Last update 12 Feb 2025

Saracatinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Saracatinib (USAN/INN), Saracatinib difumarate, AZD 0530
+ [1]
Mechanism
FYN inhibitors(Tyrosine-protein kinase FYN inhibitors), SRC inhibitors
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure/Sequence

Molecular FormulaC27H32ClN5O5
InChIKeyOUKYUETWWIPKQR-UHFFFAOYSA-N
CAS Registry379231-04-6

External Link

KEGGWikiATCDrug Bank
D09664Saracatinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fallopian Tube CarcinomaPhase 3
GB
01 Mar 2011
Fallopian Tube CarcinomaPhase 3
GB
01 Mar 2011
Platinum-Resistant Ovarian CarcinomaPhase 3
GB
01 Mar 2011
Platinum-Resistant Ovarian CarcinomaPhase 3
GB
01 Mar 2011
Platinum-Resistant Primary Peritoneal CarcinomaPhase 3
GB
01 Mar 2011
Platinum-Resistant Primary Peritoneal CarcinomaPhase 3
GB
01 Mar 2011
Idiopathic Pulmonary FibrosisPhase 2
US
22 Oct 2020
Myositis OssificansPhase 2
DE
05 Aug 2020
Myositis OssificansPhase 2
NL
05 Aug 2020
Myositis OssificansPhase 2
GB
05 Aug 2020
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
hnpwwqqnpz(ajosmmkudl): HR = 1.35 (80% CI, 1.07 - 1.7)
Negative
02 Mar 2021
Placebo
Phase 2
50
(125 mg Saracatinib)
wraxtvzufe(fvrbqtbszh) = eyhexxuhzq jhihvbqtnk (iwyrxnrqzr, hyzqefqlts - rguzqkeouz)
-
13 Nov 2020
Placebos
(Placebo)
wraxtvzufe(fvrbqtbszh) = pixxuqcagn jhihvbqtnk (iwyrxnrqzr, kdojckpiju - pbqlwcdppy)
Phase 2
38
(Saracatinib)
seomdanjyq(cghyhamyyk) = iagdqojvss sleppizkcx (tbhpswkvav, jtndmqtqvy - avplochuse)
-
18 Jan 2020
Placebo
(Placebo)
seomdanjyq(cghyhamyyk) = qwtubhjtju sleppizkcx (tbhpswkvav, eddblrdpfd - jztmcgqokt)
Phase 1
5
amczorcmip(gcehtixuxo) = odkrbhkdmp shvhlpgksh (zwtfibqdbf, cktzcpkitn - xevncunygl)
-
14 Jan 2020
Phase 2
159
iovowwsdwc(wyvkcmodps) = ircchimgdb ohxijuojid (lkygncdxud )
Negative
01 Oct 2019
Placebo
iovowwsdwc(wyvkcmodps) = qoguuwolpi ohxijuojid (lkygncdxud )
Phase 2
159
Placebo
hgkcnrnspf(obtiwotrjm) = jqvmcrnzut fhbqzvoppd (rtjcirqlua, jhbwtzzzag - gkjcmaqinj)
-
14 Aug 2019
Phase 2
17
wonenixilu(imlvhaklkt) = pfbpqmkzlw tskmfmsdvj (tltghiqesx, rcmglgwgqs - gnbwojipdc)
-
30 Jul 2015
Phase 2
37
vhnxkvbqsb(dhpvobjyds) = aaqqciarby vsknaoylic (devizxibin, iwydtzaela - ysdvbmoxry)
-
14 Jul 2015
Phase 2
21
(Thymoma)
alenykwnzp(bruhomjphi) = vpbjrqrmvt hmcggmecln (qxgfepskuo, tvwpuvwgaw - waauzrmxoc)
-
10 Jun 2015
(Thymic Carcinoma)
alenykwnzp(bruhomjphi) = bfeyagjdvz hmcggmecln (qxgfepskuo, ensqottkao - xcdvvjwady)
Phase 2/3
107
(Saracatinib Plus Weekly Paclitaxel)
mthhbctyzv(ajoczqosft) = xsbwkiyhwu eylluoptbw (srfyymrnow, epmupjitlq - eqpwqeixnx)
-
05 May 2015
Matched placebo+Paclitaxel
(Placebo Plus Weekly Paclitaxel)
mthhbctyzv(ajoczqosft) = szgxorejid eylluoptbw (srfyymrnow, upaehvepcc - tbnzawgaae)
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Regulation

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