The effectiveness of hydroquinone 4% versus hydroquinone 4% with intradermal injection of autologous platelet-rich plasma in the treatment of lichen planus pigmentosus: A comparative split-face clinical trial

Start Date10 Jun 2024

Sponsor / Collaborator-

CTRI/2023/07/054853 / Not yet recruitingPhase 3

To evaluate the skin irritation and sensitization potential of the 6 Investigational products by repeated application of occlusive patches - Not Applicable

Start Date14 Jul 2023

Sponsor / Collaborator-

CTRI/2023/07/054650 / Not yet recruitingPhase 3

To assess the safety & efficacy of SKINOVATE- Non-Hydroquinone night cream for its non-comedogenic effect. - Not Applicable

Start Date14 Jul 2023

Sponsor / Collaborator-

100 Clinical Results associated with Hydroquinone

100 Translational Medicine associated with Hydroquinone

100 Patents (Medical) associated with Hydroquinone

1,697

Literatures (Medical) associated with Hydroquinone

01 Nov 2024·Journal of Drugs in Dermatology

Isobutylamido Thiazolyl Resorcinol (Thiamidol) for Combatting Hyperpigmentation: A Systematic Review of Clinical Studies

Review

Author: Babadjouni, Arash ; Kincaid, Colin ; Klein, Paytra A. ; Mesinkovska, Natasha A.

BACKGROUNDTyrosinase is the rate-limiting enzyme of melanogenesis and thus an ideal inhibitory target for treating hyperpigmentation. There are many commercially available tyrosinase inhibitors with limited clinical efficacy. A recent screen of 50,000 compounds found isobutylamido thiazolyl resorcinol (ITR) to be the most potent inhibitor of human tyrosinase.OBJECTIVETo summarize the current evidence on the efficacy and adverse effects of ITR in treating hyperpigmentation.METHODSA literature search was conducted using PubMed and Google Scholar databases in June 2022. Fourteen clinical studies investigating the use of topical ITR in hyperpigmentation treatment or prevention were identified.RESULTSMost studies (n=13) investigated topical ITR as a treatment, while only one investigated ITR as a preventative measure against hyperpigmentation. All studies (n=14) found ITR to provide statistically significant improvements to hyperpigmentation conditions, including facial hyperpigmentation (n=3), melasma (n=5), post-inflammatory hyperpigmentation (PIH) (n=3), and UV-induced hyperpigmentation (n=3). Evidence suggests that the effective dosage and duration of topical ITR appears to be 0.1% to 0.2% ITR 2 to 4 times daily for 12 to 24 weeks. Successful prevention of UVB-induced hyperpigmentation has been seen following twice-daily topical ITR application for 3 weeks (P<0.001).CONCLUSIONTopical ITR can significantly reduce hyperpigmentation, however, the evidence for its use is limited. Further investigation is warranted to identify the optimal dosage and application schedule of ITR, as well as compare the efficacy of ITR vs hydroquinone to determine if ITR is superior to the current standard of care. J Drugs Dermatol. 2024;23(11):986-991. doi:10.36849/JDD.7985.

01 Oct 2024·Toxicology in Vitro

Nrf2 affects DNA damage repair and cell apoptosis through regulating HR and the intrinsic Caspase-dependent apoptosis pathway in TK6 cells exposed to hydroquinone

Article

Author: Guo, Pu ; Tang, Huanwen ; Luo, Hao ; Sun, Lei ; Hu, Xiaoyi ; Chen, Yuting ; Yu, Lingxue ; Sun, Qian ; Chen, Lin ; Li, Zhuanzhuan ; Zhai, Lu ; Zhu, Delong

Hydroquinone (HQ) is one of benzene metabolites that can cause oxidative stress damage and Homologous recombination repair (HR). A good deal of reactive oxygen species (ROS) generated by oxidative stress can trigger apoptotic signaling pathways. The nuclear factor erythroid 2-related factor 2 (Nrf2) can regulate the cell response to oxidative stress damage. The aim of this study was to explore whether Nrf2 participate in HQ-induced apoptosis and its mechanism. The findings displayed that HQ triggered HR, promoted Nrf2 transfer into the cell nucleus and induced cell apoptosis, while Nrf2 deficient elevated cell apoptosis, attenuated the expression of PARP1 and RAD51. We also observed that Nrf2 deficient triggered Caspase-9. Thus, we speculated that Nrf2 might participate in HQ-induced cell apoptosis through Caspase-9 dependent pathways. Meanwhile, Nrf2 participated in HQ-induced DNA damage repair by regulating the level of PARP1 and RAD51.

