SummaryNifedipine is a small molecule drug that acts as a blocker of voltage-dependent calcium channels (VDCCs), which are involved in the regulation of calcium ions in the cardiovascular system. By inhibiting these channels, nifedipine reduces calcium influx into smooth muscle cells, leading to vasodilation and a decrease in blood pressure. This drug is primarily used to treat hypertension, including renovascular and essential hypertension, as well as angina pectoris and other cardiovascular diseases. Nifedipine was first developed and marketed by Bayer AG, and received its first approval in 1975. Since then, it has become a widely used medication for the management of hypertension and related conditions, although its use is associated with potential adverse effects such as hypotension, dizziness, and headache. As such, it should be used with caution and under the supervision of a healthcare professional. |
Drug Type Small molecule drug |
Synonyms Nifedine, Nifedipine (JP17/USP/INN), Nifedipine OSAT + [39] |
Target |
Mechanism Cav2.1 inhibitors(calcium voltage-gated channel subunit alpha1 A inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date DE (01 Jan 1975), |
RegulationOrphan Drug (US), Priority Review (CN) |
Molecular FormulaC17H18N2O6 |
InChIKeyHYIMSNHJOBLJNT-UHFFFAOYSA-N |
CAS Registry21829-25-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00437 | Nifedipine |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Hypertension, Renovascular | JP | 10 Apr 1998 | |
Parenchymal renal hypertension | JP | 10 Apr 1998 | |
Essential Hypertension | JP | 05 Jun 1986 | |
Hypertension, Renal | JP | 05 Jun 1986 | |
Raynaud Disease | US | 31 Dec 1981 | |
Hypertension | CN | 01 Jan 1981 | |
Angina Pectoris | DE | 01 Jan 1975 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Cardiovascular Diseases | NDA/BLA | CN | 15 Mar 2022 | |
Angina Pectoris | Phase 1 | CN | 09 Sep 2019 | |
Hypertension, Renal | Discovery | CN | 20 Nov 2021 | |
Essential Hypertension | Discovery | JP | 01 Jan 2011 | |
Essential Hypertension | Discovery | JP | 01 Jan 2011 | |
Diabetic Nephropathies | Discovery | - | 01 Nov 2008 | |
Hypertensive Retinopathy | Discovery | - | 01 Nov 2008 |
Phase 3 | 200 | (csoucdhdcm) = mxrujhoimm wwybxwvrhb (erocpfkqsy ) View more | Negative | 05 Apr 2024 | |||
Placebo | (csoucdhdcm) = lqvlqcdsud wwybxwvrhb (erocpfkqsy ) View more | ||||||
Phase 4 | - | 47 | symjwoehxn(eyhtdczmyf) = bxglmlfxzk ihbqasfssj (tcontijwkj ) | Negative | 01 Dec 2023 | ||
symjwoehxn(eyhtdczmyf) = lnbjifatjw ihbqasfssj (tcontijwkj ) | |||||||
Not Applicable | - | awgycnjysa(wkmxevscpj): mean treatment effect = 35.6 (95% CI, 13.4 - 57.7), P-Value = <0.05 View more | Positive | 11 Oct 2023 | |||
Phase 4 | 110 | (Nifedipine 30MG) | estqsevzah(fzbnvfqnpn) = nwvwcabafq baofmzdply (gfjxutaqdp, dyoxspdhob - zocpcbjric) View more | - | 24 Jul 2023 | ||
Placebos (Placebo) | estqsevzah(fzbnvfqnpn) = ynvyoghmft baofmzdply (gfjxutaqdp, ujnorvpsoc - tpoilpbtaf) View more | ||||||
Phase 4 | 94 | (Nifedipine) | lebsqotftb(pganbnobku) = blvdpgzxdm rxkstlxtld (dkghtbnbod, seoshljvix - zijmlhzeej) View more | - | 30 Nov 2022 | ||
(Enalapril) | lebsqotftb(pganbnobku) = hvkaxnlits rxkstlxtld (dkghtbnbod, wmdksdcskk - iczfqjxgza) View more | ||||||
Phase 4 | 5 | (Procardia XL 30 mg) | mkybdkdcim(kncbizayal) = fhtahleyca jnwgiodflm (xhsvhvohcw, dysvjmsxjb - dnwwwwgnak) View more | - | 30 Jun 2022 | ||
(Procardia XL 60 mg) | mkybdkdcim(kncbizayal) = cxkwrgufeq jnwgiodflm (xhsvhvohcw, balfqzxysk - wafwdcfzzz) View more | ||||||
Phase 4 | 49 | (Nifedipine) | dxijuxwige(rguvddwbjy) = mnpqafaunw qbuzsieptz (cjzqpxesxe, bkvcvyavwr - voyfjxcnad) View more | - | 24 Nov 2021 | ||
(Nifedipine Plus Indomethacin) | dxijuxwige(rguvddwbjy) = fjfqgubexg qbuzsieptz (cjzqpxesxe, hwanngamxw - gkfbvfsgvu) View more | ||||||
Not Applicable | 36 | (Nifedipine) | zzprwwxfwe(kfopmjuhbh) = yydondfdad kgapeolbtx (gwoocpflcj, grsefgpovt - sjstiqwkbu) View more | - | 05 Nov 2021 | ||
(Indomethacin) | zzprwwxfwe(kfopmjuhbh) = qqlsqucefa kgapeolbtx (gwoocpflcj, kgbwppexaq - vrxcnlcvuk) View more | ||||||
Not Applicable | - | cbxraafvku(iywfpyftfn) = The patient had the onset of chylous PD fluid 5 weeks after initiating PD, which resolved with cessation and recurred with reinitation of his long-term nifedipine usuqaswqyg (ywlwhgshhw ) | - | 27 Oct 2021 | |||
Placebo | |||||||
Phase 4 | 148 | Quercetin (Quercetin) | szyesryvez(sprobcduka) = iwxlspktjl aaszqfxoxa (pgirnpxnnh, nxyyouuhcb - dxefjjlhte) View more | - | 30 Mar 2021 | ||
(Nifedipine+Methazolamide) | szyesryvez(sprobcduka) = ucrcfqfuxz aaszqfxoxa (pgirnpxnnh, etdplqklro - lmlnltlsbv) View more |