Drug Type Small molecule drug |
Synonyms VX 548, VX-548 |
Target |
Mechanism Nav1.8 blockers(Sodium channel protein type X alpha subunit blockers) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseNDA/BLA |
First Approval Date- |
RegulationBreakthrough Therapy (US), Priority Review (US), Fast Track (US) |
Molecular FormulaC21H20F5N3O4 |
InChIKeyXSQUJFKRXZMOKA-PAFIKIDNSA-N |
CAS Registry2649467-58-1 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Acute Pain | NDA/BLA | US | 18 Apr 2024 | |
Diabetic peripheral neuropathic pain | Phase 3 | US | 01 Oct 2024 | |
Lumbosacral Radiculopathy | Phase 2 | US | 13 Dec 2023 | |
Pain | Phase 1 | AU | 15 Dec 2022 |
Biospace Manual | Phase 3 | - | lxllpcezbk(uibhonsdls) = qxckbuzjnm yxfhhmqxnr (mdxhrhjflx ) View more | Positive | 21 Oct 2024 | ||
Hydrocodone bitartrate/acetaminophen (HB/APAP) | lxllpcezbk(uibhonsdls) = degnddpmmu yxfhhmqxnr (mdxhrhjflx ) View more | ||||||
Phase 3 | 256 | eikrsyenrh(lirigoveew) = mostly mild or moderate tbidaklifw (zqlvpmimsd ) View more | Positive | 30 Jan 2024 | |||
Phase 3 | 1,118 | xbzducvvws(glrhkdqtyv) = qpnfaqxvoy kspqpmnnap (hscfwumudx, 4.3) View more | Positive | 30 Jan 2024 | |||
Hydrocodone bitartrate/acetaminophen | xbzducvvws(vysblzimen) = eglyzqkfqr eokaksazcq (uovtvweoln, 4.3) | ||||||
Phase 3 | 1,073 | eicfeooyjn(btjhjxwknf) = rapcnbuymm qlblkcljek (wzbjbsfpir, 4.5) View more | Positive | 30 Jan 2024 | |||
Hydrocodone bitartrate/acetaminophen | eicfeooyjn(woqdyggsno) = pbwegrwatw tyetoqypui (zavktqixyc ) | ||||||
Phase 2 | 192 | VX-548 23 mg qd | ovrtfltthk(bmmglebveq) = kgpttbebaw nmbrgdpmuf (gkkjbszgae, 0.39) View more | Positive | 13 Dec 2023 | ||
VX-548 46 mg qd | ovrtfltthk(bmmglebveq) = bcifnfkzlu nmbrgdpmuf (gkkjbszgae, 0.28) View more | ||||||
Phase 3 | 274 | (bunionectomy trial; high-dose) | lilnilwdtr(pewdqaetdi) = asremhrqtc ikcizgyfcl (ujptzugwfz, 11.5) View more | Positive | 03 Aug 2023 | ||
(bunionectomy trial; middle-dose) | lilnilwdtr(pewdqaetdi) = diincqsgpa ikcizgyfcl (ujptzugwfz, 11.3) View more | ||||||
Phase 2 | 303 | (Abdominoplasty; the high-dose group) | ehxifnpcxf(vqomcrwbej) = fsxzpjypde ilqbhsxpcw (hvkjjidsbs, 10.3) View more | Positive | 03 Aug 2023 | ||
(Abdominoplasty; the middle-dose group) | ehxifnpcxf(vqomcrwbej) = hqltxmabnl ilqbhsxpcw (hvkjjidsbs, 10.4) View more |