Last update 21 Nov 2024

Avibactam Sodium/Ceftazidime

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AVE 1330/ceftazidime, AVE 1330A/ceftazidime, AVYCAZ
+ [20]
Mechanism
β-lactamase inhibitors(Beta Lactamase inhibitors)
Originator Organization
Drug Highest PhaseApproved
RegulationSpecial Review Project (CN), Fast Track (US), Priority Review (US)
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Structure

Molecular FormulaC22H32N6O12S2
InChIKeyNMVPEQXCMGEDNH-TZVUEUGBSA-N
CAS Registry78439-06-2
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Avibactam Sodium/Ceftazidime-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Intraabdominal Infections
CN
21 May 2019
Bacteremia
NO
23 Jun 2016
Bacteremia
IS
23 Jun 2016
Bacteremia
LI
23 Jun 2016
Bacteremia
EU
23 Jun 2016
Gram-Negative Bacterial Infections
IS
23 Jun 2016
Gram-Negative Bacterial Infections
NO
23 Jun 2016
Gram-Negative Bacterial Infections
EU
23 Jun 2016
Gram-Negative Bacterial Infections
LI
23 Jun 2016
Hospital-acquired pneumonia
EU
23 Jun 2016
Hospital-acquired pneumonia
LI
23 Jun 2016
Hospital-acquired pneumonia
NO
23 Jun 2016
Hospital-acquired pneumonia
IS
23 Jun 2016
Pneumonia, Ventilator-Associated
IS
23 Jun 2016
Pneumonia, Ventilator-Associated
LI
23 Jun 2016
Pneumonia, Ventilator-Associated
EU
23 Jun 2016
Pneumonia, Ventilator-Associated
NO
23 Jun 2016
Complicated intra-abdominal infection
US
25 Feb 2015
Complicated urinary tract infection
US
25 Feb 2015
Pyelonephritis
US
25 Feb 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Complicated intra-abdominal infectionPhase 2
MY
01 Mar 2012
Complicated intra-abdominal infectionPhase 2
UA
01 Mar 2012
Complicated intra-abdominal infectionPhase 2
MX
01 Mar 2012
Complicated intra-abdominal infectionPhase 2
RU
01 Mar 2012
Complicated intra-abdominal infectionPhase 2
ZA
01 Mar 2012
Complicated intra-abdominal infectionPhase 2
TH
01 Mar 2012
Complicated intra-abdominal infectionPhase 2
IN
01 Mar 2012
Complicated intra-abdominal infectionPhase 2
PE
01 Mar 2012
Complicated intra-abdominal infectionPhase 2
TW
01 Mar 2012
Complicated intra-abdominal infectionPhase 2
US
01 Mar 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
235
hmoxdiqixn(qaljokowrw) = nzwdswdwcu dvsvwalvkw (dwcmifftiy, givrmjamen - fqksvvkkat)
-
19 Sep 2024
Phase 3
60
ivjgmcyqtw(fpcfbceuqs) = flqbubiwak xjfwysmqsd (dhyumwdegt, htokrabfsl - nkpllphewg)
-
08 Mar 2024
Phase 3
Gram-Negative Bacterial Infections
ESBLs | AmpC | serine carbapenemase-producing Gram-negative pathogens
813
(cfyetznycj) = slrgcxywvc ulexjrbvzm (tzlveqrhah )
Positive
06 Nov 2023
Comparators (carbapenems)
(cfyetznycj) = wdlxhhjsjf ulexjrbvzm (tzlveqrhah )
Not Applicable
569
(taptzmqvev) = Adverse events were reported for six of the 569 patients enrolled. otcjsgzicg (ectgyaacxj )
-
10 Feb 2023
Not Applicable
47
(ftavwvlcka) = iqzukbxigc ghfkwgxcfx (xarrerqppw )
-
10 Jun 2022
Phase 1/2
48
AVYCAZ IV
(AVYCAZ IV)
(grhnsupulm) = vnhclykwqc sgrmesxfnu (vlhjjevjtk, ygvqaejnog - rhsmzjvhyq)
-
23 Dec 2021
(AVYCAZ CI)
(grhnsupulm) = mkmugohxwf sgrmesxfnu (vlhjjevjtk, sjtgieqmez - pdzopdzsnf)
Phase 2
95
(ehchsscdvy) = togmicuozu dwgydpplje (aawcsrzqaf )
Positive
01 Sep 2019
(ehchsscdvy) = orjbcnmxbj dwgydpplje (aawcsrzqaf )
Phase 2
83
(inufywdaki) = hogtmvnbgq jvlqxymyqj (xbnlvienwq )
Positive
01 Aug 2019
(inufywdaki) = dkojxjxpkh jvlqxymyqj (xbnlvienwq )
Phase 4
12
zdjehyssqy(xlonjijgcq) = mwuiafsyah xthmxezhdd (xoquqxwdkv, fyehxokmgj - jszyqtwpsu)
-
27 Nov 2018
Phase 3
-
xufdlxgeyg(ejbuxptqpf) = kevsuivyjf qgkhredxnc (myqbtlbern )
-
01 Sep 2018
Predominantly carbapenem comparators
xufdlxgeyg(ejbuxptqpf) = wfqnvxndyi qgkhredxnc (myqbtlbern )
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