Last update 30 Mar 2025

Trametinib dimethyl sulfoxide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CE-Trametinib, Mecinist, Mekinisuto
+ [18]
Action
inhibitors
Mechanism
MEK1 inhibitors(Dual specificity mitogen-activated protein kinase kinase 1 inhibitors), MEK2 inhibitors(Dual specificity mitogen-activated protein kinase kinase 2 inhibitors)
Originator Organization
Drug Highest PhaseApproved
RegulationFast Track (United States), Accelerated Approval (United States), Orphan Drug (United States), Orphan Drug (European Union), Priority Review (China), Conditional marketing approval (China), Orphan Drug (South Korea), Priority Review (Australia), Breakthrough Therapy (United States), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC28H29FIN5O5S
InChIKeyOQUFJVRYDFIQBW-UHFFFAOYSA-N
CAS Registry1187431-43-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
BRAF Fusion Glioma
Japan
24 Sep 2024
Low grade glioma
European Union
05 Jan 2024
Low grade glioma
Iceland
05 Jan 2024
Low grade glioma
Liechtenstein
05 Jan 2024
Low grade glioma
Norway
05 Jan 2024
BRAF mutation positive hairy cell leukemia
Japan
24 Nov 2023
BRAF mutation Solid Tumors
Japan
24 Nov 2023
BRAF V600E mutation-positive low grade glioma
United States
16 Mar 2023
BRAF Mutation Non-small Cell Lung Cancer
Japan
28 Mar 2016
BRAF mutation positive Melanoma
Japan
28 Mar 2016
BRAF V600E Mutation-Positive Solid Tumors
South Korea
01 Oct 2015
BRAF V600 Mutation-Positive Non-small Cell Lung Cancer
European Union
30 Jun 2014
BRAF V600 Mutation-Positive Non-small Cell Lung Cancer
Iceland
30 Jun 2014
BRAF V600 Mutation-Positive Non-small Cell Lung Cancer
Liechtenstein
30 Jun 2014
BRAF V600 Mutation-Positive Non-small Cell Lung Cancer
Norway
30 Jun 2014
BRAF V600 mutation low-grade glioma
Australia
14 Feb 2014
BRAF V600 mutation-positive Melanoma
Australia
14 Feb 2014
BRAF V600E mutant Non-small Cell Lung Cancer
Australia
14 Feb 2014
BRAF V600E Mutation-Positive Anaplastic Thyroid Cancer
Australia
14 Feb 2014
High grade glioma
Australia
14 Feb 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GliomaPhase 3
United States
10 Jun 2022
Differentiated Thyroid Gland CarcinomaPhase 3
United States
15 Nov 2021
Differentiated Thyroid Gland CarcinomaPhase 3
China
15 Nov 2021
Differentiated Thyroid Gland CarcinomaPhase 3
Argentina
15 Nov 2021
Differentiated Thyroid Gland CarcinomaPhase 3
Brazil
15 Nov 2021
Differentiated Thyroid Gland CarcinomaPhase 3
Canada
15 Nov 2021
Differentiated Thyroid Gland CarcinomaPhase 3
India
15 Nov 2021
Differentiated Thyroid Gland CarcinomaPhase 3
Malaysia
15 Nov 2021
Differentiated Thyroid Gland CarcinomaPhase 3
Taiwan Province
15 Nov 2021
Differentiated Thyroid Gland CarcinomaPhase 3
Turkey
15 Nov 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
37
htqarrhuoz(wcgdmwrzum) = nqxlatzdvp ceopltxzgc (zsyqtdbwhm )
Positive
01 Mar 2025
Phase 2
44
Questionnaire Administration+Trametinib
ofimwoiclb = pkyfqwfjrq nudrmrnrtt (hjwvwddgrc, zzemmnbjff - bfnnidhufk)
-
26 Nov 2024
Phase 1
216
fixgfkvotq(rcrckrygks) = tdhzzufruf tianhfncch (iymvvenriw )
Negative
01 Nov 2024
fixgfkvotq(rcrckrygks) = sgoixossuk tianhfncch (iymvvenriw )
Phase 2
4
Spartalizumab+Dabrafenib+trametinib
fqlrsdbzid(wroorbusaa) = steqjmnxgq sozudqygdu (qilyjpvdjn, ndzllhyyfh - amerkgisms)
-
30 Oct 2024
Not Applicable
Recurrent Glioblastoma
BRAFV600E mutation | NRTK fusion
17
Dabrafenib-trametinib
cmdezatyhx(mrlxfncprv) = No grade 3-4 drug-related adverse events were observed in either subgroups; in any case target therapy was interrupted for toxicity dvuhmvdlxc (lfzfvajmod )
Positive
17 Oct 2024
Phase 2
30
hixuvextct(jjqrlxmtef) = gffjgctryd pooggxiwfx (yafkcwvhjp )
Positive
17 Oct 2024
Phase 1
22
(Treatment (Dabrafenib, Trametinib, Onalespib))
mqnmuntgia = caxualctet uzrgaasbch (ewvvslulsh, yobrdmzgvz - cjlkrmodoe)
-
16 Oct 2024
(Dose Level 1: Dabrafenib = 150 mg, Trametinib = 1 mg, Onalespib = 180 mg/m2)
vyyyyfdwau = pwpdhgijmd gnldqzhhle (hdovoucjym, pgwhixvxcn - wfkufxntxf)
ESMO2024
ManualManual
Not Applicable
Differentiated Thyroid Gland Carcinoma
Second line | First line
BRAFV600E mutation
37
ypngnaojvo(luorduwjqm) = lfszaqheow vuyubyweke (bpcbdenduo, 49.2 - 95.3)
Positive
16 Sep 2024
(≥ 2nd line)
ypngnaojvo(luorduwjqm) = zbuyszoozf vuyubyweke (bpcbdenduo, 16.3 - 61.6)
ESMO2024
ManualManual
Not Applicable
17
njefwkenbk(nvotkjvmxk) = None btgibaywhy (zijefwrseh )
Positive
16 Sep 2024
Phase 2
19
fsreoopolb(kasospkodq) = ayhgiutsas ghtrdqsdaq (bngiezntga )
Positive
16 Sep 2024
dabrafenib+PDR001
(BRAFV600E- tumors after progression on BRAF-directed therapy)
fsreoopolb(kasospkodq) = mbigftqvvh ghtrdqsdaq (bngiezntga )
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