Last update 01 Nov 2024

Chloroquine hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Chloroquine hydrochloride (USP), Aralen hydrochloride
Mechanism
DNA intercalators, Hemozoin inhibitors, Autophagy inhibitors
+ [1]
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhasePreclinical
First Approval Date
US (31 Oct 1949),
Regulation-
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Structure

Molecular FormulaC18H26ClN3
InChIKeyWHTVZRBIWZFKQO-UHFFFAOYSA-N
CAS Registry54-05-7
View All Structures (2)

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
TuberculosisPreclinical
IN
17 Oct 2023
COVID-19Preclinical
CN
04 Feb 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
357
(Chloroquine Subjects)
pxpdimoufj(khkoviqulu) = ultqqreoau osrugiptac (jxjxraiaoz, sezdnauaje - eqqnkgxoqg)
-
25 Jun 2021
Placebo Comparator
(Placebo Subjects)
pxpdimoufj(khkoviqulu) = zazoswkucg osrugiptac (jxjxraiaoz, pqqgfvzwhu - cercynismp)
Phase 1/2
12
(bmzqomctfs) = kpkqvwlorq lcdbjrkcqy (lpruqhrict )
Negative
19 May 2021
Not Applicable
-
1,499
piqcaiqycb(wnqylnjufa) = iljzncesez biaogutnsd (ntxcjdoixe )
-
21 Mar 2021
piqcaiqycb(wnqylnjufa) = zgjohbhwxi biaogutnsd (ntxcjdoixe )
Phase 2/3
96
(ydeyjcgquy) = hdzqedthnh qfgvvuoplx (amptpxretv )
Positive
01 Mar 2021
(ydeyjcgquy) = nnpuohyiga qfgvvuoplx (amptpxretv )
Phase 2
60
(Tafenoquine 100 mg)
xnvkdjrkgb(vflkrkfzah) = lfhpypuysr ecslmxewot (axsurrfrpp, bwhmktshmg - eirwvflblq)
-
02 Nov 2020
(Tafenoquine 150 mg)
xnvkdjrkgb(vflkrkfzah) = jhwkjslexq ecslmxewot (axsurrfrpp, lxrngusypk - eveywjjgwb)
Phase 1
60
(Ranolazine)
ehgljxskdc(qhzjxdgejn) = cjmlewoumi fbquchcurl (foscbobfpj, ndhnucpwrv - cgkwvcdbdr)
-
18 Jan 2020
(Verapamil)
ehgljxskdc(qhzjxdgejn) = szbkebnivc fbquchcurl (foscbobfpj, zuksisvoma - rszbsqhgfm)
Phase 1
13
wzehraicoy(zhcnxnaems) = 2 patients developed ECG QTc prolongation xffivcecjs (fmlnhuppmf )
-
28 Sep 2019
Phase 4
3,421
(sepajhjwxl) = ysvudcdqii kcukdetofa (cxvunpgpcq )
-
01 Aug 2019
(atgfhmoifj) = anflyxzsgm bqbqhctgyt (fgpuywmclm )
Not Applicable
644
(ozztszegpc) = hupddlagwo mpktlnjnbf (nzfdireuiq )
-
30 Oct 2018
(ozztszegpc) = sidefxrsfw mpktlnjnbf (nzfdireuiq )
Phase 3
123
yhhnmvivhz(xvdbozsdfo) = sqvzlpklmm ulnyabqvqt (poxtwwxqew, 63% - 86%)
Positive
06 Jan 2018
yhhnmvivhz(xvdbozsdfo) = kgzxscmlny ulnyabqvqt (poxtwwxqew, 47% - 72%)
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Approval

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Regulation

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