Delving into the Latest Updates on Gabapentin with Synapse

Overview

Basic Info

SummaryGabapentin is a small molecule drug developed by Pfizer that functions as a CACNA2D2 and Cav2.2 blocker. The drug has been approved for the treatment of various conditions, including anxiety, cough, diabetic neuropathies, epilepsy, fibromyalgia, restless legs syndrome, and seizures. Gabapentin's mechanism of action involves blocking the influx of calcium ions into neurons, thereby reducing their excitability and relieving symptoms such as pain and convulsions. Since its initial approval in 1993, Gabapentin has become a widely prescribed medication for the treatment of these conditions. However, it is important to note that Gabapentin may cause certain side effects, such as drowsiness, dizziness, and difficulty with coordination. Therefore, its use must be closely monitored by healthcare providers, and patients should follow the prescribed dosage and usage guidelines.

Drug Type

Small molecule drug

Synonyms

1-(Aminomethyl)cyclohexaneacetic acid, Gabapentin (JAN/USP/INN), CI-945

+ [16]

Target

CACNA2D1 x CACNA2D2

Action

blockers

Mechanism

CACNA2D1 blockers(Voltage-gated calcium channel alpha2/delta subunit 1 blockers), CACNA2D2 blockers(Voltage-gated calcium channel alpha2/delta subunit 2 blockers)

Therapeutic Areas

Immune System DiseasesNervous System DiseasesEndocrinology and Metabolic Disease+ [3]

Active Indication

Peripheral neuralgiaNeuralgia, PostherpeticAnxiety Disorders+ [7]

Inactive Indication

Amyotrophic Lateral SclerosisCarpal Tunnel SyndromeDyspepsia+ [6]

Originator Organization

Pfizer Inc.

Active Organization

Viatris Pharma GmbH

Pfizer Inc.Parke Davis (India) Ltd.

+ [4]

Inactive Organization

Assertio Therapeutics, Inc.

Viatris, Inc.Hunter New England Area Health Service

Drug Highest PhaseApproved

First Approval Date

United States (30 Dec 1993),

Anxiety DisordersCoughDiabetic Neuropathies+ [5]

RegulationOrphan Drug (United States)

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Structure/Sequence

Molecular FormulaC9H17NO2

InChIKeyUGJMXCAKCUNAIE-UHFFFAOYSA-N

CAS Registry60142-96-3

Postherpetic neuralgia (PHN) is the most common clinical complication of herpes zoster. PHN can persist for months to years, and in some cases, the pain may last for more than five years. Patients suffering from severe, prolonged pain endure significant distress, which seriously affects their quality of life and daily activities. Moreover, PHN can lead to insomnia, anxiety, depression, or even suicide. Currently, the treatment of PHN primarily focuses on pain management. First-line treatment options include gabapentin, pregabalin, tricyclic antidepressants, and 5% lidocaine patches.
Acupuncture is a widely used non-pharmacological therapy. A large number of clinical trials have demonstrated its effectiveness in treating various neuropathic pain conditions, including PHN. Acupuncture not only reduces pain perception but also alleviates anxiety and improves the quality of life for PHN patients. Among different acupuncture techniques, Warm Acupuncture (WA) is considered the most effective for treating peripheral neuropathic pain. Clinical case reports have also shown its pain-relieving effects in PHN patients.
However, there has been no study in Vietnam on the effectiveness of WA in pain reduction for patients with PHN. Therefore, this study is conducted to evaluate whether WA is effective in reducing pain and ensuring safety for treating PHN patients with Qi Stagnation and Blood Stasis syndrome. The findings will serve as a basis for the broader application of WA in the treatment of PHN.

Start Date01 Apr 2025

Sponsor / Collaborator

University of Medicine & Pharmacy AT Ho Chi Minh City

CTRI/2025/03/083257

/ Not yet recruitingPhase 3IIT

Effectiveness of a Single preoperative low dose of Gabapentin 100mg in reducing postoperative pain in varicose vein surgery. - NIL

Start Date01 Apr 2025

Sponsor / Collaborator-

CTRI/2025/03/082237

/ Not yet recruitingPhase 4IIT

An open-label randomized controlled trial to evaluate the efficacy of Vidangadi Ghanavati and Gokshuradi Guggulu after Virechana Karma versus Gabapentin in managing Pittavritta Madhumeha (Diabetic Neuropathy) in patients on conventional therapy - Nil

