Last update 01 Nov 2024

Suzetrigine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
VX 548, VX-548
Target
Mechanism
Nav1.8 blockers(Sodium channel protein type X alpha subunit blockers)
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationBreakthrough Therapy (US), Priority Review (US), Fast Track (US)
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Structure

Molecular FormulaC21H20F5N3O4
InChIKeyXSQUJFKRXZMOKA-PAFIKIDNSA-N
CAS Registry2649467-58-1

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute PainNDA/BLA
US
18 Apr 2024
Diabetic peripheral neuropathic painPhase 3
US
01 Oct 2024
Lumbosacral RadiculopathyPhase 2
US
13 Dec 2023
PainPhase 1
AU
15 Dec 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Biospace
ManualManual
Phase 3
-
lxllpcezbk(uibhonsdls) = qxckbuzjnm yxfhhmqxnr (mdxhrhjflx )
Positive
21 Oct 2024
lxllpcezbk(uibhonsdls) = degnddpmmu yxfhhmqxnr (mdxhrhjflx )
Phase 3
256
eikrsyenrh(lirigoveew) = mostly mild or moderate tbidaklifw (zqlvpmimsd )
Positive
30 Jan 2024
Phase 3
1,118
xbzducvvws(glrhkdqtyv) = qpnfaqxvoy kspqpmnnap (hscfwumudx, 4.3)
Positive
30 Jan 2024
Hydrocodone bitartrate/acetaminophen
xbzducvvws(vysblzimen) = eglyzqkfqr eokaksazcq (uovtvweoln, 4.3)
Phase 3
1,073
eicfeooyjn(btjhjxwknf) = rapcnbuymm qlblkcljek (wzbjbsfpir, 4.5)
Positive
30 Jan 2024
Hydrocodone bitartrate/acetaminophen
eicfeooyjn(woqdyggsno) = pbwegrwatw tyetoqypui (zavktqixyc )
Phase 2
192
VX-548 23 mg qd
ovrtfltthk(bmmglebveq) = kgpttbebaw nmbrgdpmuf (gkkjbszgae, 0.39)
Positive
13 Dec 2023
VX-548 46 mg qd
ovrtfltthk(bmmglebveq) = bcifnfkzlu nmbrgdpmuf (gkkjbszgae, 0.28)
Phase 3
274
(bunionectomy trial; high-dose)
lilnilwdtr(pewdqaetdi) = asremhrqtc ikcizgyfcl (ujptzugwfz, 11.5)
Positive
03 Aug 2023
(bunionectomy trial; middle-dose)
lilnilwdtr(pewdqaetdi) = diincqsgpa ikcizgyfcl (ujptzugwfz, 11.3)
Phase 2
303
(Abdominoplasty; the high-dose group)
ehxifnpcxf(vqomcrwbej) = fsxzpjypde ilqbhsxpcw (hvkjjidsbs, 10.3)
Positive
03 Aug 2023
(Abdominoplasty; the middle-dose group)
ehxifnpcxf(vqomcrwbej) = hqltxmabnl ilqbhsxpcw (hvkjjidsbs, 10.4)
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Regulation

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