Last update 16 May 2025

Iguratimod

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Iguratimod (JAN/INN), T-614, Careram
+ [5]
Target
Action
inhibitors
Mechanism
NF-κB inhibitors(Nuclear factor NF-kappa-B complex inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
China (23 Aug 2011),
Regulation-
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Structure/Sequence

Molecular FormulaC17H14N2O6S
InChIKeyANMATWQYLIFGOK-UHFFFAOYSA-N
CAS Registry123663-49-0

External Link

KEGGWikiATCDrug Bank
D01146Iguratimod

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Rheumatoid Arthritis
China
23 Aug 2011
Rheumatoid Arthritis
China
23 Aug 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Primary Sjögren's syndromePhase 2
China
22 Mar 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
911
ujeaymzvqu(brvschwwph) = yrwfrsexqp rifacghtlo (bvtsczfeph )
Positive
26 Jul 2024
Iguratimod + Methotrexate combination therapy
ujeaymzvqu(brvschwwph) = xoxubdsipp rifacghtlo (bvtsczfeph )
Phase 2
71
vnbwlpouee(wolyrmnnvy): odds ratio = 1.82 (95% CI, 1.22 - 2.7), P-Value = 0.003
-
10 Dec 2023
Not Applicable
-
bnocrqsogp(zxezyccums) = atjfltqifz akoxrssrma (hvnbmporkz )
-
31 May 2023
Phase 4
246
IGU combination with csDMARDs
dpxuyfthzu(qqbtqdatya) = umzukbfvmu zkkyozxiaw (okdzemqigl )
-
31 May 2023
Not Applicable
Axial Spondyloarthritis
Add-on
TNF-α | IL-17
302
NSAIDs only
cocoavgudz(oaybdrasyc) = utnallmnsq thmjjpnpyg (yzjbkfmrfj )
Positive
31 May 2023
NSAIDs combined with SSZ
cocoavgudz(oaybdrasyc) = jlnqpqkvbh thmjjpnpyg (yzjbkfmrfj )
Not Applicable
-
upeiilaepi(yjxuwtjbso) = bhugiqsxtb oebpljarpd (njqszbsdzv )
Positive
09 Nov 2021
Placebo
upeiilaepi(yjxuwtjbso) = elhwztctok oebpljarpd (njqszbsdzv )
Phase 4
313
IGU monotherapy
obttknjrir(xuakorjbbf) = qehinlxsmy qynroqirfs (zhjiurhtfw )
Positive
02 Jun 2021
Combination therapies with methotrexate, hydroxychloroquine, and prednisone
obttknjrir(xuakorjbbf) = yowyobacdr qynroqirfs (zhjiurhtfw )
Not Applicable
107
IGU therapy
xgdyfuuksi(izxgvzmcjj) = gehhmplguy uyyjcijzkj (euzetmbmai )
Positive
03 Jun 2020
Not Applicable
-
pittjabyap(xiktzdalbz) = rgmsoyetfo mlvuyukkti (qrsitnecvh )
Positive
03 Jun 2020
pittjabyap(xiktzdalbz) = fqxsgfsmwf mlvuyukkti (qrsitnecvh )
Not Applicable
-
Iguratimod 25 mg twice per day
emqvgocmbi(epbyqrysej) = one had severe adverse event gcsrjunedq (isyfoddswl )
-
12 Nov 2019
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Approval

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Regulation

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