A Phase Ib/II Open-Label, Dose-Escalation, Safety, Pharmacokinetic, Pharmacodynamic and Efficacy Study of Bemcentinib Plus Pacritinib In Patients With Advanced Lung Adenocarcinoma

This is a Phase Ib/II, open-label, single institution dose-escalation, safety, pharmacokinetics, pharmacodynamic and efficacy study.

Start Date01 Jan 2025

Sponsor / Collaborator

University of Texas Health Science Center At San Antonio

[+1]

NCT05469178

/ RecruitingPhase 1/2

Phase 1b/2a Safety and Tolerability Study of Bemcentinib with Pembrolizumab/carboplatin/pemetrexed in Subjects with Untreated Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) Without/with a STK11 Mutation

The primary purpose of this study is to determine the safety and tolerability of the combination of bemcentinib with chemo-immunotherapy (CIT) to identify the recommended phase 2 dose (RP2D) when administered as first line (1L) treatment in participants with locally advanced (Stage IIIb/IIIC) or metastatic (Stage IV) non-squamous NSCLC with no actionable mutations and to determine the anti-tumor activity of the combination of bemcentinib with CIT when administered as 1L treatment in participants with locally advanced (Stage IIIb/IIIc) or metastatic (Stage IV) non-squamous NSCLC with serine/threonine kinase 11 (STK11) mutation and no actionable mutations.

Start Date06 Mar 2023

Sponsor / Collaborator

BerGenBio ASA

CTIS2022-500363-12-00

/ Not yet recruitingPhase 2IIT

Efficacy and Safety of AXL-Inhibitor bemcentinib for the Treatment of Moderate COVID-19 (AXL-SolidAct) - AXL-SolidAct

Start Date27 Sep 2022

Sponsor / Collaborator-

100 Clinical Results associated with Bemcentinib

100 Translational Medicine associated with Bemcentinib

100 Patents (Medical) associated with Bemcentinib

147

Literatures (Medical) associated with Bemcentinib

20 Dec 2024·Journal of Biomolecular Structure and Dynamics

The promising impact of Bemcentinib and Repotrectinib on sleep impairment in Alzheimer’s disease

Article

Author: Ramezani, Fatemeh ; Ariaei, Armin

Alzheimer's disease (AD), the most prevalent neurodegenerative disease, demands effective medication to alleviate symptoms. This study focused on sleep impairment as an overt clinical symptom and tauopathy as a prominent molecular symptom of this disease. Multiple compounds from three biomolecule libraries (719 compounds; ChemDiv:366 - ChEMBL:180 - PubChem:173) were evaluated for potential binding affinity and safety using AutoDock Vina and pkCSM, respectively, resulting in the selection of four candidate compounds (Lestaurtinib, Repotrectinib, Bemcentinib, and Zotiraciclib). Due to the similarity of Repotrectinib and Bemcentinib binding sites to ATP, 300 ns Martini 3 coarse-grained molecular dynamics (MD) was performed on these two molecules and ATP by NAMD. The stability of tau protein in the presence of drugs was assessed using a 200 ns Martini 3 MD simulation. Binding site analysis discloses Bemcentinib and Repotrectinib as two inhibitors occupying most amino acids in binding with ATP. The RMSD and RMS average correlation results revealed protein containing Bemcentinib and Repotrectinib to have a more stable state compared to ATP in the first 220 ns simulation. There was only a single detachment of Bemcentinib, while Repotrictinib detached twice at the end of the simulation. Eventually, adding Bemcentinib and Repotrectinib to the enzyme-tau complex significantly increased the number of tau detachments during the 200 ns simulation. We report Bemcentinib and Repotrectinib, formerly prescribed for cancer, as potential inhibitors of the CK1 δ. Besides their high binding affinity compared to ATP, they can inhibit all ATP-binding sites and alter the tau binding stability.Communicated by Ramaswamy H. Sarma.