01 Oct 2024·Toxicology and Applied Pharmacology

Extracellular vesicles-derived long noncoding RNAs participated in benzene hematotoxicity by mediating apoptosis and autophagy

Article

Author: Chen, Yujiao ; Guo, Xiaoli ; Wang, Jingyu ; Zhang, Wei ; Gao, Ai ; Zhang, Lei ; Ren, Jing

Benzene is a common contaminant in the workplace and wider environment, which induces hematotoxicity. Our previous study has implicated that lncRNAs mediated apoptosis and autophagy induced by benzene. Nevertheless, the roles of extracellular vesicle(EVs)-derived lncRNAs in benzene toxicity are unknown. However, the role of EVs and EVs-derived lncRNAs in benzene-induced toxicity remains unclear. In this research, we explored the function of EVs and EVs-derived lncRNAs in cell-cell communication through benzene-induced apoptosis and autophagy. Our findings demonstrated that EVs derived from 1,4-BQ-treated cells treated cells and coculture with 1,4-BQ-treated cells enhanced apoptosis and autophagy via regulating the pathways of PI3K-AKT-mTOR and chaperone-mediated autophagy. Treating with GW4869 in 1,4-BQ-treated cells significantly inhibited EV secretion, which reduced apoptosis and autophagy. Furthermore, we identified a set of differentially expressed autophagy- and apoptosis-related lncRNAs using EVs-derived lncRNA sequencing. Among them, 8 candidate lncRNAs were upregulated in EVs derived from 1,4-BQ-treated cells, as determined by lncRNA sequencing and qRT-PCR. Importantly, these lncRNAs were also increased in the serum EVs of benzene-exposed workers. 1,4-BQ-treated cells released EVs that transfer differentially expressed lncRNAs, thereby inducing apoptosis and autophagy in the recipient cells. The above results support the hypothesis that EVs-derived lncRNAs participate in intercellular communication during benzene-induced hematotoxicity and function as potential biomarkers for risk assessment of benzene-exposed workers.

News (Medical) associated with Hydroquinone

17 Oct 2024

·www.prnewswire.com

Nikon Small World Competition Celebrates 50 Years with Groundbreaking Image of Brain Tumor Cells