Start Date01 Apr 2025

Sponsor / Collaborator-

100 Clinical Results associated with Gabapentin

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100 Translational Medicine associated with Gabapentin

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100 Patents (Medical) associated with Gabapentin

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11,367

Literatures (Medical) associated with Gabapentin

01 Dec 2025·CURRENT ALLERGY AND ASTHMA REPORTS

Treatment of COVID-19 Associated Olfactory Dysfunction: A Systematic Review

Review

Author: Vanderbroek, Annabelle ; Moyaert, Mathilde ; Clijsters, Marnick ; Van Gerven, Laura ; Bischoff, Sabrina

PURPOSE OF REVIEW:

COVID -19 associated olfactory dysfunction is widespread, yet effective treatment strategies remain unclear. This article aims to provide a comprehensive systematic review of therapeutic approaches and offers evidence-based recommendations for their clinical application.

RECENT FINDINGS:

A living Cochrane review, with rigorous inclusion criteria, has so far included 2 studies with a low certainty of evidence. In this systematic review we list clinical data of 36 randomised controlled trials (RCTs) and non-randomised studies published between Jan 1, 2020 and Nov 19, 2023 regarding treatment options for COVID-19 associated olfactory dysfunction. Nine treatment groups were analysed, including olfactory training, local and systemic corticosteroids, platelet-rich plasma (PRP), calcium chelators, vitamin supplements including palmitoylethanolamide with luteolin, insulin, gabapentin and cerebrolysin. Primary objective was the effect of the studied treatments on the delta olfactory function score (OFS) for objective/psychophysical testing. Treatments such as PRP and calcium chelators demonstrated significant improvements on OFS, whereas olfactory training and corticosteroids did not show notable efficacy for COVID-19 associated olfactory dysfunction.

01 Dec 2025·Current Pain and Headache Reports

Perioperative Pain Management for Major Limb Amputation – A Systematic-Narrative Hybrid Review

Review

Author: Chitneni, Ahish ; Lehle, Carla H ; Kumar, Nicolas ; Valerio, Ian L ; Hao, David ; Caragher, Seamus P ; Raasveld, Floris V ; Eberlin, Kyle R

INTRODUCTION:

Post-amputation pain, including residual limb pain (RLP) and phantom limb pain (PLP), can affect the outcome of surgery and have an impact on quality of life. Effective management of acute post-amputation pain requires a multidisciplinary approach with collaboration among the surgical and anesthesia teams to optimize pain management. A systematic-narrative hybrid review was conducted to assess and report the effectiveness of various interventions in perioperative pain management for amputation surgery.

METHODS:

MEDLINE, Embase, CENTRAL, and ClinicalTrials.gov databases were searched for studies evaluating interventional and/or pharmacological approaches to managing perioperative pain in major extremity amputation surgery. The data collected included treatment options, average dosage and/or duration of treatments, and reported pain outcomes.

RESULTS:

Of the 27 studies evaluating interventions, 8 addressed neuraxial or perineural analgesia, 16 focused on peripheral nerve blocks (PNB), 2 examined peripheral nerve stimulators (PNS), and 1 investigated transcutaneous electrical nerve stimulation. Preoperative epidural analgesia was associated with a reduced incidence of postoperative pain. PNS, PNB, and catheter-based infusions were found to be effective in managing postoperative pain. The role of ketamine in treating post-amputation pain yielded mixed results, while other pharmacological agents, such as valproic acid and gabapentin, demonstrated limited efficacy.

CONCLUSIONS:

While numerous pain interventions are available, no single approach has been shown to be superior. A multimodal strategy, incorporating PNBs, preoperative pain control, and potentially ketamine, appears to provide the most comprehensive pain management strategy. Further long-term prospective studies are required to refine and optimize pain management techniques for major extremity amputation surgery.

LEVEL OF EVIDENCE:

III-Systematic reviews.

31 Dec 2025·Future Science OA

Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model

Article

Author: Qnais, Esam Y. ; Alzaghari, Lujain F. ; Barakat, Muna ; Al-Najjar, Mohammad A. A. ; Chellappan, Dinesh Kumar ; Alqudah, Abdelrahim ; Athamneh, Rabaa Y.

AIMS:

To evaluate the analgesic and neuroprotective effects of cytidine, uridine, and gabapentin-administered alone and in combination-in models of diabetic neuropathy and formalin-induced acute and inflammatory pain.

