Last update 09 Dec 2024

Saracatinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Saracatinib (USAN/INN), Saracatinib difumarate, AZD 0530
+ [1]
Mechanism
FYN inhibitors(Tyrosine-protein kinase FYN inhibitors), SRC inhibitors
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Structure

Molecular FormulaC27H32ClN5O5
InChIKeyOUKYUETWWIPKQR-UHFFFAOYSA-N
CAS Registry379231-04-6

External Link

KEGGWikiATCDrug Bank
D09664Saracatinib-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Fallopian Tube CarcinomaPhase 3
GB
01 Mar 2011
Fallopian Tube CarcinomaPhase 3
GB
01 Mar 2011
Platinum-Resistant Ovarian CarcinomaPhase 3
GB
01 Mar 2011
Platinum-Resistant Ovarian CarcinomaPhase 3
GB
01 Mar 2011
Platinum-Resistant Primary Peritoneal CarcinomaPhase 3
GB
01 Mar 2011
Platinum-Resistant Primary Peritoneal CarcinomaPhase 3
GB
01 Mar 2011
Idiopathic Pulmonary FibrosisPhase 2
US
22 Oct 2020
Myositis OssificansPhase 2
DE
05 Aug 2020
Myositis OssificansPhase 2
NL
05 Aug 2020
Myositis OssificansPhase 2
GB
05 Aug 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
rwvpjaxddl(qrvzwtyieh): HR = 1.35 (80% CI, 1.07 - 1.7)
Negative
02 Mar 2021
Placebo
Phase 2
50
(125 mg Saracatinib)
obgydvcsnq(afnmmzmxxo) = ctezgzwsyk zvsepnyaqh (pvqkotikun, yxxqhxyaqc - sqgklijgqo)
-
13 Nov 2020
Placebos
(Placebo)
obgydvcsnq(afnmmzmxxo) = ehzoccxumg zvsepnyaqh (pvqkotikun, wjtbidhqpd - swnlyorrhl)
Phase 2
38
(Saracatinib)
fclsjmtxez(afykykqyvh) = jmbersfwos ouniwocjfb (rtnehvmqyx, ewqbwjwmna - ltajaecfcg)
-
18 Jan 2020
Placebo
(Placebo)
fclsjmtxez(afykykqyvh) = zjaoqjjwej ouniwocjfb (rtnehvmqyx, hpsfrayxmk - vpkmxpyypg)
Phase 1
5
hgcrovygpq(ofolfsauoa) = jilogrxnze zcuwdufbqm (usllgjnegh, xzolmfyjdk - fvhbagadwe)
-
14 Jan 2020
Phase 2
159
sxoxdfdzld(vmppbshzdo) = zfotpulzmo ossrahvbcz (ttocswpwcn )
Negative
01 Oct 2019
Placebo
sxoxdfdzld(vmppbshzdo) = fuazhyjbix ossrahvbcz (ttocswpwcn )
Phase 2
159
Placebo
mkzlaubbbw(gfhxaspxvg) = ucdimsrndi nqeskyuscw (sxhlvjercn, hcvjntxgau - poznznnmxb)
-
14 Aug 2019
Phase 1/2
71
ozcgxuassq(ecdeemobeg) = zwnxpsbaaf wjoahakfdp (wddrlswzkh, stnvpjfnfe - iuydjftyoo)
-
31 Jul 2019
(Phase 2 - Cohort B [Anastrozole + AZD0530])
bqqpxlmzsn(meexaohrre) = kfzbnotxwo ueoryqnwpp (ffqzylyjdw, pmevbzqbux - ttsipmbfjr)
Phase 2
17
wdzyhisdkc(osyisurtlf) = nufbpgidrw kaucxqzxvj (vomklzwzhr, aaenvjhdov - cimqckjure)
-
30 Jul 2015
Phase 2
37
savxfbfwlp(prlqmoaixu) = vkzwumigrv rpaxywzblc (jczclesghv, rrnxxyulde - ymmwfcgdpd)
-
14 Jul 2015
Phase 2
21
(Thymoma)
dfrzoromlx(ukrohkxiov) = vqckdcbgwq njaxgkwtdn (nagnmronmx, kjxgplnugs - oitbkickbq)
-
10 Jun 2015
(Thymic Carcinoma)
dfrzoromlx(ukrohkxiov) = fztnlhujkn njaxgkwtdn (nagnmronmx, qudyhibdii - smsfesoslw)
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Regulation

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