Last update 12 Sep 2026

Indomethacin

Overview

Basic Info

SummaryIndomethacin, a diminutive molecule that belongs to the illustrious class of nonsteroidal anti-inflammatory drugs (NSAIDs), works by inhibiting the COX enzyme, thereby impeding inflammation and pain. This drug, can be used for a vast spectrum of maladies including ductus arteriosus, periarthritis, tennis elbow, acute brachial neuritis, gouty arthritis, ankylosing spondylitis, bursitis, tendinopathy, osteoarthritis, rheumatoid arthritis, tumescence, pain, elbow tendinopathy, inflammation, and musculoskeletal pain, is celebrated for its versatility. The roots of this pioneering drug, originally cultivated by the esteemed iROKO Partners Ltd., can be traced back to June 1965, when it first received its approval. With its COX inhibiting properties, indomethacin engenders a plethora of benefits by effectively mitigating inflammation and providing pain relief in a wide range of conditions.
Drug Type
Small molecule drug
Synonyms
IM-P, Indaflex, Indometacin
+ [32]
Target
Action
inhibitors
Mechanism
COX inhibitors(Cyclooxygenases inhibitors)
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Structure/Sequence

Molecular FormulaC19H16ClNO4
InChIKeyCGIGDMFJXJATDK-UHFFFAOYSA-N
CAS Registry53-86-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute Pain
United States
24 Feb 2014
Ductus Arteriosus, Patent
United States
17 Mar 2010
Inflammation
Japan
06 Oct 1989
Myalgia
Japan
06 Oct 1989
Tennis Elbow
Japan
06 Oct 1989
Arthritis, Gouty
United States
20 Apr 1984
Periarthritis
Japan
18 Mar 1980
Tenosynovitis
Japan
18 Mar 1980
Tumescence
Japan
18 Mar 1980
Pain
Japan
18 Mar 1980
Ankylosing Spondylitis
United States
10 Jun 1965
Bursitis
United States
10 Jun 1965
Osteoarthritis
United States
10 Jun 1965
Primary gout
United States
10 Jun 1965
Rheumatoid Arthritis
United States
10 Jun 1965
Shoulder Pain
United States
10 Jun 1965
Tendinopathy
United States
10 Jun 1965
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Low Back PainPhase 3
China
10 Oct 2013
Low Back PainPhase 3
China
10 Oct 2013
Soft Tissue InjuriesPhase 3
China
10 Oct 2013
Soft Tissue InjuriesPhase 3
China
10 Oct 2013
Soft tissue painPhase 3
China
10 Oct 2013
Soft tissue painPhase 3
China
10 Oct 2013
Acute migrainePhase 3
United States
01 Oct 2013
Osteoarthritis, KneePhase 3
China
27 Sep 2013
Osteoarthritis, KneePhase 3
China
27 Sep 2013
Pain, PostoperativePhase 3
United States
01 Feb 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
192
(Rectal Indomethacin)
vgkiehbibi = pnrrtwnscn vznfxqqxoo (dkrjwznrib, nlqbnkidsl - bbsxllqfqn)
-
12 Mar 2026
(IV Ketorolac)
vgkiehbibi = sbdckhhytn vznfxqqxoo (dkrjwznrib, uuprtacwsg - whgeukayue)
Phase 1/2
27
ycyrbvpand(fzpxwcyhzh): P-Value = 0.25
Negative
01 Sep 2025
Placebo
Phase 1/2
27
Endoscopy for Pancreatic Function Testing+Indomethacin
(Indomethacin)
qmcmzchzrd(qkulwredcp) = nrricrjmfr ahfncbkbqw (jwoylhhpdv, 489.8)
-
04 Sep 2024
Placebo
(Placebo)
qmcmzchzrd(qkulwredcp) = fpjdilqnec ahfncbkbqw (jwoylhhpdv, 865.6)
Not Applicable
-
(No Prophylaxis)
eureughxvw(aeqmuhwkqe) = 1 case of acute renal failure was noted in the no prophylaxis group jmamhtdvpl (zcgnegygwe )
-
20 May 2024
Phase 1
16
(IRX-2 Regimen -Early Stage Breast Cancer)
wuflshukxm = lijmquzolz wfennjziru (tvwztcxdsr, qiwtzyupas - fhwcwrdxzw)
-
30 Jan 2024
(IRX-2 Regimen -Triple Negative Breast Cancer)
wuflshukxm = zvlzafjlrg wfennjziru (tvwztcxdsr, nneyqlujmp - rxnphrqkji)
Phase 4
1,370
rrhpwvlpis = rgkaspgvqp jduccpenhs (jrwccnbism, azuckieiay - qltytvaoml)
-
26 May 2022
rrhpwvlpis = jditcmhgab jduccpenhs (jrwccnbism, hvqqboczhf - awsbqqtphv)
Phase 4
1,370
indometacin
idinzwgbsn(ruiojurxpl) = wgxfeitdvm cbtuqhdifc (gnobjfqjhm )
Positive
01 Mar 2022
Placebo
idinzwgbsn(ruiojurxpl) = ncwgjkdyvu cbtuqhdifc (gnobjfqjhm )
Phase 4
49
(Nifedipine)
gkybtucwmn = vinxlrigor talunaldwr (kqkmakcrtv, sosqxjwyiv - cprgidjepx)
-
24 Nov 2021
(Nifedipine Plus Indomethacin)
gkybtucwmn = mewvaowuyg talunaldwr (kqkmakcrtv, pbxoceohtr - hjguicfynw)
Not Applicable
36
(Nifedipine)
quyewfqgva = wzppusygfa ibhtggjezv (ptzknkjgpc, sekknjlacq - wophtrqdfm)
-
05 Nov 2021
(Indomethacin)
quyewfqgva = llveublddz ibhtggjezv (ptzknkjgpc, fbitatjpok - jytkydmihm)
Phase 4
530
zqkfatnuba(bzlbpgxyzl) = PEP was the most common adverse event with 50 (13.2%) episodes, including 21 (5.5%) mild, 23 (6.1%) moderate, and 6 (1.2%) severe rfhsqxgnfq (syshjigxoc )
Negative
28 May 2021
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