01 Dec 2024·Experimental Neurology

Gas6/Axl signaling promotes hematoma resolution and motivates protective microglial responses after intracerebral hemorrhage in mice

Article

Author: Ye, Xiang-Hua ; Shen, Dan ; Tong, Lu-Sha ; Gao, Feng ; Jin, Yu-Jia ; Xu, Xu-Hua ; Li, Jia-Wen ; Xu, Zhi-Ming

BACKGROUNDIntracerebral hemorrhage (ICH) stands out as the most fatal subtype of stroke, currently devoid of effective therapy. Recent research underscores the significance of Axl and its ligand growth arrest-specific 6 (Gas6) in normal brain function and a spectrum of neurological disorders, including ICH. This study is designed to delve into the role of Gas6/Axl signaling in facilitating hematoma clearance and neuroinflammation resolution following ICH.METHODSAdult male C57BL/6 mice were randomly assigned to sham and ICH groups. ICH was induced by intrastriatal injection of autologous arterial blood. Recombinant mouse Gas6 (rmGas6) was administered intracerebroventricularly 30 min after ICH. Virus-induced knockdown of Axl or R428 (a selective inhibitor of Axl) treatment was administrated before ICH induction to investigate the protective mechanisms. Molecular changes were assessed using western blot, enzyme-linked immunosorbent assay and immunohistochemistry. Coronal brain slices, brain water content and neurobehavioral tests were employed to evaluate histological and neurofunctional outcomes, respectively. Primary glia cultures and erythrophagocytosis assays were applied for mechanistic studies.RESULTSThe expression of Axl increased at 12 h after ICH, peaking on day 3. Gas6 expression did not remarkably changed until day 3 post-ICH. Early administration of rmGas6 following ICH significantly reduced hematoma volume, mitigated brain edema, and restored neurological function. Both Axl-knockdown and Axl inhibitor treatment abolished the neuroprotection of exogenous Gas6 in ICH. In vitro studies demonstrated that microglia exhibited higher capacity for phagocytosing eryptotic erythrocytes compared to normal erythrocytes, a process reversed by blocking the externalized phosphatidylserine on eryptotic erythrocytes. The erythrophagocytosis by microglia was Axl-mediated and Gas6-dependent. Augmentation of Gas6/Axl signaling attenuated neuroinflammation and drove microglia towards pro-resolving phenotype.CONCLUSIONSThis study demonstrated the beneficial effects of recombinant Gas6 on hematoma resolution, alleviation of neuroinflammation, and neurofunctional recovery in an animal model of ICH. These effects were primarily mediated by the phagocytotic role of Axl expressed on microglia.

01 Dec 2024·Alzheimer's & Dementia

Evaluate the Efficacy of the Axl inhibitor Bemcentinib in the 5xFAD mouse model of Alzheimer’s Disease

Article

Author: Porta, Sílvia ; Lee, Virginia M.‐Y. ; Chen, Guyin ; Ozturk, Gizem

AbstractBackgroundAlzheimer’s disease (AD) is a neurodegenerative disease characterized by the presence of phosphorylated tau neurofibrillary tangles and extracellular deposits of amyloid beta plaques (Aβ) in the brain. Microglia cells have been proposed to be involved in amyloid plaque formation since activated microglia produce inflammatory cytokines that contribute to a hostile neuronal environment, exacerbating AD pathogenesis.MethodWe aim to evaluate if the pharmacological inhibition of the myeloid/microglial receptor tyrosine kinase AXL, with bemcentinib (BGB) could be used as a novel therapeutic approach for AD. The objective is to evaluate the efficacy of the BGB inhibiting Axl activity in the brain of the 5xFAD mouse model, which recapitulates pathological hallmarks of AD, including Aβ plaques formation and overactive microglia. We evaluated target engagement and performed an efficacy study in 5xFAD and WT mice orally dosed with BGB and Vehicle (Veh) as control. Mice were dosed twice a day for 1 week. Mice were anesthetized to collect CSF and plasma and perfused to obtain their brains.ResultIn the present work, we have used the pharmacological Axl inhibitor BGB, to evaluate the therapeutic potential of targeting Axl signaling in 5xFAD mice. We have evaluated the effect of Axl inhibition measuring changes in total Axl levels and its soluble fragment (sAxl) across the hippocampus, plasma, and CSF of 5xFAD mice and WT mice. As expected, we found a significant upregulation of Aβ plaques and microglia in 5xFAD mice, and interestingly, a concomitant upregulation of Axl levels in the hippocampus of 5xFAD mice. We observed, although not statistically significant, a trend of increasing levels of sAxl in CSF and plasma of mice receiving BGB. Unfortunately, no significant effect of BGB drug was detected in 5xFAD mice when Aβ‐plaque burden and Iba1 immunoreactivity was measured after the treatment.ConclusionOverall, the preliminary findings do not show a significant effect of Axl inhibitor BGB in the brain. The reduced BBB penetrance of the drug could be a potential explanation for lack of significant changes in Axl levels and microglia activation. Further studies of increasing dosing time and cohort size could potentially improve the outcome.

