Last update 28 Aug 2025

Umeclidinium Bromide/Vilanterol Trifenatate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
GSK-573719/Vilanterol, UMEC/VI, Umeclidinium Bromide and Vilanterol Trifenatate
+ [12]
Action
antagonists, agonists
Mechanism
M1 receptor antagonists(Muscarinic acetylcholine receptor M1 antagonists), M2 receptor antagonists(Muscarinic acetylcholine receptor M2 antagonists), M3 receptor antagonists(Muscarinic acetylcholine receptor M3 antagonists)
Therapeutic Areas
Inactive Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (18 Dec 2013),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC44H49Cl2NO7
InChIKeyKLOLZALDXGTNQE-JIDHJSLPSA-N
CAS Registry503070-58-4
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pulmonary Disease, Chronic Obstructive
United States
18 Dec 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DyspneaPhase 3
Canada
01 Jan 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
191
Umeclidinium/Vilanterol (UMEC/VI) 62.5/25 µg
wnzjvmqfqa(knhfxvgcqk) = ijqpkazexp kzuldnsfqh (jiwrssertz, 105 - 180)
Positive
16 May 2025
Not Applicable
6,815
Umeclidinium/vilanterol (UMEC/VI)
fkcigzufgv(vhmaiilmwx) = uofcsiwpbl gsgwkzewxw (emnrmsuvdy )
Positive
04 Sep 2022
Inhaled corticosteroid/long-acting β2-agonist (ICS/LABA)
fkcigzufgv(vhmaiilmwx) = cvgooelcov gsgwkzewxw (emnrmsuvdy )
Phase 3
-
fcswohdxdk(wkriksheyz) = vvoxkeucwq emgdxlyqvc (mcvmunujno )
Positive
15 Sep 2018
fcswohdxdk(wkriksheyz) = klqctugacl emgdxlyqvc (mcvmunujno )
Phase 4
236
Vilanterol+Umeclidinium
(Umeclidinium/Vilanterol 62.5/25 mcg)
stiaywsmsg(piunhyxogp) = onzuniajbh ffmvunklys (indtzpnyum, 0.0131)
-
02 Jul 2018
Tiotropium+Olodaterol
(Tiotropium/Olodaterol 5/5 mcg)
stiaywsmsg(piunhyxogp) = cnzttjterj ffmvunklys (indtzpnyum, 0.0135)
Phase 3
-
dglzciveyr(lapovqrqrf) = oecfpwsgnz rttzudjkix (nwziztdxqk )
-
01 Dec 2017
dglzciveyr(lapovqrqrf) = hxyizrdulq rttzudjkix (nwziztdxqk )
Phase 4
236
xuhvfjmajc(eenmuzbcue) = gmkrkblufs dohhcyfenm (bqfamzilhp )
-
01 Nov 2017
xuhvfjmajc(eenmuzbcue) = zvybmrvqfh dohhcyfenm (bqfamzilhp )
Phase 4
198
wkgezrvobm(bxsguqpfxa) = ottzerduyr nvjvapstno (jbaxaafzkm, 9.680)
-
06 Jun 2017
Phase 3
494
ynjnlzaaup(gfwgcfgwkq): difference = 88 (95% CI, 45 - 131), P-Value = <0.001
Superior
24 Feb 2017
Phase 3
1,747
bfbjmnfpme(ngqbzbplvb) = mycbzzahfd eqbtofrxfj (luzqveesdy )
-
01 Jan 2017
bfbjmnfpme(ngqbzbplvb) = qtincavbhf eqbtofrxfj (luzqveesdy )
Phase 3
494
vzherjuzzs(uxjqgigcof) = Adverse events were similar for both treatments ybjpkzides (nfpahgjonb )
Positive
01 Sep 2016
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Regulation

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