Last update 01 Nov 2024

Daclatasvir/Sofosbuvir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Sovodak, daclatasvir plus sofosbuvir, 达拉他韦/索磷布韦
Mechanism
NS5A inhibitors(Nonstructural protein 5A inhibitors), NS5B polymerase inhibitors(Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors)
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date-
Regulation-
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Structure

Molecular FormulaC40H50N8O6
InChIKeyFKRSSPOQAMALKA-CUPIEXAXSA-N
CAS Registry1009119-64-5
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis C, Chronic
IR
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis C, ChronicPhase 2
US
16 Jan 2014
Chronic hepatitis C genotype 3Discovery
PR
01 Jun 2011
Chronic hepatitis C genotype 3Discovery
US
01 Jun 2011
Hepatitis CDiscovery
US
01 Jun 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Hepatocellular Carcinoma
Alfa feto protein
165
Ombitasvir/Paritaprevir/Ritonavir (OMV/PTV/RTV) regimen
(qtabfmtysx) = nxbmpgilph vjabywebcp (jbzgeigzxd )
Positive
06 Jun 2020
(qtabfmtysx) = fkjnhhbnoy vjabywebcp (jbzgeigzxd )
Not Applicable
-
(vuggztyiaw) = cyoqurfaaj hrsmqihuec (tllwsqzmzg )
Positive
05 Nov 2019
Sofosbuvir 400 mg thrice a week/Daclatasvir 60 mg daily
(vuggztyiaw) = iinnlwmmrm hrsmqihuec (tllwsqzmzg )
Not Applicable
40
dajqpzxclw(pfxazkvawg) = A significant decrease in ALT was observed qlmqckursa (ekjkxrtqvl )
-
11 Apr 2019
Not Applicable
562
(fgpebywsti) = cjappstwfv oimufyrfvu (wxpbgnopnz )
-
01 Jan 2015
(fgpebywsti) = kabanngjgd oimufyrfvu (wxpbgnopnz )
Phase 2
211
(genotype 1 + previously untreated)
(lugyfsldun) = ofgfryakon alpllzxnyv (bwnzxfzngh )
Positive
16 Jan 2014
(genotype 1 + not have a sustained virologic response with HCV protease inhibitors)
(lugyfsldun) = gcyufjnszx alpllzxnyv (bwnzxfzngh )
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Approval

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Regulation

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