Celebrating its golden anniversary, Nikon Small World honors a stunning photo of brain tumor cell structures, advancing our understanding of neurodegenerative diseases. MELVILLE, N.Y., Oct. 17, 2024 /PRNewswire/ -- Nikon Instruments Inc. today announced the winners of the 50th annual Nikon Small World Photomicrography Competition, celebrating five decades of excellence in microscopy and digital imaging. This year's first place prize was awarded to Dr. Bruno Cisterna, with assistance from Dr. Eric Vitriol of Augusta University, for his groundbreaking image of differentiated mouse brain tumor cells, highlighting the actin cytoskeleton, microtubules, and nuclei. This image reveals how disruptions in the cell's cytoskeleton – the structural framework and "highways" known as microtubules – can lead to diseases like Alzheimer's and ALS. Continue Reading Differentiated mouse brain tumor cells (actin, microtubules, and nuclei) Dr. Cisterna's research revealed that profilin 1 (PFN1), a protein crucial for building the cell's structure, plays a key role in maintaining the microtubule highways essential for cellular transport. When PFN1 or related processes are disrupted, these highways can malfunction, leading to cellular damage similar to what is observed in neurodegenerative diseases. "One of the main problems with neurodegenerative diseases is that we don't fully understand what causes them," said Dr. Cisterna. "To develop effective treatments, we need to figure out the basics first. Our research is crucial for uncovering this knowledge and ultimately finding a cure. Differentiated cells could be used to study how mutations or toxic proteins that cause Alzheimer's or ALS alter neuronal morphology, as well as to screen potential drugs or gene therapies aimed at protecting neurons or restoring their function." His patience and determination were crucial in capturing his image. "I spent about three months perfecting the staining process to ensure clear visibility of the cells. After allowing five days for the cells to differentiate, I had to find the right field of view where the differentiated and non-differentiated cells interacted. This took about three hours of precise observation under the microscope to capture the right moment, involving many attempts and countless hours of work to get it just right." The hard work behind this discovery underscores its significance, bringing researchers closer to answers that could potentially transform millions of lives. "After three years of research, we finally published our findings four months ago in the Journal of Cell Biology, and there's still more work to be done," said Dr. Cisterna. "I'm deeply passionate about scientific imaging; I've been following the Nikon Small World contest for about 15 years. It's an incredible contest that highlights the beauty of photomicrography but also inspires continued exploration and innovation in the field." Eric Flem, Senior Manager, CRM and Communications at Nikon Instruments, shares a similar perspective on the competition. "At 50 years, Nikon Small World is more than just an imaging competition – it's become a gallery that pays tribute to the extraordinary individuals who make it possible. They are the driving force behind this event, masterfully blending science and art to reveal the wonders of the microscopic world and what we can learn from it to the public." He went on to add, "Sometimes, we overlook the tiny details of the world around us. Nikon Small World serves as a reminder to pause, appreciate the power and beauty of the little things, and to cultivate a deeper curiosity to explore and question." Second place was awarded to Dr. Marcel Clemens for his image of an electrical arc between a pin and a wire, produced by applying a potential difference of 10,000 volts. Third place was awarded to Chris Romaine for his image of a cannabis plant leaf. The bulbous structures are trichomes, or hair-like plant appendages, and the bubbles inside are cannabinoid vesicles, fluid-filled, blister-like structures. In total, Nikon Small World recognized 87 photos out of thousands of entries from scientists and artists across the globe. The 2024 judging panel included: Adrian Coakley, Director of Photography at National Geographic Books Michelle S. Itano, Ph.D., Assistant Professor of Cell Biology and Physiology and Director of the Neuroscience Microscopy Core at the University of North Carolina at Chapel Hill Emily Petersen, Photography Managing Editor at Science Magazine Clare Waterman, Ph.D., Cell Biologist and Member of the National Academy of Sciences Jennifer C. Waters, Ph.D., Director of the Core for Imaging Technology & Education at Harvard Medical School Samantha Yammine, Ph.D., Neuroscientist and Science Communicator For additional information, please visit , or follow the conversation on Facebook, Twitter @NikonSmallWorld and Instagram @NikonInstruments. NIKON SMALL WORLD WINNERS 1st Place Dr. Bruno Cisterna & Dr. Eric Vitriol Medical College of Georgia at Augusta University Department of Neuroscience & Regenerative Medicine Augusta, Georgia, USA Differentiated mouse brain tumor cells (actin, microtubules, and nuclei) Super-Resolution 100X (Objective Lens Magnification) 2nd Place Dr. Marcel Clemens Verona, Veneto, Italy Electrical arc between a pin and a wire Image stacking for the pin and wire combined with long exposure for the electrical arcs 10X (Objective Lens Magnification) 3rd Place Chris Romaine Kandid Kush Port Townsend, Washington, USA Leaf of a cannabis plant. The bulbous glands are trichomes. The bubbles inside are cannabinoid vesicles. Image Stacking 20X (Objective Lens Magnification) 4th Place Dr. Amy Engevik Medical University of South Carolina Department of Regenerative Medicine & Cell Biology Charleston, South Carolina, USA Section