News (Medical) associated with Bemcentinib

07 Jan 2025

·www.prnewswire.com

BerGenBio Announces First Patient Entered Into Advanced Adenocarcinoma Lung Cancer Trial

BERGEN, Norway, Jan. 7, 2025 /PRNewswire/ -- BerGenBio ASA (OSE: BGBIO), a clinical-stage biopharmaceutical company developing the novel, selective AXL kinase inhibitor bemcentinib for lung cancer announced today that the first patient has been included in a clinical trial sponsored by the Mays Cancer Center at The University of Texas Health Science Center at San Antonio (UT Health San Antonio). The study is led by Josephine A. Taverna, MD, a thoracic oncologist at the Mays Cancer Center and Associate Professor in the Division of Hematology and Oncology at UT Health San Antonio. "Dr. Taverna's research has shown that AXL and JAK-STAT3 work in tandem to transmit signals promoting tumor growth and metastasis in advanced lung cancer. We are pleased to see this research advancing into clinical application and believe this study aligns closely with BerGenBio's strategic focus on addressing the significant unmet needs of lung cancer patients, including first-line Non-Small Cell Lung Cancer patients with mutations in the STK11 gene," said Olav Hellebø, Chief Executive Officer of BerGenBio. The trial is designed to study BerGenBio's bemcentinib in combination with pacritinib, which is a JAK2 inhibitor indicated for treatment of the bone marrow disorder myelofibrosis in patients with platelet counts below 50 x 109/L. It works by blocking certain growth factors and cytokines. Pacritinib is marketed in the United States as VONJO® and owned by Swedish Orphan Biovitrum AB (Sobi®) (STO: SOBI), a specialized international biopharmaceutical company. Bemcentinib is a first-in-class, selective, oral once-a-day inhibitor of AXL receptor tyrosine kinase, a promising therapeutic target for serious diseases. The study will include patients with lung adenocarcinoma, the most common type of lung cancer in the United States, accounting for approximately 40% of all lung cancers. The study is funded by a grant from the National Cancer Institute (NCI) of the National Institutes of Health (NIH). Contacts Olav Hellebø, CEO, BerGenBio ASA [email protected] Rune Skeie, CFO, BerGenBio ASA [email protected] About the Trial (NCT 06516887) The trial sponsored by the Mays Cancer Center at The University of Texas Health Science Center at San Antonio is entitled "Study of Bemcentinib plus Pacritinib in Patients with Advanced adenocarcinoma" is a Phase Ib/II, open-label, single institution dose-escalation, safety, pharmacokinetics, pharmacodynamic and efficacy study. It is anticipated that a total of 44 patients will be enrolled in the trial. In the PhIb portion varying doses of bemcentinib and pacritinib will be studied in combination to determine safety, tolerability and the maximum tolerated dose. The Phase II portion of the trial will study the dose(s) selected in Phase Ib and will assess the overall response rate and progression free survival of treated patients. About BerGenBio ASA BerGenBio is a clinical-stage biopharmaceutical company focused on developing transformative drugs targeting AXL as a potential cornerstone of therapy for aggressive diseases, including cancer. The Company is focused on its proprietary lead candidate, bemcentinib, a potentially first-in-class selective AXL inhibitor in development for STK11 mutated NSCLC. BerGenBio is based in Bergen, Norway with a subsidiary in Oxford, UK. The company is listed on the Oslo Stock Exchange (ticker: BGBIO). For more information, visit . Forward looking statements This announcement may contain forward-looking statements, which as such are not historical facts, but are based upon various assumptions, many of which are based, in turn, upon further assumptions. These assumptions are inherently subject to significant known and unknown risks, uncertainties, and other important factors. Such risks, uncertainties, contingencies and other important factors could cause actual events to differ materially from the expectations expressed or implied in this announcement by such forward-looking statements. This information is subject to the disclosure requirements pursuant to section 5-12 of the Norwegian Securities Trading Act. This information was brought to you by Cision SOURCE BerGenBio ASA WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Phase 2Phase 1

