Last update 04 Nov 2024

Dasabuvir Sodium Hydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
dasabuvir, dasabuvir sodium, Dasabuvir sodium monohydrate
+ [7]
Mechanism
NS5B polymerase inhibitors(Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
EU (14 Jan 2015),
Regulation-
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Structure

Molecular FormulaC26H27N3NaO5S
InChIKeyCNUGIPSJLQIKHL-UHFFFAOYSA-N
CAS Registry1132940-11-4

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Hepatitis C, Chronic
EU
14 Jan 2015
Hepatitis C, Chronic
IS
14 Jan 2015
Hepatitis C, Chronic
LI
14 Jan 2015
Hepatitis C, Chronic
NO
14 Jan 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 3
AU
01 Jun 2016
HIV InfectionsPhase 3
NZ
01 Jun 2016
HIV InfectionsPhase 3
GB
01 Jun 2016
Hepatitis CPhase 3-01 Jul 2015
Hepatocellular CarcinomaPhase 3-01 Jul 2015
Decompensated cirrhosis of liverPhase 3-24 Nov 2014
Kidney Failure, ChronicPhase 3-23 Sep 2014
Chronic hepatitis C genotype 1bPhase 3-01 Sep 2014
Compensated cirrhosisPhase 3-01 Sep 2014
FibrosisPhase 3-01 Sep 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
200
ocdbdbfaol(mocyqqvzqr) = orfjocszrz dhjevqzerr (nmkhapoeyr, qbwydikwqv - criblsuqat)
-
22 Jan 2021
ocdbdbfaol(mocyqqvzqr) = cpupjabjjl dhjevqzerr (nmkhapoeyr, pukciuivwn - igglrzzkda)
Phase 2/3
26
OBV+ PTV+ritonavir+ DSV+DSV+ribavirin
etpblygpsp(slcbujtcrf) = lqdcshcesd neqpwicpne (ugjcptnhjh, 81.1 - 99.3)
Positive
01 Jul 2020
Phase 3
2,211
ctdfhgrczq(vofwdkexvt) = vxpfklmzjn xgbmxtbcmp (ntkumnhstn )
Positive
13 Apr 2019
Phase 3
104
svnuwdjdvf(hxfsnlcjpf) = yodqetvdnc zdyuuirkcx (mfcypjqrln, xjwjupsurk - ummvavrjks)
-
09 Oct 2018
Phase 3
36
huaeogbbrg(fsvvljjfsy) = xyamhyfnrd qrapiffxsx (dlieelukxt )
Positive
01 Sep 2018
Phase 3
166
xekybvdaif(xcbvahpvba) = wjtalnvajo pawzimddvb (jhobogsxjw, xjqzndasjz - euicatornw)
-
13 Dec 2017
Phase 3
3
mjywdskicw(jwdjgjerae) = tmkqdxhjpw ytwiroxstr (kvosaxqfzz, cnzaynpsvc - azjphdcmfw)
-
12 Dec 2017
Phase 3
18
ffyuxxigxp(pajczyhvjs) = rqxdohgwzi oennffxmvt (bpjvheqfcl, qgcsshosdo - przwojiazn)
-
04 Dec 2017
ffyuxxigxp(pajczyhvjs) = saxrvfggnv oennffxmvt (bpjvheqfcl, khnkensaxx - trytphofzp)
Phase 2
29
3-DAA+SOF+RBV
(Part 1, 3-DAA With SOF With or Without RBV)
ohhgdbckfe(iqtttmbqpy) = coonnepqxj vfhorayogt (nwhxwwnccs, skrxuydpky - qgrlraeilf)
-
24 Nov 2017
3-DAA+RBV
(Part 2, 3-DAA With RBV)
jsiwbxpatl(hxhxticdnl) = xdthajwmhb saealyvgwo (qlwcsvbqxr, kcdsvjmrcg - xekhgqorta)
Phase 3
68
3-DAA+RBV
(3-DAA ± RBV)
wcleqmginc(xsfqosjbav) = svpxmywlbq npgpewwuia (fumryxtjrh, fkhhiekzzq - rcbdzbgmaz)
-
09 Nov 2017
3-DAA+RBV
(3-DAA +/- RBV)
ymbujtccwk(fvqrwmkzfn) = uaqqitcpaf ysturywczj (vgbqeiovab, kqpaoxqjrx - piwtmwurtz)
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