of a small intestine of a mouse Fluorescence 10X (Objective Lens Magnification) 5th Place Thomas Barlow & Connor Gibbons Columbia University Department of Neurobiology and Behavior New York, New York, USA Cluster of octopus (Octopus hummelincki) eggs Darkfield, Stereomicroscopy, Focus Stacking 3X (Objective Lens Magnification) 6th Place Henri Koskinen Helsinki University Helsinki, Uudenmaan lääni, Finland Slime mold (Cribraria cancellata) Image Stacking, Polarized Light, Reflected Light 10X (Objective Lens Magnification) 7th Place Gerhard Vlcek Maria Enzersdorf, Austria Cross section of European beach grass (Ammophila arenaria) leaf Brightfield, Image Stacking 10X (Objective Lens Magnification) 8th Place Stephanie Huang Victoria University of Wellington School of Biological Sciences; School of Psychology Wellington, New Zealand A neuron densely covered in dendritic spines from the striatum of an adult rat brain Confocal, Deconvolution, Image Stacking 60X (Objective Lens Magnification) 9th Place John-Oliver Dum Medienbunker Produktion Bendorf, Rheinland Pfalz, Germany Pollen in a garden spider (Araneus) web Image Stacking 20X (Objective Lens Magnification) 10th Place Jan Martinek Charles University Department of Experimental Plant Biology Prague, Czech Republic Spores of black truffle (Tuber melanosporum) Confocal 63X (Objective Lens Magnification) 11th Place Dr. Ferenc Halmos Bánd, Veszprém, Hungary Slime mold on a rotten twig with water droplets Image Stacking 0.7X - 4.5X (Objective Lens Magnification) 12th Place Daniel Knop Oberzent-Airlenbach, Hessen, Germany Wing scales of a butterfly (Papilio ulysses) on a medical syringe needle Image Stacking 20X (Objective Lens Magnification) 13th Place Paweł Błachowicz Bedlno, Świętokrzyskie, Poland Eyes of green crab spider (Diaea dorsata) Image Stacking, Reflected Light 20X (Objective Lens Magnification) 14th Place Marek Miś Marek Miś Photography Suwalki, Podlaskie, Poland Recrystallized mixture of hydroquinone and myoinositol Polarized Light 10X (Objective Lens Magnification) 15th Place Sébastien Malo Saint Lys, Haute-Garonne, France Isolated scales on Madagascan sunset moth wing (Chrysiridia ripheus) Darkfield, Image Stacking, Reflected Light 40X (Objective Lens Magnification) 16th Place Marek Miś Marek Miś Photography Suwalki, Podlaskie, Poland Two water fleas (Daphnia sp.) with embryos (left) and eggs (right) Darkfield, Polarized Light 10X (Objective Lens Magnification) 17th Place Dr. Frantisek Bednar Svosov, Zilinsky, Slovak Republic Stonewort algae (Chara virgata) reproductive organs - oogonia (female organs) and antheridia (male organs) Darkfield 4X (Objective Lens Magnification) 18th Place Alison Pollack San Anselmo, California, USA An insect egg parasitized by a wasp Image Stacking, Reflected Light 10X (Objective Lens Magnification) 19th Place Alison Pollack San Anselmo, California, USA Seed of a Silene plant Image Stacking, Reflected Light 10X (Objective Lens Magnification) 20th Place Dr. Bruno Cisterna & Dr. Eric Vitriol Medical College of Georgia at Augusta University Department of Neuroscience & Regenerative Medicine Augusta, Georgia, USA Early stage of mouse neuroblastoma cell differentiation (actin, microtubules, and mitochondria) Super-Resolution 100X (Objective Lens Magnification) HM Christopher Algar Hounslow, Middlesex, United Kingdom Brine shrimp Darkfield, Image Stacking, Polarized Light 4X (Objective Lens Magnification) HM Dr. Kseniia Bondarenko University of Edinburgh Institute for Immunology and Infection Research Edinburgh, MidLothian, United Kingdom Acute-stage parasites of Toxoplasma gondii in a human skin cell Expansion Microscopy, Confocal, Deconvolution 100X (Objective Lens Magnification) HM Dr. Anja de Lange University of Cape Town Neuroscience Institute & Department of Human Biology Cape Town, Western Cape, South Africa Astrocytes surrounding a blood vessel in a thin slice of human brain Confocal 40X (Objective Lens Magnification) HM Dr. Amy Engevik Medical University of South Carolina Department of Regenerative Medicine & Cell Biology Charleston, South Carolina, USA Intestinal villi Fluorescence 20X (Objective Lens Magnification) HM Daniel Evrard Aywaille, Liege, Belgium Vinyl player needle on scratched vinyl disk Image Stacking, Polarized Light 20X (Objective Lens Magnification) HM Randy Fullbright Fullbright Studio Vernal, Utah, USA Agatized dinosaur bone Image Stacking 10X (Objective Lens Magnification) HM Dr. David Maitland St. Andrews, Fife, United Kingdom Transverse section of rachis (stem) of bracken fern (Pteridium aquilinum) Differential Interference Contrast (DIC) 5X (Objective Lens Magnification) HM Angus Rae Australian National University Centre for Advanced Microscopy MacGregor, Australian Capital Territory, Australia Autofluorescence in the face of a little two-spotted ladybird (Diomus notescens) Fluorescence lifetime imaging microscopy (FLIM) 20X (Objective Lens Magnification) HM Dr. Igor Robert Siwanowicz Howard Hughes Medical Institute (HHMI), Janelia Research Campus Ashburn, Virginia, USA Antenna of a mole crab Confocal 10X (Objective Lens Magnification) HM Jochen Stern Mannheim, Baden-Wuerttemberg, Germany Golden bug eggs on a sage leaf Image Stacking 20X (Objective Lens Magnification) HM Dr. Bruce Douglas Taubert Glendale, Arizona, USA Ocelli between the compound eyes of a yellow jacket Reflected Light 10X (Objective Lens Magnification) HM Kevin Terretaz CRBM-CNRS Montpellier, Hérault, France Mosquito cells in culture with fluorescent markers for DNA and microtubules Confocal 63X (Objective Lens Magnification) IoD Dr. Sherif Abdallah Ahmed Tanta University, Faculty of Science Department of Zoology Tanta, Egypt, Arab Republic Anterior section of palm weevil Image Stacking 4X (Objective Lens Magnification) IoD Anne Patricia