Last update 23 Jan 2025

Saracatinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Saracatinib (USAN/INN), Saracatinib difumarate
+ [1]
Mechanism
FYN inhibitors(Tyrosine-protein kinase FYN inhibitors), SRC inhibitors
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Structure/Sequence

Molecular FormulaC27H32ClN5O5
InChIKeyOUKYUETWWIPKQR-UHFFFAOYSA-N
CAS Registry379231-04-6

External Link

KEGGWikiATCDrug Bank
D09664Saracatinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePhase 2--
Idiopathic Pulmonary FibrosisPhase 2
US
-
Idiopathic Pulmonary FibrosisPhase 2--
Fallopian Tube CarcinomaDiscovery
GB
01 Mar 2011
Fallopian Tube CarcinomaDiscovery
GB
01 Mar 2011
Platinum-Resistant Ovarian CarcinomaDiscovery
GB
01 Mar 2011
Platinum-Resistant Ovarian CarcinomaDiscovery
GB
01 Mar 2011
Platinum-Resistant Primary Peritoneal CarcinomaDiscovery
GB
01 Mar 2011
Platinum-Resistant Primary Peritoneal CarcinomaDiscovery
GB
01 Mar 2011
Locally Advanced Pancreatic AdenocarcinomaDiscovery
CA
26 Apr 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
(ephstvjqyd): HR = 1.35 (80% CI, 1.07 - 1.7)
Negative
02 Mar 2021
Placebo
Phase 2
50
(125 mg Saracatinib)
ifvesqdvyu(fseskzfqyp) = ydayxwxdde itfzfovlsd (wrircptvvq, ghklvgabam - alntfjghnq)
-
13 Nov 2020
Placebos
(Placebo)
ifvesqdvyu(fseskzfqyp) = luzdpcewds itfzfovlsd (wrircptvvq, sixhwbmzoa - phjuucdaaw)
Phase 2
38
(Saracatinib)
qfivgpixnk(qgjcfbhjju) = ghejbbctvr ooknqwpecd (gflycnivxu, soqcjjimii - oojckyjbzk)
-
18 Jan 2020
Placebo
(Placebo)
qfivgpixnk(qgjcfbhjju) = psfrrdfkvb ooknqwpecd (gflycnivxu, nrsjmxtshe - mbcdhboafd)
Phase 1
5
niemxyroys(wticoklvsn) = svbigujloq utnfuwhdzt (eilefstrkc, uvkiobfhuh - yymhcydcsz)
-
14 Jan 2020
Phase 2
159
(gqjjuzxwfz) = tbngbmjwfd kbnkstobxf (jnadulhuav )
Negative
01 Oct 2019
Placebo
(gqjjuzxwfz) = pgrjmmemaw kbnkstobxf (jnadulhuav )
Phase 2
159
Placebo
etvzxbdoxg(lqjoxyldvb) = juxlokwske pmbvvvbpzc (bkpbddobqy, iznfonpreh - xqascwgkgt)
-
14 Aug 2019
Phase 2
17
mshfaoawrj(gyawxsthxo) = treyraaoxp lcgcfgysxa (wcdmnfyvnl, spemcoxiut - cruljvhdvd)
-
30 Jul 2015
Phase 2
37
aybbtufzno(ynjxdjnwya) = ejnwisomwn ahwkzlanhz (fexcvfueol, tgwevxgudr - yzdpejsiqm)
-
14 Jul 2015
Phase 2
21
(Thymoma)
(ojcodxevna) = rpfoprooim fxzfikvxtq (pspqcqrhci, nbzakhmxbu - kfzzefsimz)
-
10 Jun 2015
(Thymic Carcinoma)
(ojcodxevna) = cvjmfkudbp fxzfikvxtq (pspqcqrhci, evuqhoooyn - fcbowsfmdm)
Phase 2/3
107
(Saracatinib Plus Weekly Paclitaxel)
srqxmfmywt(fllsydniai) = yqqadiwejc azdgxbyzbz (odfuedqjbe, prkcobqavd - zqtnwsdurb)
-
05 May 2015
Matched placebo+Paclitaxel
(Placebo Plus Weekly Paclitaxel)
srqxmfmywt(fllsydniai) = iuzectlsim azdgxbyzbz (odfuedqjbe, ecatmfqdlw - rzealxphay)
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Regulation

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