07 Oct 2024

·www.prnewswire.com

BerGenBio Announces Safety Data from Dose Escalation Phase 1b in First Line NSCLC Patients

Ph1b data support safety, predictable PK and adequate plasma exposure BERGEN, Norway, Oct. 7, 2024 /PRNewswire/ -- BerGenBio ASA (OSE: BGBIO), a clinical-stage biopharmaceutical company developing novel, selective AXL kinase inhibitors for severe unmet medical needs, announced today preliminary safety data from the Phase 1b portion of the BGBC016 study in first-line (1L) Non-Small Cell Lung Cancer (NSCLC) patients. The Phase 1b part of the study evaluated three escalating doses of BerGenBio's selective AXL inhibitor bemcentinib in combination with standard chemo-immunotherapy (CIT), doublet chemotherapy and pembrolizumab, Keytruda®, for the 1L treatment of advanced/metastatic NSCLC patients. The primary endpoint was the assessment of the safety profile of the combination in NSCLC patients regardless of their STK11 mutational status. Key conclusions include: All three selected doses demonstrated that the triplet combination is well tolerated with no new safety signals identified, supporting the further clinical development of bemcentinib and CIT in 1L NSCLC patients. No dose-related impact on electrocardiographic changes (QTc), a known class effect of tyrosine kinase inhibitors, was reported for bemcentinib during the observation period. Pharmacokinetic analyses confirmed adequate plasma exposure of bemcentinib, achieving levels consistent with that previously observed in responders in BerGenBio's BGBC008 study of bemcentinib and pembrolizumab in second-line NSCLC patients. Martin Olin, Chief Executive Officer of BerGenBio, commented: "The data show that bemcentinib has a manageable safety profile and gives us increased confidence in continuing the BGBC016 clinical trial. The global trial is currently enrolling patients in Phase 2a targeting patients with a mutation in the STK11 gene, and we look forward to sharing the first preliminary data as they mature." Contacts Martin Olin CEO, BerGenBio ASA [email protected] Rune Skeie, CFO, BerGenBio ASA [email protected] Investor Relations / Media Relations Jan Lilleby [email protected] About STK11m NSCLC Patients with STK11m NSCLC have a significantly poorer response to current therapies, including immune checkpoint inhibitors, when compared with patients with wild-type (non-mutated) STK11. AXL plays a significant role in the survival and spread of cancer and STK11m NSCLC patients have a high expression of AXL suggesting that AXL is an important target to prevent disease progression and resistance to existing therapies. Bemcentinib's selective inhibition of AXL has been shown to improve the response to immune checkpoint inhibition in STK11m patient-derived preclinical models and in early clinical studies. There are currently no targeted therapies available for the STK11m NSCLC patient population, which represents up to 20% of 1L NSCLC patients. About BerGenBio ASA BerGenBio is a clinical-stage biopharmaceutical company focused on developing transformative drugs targeting AXL as a potential cornerstone of therapy for aggressive diseases, including cancer and severe respiratory infections. The Company is focused on its proprietary lead candidate, bemcentinib, a potentially first-in-class selective AXL inhibitor in development for STK11 mutated NSCLC and severe respiratory infections. BerGenBio is based in Bergen, Norway with a subsidiary in Oxford, UK. The company is listed on the Oslo Stock Exchange (ticker: BGBIO). For more information, visit This information is subject to the disclosure requirements pursuant to section 5-12 of the Norwegian Securities Trading Act. This information was brought to you by Cision SOURCE BerGenBio ASA WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