Algar Hounslow, Middlesex, United Kingdom Mosquito larva Darkfield, Image Stacking, Polarized Light 4X (Objective Lens Magnification) IoD Dr. Florian Alonso University of Bordeaux BioTis-INSERM U1026 Pessac, Gironde, France Mouse aortic endothelium stained for beta-catenin (green), laminin (purple), smooth muscle actin (red), and Hoechst (cyan) Confocal 63X (Objective Lens Magnification) IoD Didier Barbet Club Français de Microscopie Bailly, France Fracture surface of mica (mineral) Differential Interference Contrast (DIC) 10X (Objective Lens Magnification) IoD Timothy Boomer WildMacro.com Vacaville, California, USA Slime mold (Prototrichia metallica) Image Stacking 10X (Objective Lens Magnification) IoD Zhang Chao National Astronomical Observatories, Chinese Academy of Sciences Beijing, China Beach sand Reflected Light 10X (Objective Lens Magnification) IoD Joshua Coogler Dallas, North Carolina, USA Moss sporophyte with spores (green) Image Stacking 10X (Objective Lens Magnification) IoD Nikky Corthout & Miranda Dyson VIB (Flanders Institute of Biotechnology) Center for Brain and Disease Research Leuven, Vlaams-Brabant, Belgium Fruit fly (Drosophila) brain vasculature Confocal, Fluorescence, Image Stacking, Super-Resolution 25X (Objective Lens Magnification) IoD Nadia Efimova Amicus Therapeutics Philadelphia, Pennsylvania, USA Dandelion pappus Confocal, Fluorescence 20X (Objective Lens Magnification) IoD Dr. Laurent Formery & Dr. Nathaniel Clarke Stanford University Department of Molecular and Cell Biology Pacific Grove, California, USA Nervous system of a young sea star Confocal, Fluorescence 10X (Objective Lens Magnification) IoD Karl Gaff Dublin, Ireland Larva of a midge fly (Chironomidae) Darkfield, Image Stacking, Polarized Light 20X (Objective Lens Magnification) IoD Dr. Nick Gatford University of Oxford Nuffield Department of Clinical Neurosciences (NDCN) Oxford, Oxfordshire, United Kingdom A network of dopaminergic neurons generated from human stem cells Super-Resolution 63X (Objective Lens Magnification) IoD Dr. Saikat Ghosh National Institutes of Health NICHD Bethesda, Maryland, USA Human neurons Confocal 40X (Objective Lens Magnification) IoD Gerd A. Günther Düsseldorf, Germany Cross section of a beach grass (Ammophila arenaria) leaf Fluorescence 20X (Objective Lens Magnification) IoD Anna-Mari Elisabeth Haapanen-Saaristo University of Turku Turku Bioscience Centre / Cell Imaging & Cytometry Core and Zebrafish Core RAISIO, Varsinais-Suomi, Finland Nutrient storage cells in a tardigrade Confocal 25X (Objective Lens Magnification) IoD Dr. Martin Hein Lions Eye Institute Physiology and Pharmacology laboratory Nedlands, Western Australia, Australia Abnormal blood vessel formation in a human retina with severe diabetic retinopathy Confocal 20X (Objective Lens Magnification) IoD Wen Jie Ji Yin Works The Bureau of Microworld Exploration Beijing, China Integrated circuit chip Reflected Light 10X (Objective Lens Magnification) IoD Ted Kinsman Rochester Institute of Technology Photosciences Department Rochester, New York, USA A common house cat claw Polarized Light 10X (Objective Lens Magnification) IoD Daniel Knop Oberzent-Airlenbach, Hessen, Germany Opening of a hibiscus flower (Hibiscus moscheutos) exposing the pollen in four stages, each ten minutes apart Image Stacking 20X (Objective Lens Magnification) IoD Daniel Knop Oberzent-Airlenbach, Hessen, Germany Dorsal part of cuckoo wasp (Hedychrum gerstaeckeri) abdomen Image Stacking 20X (Objective Lens Magnification) IoD Dr. Håkan Kvarnström Bromma, Sweden Peacock plume feather Epi-Illumination, Image Stacking 4X (Objective Lens Magnification) IoD Dr. Ewa Langner Washington University in St Louis Department of Medicine - Renal Division, Mahjoub Lab St Louis, Missouri, USA Mouse embryonic kidney showing interstitial fibroblasts (yellow), tubular epithelium (cyan), and nuclei (magenta) Confocal, Fluorescence, Image Stacking 40X (Objective Lens Magnification) IoD Dr. Amir Maqbool Lovely Professional University Department of Zoology Srinagar, Jammu and Kashmir, India Small fly killed by "zombie fly" fungus (Entomophthora muscae) Image Stacking 2X (Objective Lens Magnification) IoD Dr. Robert Markus University of Nottingham School of Life Sciences, Super Resolution Microscopy Nottingham, Nottinghamshire, United Kingdom Dandelion (Traxacum officinale) cross section showing curved stigma with pollen Confocal 10X (Objective Lens Magnification) IoD Dr. Robert Markus, Dr. Zeeshan Mohammad, Dr. Sarah Pashley & Dr. Rita Tewari University of Nottingham School of Life Sciences, Super Resolution Microscopy Nottingham, Nottinghamshire, United Kingdom Malaria parasites and mouse blood cells - tubulin (green), all proteins (purple), DNA (red) Confocal 63X (Objective Lens Magnification) IoD Jan Martinek Charles University Department of Experimental Plant Biology Prague, Czech Republic Spores of a black Bagnoli truffle (Tuber mesentericum) Confocal 63X (Objective Lens Magnification) IoD Dr. Guillermo Moya Johns Hopkins University Department of Biology Baltimore, Maryland, USA Neuronal axons connecting to the muscles of the iris and the cornea Confocal, Fluorescence 10X (Objective Lens Magnification) IoD Jacek Myslowski Wloclawek, Kujawko-Pomorskie, Poland Water mite (Arrenurus) Fluorescence, Image Stacking 6.3X (Objective Lens Magnification) IoD Aryah Nagarajan Falmouth University Institute of Photography Penryn, Cornwall, United Kingdom Spores releasing from the sori of a Polypody fern (Polypodium vulgare) Reflected Light, Transmitted Light, Focus Stacking 10X (Objective Lens Magnification) IoD Thomas Neumann Tübingen, Baden-Württemberg, Germany Ink dot on Japanese washi paper Brightfield, Image Stacking 20X (Objective Lens Magnification) IoD Satu Paavonsalo & Dr. Sinem Karaman University of