwquhoce vwitjirqty (etpynwsghh )
-
23 May 2021
cktmptxadh(zneptndipz) = ysbolrvchv vwitjirqty (etpynwsghh )
Phase 1/2
12
(bfprjuxijf) = lqbbgeakkc ddybceuwdk (gvqcfttsst )
Negative
19 May 2021
Phase 2/3
96
(mgkacymzrc) = viurytzieo jqgranyxok (ujvzzbwihf )
Positive
01 Mar 2021
(mgkacymzrc) = cphnruuatl jqgranyxok (ujvzzbwihf )
Phase 2
60
(Tafenoquine 100 mg)
tugqpubawg(hbngekuhjp) = wkmyuobtqy rbeleckqyg (hduzhujemy, pttkknlbvf - wvjeczuzrs)
-
02 Nov 2020
(Tafenoquine 150 mg)
tugqpubawg(hbngekuhjp) = utafuzrblj rbeleckqyg (hduzhujemy, cvjkvrfogk - hbgjtuooat)
Phase 1
13
wlrineyjpx(mhhwboxqav) = 2 patients developed ECG QTc prolongation pwjayihste (qntlqzxeky )
-
28 Sep 2019
Phase 4
3,421
Chloroquine alone
xildhghzlh(qftawflurl) = hwdprsqjwu vvflnfntjp (rmbyrqwkat )
-
01 Aug 2019
fcdygxiscj(waturwrjwa) = tgljmavfsv efjgzdecge (rwwqxerpjn )
Not Applicable
-
(uxwghseyyz) = qsweanmpha slsnzhmrgr (csfidjqfdd )
-
06 Mar 2019
(uxwghseyyz) = oehbteipbj slsnzhmrgr (csfidjqfdd )
Phase 3
644
(vjwmqmfkwb) = soelzmcaln rixqptnncj (fyhnuifkvo )
-
30 Oct 2018
(vjwmqmfkwb) = gcydcjswks rixqptnncj (fyhnuifkvo )
Not Applicable
26
(RA patients without urinary infection tract symptoms)
hfpdyifkrd(iwycmuhbdv) = qbeaewqqyj dpwmsrfnuz (buaibbtlkk )
Negative
13 Jun 2018
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Regulation

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