ImmunotherapyPhase 1Phase 2Clinical Result

21 Aug 2024

·www.prnewswire.com

BerGenBio Second Quarter Results 2024: Solid clinical and financial progress

BERGEN, Norway, Aug. 21, 2024 /PRNewswire/ -- BerGenBio ASA (OSE: BGBIO), a clinical-stage biopharmaceutical company developing novel, selective AXL kinase inhibitors for severe unmet medical needs, today announced financial results for the quarter and half year ended June 30, 2024, and provided a business update. Highlights, including post period: BGBC016 1L NSCLC STK11m study continues to progress as planned. Enrollment in the Ph1b part completed. Data Safety Monitoring Board review of data from the final Ph1b dose cohort supports safety and tolerability of the combination of bemcentinib with standard of care chemo/immunotherapy allowing initiation of the 2 nd dose in the Ph2a part. All Ph2a sites have now been activated. Innovative approach established with leading genomic AI provider to accelerate development of bemcentinib. Established data and regulatory collaboration with technology company Tempus AI (Nasdaq: TEM) to provide prospective comparative clinical data from 1L STK11m NSCLC patients to aid in the evaluation of BGBC016 results. Strengthened financial position. Secured gross funding of NOK 138.9 million from warrant exercise in June 2024 securing funding into H2 2025. Financial position of NOK 200.1 million end of Q2 2024. Stable cash use. Continued decreased and stabilized operating expenses at NOK 90.5 million for first half 2024 compared to NOK 120.2 million in first half 2023. Operating expenses NOK 50.8 million in Q2 2024 compared to NOK 47.8 million in Q2 2023. Martin Olin, Chief Executive Officer of BerGenBio stated: "The BGBC016 clinical trial continued to progress well during the quarter. An independent review of the final cohort in the Ph1b part showed acceptable safety allowing initiation of the 2nd dose in the Ph2a part, and we completed the activation of the Ph2a sites. We now look forward to sharing preliminary efficacy data from the Ph2a portion of the study as they mature. During the quarter we strengthened our financial position which will, combined with our continuing cost discipline, fund our planned activities into the second half of 2025. The BGBC016 clinical trial is our highest priority, and we remain dedicated to unlocking the significant value potential in bemcentinib." Presentation and Financial Report The Q2 2024 Financial report is attached to this stock exchange announcement and the report and the Q2 2024 presentation are available at the Company's website . Webcast details BerGenBio's senior management team will provide a business update today at 9:45 am CET. The presentation will webcast live. To participate in the webcast, please use the following link: A recording of the webcast will be available at in the Investors/Financial Reports section () shortly afterwards. Contacts Martin Olin CEO, BerGenBio ASA [email protected] Rune Skeie, CFO, BerGenBio ASA [email protected] Media Relations Jan Lilleby [email protected] About BerGenBio ASA BerGenBio is a clinical-stage biopharmaceutical company focused on developing transformative drugs targeting AXL as a potential cornerstone of therapy for aggressive diseases, including cancer and severe respiratory infections. The Company is focused on its proprietary lead candidate, bemcentinib, a potentially first-in-class selective AXL inhibitor in clinical development for STK11 mutated NSCLC and preclinical development for severe respiratory infections. BerGenBio is based in Bergen, Norway, with a subsidiary in Oxford, UK. The company is listed on the Oslo Stock Exchange (ticker: BGBIO). For more information, visit Forward looking statements This announcement may contain forward-looking statements, which as such are not historical facts, but are based upon various assumptions, many of which are based, in turn, upon further assumptions. These assumptions are inherently subject to significant known and unknown risks, uncertainties, and other important factors. Such risks, uncertainties, contingencies and other important factors could cause actual events to differ materially from the expectations expressed or implied in this announcement by such forward-looking statements. This information is considered to be inside information pursuant to the EU Market Abuse Regulation and subject to the disclosure requirements pursuant to section 5-12 of the Norwegian Securities Trading Act. This information was brought to you by Cision The following files are available for download:

Financial StatementClinical Study

100 Deals associated with Bemcentinib

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KEGG	Wiki	ATC	Drug Bank
D11438	Bemcentinib	-	DB12411

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Indication	Highest Phase	Country/Location	Organization	Date
Metastatic melanoma	Phase 2	NO	BerGenBio ASA	13 Feb 2017
Non-Small Cell Lung Cancer	Phase 2	US	Rigel Pharmaceuticals, Inc.	-
Myelodysplastic Syndromes	Phase 1	IT	BerGenBio ASA	22 Oct 2014
Myelodysplastic Syndromes	Phase 1	NO	BerGenBio ASA	22 Oct 2014
Myelodysplastic Syndromes	Phase 1	US	BerGenBio ASA	22 Oct 2014
Refractory acute myeloid leukemia	Phase 1	IT	BerGenBio ASA	22 Oct 2014
Refractory acute myeloid leukemia	Phase 1	US	BerGenBio ASA	22 Oct 2014
Refractory acute myeloid leukemia	Phase 1	DE	BerGenBio ASA	22 Oct 2014
Refractory acute myeloid leukemia	Phase 1	NO	BerGenBio ASA	22 Oct 2014
Triple Negative Breast Cancer	Discovery	US	BerGenBio ASA	26 Jul 2017

