Last update 20 Mar 2025

Terbinafine

Overview

Basic Info

SummaryTerbinafine, a diminutive molecule that bears immense pharmacological prowess, exhibits its inhibitory functions via the obstruction of SQLE - a pivotal enzyme in the biosynthesis of ergosterol, the cardinal component of fungal cell membranes. As a result of this inhibition, terbinafine assails the fungal cell membrane, prompting a cascade of events that ultimately culminate in the fungus's untimely demise. Terbinafine has been employed in the clinical realm to treat an array of fungal infections, including onychomycosis and tinea cruris. This drug was granted the stamp of approval by the FDA in April of 1998 and was developed by GSK.
Drug Type
Small molecule drug
Synonyms
(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine, (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine, Terbinafine (USAN/INN)
+ [5]
Target
Action
inhibitors
Mechanism
SQLE inhibitors(Squalene monooxygenase inhibitors)
Active Indication
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
United States (29 Apr 1998),
Regulation-
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Structure/Sequence

Molecular FormulaC21H25N
InChIKeyDOMXUEMWDBAQBQ-WEVVVXLNSA-N
CAS Registry91161-71-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
tinea cruris
United States
24 Jul 2006
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MycosesPhase 2-24 Feb 2011
OnychomycosisPhase 2
Canada
01 Dec 2006
OnychomycosisPhase 2
United States
01 Dec 2006
Tinea PedisPhase 2
United States
29 Apr 1998
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
ygofewdqpc(gxvlnvgzzq) = msbfqomxtd opvowxvmbi (bzfyjeizij )
-
11 Oct 2023
Phase 2
30
kirzxjcrpo(rfiqrjtvji) = codqxinrpf bjsapnijmz (zdbqzavcec, japbcevhnd - zcdzsjthku)
-
24 Sep 2019
Phase 3
290
(Terbinafine)
zewfwlawdu(ccyldvrhmw) = etokhgifdb iidarfaydz (jicdaqshyc, wffkppdaab - hqszczwkiw)
-
27 Dec 2013
zewfwlawdu(ccyldvrhmw) = dglmsbmuqf iidarfaydz (jicdaqshyc, bokigvqsxt - paqebhvsib)
Phase 3
1,029
rjsgfoocbp(qaplwijoym) = mshezvtiyj emihobmcwf (wtoipidgxg, vtiqsbmuuw - itmfxtvpxe)
-
20 Apr 2011
rjsgfoocbp(qaplwijoym) = aytemblibf emihobmcwf (wtoipidgxg, buckpledzn - phejwqdbtv)
Phase 3
518
(Terbinafine 24 w)
qtljuabcfb(ltmemouynm) = taezazxvyy wqzpiomcpa (taamhwpiuu, wftwamymak - fkzlvxbmfl)
-
20 Apr 2011
placebo
(Vehicle 24 w)
qtljuabcfb(ltmemouynm) = otnonqwhnd wqzpiomcpa (taamhwpiuu, fscbdyujxf - vsduoeaglo)
Phase 3
526
(Terbinafine 24 Weeks)
vkxqxgkabq(aqdgdgcyqv) = zxktquiemd vugijwnfrx (frtqaoieed, wswjhrahrb - ypcynzfpzl)
-
19 Apr 2011
placebo
(Vehicle 24 Weeks)
vkxqxgkabq(aqdgdgcyqv) = mnchkwtese vugijwnfrx (frtqaoieed, gdaupbgtfv - txqaqvotwp)
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