Helsinki Individualized Drug Therapy Research Program, Faculty of Medicine, Helsinki, Finland Helsinki, Finland Blood vessels (color gradient) and endothelial cell nuclei (white) in the intestinal villi of a mouse Confocal 10X (Objective Lens Magnification) IoD Uwe Lange Hannover, Niedersachsen, Germany Pollen on the compound eyes of a fly Image Stacking 60X (Objective Lens Magnification) IoD Dr. Marko Pende MDI Biological Laboratory Murawala Lab Bar Harbor, Maine, USA Ladybug (Coccinellidae) on a clover (Trifolium repens) Confocal, Fluorescence, Image Stacking 4X (Objective Lens Magnification) IoD Dr. Felice Placenti FP Nature and Landscape Photography Siracusa, Sicilia, Italy Potato tuber sprout Image Stacking, Reflected Light 1X (Objective Lens Magnification) IoD Alison Pollack San Anselmo, California, USA Slime mold (Lamproderma arcyrioides) Image Stacking, Reflected Light 10X (Objective Lens Magnification) IoD Dr. Gonzalo Quiroga Artigas CRBM-CNRS Montpellier, Herault, France Tardigrade (Hypsibius exemplaris) Confocal 40X (Objective Lens Magnification) IoD Chris Romaine Kandid Kush Port Townsend, Washington, USA Bract (part of the plants reproductive structures) of a cannabis plant. The bulbous glands are trichomes. Image Stacking 20X (Objective Lens Magnification) IoD Dr. Adolfo Ruiz De Segovia PARTICULAR Madrid, Spain Plant root Fiber Optic 2X (Objective Lens Magnification) IoD Yurim Seo, Dr. Mark Looney & Dr. Simon Cleary University of California, San Francisco Pulmonary, Critical Care, Allergy and Sleep Medicine San Francisco, California, USA Lymphatic vasculature (cyan) and vessels (red) of a mouse lung Confocal 4X (Objective Lens Magnification) IoD Dr. Leo Serra University of Cambridge Sainsbury Laboratory Cambridge, Cambridgeshire, United Kingdom Leaves arising from thale cress (Arabidopsis thaliana) meristem Confocal 20X (Objective Lens Magnification) IoD Dr. Igor Robert Siwanowicz Howard Hughes Medical Institute (HHMI), Janelia Research Campus Ashburn, Virginia, USA Aster anther cross section with pollen grains (green) Confocal 40X (Objective Lens Magnification) IoD Dr. Igor Robert Siwanowicz Howard Hughes Medical Institute (HHMI), Janelia Research Campus Ashburn, Virginia, USA Floret of a common chicory with pollen grains (spiky balls) Confocal 40x (Objective Lens Magnification) IoD Luna Šošo Zdravković, Michael Surala & Christian Madry Charité Universitätsmedizin Berlin Institute of Neurophysiology Berlin, Germany Pyramidal neuron in mouse hippocampus Confocal, Fluorescence, Image Stacking 30X (Objective Lens Magnification) IoD Dr. Bruce Douglas Taubert Glendale, Arizona, USA Mid-tibial tuft on a male orchid bee, used to attract mates Reflected Light 10X (Objective Lens Magnification) IoD Maxime Teixeira Laval University Department of Molecular Medicine Québec, Canada Cultured monkey kidney cells labeled for tubulin (blue) and actin (orange) showing pathological accumulation of alpha-syn aggregates (red) Confocal, Deconvolution, Image Stacking, Super-Resolution 100X (Objective Lens Magnification) IoD Dr. Theo Theune Oost-Souburg, Zeeland, Netherlands Abdominal skin of a tick that engorged with blood Image Stacking 50X (Objective Lens Magnification) IoD Dr. Grigorii Timin & Dr. Michel Milinkovitch University of Geneva Department of Genetics and Evolution Geneva, Switzerland Skin scales of a snake embryo stained with Fast Green dye Confocal 63X (Objective Lens Magnification) IoD Steven A. Valley Oregon Department of Agriculture (ODA) Entomology Lab Albany, Oregon, USA Immature male damselfly (Calopteryx aequabilis) Image Stacking, Reflected Light 5X (Objective Lens Magnification) IoD Dr. Bruno Vellutini Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Saxony, Germany Gene expression patterns in a drain fly embryo (Clogmia albipunctata) with an open eggshell Confocal 20X (Objective Lens Magnification) IoD Susannah Waxman & Dr. Ian Sigal University of Pittsburgh Department of Ophthalmology Pittsburgh, Pennsylvania, USA Optic nerve head collagen of a pig Image Stacking, Multiphoton 25X (Objective Lens Magnification) IoD Shao Yang Beijing Miteyide Culture Co., Ltd. Beijing, China Fiber of nylon stockings Polarized Light 5X (Objective Lens Magnification) IoD Chew Yen Fook Woodend, Waimakiriri, New Zealand Graffiti from Berlin Wall stone section Image Stacking, Top Illumination 10X (Objective Lens Magnification) IoD Chew Yen Fook Woodend, Waimakiriri, New Zealand Water mite (Hydrachna sp.) Darkfield, Image Stacking, Polarized Light 20X (Objective Lens Magnification) IoD Elkhan Yusifov & Dr. Martina Schaettin University of Zurich Department of Molecular Life Sciences Zurich, Switzerland Developing nervous system in the eye of a 7-day-old chick embryo Stereomicroscopy 10X (Objective Lens Magnification) IoD Ou Zhilei Guangdong Radio and Television Guangzhou, Guagndong, China Stamens of flowers (Anemone cathayensis Kitag. ex Ziman & Kadota) Image Stacking 10X (Objective Lens Magnification) About Nikon Small World Photomicrography Competition The Nikon Small World Competition is open to anyone with an interest in photography or video. Participants may upload digital images and videos directly at . For additional information, contact Nikon Small World, Nikon Instruments Inc., 1300 Walt Whitman Road, Melville, NY 11747, USA, or phone (631) 547-8569. Entry forms for Nikon's 2025 Small World and Small World in Motion Competitions are available at . About Nikon Instruments Inc. Nikon Instruments Inc. is the US microscopy arm of Nikon Healthcare, a world leader in the development and manufacturing of optical, digital imaging technology and software for biomedical applications. For more information, please visit or contact us at 1-800-52-NIKON. SOURCE Nikon Instruments Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

