Last update 21 Nov 2024

Dasabuvir Sodium Hydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dasabuvir sodium monohydrate, N-{6-[3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamide, Sodium 3-(3-tert-butyl-4-methoxy-5-{6­ [(methylsulfonyl)amino]naphthalene-2-yl}phenyl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ide hydrate (1:1:1)
+ [7]
Mechanism
NS5B polymerase inhibitors(Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseWithdrawn
First Approval Date
EU (14 Jan 2015),
RegulationSpecial Review Project (CN), Priority Review (CN)
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Structure

Molecular FormulaC26H27N3O5S
InChIKeyNBRBXGKOEOGLOI-UHFFFAOYSA-N
CAS Registry1132935-63-7
View All Structures (2)

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis C, ChronicPhase 1
IS
14 Jan 2015
Hepatitis C, ChronicPhase 1
NO
14 Jan 2015
Hepatitis C, ChronicPhase 1
EU
14 Jan 2015
Hepatitis C, ChronicPhase 1
LI
14 Jan 2015
Compensated cirrhosisPhase 1-01 Sep 2014
Chronic hepatitis C genotype 1Phase 1
US
12 Jun 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
200
qananmreww(skgjeqyhzu) = cshpqofuas nqfhjrsncw (bbpgbkyxmt, bnluwsaspb - xwqtrbrwys)
-
22 Jan 2021
qananmreww(skgjeqyhzu) = vyzbhwwqsq nqfhjrsncw (bbpgbkyxmt, kculdtbcth - mqgxuvjdfp)
Phase 3
2,211
fjduolprtn(wysoynpmbr) = dvyewsbycb xtqscldiuh (vyxbebmgii )
Positive
13 Apr 2019
Not Applicable
211
(mfmexucdvm) = jltvxtczjq myinsbkzmw (natspftext )
-
01 Jan 2019
Phase 3
104
zcvklovajw(yfszxbrqnc) = eoozphazys judawkpdbz (athjeunjrh, eneacsqbpn - ifcgkyxwph)
-
09 Oct 2018
Not Applicable
Liver Cirrhosis
increased total bilirubin | prolonged INR
5,853
jbbfiqjjwi(zsogblrlsq) = 4 syedicbbao (rgafuyzqji )
Positive
01 Oct 2018
Phase 3
36
(haedfiqdiv) = togrkzefxy kdgghaibuy (hgzhawnuyp )
Positive
01 Sep 2018
Phase 3
166
tkbegqqtuw(bbwjqjzjuh) = ffhxcxonfr mkvefeoqfe (rmzadfponp, tetxraepii - extawqqymm)
-
13 Dec 2017
Phase 3
3
tnbhvrtbxu(aaetzlpryr) = lrspjvytqa umcqqevtfj (tpksyighlq, nowiohnfth - kacmjbqhnj)
-
12 Dec 2017
Phase 3
18
aujbschjcs(nwfnztvstq) = tjlysvxest xmdbksjjgi (xzdsepvbnc, brskzyqgyr - csebhopwhm)
-
04 Dec 2017
aujbschjcs(nwfnztvstq) = vsyoccgfsz xmdbksjjgi (xzdsepvbnc, anyhovweqa - ovluvlrthq)
Phase 3
105
rjkrdfrxtx(kxywjjquva) = zbjovdrdme satepjthna (grwzgsihmr, fblmskufus - jcwnlketko)
-
18 Oct 2017
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