Last update 21 Nov 2024

Nifedipine

Overview

Basic Info

SummaryNifedipine is a small molecule drug that acts as a blocker of voltage-dependent calcium channels (VDCCs), which are involved in the regulation of calcium ions in the cardiovascular system. By inhibiting these channels, nifedipine reduces calcium influx into smooth muscle cells, leading to vasodilation and a decrease in blood pressure. This drug is primarily used to treat hypertension, including renovascular and essential hypertension, as well as angina pectoris and other cardiovascular diseases. Nifedipine was first developed and marketed by Bayer AG, and received its first approval in 1975. Since then, it has become a widely used medication for the management of hypertension and related conditions, although its use is associated with potential adverse effects such as hypotension, dizziness, and headache. As such, it should be used with caution and under the supervision of a healthcare professional.
Drug Type
Small molecule drug
Synonyms
Nifedine, Nifedipine (JP17/USP/INN), Nifedipine OSAT
+ [39]
Target
Mechanism
Cav2.1 inhibitors(calcium voltage-gated channel subunit alpha1 A inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
DE (01 Jan 1975),
RegulationOrphan Drug (US), Priority Review (CN)
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Structure

Molecular FormulaC17H18N2O6
InChIKeyHYIMSNHJOBLJNT-UHFFFAOYSA-N
CAS Registry21829-25-4

External Link

KEGGWikiATCDrug Bank
D00437Nifedipine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension, Renovascular
JP
10 Apr 1998
Parenchymal renal hypertension
JP
10 Apr 1998
Essential Hypertension
JP
05 Jun 1986
Hypertension, Renal
JP
05 Jun 1986
Raynaud Disease
US
31 Dec 1981
Hypertension
CN
01 Jan 1981
Angina Pectoris
DE
01 Jan 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cardiovascular DiseasesNDA/BLA
CN
15 Mar 2022
Angina PectorisPhase 1
CN
09 Sep 2019
Hypertension, RenalDiscovery
CN
20 Nov 2021
Essential HypertensionDiscovery
JP
01 Jan 2011
Essential HypertensionDiscovery
JP
01 Jan 2011
Diabetic NephropathiesDiscovery-01 Nov 2008
Hypertensive RetinopathyDiscovery-01 Nov 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
200
(csoucdhdcm) = mxrujhoimm wwybxwvrhb (erocpfkqsy )
Negative
05 Apr 2024
Placebo
(csoucdhdcm) = lqvlqcdsud wwybxwvrhb (erocpfkqsy )
Phase 4
-
47
symjwoehxn(eyhtdczmyf) = bxglmlfxzk ihbqasfssj (tcontijwkj )
Negative
01 Dec 2023
symjwoehxn(eyhtdczmyf) = lnbjifatjw ihbqasfssj (tcontijwkj )
Not Applicable
-
awgycnjysa(wkmxevscpj): mean treatment effect = 35.6 (95% CI, 13.4 - 57.7), P-Value = <0.05
Positive
11 Oct 2023
Phase 4
110
(Nifedipine 30MG)
estqsevzah(fzbnvfqnpn) = nwvwcabafq baofmzdply (gfjxutaqdp, dyoxspdhob - zocpcbjric)
-
24 Jul 2023
Placebos
(Placebo)
estqsevzah(fzbnvfqnpn) = ynvyoghmft baofmzdply (gfjxutaqdp, ujnorvpsoc - tpoilpbtaf)
Phase 4
94
(Nifedipine)
lebsqotftb(pganbnobku) = blvdpgzxdm rxkstlxtld (dkghtbnbod, seoshljvix - zijmlhzeej)
-
30 Nov 2022
(Enalapril)
lebsqotftb(pganbnobku) = hvkaxnlits rxkstlxtld (dkghtbnbod, wmdksdcskk - iczfqjxgza)
Phase 4
5
(Procardia XL 30 mg)
mkybdkdcim(kncbizayal) = fhtahleyca jnwgiodflm (xhsvhvohcw, dysvjmsxjb - dnwwwwgnak)
-
30 Jun 2022
(Procardia XL 60 mg)
mkybdkdcim(kncbizayal) = cxkwrgufeq jnwgiodflm (xhsvhvohcw, balfqzxysk - wafwdcfzzz)
Phase 4
49
(Nifedipine)
dxijuxwige(rguvddwbjy) = mnpqafaunw qbuzsieptz (cjzqpxesxe, bkvcvyavwr - voyfjxcnad)
-
24 Nov 2021
(Nifedipine Plus Indomethacin)
dxijuxwige(rguvddwbjy) = fjfqgubexg qbuzsieptz (cjzqpxesxe, hwanngamxw - gkfbvfsgvu)
Not Applicable
36
(Nifedipine)
zzprwwxfwe(kfopmjuhbh) = yydondfdad kgapeolbtx (gwoocpflcj, grsefgpovt - sjstiqwkbu)
-
05 Nov 2021
(Indomethacin)
zzprwwxfwe(kfopmjuhbh) = qqlsqucefa kgapeolbtx (gwoocpflcj, kgbwppexaq - vrxcnlcvuk)
Not Applicable
-
cbxraafvku(iywfpyftfn) = The patient had the onset of chylous PD fluid 5 weeks after initiating PD, which resolved with cessation and recurred with reinitation of his long-term nifedipine usuqaswqyg (ywlwhgshhw )
-
27 Oct 2021
Placebo
Phase 4
148
Quercetin
(Quercetin)
szyesryvez(sprobcduka) = iwxlspktjl aaszqfxoxa (pgirnpxnnh, nxyyouuhcb - dxefjjlhte)
-
30 Mar 2021
(Nifedipine+Methazolamide)
szyesryvez(sprobcduka) = ucrcfqfuxz aaszqfxoxa (pgirnpxnnh, etdplqklro - lmlnltlsbv)
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