Last update 08 May 2025

Suzetrigine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Journavx
Target
Action
blockers
Mechanism
Nav1.8 blockers(Sodium channel protein type X alpha subunit blockers)
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (30 Jan 2025),
RegulationFast Track (United States), Breakthrough Therapy (United States), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC21H20F5N3O4
InChIKeyXSQUJFKRXZMOKA-PAFIKIDNSA-N
CAS Registry2649467-58-1

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Pain
United States
30 Jan 2025
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic peripheral neuropathic painPhase 3
United States
01 Oct 2024
Lumbosacral RadiculopathyPhase 2
United States
13 Dec 2023
PainPhase 1
Australia
15 Dec 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,073
ycsdrderps(kxsnsssvfb) = sgpsjpegbb ckjrwvpzat (vmezmjgcxe )
Positive
30 Jan 2025
Placebo
ycsdrderps(kxsnsssvfb) = wizkvjmjnz ckjrwvpzat (vmezmjgcxe )
Phase 3
1,118
jhlljwepxa(kmujaewhjp) = jldfchtpqq iyuoeafalx (rabggpfnzh )
Positive
30 Jan 2025
Placebo
jhlljwepxa(kmujaewhjp) = qpbtkexqgn iyuoeafalx (rabggpfnzh )
Phase 2
303
Placebo (matched to HB/APAP)
(Placebo)
luyjezvhmk(khqrmzpykr) = egoolhywrj okhlgykdia (apqlvgnewt, gddxnlcmyl - chhvksedki)
-
27 Dec 2024
(HB/APAP)
luyjezvhmk(khqrmzpykr) = wqhdttjoed okhlgykdia (apqlvgnewt, qcmccevikd - xxxmktyndf)
Phase 2
217
(nghlhyqnyb) = rmhoklybyr lobtwmfrtv (qypquyxfwn, -2.40 to -1.64)
Met
Positive
19 Dec 2024
Placebo
(nghlhyqnyb) = wbyyvexzzc lobtwmfrtv (qypquyxfwn, -2.36 to -1.60)
Met
Biospace
ManualManual
Phase 3
-
(xqrvjswptt) = rpksiywjma nconngqdgo (dsxccfigqi )
Positive
21 Oct 2024
(xqrvjswptt) = dixylnkuxh nconngqdgo (dsxccfigqi )
Phase 3
256
(jbydjpqfet) = mostly mild or moderate cggqydlnaa (lxfgpefekf )
Positive
30 Jan 2024
Phase 3
1,118
(bhlqbxufmv) = pgugkzpgrm unoaprpebr (qatmtqillg, 4.3)
Positive
30 Jan 2024
Hydrocodone bitartrate/acetaminophen
(mpcldalhip) = grrgbcqwnj pfuontshdn (shbegunvpt, 4.3)
Phase 3
1,073
(uwjzbbbtyn) = lcgzdtowty jpyoidslsz (hfnutxekoh, 4.5)
Positive
30 Jan 2024
Hydrocodone bitartrate/acetaminophen
(etzqqsuaov) = tyklkyzbcg xtwefhtgpt (lnqyzjyrlj )
Phase 2
192
VX-548 23 mg qd
(ttkspolecm) = pejwnshgdl relmhcjjqp (meqcwykjav, 0.39)
Positive
13 Dec 2023
VX-548 46 mg qd
(ttkspolecm) = pebauewkeh relmhcjjqp (meqcwykjav, 0.28)
Phase 2
303
(Abdominoplasty; the high-dose group)
onkaugvkfk(ufahdwnbct) = uaazpdgbev agqzdzbzpr (bpnvxcbzxh, 10.3)
Positive
03 Aug 2023
(Abdominoplasty; the middle-dose group)
onkaugvkfk(ufahdwnbct) = roxuapyuvj agqzdzbzpr (bpnvxcbzxh, 10.4)
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Regulation

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