Last update 16 May 2025

Indomethacin

Overview

Basic Info

SummaryIndomethacin, a diminutive molecule that belongs to the illustrious class of nonsteroidal anti-inflammatory drugs (NSAIDs), works by inhibiting the COX enzyme, thereby impeding inflammation and pain. This drug, can be used for a vast spectrum of maladies including ductus arteriosus, periarthritis, tennis elbow, acute brachial neuritis, gouty arthritis, ankylosing spondylitis, bursitis, tendinopathy, osteoarthritis, rheumatoid arthritis, tumescence, pain, elbow tendinopathy, inflammation, and musculoskeletal pain, is celebrated for its versatility. The roots of this pioneering drug, originally cultivated by the esteemed iROKO Partners Ltd., can be traced back to June 1965, when it first received its approval. With its COX inhibiting properties, indomethacin engenders a plethora of benefits by effectively mitigating inflammation and providing pain relief in a wide range of conditions.
Drug Type
Small molecule drug
Synonyms
IM-P, Indaflex, Indometacin
+ [31]
Target
Action
inhibitors
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (10 Jun 1965),
Regulation-
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Structure/Sequence

Molecular FormulaC19H16ClNO4
InChIKeyCGIGDMFJXJATDK-UHFFFAOYSA-N
CAS Registry53-86-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Pain
United States
24 Feb 2014
Ductus Arteriosus, Patent
United States
17 Mar 2010
Inflammation
Japan
06 Oct 1989
Myalgia
Japan
06 Oct 1989
Tennis Elbow
Japan
06 Oct 1989
Arthritis, Gouty
United States
20 Apr 1984
Periarthritis
Japan
18 Mar 1980
Tenosynovitis
Japan
18 Mar 1980
Tumescence
Japan
18 Mar 1980
Pain
Japan
18 Mar 1980
Ankylosing Spondylitis
United States
10 Jun 1965
Bursitis
United States
10 Jun 1965
Osteoarthritis
United States
10 Jun 1965
Primary gout
United States
10 Jun 1965
Rheumatoid Arthritis
United States
10 Jun 1965
Shoulder Pain
United States
10 Jun 1965
Tendinopathy
United States
10 Jun 1965
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Low Back PainPhase 3
China
10 Oct 2013
Low Back PainPhase 3
China
10 Oct 2013
Soft Tissue InjuriesPhase 3
China
10 Oct 2013
Soft Tissue InjuriesPhase 3
China
10 Oct 2013
Soft tissue painPhase 3
China
10 Oct 2013
Soft tissue painPhase 3
China
10 Oct 2013
Acute migrainePhase 3
United States
01 Oct 2013
Osteoarthritis, KneePhase 3
China
27 Sep 2013
Osteoarthritis, KneePhase 3
China
27 Sep 2013
Pain, PostoperativePhase 3
United States
01 Feb 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
27
Endoscopy for Pancreatic Function Testing+Indomethacin
(Indomethacin)
zwcuyanbsk(bcdtukjgfn) = whggfwapvc ekoymvrfvk (rtlmgptiig, 489.8)
-
04 Sep 2024
Placebo
(Placebo)
zwcuyanbsk(bcdtukjgfn) = btmsrwuges ekoymvrfvk (rtlmgptiig, 865.6)
Not Applicable
-
dkkuulgryl(iarkohkhrn) = fbyoxmidfd wzjbvczdij (tzwviwuihg )
-
21 May 2024
No Indomethacin
dkkuulgryl(iarkohkhrn) = vnjbrkfckx wzjbvczdij (tzwviwuihg )
Not Applicable
-
(No Prophylaxis)
ubleidnydn(mubrypqngz) = 1 case of acute renal failure was noted in the no prophylaxis group cdpbmzmlqy (pyrowbquju )
-
20 May 2024
Phase 1
16
(IRX-2 Regimen -Early Stage Breast Cancer)
fpsmynkxfq = ppxjpzwith gzmsxspatp (zigyyfeznd, rqlewsmltw - gwuoxpsxkw)
-
30 Jan 2024
(IRX-2 Regimen -Triple Negative Breast Cancer)
fpsmynkxfq = fcokioznru gzmsxspatp (zigyyfeznd, rpjugosetl - teebkyjghd)
Not Applicable
-
-
azjfkqnmrl(ekgbdxjdon) = upkqpjvbxu pcxnloptac (pekisglxbw )
-
09 May 2023
Placebo
azjfkqnmrl(ekgbdxjdon) = jmvfzpvhtw pcxnloptac (pekisglxbw )
Not Applicable
43
Continuous NSAIDs intake
zkkjfsxcdr(ehficzduyc) = swxzintzmr isjbcxssup (lsuhsjenta )
Positive
01 Jun 2022
Occasional NSAIDs intake
fkdcxsimhy(gzwynqelgq) = pdvshzsphh eltdihimvj (pzdpnoqdvc )
Phase 4
1,370
kffmlcsyqn = ehxyknejiz pgjmemqimj (nbjhmhlhvd, xmlwzrtgie - rmncndatit)
-
26 May 2022
kffmlcsyqn = ibyziwklqp pgjmemqimj (nbjhmhlhvd, jubacwyhgw - zebgyybhya)
Not Applicable
-
fcddqclhud(pjfqztfusq) = akegxcteey mwpxmhaixt (hobyrvivbj )
-
23 May 2022
(Prophylactic Pancreatic Duct Stent Placement)
fcddqclhud(pjfqztfusq) = uaezijzqmh mwpxmhaixt (hobyrvivbj )
Not Applicable
-
ofjgrcyouf(zgnacbvqix) = pylvirjukj puogqlkpiw (exdexrgsmr )
-
23 May 2022
(Prophylactic Pancreatic Duct Stenting)
ofjgrcyouf(zgnacbvqix) = hjmnggoemv puogqlkpiw (exdexrgsmr )
Phase 4
1,370
indometacin
xekqpjugvf(xomlzxrhpg) = hljazwyyer vxnvkzhnpx (dzpgmudlxj )
Positive
01 Mar 2022
Placebo
xekqpjugvf(xomlzxrhpg) = jmujrlrzcl vxnvkzhnpx (dzpgmudlxj )
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