18 Sep 2024

·www.prnewswire.com

Stealth BioTherapeutics Presents New Bevemipretide (SBT-272) Data at Keystone Symposium Targeting Dry Age-Related Macular Degeneration

NEEDHAM, Mass., Sept. 18, 2024 /PRNewswire/ -- Stealth BioTherapeutics Inc. (the "Company" or "Stealth"), a clinical-stage biotechnology company focused on the discovery, development and commercialization of novel therapies for diseases involving mitochondrial dysfunction, today announced the presentation of new bevemipretide (SBT-272) preclinical data demonstrating topical ocular delivery to the retina with protective effects observed in models of AMD. The data were presented at the Keystone Symposium Targeting Dry Age-related Macular Degeneration: Pathophysiology and Emerging Therapies held September 17-19, 2024, in Pacific Grove, CA. In this study, the distribution profile of ocular topical bevemipretide and its protective effects in models of AMD were evaluated. In animal models, bevemipretide eyedrops were well-tolerated and demonstrated desirable ocular posterior segment and systemic exposure profiles with optimized delivery to the retina and low plasma concentrations. In a rat model of bright light-induced retinal degeneration, topical administration of bevemipretide significantly attenuated the loss of retinal thickness. Protective effects of bevemipretide were also investigated using iPSC-derived retinal pigment epithelial (RPE) cells from patients with AMD. Treatment with bevemipretide significantly improved viability of patient-derived RPE cells and reduced cellular and mitochondrial ROS production in ARPE-19 cells treated with hydroquinone, a model used to mimic cigarette smoke-induced oxidative stress in AMD. "In dry AMD, mitochondrial dysfunction ultimately leads to the degeneration and loss of photoreceptors and reduction in the EZ to RPE thickness within the macula, resulting in progressive loss of visual function," said Reenie McCarthy, CEO of Stealth BioTherapeutics. "We demonstrated in our ReCLAIM-2 study of elamipretide, our lead investigational compound, that our mitochondrial-targeted approach may reduce the progressive photoreceptor loss associated with declining visual function. We designed bevemipretide as a next-generation approach to offer a broader range of potential therapeutic options to patients living with this devastating disease. We plan to initiate clinical studies to support further development of topical bevemipretide as a potentially disease-modifying therapy in dry AMD." About Dry AMD AMD is a leading cause of irreversible blindness estimated by the Vision and Eye Health Surveillance System to affect 19.8 million Americans aged 40 and older (Rein 2022). Dry AMD, which accounts for 85% to 90% of these cases (Schultz 2021), is a progressive retinal disease in which the mitochondrial-rich photoreceptors (specialized neurons that convert light into electrical signals required for normal visual function) in the retina suffer progressive damage and death, leading to loss of vision. Mitochondrial dysfunction is known to precede clinical symptoms of AMD and increase commensurate with AMD disease progression (Feher 2006; Karunadharma 2010; Terluk 2015). Photoreceptor loss can be quantified using optical coherence tomography (OCT), a noninvasive imaging technique, to measure thickness between the ellipsoid zone (EZ), a mitochondrial-dense layer of the photoreceptors, and the RPE (i.e., EZ-RPE thickness). Loss of photoreceptors has been shown to precede and predict the loss of visual function and areas of geographic atrophy in dry AMD. About Stealth BioTherapeutics Stealth BioTherapeutics is a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of novel therapies for age-related and rare genetic diseases involving mitochondrial dysfunction. The Company is studying elamipretide, its lead investigational product candidate, in a Phase 3 development effort in dry AMD. Elamipretide is also under evaluation for primary mitochondrial myopathy, a rare skeletal myopathic disease, with pivotal Phase 3 data expected by year-end, and is under review by the Food and Drug Administration for Barth syndrome, an ultra-rare cardioskeletal disease, with a Prescription Drug User Fee Act date in January 2025. The Company is developing its second-generation clinical-stage candidate, bevemipretide (SBT-272), for ophthalmic and neurological disease indications. The Company has a deep pipeline of novel mitochondria-targeted compounds under evaluation as therapeutic product candidates. Media Contact Anna Stallmann Anna Stallmann Communications [email protected] Investor Contact Austin Murtagh Precision AQ [email protected] SOURCE Stealth BioTherapeutics Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Phase 3

24 Oct 2023

·www.biospace.com

DermBiont Announces First Close of $35.2 Million in a Series B Financing to Advance First-in-Class Targeted Topical Dermatological Therapeutics