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04890509 (CTgov)	Phase 2	COVID-19	115	SoC	myjqajehrm(ooaawmlxay) = cwefedwbri qnrysovuyl (pgihazkfec, nqpiugwgzd - ohqvghyjck) View more	-	16 Oct 2024
NCT02488408 (BGBC003, ASH2023)	Phase 1/2	Acute Myeloid Leukemia	32	Bemcentinib + Low-dose Cytarabine	(iavqymadrg) = rpnsfhqqvm luholxbgbo (sylhcevknz ) View more	-	09 Dec 2023
NCT03649321 (CTgov)	Phase 1/2	Metastatic Pancreatic Cancer	9	Nab-paclitaxel+gemcitabine+cisplatin+Bemcentinib (Phase 1b)	(ntftlmziah) = eetrjvtszo pkofuwkihq (ygnibamulx, bmtktopacd - wutyfdksrk) View more	-	09 Nov 2023
				Nab-paclitaxel+gemcitabine+Bemcentinib (Phase 2)	(ntftlmziah) = yfivvquozf pkofuwkihq (ygnibamulx, wsomdeuzpn - xqxzrgqyiz) View more
NCT03184571 (BGBC008, ESMO 12023 \| ESMO 22023) Manual	Phase 2	Non-Small Cell Lung Cancer Second line	99	Bemcentinib + Pembrolizumab	(aygndlscnz) = rcxmfiebvj ningctzgah (lctauejqgp ) View more	Positive	23 Oct 2023
				Bemcentinib + Pembrolizumab (AXL TPS > 5)	(aygndlscnz) = sosphmnagg ningctzgah (lctauejqgp ) View more
NCT02872259 (BGBIL006, ESMO 12023 \| ESMO 22023) Manual	Phase 1/2	Metastatic melanoma	68	Bemcentinib+PembrolizumabPem or D/TDabrafenibTrametinib (Bemcentinib+Pembrolizumab or Dabrafenib/Trametinib)	(gyjeqkhvbb) = dshadjudhn ehuzaddozm (wpwqvwyiwh ) View more	Negative	21 Oct 2023
				PembrolizumabPem or D/TDabrafenibTrametinib (Pembrolizumab or Dabrafenib/Trametinib)	-
NCT03654833 (MiST3, ASCO 12023 \| ASCO 22023) Manual	Phase 2	Mesothelioma	26	Pembrolizumab+Bemcentinib	(xhqcrqbqzb) = khyzvomvar idlmbsqvmz (ezaydtqiab, 29.2 - 63.4) View more	Positive	26 May 2023
NCT02922777 (ASCO2022) Manual	Phase 1	Non-Small Cell Lung Cancer First line	21	Docetaxel+Bemcentinib	(rdutpfknfb) = 60 mg/m2 docetaxel plus 200 mg bemcentinib daily tnszozjpcm (atsjhdjtvo ) View more	Positive	02 Jun 2022
NCT02488408 (BGBC003, EHA2022) Manual	Phase 2	Acute Myeloid Leukemia	22	Cytarabine+Bemcentinib	(qpihnsncri) = psjvbcckqv rkfpnliuck (egmcogumzo ) View more	Positive	12 May 2022
				Cytarabine+Bemcentinib (in 1st relapse)	(qpihnsncri) = idpvhwdggd rkfpnliuck (egmcogumzo ) View more
NCT04890509 (BGBIL019 \| ACCORD2, PRNewswire) Manual	Phase 2	COVID-19	61	Standard of Care+bemcentinib	(mjhnbcbrca) = qlcmsncsvl qqgiepewpw (hwgcwogguy ) View more	Positive	26 Apr 2022
				Standard of Care	(mjhnbcbrca) = pqxsjmsptp qqgiepewpw (hwgcwogguy ) View more
NCT03184558 (CTgov)	Phase 2	Triple Negative Breast Cancer \| Metastatic breast cancer	29	Pembrolizumab+Bemcentinib	(tzskzvxhnx) = waxlixfybm slttzauaiv (qnrhvauhkk, pqcdpicvvm - aymtkvoiyx) View more	-	09 Nov 2021

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