MATERIALS & METHODS:

Oral doses of cytidine, uridine, and gabapentin (100 mg/kg each) were administered to rats with streptozotocin-induced diabetic neuropathy and in a formalin test model. Behavioral responses were recorded at 30, 60, and 120 minutes following treatment after five weeks of diabetes induction. Spinal cord p-CREB expression was measured to assess molecular changes, and pretreatments with naloxone, yohimbine, and methysergide were employed to explore opioid, adrenergic, and serotonergic contributions.

RESULTS:

All treatments significantly reduced formalin-induced pain in both acute and inflammatory phases (p < 0.05; p < 0.001) and increased mechanical pain thresholds in the diabetic neuropathy model at all-time points (p < 0.05). Combination therapy proved more effective than gabapentin alone (p < 0.05) and was associated with decreased spinal p-CREB levels, indicating altered anti-nociceptive signaling.

CONCLUSIONS:

The combined use of cytidine, uridine, and gabapentin enhances analgesia and neuroprotection compared to monotherapy, supporting its potential as a novel, analgesic-free treatment strategy for diabetic neuropathy.

56

News (Medical) associated with Gabapentin

09 Jan 2025

·www.drugs.com

Gabapentin Doesn't Increase Fall Risk, Study Suggests

THURSDAY, Jan. 9, 2025 -- A pain-relieving medication might be safer for seniors than first thought. A new study published Jan. 7 in the Annals of Internal Medicine says Gabapentin is widely used to help treat chronic pain and nerve pain, particularly as an alternative to opioid painkillers. However, some have argued that gabapentin shouldn’t be prescribed to seniors, as it might increase their risk of damaging falls . Those concerns are baseless, according to the study. The study’s results show that gabapentin “was associated with fewer fall-related health care visits and … was not associated with an increase in more severe fall-related events,” concluded a research team led by Dr. Alexander Chaitoff , an assistant professor of internal medicine with the University of Michigan. “These considerations should be incorporated into conversations with patients who are considering starting gabapentin treatment,” the team added. Nearly 50 million prescriptions for gabapentin were written in 2020, but by 2022 those scripts had fallen by 20% after several studies found that the drug might increase fall risk for seniors. Chaitoff and his colleagues suspected that this risk might be overblown, given that the painful conditions for which gabapentin is prescribed also increases risk of falls. “Neuropathy, the most common indication for which gabapentin is prescribed, is also a known contributor to adverse health events, especially falls,” the researchers noted. The researchers decided to compare the safety of gabapentin against that of duloxetine , another drug prescribed for nerve pain that doesn’t have the same reputation for increasing fall risk. The team gathered data for more than 57,000 seniors 65 or older prescribed either gabapentin or duloxetine between Jan. 2014 and Dec. 2021 for nerve pain related to diabetes , shingles or fibromyalgia. The results showed that gabapentin users actually had a 48% lower overall risk of any falls, compared to those taking duloxetine. However, there was no difference between the two drugs when it came to the risk of experiencing a severe fall. “Although we cannot claim that gabapentin does not lead to higher risk for falls at any time, our study does suggest that the risks of gabapentin as they relate to fall risk in the first 6 months of initiation are not greater, or potentially favorable, versus an alternative medication that might be prescribed instead,” the research team concluded. Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

Clinical ResultDrug Approval

07 Jan 2025

·www.drugs.com

Incident Gabapentin Use Not Linked to Increase in Falls Versus Duloxetine

TUESDAY, Jan. 7, 2025 -- Incident use of gabapentin is not associated with an increase in fall-related hospital visits compared with duloxetine use, according to a study published online Jan. 7 in the Annals of Internal Medicine . Alexander Chaitoff, M.D., M.P.H., from the University of Michigan School of Medicine in Ann Arbor, and colleagues describe the risk for fall-related outcomes in older adults with diabetic neuropathy, postherpetic neuralgia, or fibromyalgia starting gabapentin versus duloxetine treatment. The analytic cohort included 57,086 older adults initiating treatment with gabapentin (52,152 adults) or duloxetine (4,934 adults). The researchers found that the weighted cumulative incidence rates of a fall-related visit at 30, 90, and 180 days were 103.60, 90.44, and 84.44 per 1,000 person-years, respectively, for gabapentin users and 203.43, 177.73, and 158.21 per 1,000 person-years, respectively, for duloxetine users. A lower hazard of falls was seen for incident gabapentin users at six-month follow-up (hazard ratio, 0.52), but no difference was seen in the risk for experiencing severe falls. Across sensitivity and subgroup analyses, the results were similar. "Incident gabapentin use, compared with incident duloxetine use, was associated with fewer fall-related health care visits and smaller differences in absolute measures and was not associated with an increase in more severe fall-related events," the authors write. "These considerations should be incorporated into conversations with patients who are considering starting gabapentin treatment."

