Delving into the Latest Updates on Codeine Phosphate/Acetaminophen with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Ultracod

Target

COXs x Opioid receptors

Action

inhibitors, agonists

Mechanism

COX inhibitors(Cyclooxygenases inhibitors), Opioid receptors agonists(Opioid receptors agonists)

Therapeutic Areas

Nervous System Diseases

Active Indication

Severe pain

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC18H26NO8P

InChIKeyJPGKFBXFEQWCAI-CCLYOLAMSA-N

CAS Registry41444-62-6

View All Structures (2)

Patients with class I malocclusion who have mild to moderate crowding will be treated in this study. The efficacy of low level laser therapy and Panadol-extra® in relieving pain due to orthodontic treatment will be assessed. The effect of these two interventions on oral-health related quality of life during all stages of orthodontic treatment will be explored, i.e. at the following stages: (1) separation between teeth, (2) archwire changing, (3) bonding of brackets, (4) removal of the fixed appliances.
There are three groups :
a group of patient being irradiated with low-level laser therapy (LLLT) at specific time points to relieve pain and discomfort.
a group of patient in which pain control will be accomplished by prescribing Panadol Extra tablets in a regular manner.
a group of patients in which nothing will be given to them during the course of treatment.

Start Date15 Sep 2017

Sponsor / Collaborator

Damascus University

100 Clinical Results associated with Codeine Phosphate/Acetaminophen

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100 Translational Medicine associated with Codeine Phosphate/Acetaminophen

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100 Patents (Medical) associated with Codeine Phosphate/Acetaminophen

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2

Literatures (Medical) associated with Codeine Phosphate/Acetaminophen

01 Mar 2018·Operative DentistryQ3 · MEDICINE

Combination of Acetaminophen/Codeine Analgesics Does Not Avoid Bleaching-Induced Tooth Sensitivity: A Randomized, Triple-Blind Two-Center Clinical Trial

Q3 · MEDICINE

Article

Author: de Paula, E ; Reis, A ; Kossatz, S ; Coppla, FM ; Farago, PV ; Loguercio, AD ; Rezende, M

SUMMARYBleaching-induced tooth sensitivity (TS) is highly prevalent. Objective: This study aimed to determine if the combination of opioids and nonopioids analgesics (Tylex) may provide a better analgesic effect. Method: A triple-blind, parallel, randomized two-center clinical trial was conducted with 105 healthy patients who received either a placebo or a combination of acetaminophen/codeine. The first dose of Tylex 30 mg (acetaminophen 500 mg/codeine 30 mg) or placebo was administered one hour before the in-office bleaching (35% hydrogen peroxide), and extra doses were administered every six hours for 48 hours. The TS was recorded using a visual analog scale of 0 to 10 and a numeric rating scale of 0 to 4 in different periods: during bleaching, one hour up to 24 hours, and 24 hours up to 48 hours postbleaching. The color was measured before and one month after dental bleaching with a visual shade guide (Vita Classical), Vita Bleachedguide 3D-MASTER, and the spectrophotometer Vita Easyshade. The absolute risk of TS was evaluated using the Fisher exact test. Data of TS intensity with numeric rating scale of the two groups were compared with the Mann-Whitney U-test and the Friedman test, while data from the visual analog scale were evaluated by two-way repeated measures analysis of variance and the Tukey test for pairwise comparison. The color changes between groups were compared using the Student t-test (α=0.05). Results: No significant differences between the groups were observed in the risk and intensity of TS. The overall absolute risk of TS was approximately 96%. No significant differences between groups were observed in terms of color change (p>0.05) for any scale. Conclusion: The use of an acetaminophen/codeine combination prior to in-office bleaching does not reduce the risk and intensity of bleaching-induced TS.

01 Jun 2001·Scottish Medical JournalQ4 · MEDICINE

Mortality during the Winter Flu Epidemic — Two Cases of Death Associated with Self-Medication

Q4 · MEDICINE

Article

Author: E Wilson ; R Stevenson ; J D Harmse ; R S MacWalter

We report two cases of mortality associated with the recent winter influenza outbreak. Both cases were associated with self-medication. In one case an elderly lady died from haemorrhagic duodenitis induced by over the counter ibuprofen. In the second case the lady died from the consequences of exceeding the recommended doses of paracetamol by combining doses of the generic product with proprietary flu-remedies and Tylex (paracetamol and codeine).

100 Deals associated with Codeine Phosphate/Acetaminophen

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	N02AA59	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Severe pain	United States	-	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01229449 (CTgov)	Phase 3	Toothache \| Pain, Postoperative	678	Nurofen Plus® (Nurofen Plus®)	mjaseyqheg(ddzrrselef) = rqhchozlwc sukwzlseqi (xknuntjhzq, gnkiwkabeb - gadjemwgnp) View more	-	17 Sep 2018
				Panadeine® Extra (Panadeine® Extra)	mjaseyqheg(ddzrrselef) = vmghdqtvej sukwzlseqi (xknuntjhzq, omvmqafepc - eeadjhldss) View more
NCT02455518 (CTgov)	Phase 4	Musculoskeletal Pain	416	Oxycodone/acetaminophen (Oxycodone/Acetaminophen)	uxqwbplfhj(jbfwdccvzf) = yiunuqwwum ckrbhfanqf (zkumbhegva, zpynotjmgc - zuqkrvxess) View more	-	13 Feb 2018
				Hydrocodone/acetaminophen (Hydrocodone/Acetaminophen)	uxqwbplfhj(jbfwdccvzf) = xvazgrcpaw ckrbhfanqf (zkumbhegva, cfzgmfwngp - ofwapbofly) View more