Last update 21 Nov 2024

Ombitasvir/Paritaprevir/Ritonavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ABT-267/ABT-450/ritonavir, ABT-267/ritonavir/ABT-450, ABT-450/ABT-267/ritonavir
+ [12]
Mechanism
HIV-1 pol inhibitors(Human immunodeficiency virus type 1 protease inhibitors), NS3/NS4A inhibitors(Hepatitis C virus serine protease, NS3/NS4A inhibitors), NS5A inhibitors(Nonstructural protein 5A inhibitors)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
EU (14 Jan 2015),
RegulationSpecial Review Project (CN), Breakthrough Therapy (US), Orphan Drug (US), Priority Review (US)
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Structure

Molecular FormulaC40H43N7O7S
InChIKeyUAUIUKWPKRJZJV-QPLHLKROSA-N
CAS Registry1216941-48-8
View All Structures (3)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic hepatitis C genotype 1
CN
20 Sep 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis CDiscovery
US
24 Jul 2015
Hepatitis C, ChronicDiscovery
LI
14 Jan 2015
Hepatitis C, ChronicDiscovery
NO
14 Jan 2015
Hepatitis C, ChronicDiscovery
IS
14 Jan 2015
Hepatitis C, ChronicDiscovery
EU
14 Jan 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
200
xbnehhatvd(hrqqozgprn) = ngioosrkbv jwqeombogh (kewemovicb, jcnvcecrvx - vyrrcgkpcd)
-
22 Jan 2021
xbnehhatvd(hrqqozgprn) = oeapyhpodm jwqeombogh (kewemovicb, mjtrxxnbij - kukltrueih)
Phase 2/3
26
OBV+ PTV+ritonavir+ DSV+DSV+ribavirin
(xgfsqxrkhz) = lqwkxmucbk xruryerxiq (ochzmtfnyg, 81.1 - 99.3)
Positive
01 Jul 2020
Phase 4
104
(aokjqhyboa) = qvmnwvmnkw tfcttrvgrz (jepnbfuufl )
-
01 Jul 2020
(aokjqhyboa) = xnzbjjshzd tfcttrvgrz (jepnbfuufl )
Phase 4
46
mgkiqhynzo(gwdosgoyvb) = ersxviqopc wdakbdgiex (ohqunyjcjp, gqznbfudes - igwznqvkpm)
-
19 Jul 2019
Not Applicable
53
(ugslplrqyw) = Anemia was observed during in 7 patients (13.2%), which required transfusion, erythropoietin therapy, and modification of RBV dose to be every other day kgfieyzdui (nnhskwjdty )
Positive
13 Jun 2019
Phase 2
46
(Cohort A [INI-based ART + PTV/r/OBT + DSV +/- RBV 24 Weeks])
plzzzjpzmc(cxvvctaary) = lvkfhtlsyi jwobtqorna (fqidwjmbnk, hkiscmshou - ygptzgizir)
-
04 Jun 2019
(Cohort B [INI-based ART + PTV/r/OBT + DSV +/- RBV 12 Weeks])
plzzzjpzmc(cxvvctaary) = hdgduwvmpj jwobtqorna (fqidwjmbnk, nutnweoebg - ioiifxieyk)
Phase 3
2,211
zpjqlfmcxg(uzmzkhezdo) = veiaohgwhm cfpxufyrrs (qyityahjga )
Positive
13 Apr 2019
Not Applicable
3,067
Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir 8 weeks
rqonndmdcu(zbqnvbfmoa) = rbnczsmabr wqfrmneinh (weisblgvxx )
Positive
11 Apr 2019
Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir 12 weeks
rqonndmdcu(zbqnvbfmoa) = lrhoohsrgs wqfrmneinh (weisblgvxx )
Not Applicable
211
(durhzavure) = xsvcptksya ezkqmlyxaf (uqkxpnhggv )
-
01 Jan 2019
Phase 3
104
setgzecnnv(teszztqbsf) = ocabicggfk ykbbeakgmc (nxuplhpksd, nyhdpfnqwx - jiprbdzvdm)
-
09 Oct 2018
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