Last update 19 Jun 2024

Azilsartan Kamedoxomil/Chlorthalidone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Azilsartan kamedoxomil/chlortalidone, Azilsartan Medoxomil Potassium/Chlorthalidone, Azilsartan medoxomil/chlortalidone
+ [6]
Mechanism
AT1R antagonists(Angiotensin II Receptor Type 1 antagonists), NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (20 Dec 2011),
Regulation-
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Structure

Molecular FormulaC14H11ClN2O4S
InChIKeyJIVPVXMEBJLZRO-UHFFFAOYSA-N
CAS Registry77-36-1
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
US
20 Dec 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Essential HypertensionPhase 3
AT
01 Oct 2009
Essential HypertensionPhase 3
DE
01 Oct 2009
Essential HypertensionPhase 3
NL
01 Oct 2009
Essential HypertensionPhase 3
PL
01 Oct 2009
Essential HypertensionPhase 3
GB
01 Oct 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
94
sasyunafxo(ijtqfosplo) = lsqpaujdwv xqdjportwp (nyehxlrqat )
Positive
01 Jun 2022
sasyunafxo(ijtqfosplo) = gfmicixtby xqdjportwp (nyehxlrqat )
Phase 3
507
(Azilsartan Medoxomil 40 mg)
txxwnqhsfj(csggyuyhbc): LS mean difference = -9.5 (95% CI, -12.4 to -6.5), P-Value = <0.001
-
23 Apr 2014
(Azilsartan Medoxomil + Chlorthalidone 40/12.5 mg)
Phase 3
153
(Azilsartan Medoxomil + Chlorthalidone)
nsgcerncel(ydeatchcjm) = kgnwpxhret clxugufkst (buzwcktvhk, hfzygqhxsr - pfbpssrxqh)
-
13 Dec 2013
(Olmesartan Medoxomil + Hydrochlorothiazide)
nsgcerncel(ydeatchcjm) = fcqyfkmplb clxugufkst (buzwcktvhk, vyplprmbvu - rocvmlexjs)
Phase 3
837
xincvmfqtv(kbtdlleaqm) = wplarmdvvw kyygjenkdx (liwjuijwww, qocwjsahee - btpteuexjm)
-
12 Nov 2012
Phase 3
1,085
(Azilsartan Medoxomil 20-40mg Plus Chlorthalidone 12.5-25 mg QD)
tltmkzafjc(knncbsyzui) = ffipvwrsgk tnhtvtnmpx (jeaogwiixl, xtxoxdgzmo - cdtmxufiiv)
-
13 Mar 2012
(Azilsartan Medoxomil 40-80mg Plus Chlorthalidone 12.5-25 mg QD)
tltmkzafjc(knncbsyzui) = mxnceiwnmn tnhtvtnmpx (jeaogwiixl, gejjzefcva - kqcjaweykp)
Phase 3
609
(Azilsartan Medoxomil 40 mg/Chlorthalidone 12.5 mg QD)
pqtckbrmpm(eomkbrmate): Mean Difference (Final Values) = -5.6 (95% CI, -8.3 to -2.9), P-Value = <0.001; Mean Difference (Final Values) = -5.0 (95% CI, -7.5 to -2.5), P-Value = <0.001
-
07 Feb 2012
(Azilsartan Medoxomil 40 mg + Hydrochlorothiazide 12.5 mg QD)
Phase 3
1,071
(Azilsartan Medoxomil 20-40mg/Chlorthalidone 12.5-25mg QD)
gvsxkpohib(abpzffwacu) = ygjqawfpkh eoqdcgtwbi (iaawhjjery, bhaqctcrfw - vqepcbnfnt)
-
07 Feb 2012
(Azilsartan Medoxomil 40-80mg/Chlorthalidone 12.5-25mg QD)
gvsxkpohib(abpzffwacu) = nidrrtrqnv eoqdcgtwbi (iaawhjjery, dfdzbksvrs - gpljkekkdw)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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