Clinical Result

19 Dec 2024

·www.accesswire.com

MIRA Pharmaceuticals Submits IND for Ketamir-2 to FDA, Marking a Significant Milestone in the Company's Pipeline Development

MIAMI, FL / ACCESSWIRE / December 19, 2024 / MIRA Pharmaceuticals, Inc. (NASDAQ:MIRA), a preclinical-stage pharmaceutical company focused on developing therapies for neurological and neuropsychiatric disorders, today announced that it has submitted an Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA) for Ketamir-2, its novel oral ketamine analog for the treatment of neuropathic pain. The IND submission marks a major step in advancing Mira's lead drug candidate while reflecting its commitment to meeting milestones and timelines.Erez Aminov, Chairman & CEO of Mira, stated: "This IND submission highlights our team's commitment to executing efficiently as we advance transformative therapies. Ketamir-2 not only has demonstrated remarkable potential for neuropathic pain but also offers a broad opportunity across other major neuropsychiatric conditions. We look forward to beginning Phase I trials and continuing to deliver on our mission to address unmet medical needs."The IND application includes comprehensive data and reports detailing Ketamir-2's pharmacology, pharmacokinetics, and toxicology, along with results from both in vitro and in vivo studies, including validated neuropathic pain disease models. In parallel with the submission, the company is preparing to conduct a complementary neurotoxicity study, as required by the FDA's written feedback to the pre-IND documentation.According to a market analysis report from Fortune Business Insights, the neuropathic pain market in North America, including the United States, Canada, and Mexico, is valued at $3.1 billion and is expected to grow at a 6-7% compound annual growth rate (CAGR), reaching $4.5 billion by 2030. Despite this growth, existing treatments remain inadequate. Gabapentin and pregabalin, while widely prescribed, provide limited efficacy and are associated with side effects such as sedation, dizziness, and weight gain. Opioids remain a common treatment option but come with well-known risks of dependency, addiction, and respiratory depression. Intravenous ketamine, though effective for some patients, requires invasive administration and is often associated with psychotropic side effects, including hallucinations and dissociation.Ketamir-2 is specifically designed to address the limitations of existing treatments through its selective targeting of the NMDA receptor. By binding to a specific site on the NMDA receptor with low affinity, Ketamir-2 significantly reduces the risk of psychotropic effects commonly associated with traditional ketamine. Furthermore, it is not a substrate for P-glycoprotein (P-gp), which allows for better oral absorption and enhanced blood-brain barrier penetration. Unlike traditional ketamine, Ketamir-2 does not cause sedation or hyperactivity-side effects often linked to psychiatric conditions such as schizophrenia, bipolar mania, and ADHD. As a non-opioid therapy, Ketamir-2 is designed to eliminate the risks of dependency and addiction. Additionally, the DEA has determined that Ketamir-2 is not a controlled substance, streamlining accessibility and minimizing regulatory hurdles.Preclinical studies have demonstrated Ketamir-2's ability to achieve 100% pain reversal, fully normalizing pain thresholds in validated neuropathic pain models. Furthermore, Ketamir-2 has shown a strong safety and toxicological profile, observed across cardiovascular, CNS, respiratory, or toxicology assessments.Dr. Itzchak Angel, Chief Scientific Advisor at Mira, commented: "Ketamir-2's selective mechanism of action, strong safety profile, and ability to achieve full pain reversal underscore its potential as a transformative therapy."With the IND submitted, MIRA expects to initiate Phase I Clinical Trials in Q1 2025 to evaluate safety, tolerability, pharmacokinetics and pharmacodynamics in healthy volunteers. Phase IIa trials are expected to follow in late 2025 to assess efficacy in neuropathic pain patients. Beyond neuropathic pain, the company is exploring additional indications for Ketamir-2, including MDD, MDD-SI, TRD and PTSD.About MIRA Pharmaceuticals, Inc.MIRA Pharmaceuticals, Inc. (NASDAQ:MIRA) is a pre-clinical-stage pharmaceutical development company with two neuroscience programs targeting a broad range of neurologic and neuropsychiatric disorders. MIRA holds the exclusive U.S., Canadian, and Mexican rights for Ketamir-2, a novel, patent-pending oral ketamine analog under investigation to treat neuropathic pain (NP), treatment-resistant depression (TRD), major depressive disorder with suicidal ideation (MDD-SI), and post-traumatic stress disorder (PTSD).MIRA's novel oral pharmaceutical marijuana analog, MIRA-55, is currently under investigation for treating adult patients suffering from anxiety and cognitive decline, often associated with early-stage dementia. If approved by the FDA, MIRA-55 could mark a significant advancement in addressing various neuropsychiatric, inflammatory, and neurologic diseases and disorders.The U.S. Drug Enforcement Administration's scientific review concluded that both Ketamir-2 and MIRA-55 would not be considered controlled substances or listed chemicals under the Controlled Substances Act and its governing regulations.Additional information about MIRA Pharmaceuticals is available at www.mirapharmaceuticals.com.Cautionary Note Regarding Forward-Looking StatementsThis press release and the statements of MIRA Pharmaceuticals' (or the "Company") management related thereto contain "forward-looking statements," which are statements other than historical facts made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These statements may be identified by words such as "aims," "anticipates," "believes," "could," "estimates," "expects," "forecasts," "goal," "intends," "may," "plans," "possible," "potential," "seeks," "will," and variations of these words or similar expressions that are intended to identify forward-looking statements. Any statements in this press release that are not historical facts may be deemed forward-looking. These forward-looking statements include, without limitation, statements regarding the anticipated benefits of the study results described herein as well as the timing for the Company's other preclinical studies and the filing of an IND for Ketamir-2. Any forward-looking statements in this press release are based on the Company's current expectations, estimates, and projections only as of the date of this release and are subject to a number of risks and uncertainties (many of which are beyond the Company's control) that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These and other risks concerning the Company's programs and operations are described in additional detail in the Annual Report on Form 10-K for the year ended December 31, 2023, and other SEC filings, which are on file with the SEC at www.sec.gov and the Company's website at https://www.mirapharmaceuticals.com/investors/sec-filings. The Company explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law.Contact InformationHelga Moya [email protected](786) 432-9792SOURCE: Mira Pharmaceuticals, Inc.

Phase 1Phase 2IND

100 Deals associated with Gabapentin

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External Link

KEGG	Wiki	ATC	Drug Bank
D00332	Gabapentin	N03AX12	DB00996

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Peripheral neuralgia	Belgium	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Czechia	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	France	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Germany	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Hungary	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Iceland	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Ireland	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Italy	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Latvia	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Luxembourg	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Netherlands	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Norway	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Poland	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Portugal	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Slovenia	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	Sweden	Viatris Pharma GmbH	27 Oct 2006
Peripheral neuralgia	United Kingdom	Viatris Pharma GmbH	27 Oct 2006
Neuralgia, Postherpetic	United States	Viatris Specialty LLC	02 Mar 2000
Anxiety Disorders	Japan	Pfizer Inc.	30 Dec 1993
Cough	Japan	Pfizer Inc.	30 Dec 1993

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Dyspepsia	Phase 3	United States	Pfizer Inc.	01 Mar 2010
Refractory chronic cough	Phase 3	Australia	Hunter New England Area Health Service	15 Oct 2008
Hot Flashes	Phase 3	United States	Assertio Therapeutics, Inc.	01 Sep 2008
Vasomotor symptom	Phase 3	United States	Assertio Therapeutics, Inc.	01 Sep 2008
Sleep Initiation and Maintenance Disorders	Phase 3	United States	Viatris, Inc.	01 Oct 2004
Tremor	Phase 3	United States	Pfizer Inc.	01 Mar 2004
Carpal Tunnel Syndrome	Phase 3	Hong Kong	Pfizer Inc.	01 Oct 2003
Amyotrophic Lateral Sclerosis	Phase 3	United States	Pfizer Inc.	31 Dec 1999
Herpes Labialis	Phase 1	Belgium	Pfizer Inc.	01 Jul 2008

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03859024 (CTgov)	Phase 4	Urethral Stricture \| Pain, Postoperative	48	Acetaminophen+Ibuprofen 800 mg+Oxycodone (Standard Protocol)	kkdbvbmicj(qqdletikuk) = pmsochkapo bbkhttomwz (egoluvubgm, blonocbahq - yquadwmrsf) View more	-	19 Sep 2024
				Acetaminophen+Ibuprofen 800 mg+celebrex+Dexamethasone+Oxycodone+Bupivacaine+Gabapentin (Enhanced Recovery Protocol)	kkdbvbmicj(qqdletikuk) = tnuywaisou bbkhttomwz (egoluvubgm, qipnjlgfaa - cxeqvsovbo) View more
NCT05156060 (ASCO2024)	Phase 1/2	Head and Neck Neoplasms	-	Gabapentin 300mg TID	kzdjkewjnp(npjtcvmwbw) = zaulqccaqb fanbmbkdxt (qpujkfkjnb )	-	24 May 2024
				Intranasal Ketamine 30mg TID	kzdjkewjnp(npjtcvmwbw) = ojswetzxuv fanbmbkdxt (qpujkfkjnb )
NCT01678586 (CTgov)	Not Applicable	Radicular Pain	56	acupuncture (True Acupuncture)	xvwclkpqbk(keclnxerhi) = bcdvgeyihw eumewhkfvn (hetfxzfasx, 5.01) View more	-	23 Apr 2024
				Sham acupuncture (Sham Acupuncture)	xvwclkpqbk(keclnxerhi) = jhoykhjskk eumewhkfvn (hetfxzfasx, 2.44) View more
NCT03818919 (CTgov)	Phase 2	Analgesia \| Rotator Cuff Tear Arthropathy	70	Acetaminophen+Diazepam+Ketorolac+Celecoxib+Gabapentin (Post-Operative Non Opioid Pain Protocol)	nxpjqjjxsd(oxbnkolznj) = shvidiaroh eswkgsfzjl (rislqvticj, 2.1) View more	-	02 Apr 2024
				Hydrocodone-Acetaminophen (Post-Operative Traditional Pain Protocol)	nxpjqjjxsd(oxbnkolznj) = zwdwztbzzk eswkgsfzjl (rislqvticj, 1.8) View more
NCT05172570 (CTgov)	Phase 3	Pain, Postoperative	20	gabapentin (No Gabapentin)	ntoahlvjdr(izqyycayxo) = ndlwhzebrs gxkylfidxg (kzwpapjycj, srpdpjgfoy - yiwscszxnp) View more	-	21 Mar 2024
				gabapentin (300 mg Gabapentin 3X Per Day)	ntoahlvjdr(izqyycayxo) = rjgnybjojw gxkylfidxg (kzwpapjycj, muprmpmnoy - lpxddreiwr) View more
NCT04570436 (CTgov)	Phase 4	Sedative abuse	52	placebo (Placebo)	yvywercxlj(qaexgnunny) = wkptydqcyj rhqabihmvv (wlvycgopqn, 0.955) View more	-	06 Dec 2023
				diazepam 20 mg (Diazepam 20 mg)	yvywercxlj(qaexgnunny) = fkqyugcxem rhqabihmvv (wlvycgopqn, 2.533) View more
NCT04230980 (CTgov)	Phase 3	Azoospermia, Nonobstructive \| Pain, Postoperative	74	Gabapentin (Gabapentin)	biuwcduikl(jagjdyegpo) = myvzdkodxj lsuxquvfcd (ojdwjeoiye, 1.63) View more	-	18 Oct 2023
				Placebo (Placebo)	biuwcduikl(jagjdyegpo) = xeqstbtnvm lsuxquvfcd (ojdwjeoiye, 2.68) View more
NCT04429022 (RA-TLH, CTgov)	Phase 3	Pain, Postoperative	68	Local anesthetic injection+Local anesthetic injection with ropivacaine at abdominal laparoscopic port sites+Hydromorphone+Acetaminophen+Oxycodone+Ketorolac+Celecoxib+Gabapentin (Prospective Cohort)	tbemcsuhsp(jpydopavyl) = goxgqpgopy ptcbdpyuor (yptpgcpbbi, wgpxcusixp - znwueprdae) View more	-	01 Aug 2023
				Hydromorphone (Historical Control)	tbemcsuhsp(jpydopavyl) = nfboorhdgd ptcbdpyuor (yptpgcpbbi, lwpebtmvok - igauybnxxz) View more
WCD2023	Not Applicable	Flushing	318	Gabapentin 200 mg bid	riruuuquvb(puocofkslp) = kupifjkfrk wktdpzvpbw (ucljddtnom )	-	03 Jul 2023
				Gabapentin 400 mg tid	riruuuquvb(puocofkslp) = cffhvxkxak wktdpzvpbw (ucljddtnom )