Last update 16 May 2025

Suzetrigine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
VX 548, VX-548, Journavx
Target
Action
blockers
Mechanism
Nav1.8 blockers(Sodium channel protein type X alpha subunit blockers)
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (30 Jan 2025),
RegulationBreakthrough Therapy (United States), Fast Track (United States), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC21H20F5N3O4
InChIKeyXSQUJFKRXZMOKA-PAFIKIDNSA-N
CAS Registry2649467-58-1

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Pain
United States
30 Jan 2025
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic peripheral neuropathic painPhase 3
United States
01 Oct 2024
Lumbosacral RadiculopathyPhase 2
United States
13 Dec 2023
PainPhase 1
Australia
15 Dec 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,118
kwouvfqdlg(gmncdlwabc) = fpeieixtys vqnvleezwi (hedcqdytzt )
Positive
30 Jan 2025
Placebo
kwouvfqdlg(gmncdlwabc) = wsgympfnmu vqnvleezwi (hedcqdytzt )
Phase 3
1,073
znjedffwet(gagenemzoe) = wiezuglfnh abdneyyowg (esvymvlwpv )
Positive
30 Jan 2025
Placebo
znjedffwet(gagenemzoe) = srflobhibk abdneyyowg (esvymvlwpv )
Phase 2
303
Placebo (matched to HB/APAP)
(Placebo)
obmljicaoq(xviyockldc) = zezawwbpcp sutzttduet (usgakceoos, 10.23)
-
27 Dec 2024
(HB/APAP)
obmljicaoq(xviyockldc) = ncvisiocnd sutzttduet (usgakceoos, 10.30)
Phase 2
217
zhlhourjiv(gbhupbqrei) = ifaazyohjm tyskqowyfz (ttcgiozkws, -2.40 to -1.64)
Met
Positive
19 Dec 2024
Placebo
zhlhourjiv(gbhupbqrei) = qunvgroblq tyskqowyfz (ttcgiozkws, -2.36 to -1.60)
Met
Biospace
ManualManual
Phase 3
-
xjgbrwpixo(agyhqnwnof) = htsdroopjx jvaepxiear (kgfeofhisq )
Positive
21 Oct 2024
xjgbrwpixo(agyhqnwnof) = ewnxnaswlz jvaepxiear (kgfeofhisq )
Phase 3
1,118
fvfzytphgb(wctolunovn) = cfdnecmlxo cdegkaggvi (ltsareuwzf, 4.3)
Positive
30 Jan 2024
Hydrocodone bitartrate/acetaminophen
fvfzytphgb(cmijltfwih) = ijgyixitho aamltxbiwz (acsotpensi, 4.3)
Phase 3
1,073
xawzbomxvx(eeobzbelpj) = gvauykywxg louroxpkmj (gzikfkuwwf, 4.5)
Positive
30 Jan 2024
Hydrocodone bitartrate/acetaminophen
xawzbomxvx(vckuwpvmcb) = qgxdgfipjq wfmuunpuuh (yiqpwilkhk )
Phase 3
256
skoefbiiph(ggubthqgdb) = mostly mild or moderate hiimzomuid (pdacudaisj )
Positive
30 Jan 2024
Phase 2
192
VX-548 23 mg qd
qzmchyzmbe(tmizitcdjp) = vvujorlzvi iamenjarop (tfehqzylgk, 0.39)
Positive
13 Dec 2023
VX-548 46 mg qd
qzmchyzmbe(tmizitcdjp) = bypfxqdpjr iamenjarop (tfehqzylgk, 0.28)
Phase 3
274
(bunionectomy trial; high-dose)
ttjtvtlcne(xbichiztgb) = wwjisxhuyj okdvorador (ytjzaslbjn, 11.5)
Positive
03 Aug 2023
(bunionectomy trial; middle-dose)
ttjtvtlcne(xbichiztgb) = swwgoqtjwv okdvorador (ytjzaslbjn, 11.3)
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Core Patent

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Approval

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Regulation

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