- Series B led by Double Point Ventures with major support from Viking Global Investors as well as other new and existing investors - - A combined $27.1 million Series B first close and $8.1 million in converting outstanding notes funds the company’s two assets in development, SM-020 for the treatment of seborrheic keratoses and SM-030 for the treatment of melasma, through end of Phase 2 meetings with FDA and commencement of Phase 3 trials - BOSTON--(BUSINESS WIRE)-- DermBiont, Inc., a clinical-stage biotechnology company that is advancing targeted topical therapeutics for the treatment of dermatological indications, today announced a $35.2 million Series B financing, including a $27.1 million Series B first close and $8.1 million in converting outstanding notes. Proceeds will be used to advance two drugs in development, SM-020, a topical novel AKT kinase inhibitor for the treatment of seborrheic keratoses (SKs), and SM-030, a topical novel PKC-beta inhibitor for the treatment of melasma and other hyperpigmentation disorders of the skin. The Series B was led by new institutional investor, Double Point Ventures, and includes continued support from Viking Global Investors, Civilization Ventures, Olive Tree Capital, and others. Concurrent with the financing, Daniel Yadegar, M.D., Managing Partner at Double Point Ventures, joined DermBiont’s board of directors, adding, “I am excited to be working closely with DermBiont’s team to advance two products, one for the treatment of seborrheic keratoses and the other for the treatment of melasma, two of the most frequently diagnosed skin diseases by dermatologists. These products prioritize the patient experience by addressing the root cause of both diseases with excellent efficacy, safety, and tolerability. Physicians understand that patients with SKs and hyperpigmentation disorders of the skin are seeking effective, safe, and well-tolerated topical treatment options compared with existing ablative surgical procedures for treating SKs or ineffective lasers with frequent recurrence or unsafe toxic chemicals with very low efficacy like hydroquinone for treating melasma.” The proceeds from the Series B financing will be used to advance the clinical development of SM-020 and SM-030. They are expected to fund the company through end of its Phase 2 meetings with the U.S. Food and Drug Administration (FDA), which are expected in the second half of 2024 for both programs. In the next twelve months, DermBiont will commence enrollment for three planned seborrheic keratoses clinical trials and one melasma trial as follows: Phase 2b randomized, double-blind, vehicle-controlled clinical trial in 60 subjects with seborrheic keratoses treated with SM-020 gel 1% or vehicle twice daily for 28 days. Phase 2b open label clinical trial in 10 subjects with DPN (Dermatosis Papulosa Nigra) treated with SM-020 gel 1% twice daily for 28 days. Phase 2 open label clinical trial extension in 25 additional subjects with seborrheic keratoses treated with SM-020 gel 0.1% or SM-020 gel 1% daily or twice daily for 28 to 56 days. Phase 2b randomized, observer-blinded, placebo-controlled clinical trial in 138 subjects with melasma treated with SM-030 gel 0.64%, SM-030 gel 0.08%, or placebo gel twice daily for 12 weeks “The addition of Double Point Ventures as a major backer alongside continued financial and strategic support from Viking Global Investors and other investors allows us to accelerate the development of our pipeline of novel topical therapeutics for the treatment of the number one and number three most frequently diagnosed disorders of the skin by dermatologists in the US, seborrheic keratoses and hyperpigmentation, respectively,” stated Karl Beutner, M.D., Ph.D., Chief Executive Officer and Co-Founder of DermBiont. “This funding comes on the heels of our successful Phase 2 proof of concept trials, where SM-030 gel 0.64% achieved greater efficacy than 4% hydroquinone, and where over 80% of SKs responded to treatment with SM-020 gel 1.0% twice daily for 14 to 28 days and over 50% of SK lesions completely cleared in the most effective dosing regimen.” About DermBiont DermBiont’s mission is to become the world’s leading precision dermatology company developing and commercializing targeted topical therapeutics that treat, cure, and prevent skin diseases. The company aims to impact the root causes of skin diseases through the development of first-in-class targeted therapeutics with well-defined mechanisms of action. The company’s targeted topical therapeutics pipeline includes two lead assets: SM-020 for the treatment of seborrheic keratoses and SM-030 for the treatment of melasma and other hyperpigmentation disorders of the skin. For more information, please visit . About Double Point Ventures At Double Point Ventures, we see beyond today's treatments to envision tomorrow's cures. Our fund invests in revolutionary companies developing cutting-edge therapeutics, from gene therapies to precision medicines. While novel drugs are our focus, we also target innovative early revenue-stage diagnostic companies, medical device startups, digital health startups, and healthcare services providers catalyzing the future of healthcare. Backed by visionary investors, our mission is clear - fund the science superstars solving the medical mysteries of our time. By powering pioneering companies, we strive to bring groundbreaking treatments from bench to bedside. Double Point Ventures is led by Managing Partner, Daniel Yadegar, M.D. For more information, please visit .

Phase 2Clinical ResultPhase 3

100 Deals associated with Hydroquinone

External Link

KEGG	Wiki	ATC	Drug Bank
D00073	Hydroquinone	D11AX11	DB09526

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Nevus	-	-	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ARVO2018	Not Applicable	-	-	Hydroquinone	goonkzjjiu(pxnaqctxih) = xrpkxpnzkd hxrltahbzv (srvhieufay )	-	01 Jul 2018
ARVO2017	Not Applicable	Functional disorder	5	Hydroquinone	xghyfxhqmh(sabtnmqkyf) = pufcrzhpjm zqkxvyiiyj (dvygixzbzj )	-	07 May 2017

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis