Delving into the Latest Updates on Betamethasone Dipropionate/Clotrimazole with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Betamethasone Dipropionate/Clotrimazole/Gentamycin Sulfate Cream, CLOTRIMAZOLE AND BETAMETHASONE DIPROPIONATE CREAM, Clotrimazole and Betamethasone Dipropionate Lotion

+ [5]

Target

CYP51A1 x GR

Action

inhibitors, agonists

Mechanism

CYP51A1 inhibitors(Cytochrome P450 51 inhibitors), GR agonists(Glucocorticoid receptor agonists)

Therapeutic Areas

Infectious DiseasesSkin and Musculoskeletal DiseasesUrogenital Diseases

Active Indication

ParonychiaTineaTinea Capitis+ [3]

Inactive Indication

Tinea corporistinea cruris

Originator Organization

Merck & Co., Inc.

Active Organization

Tianjin Jinyao Pharmaceutical Co., Ltd.

Inactive Organization

Organon & Co.

Drug Highest PhaseApproved

First Approval Date

United States (10 Jul 1984),

Tinea corporistinea crurisTinea Pedis

Regulation-

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Structure/Sequence

Molecular FormulaC28H37FO7

InChIKeyCIWBQSYVNNPZIQ-XYWKZLDCSA-N

CAS Registry5593-20-4

View All Structures (2)

BACKGROUNDVulvovaginal candidiasis is a common gynecologic infection, and recurring cases are yet incurable. This trial was based on Persian medicine to compare how effective marshmallow aqueous extract 4% plus clotrimazole 1% (CLOT-M) is compared to clotrimazole 1% vaginal creams on VVC.METHODSThis study randomly assigned 100 women with VVC into two groups. The target group (n = 50) was treated with CLOT-M while controls (n = 50) with clotrimazole vaginal creams for seven consecutive nights. Different VVC symptoms and signs, and yeast culture from vaginal discharge were evaluated as the outcome measures before the intervention and 7 and 30 days after.RESULTSThe efficacy of CLOT-M vaginal cream was assessed during the 1st and 2nd follow-ups, indicating a significant decrease in mean itching (P = 0.001 for both comparisons) and dyspareunia score (P = 0.001 and P = 0.04, respectively) as compared to treatment with clotrimazole vaginal cream. Moreover, after 7 days of the intervention, patients in the CLOT-M group experienced significant improvement in mean dysuria score compared to those in the control group (P = 0.001). Neither cream caused any significant adverse events.CONCLUSIONIt seems that CLOT-M vaginal cream had a significant effect on the VVC symptoms improvement, without any significant side effects. However, larger sample-sized trials are needed for more evidence-based judgment.

31 Dec 2021·Journal of Pharmacopuncture

Chamomile Extract versus Clotrimazole Vaginal Cream in Treatment of Vulvovaginal Candidiasis: A Randomized Double-Blind Control Trial

Article

Author: Shiravani, Zahra ; Alamdarloo, Shaghayegh Moradi ; Poordast, Tahereh ; Najib, Fateme sadat ; Hosseinzadeh, Fatemeh ; Shahraki, Hadi Raeisi

OBJECTIVESVulvovaginal candidiasis (VVC) treatment is advised for all women due to its symptoms and complications. In this study, the standard treatment, clotrimazole, was compared with chamomile extract cream in outpatient clinics.METHODSWe recruited 73 women with VVC, who were randomly allocated into two groups, clotrimazole versus chamomile extract cream. After two weeks of treatment with the same criteria, cheese-like vaginal discharge, itching and burning sensations, strawberry cervix, and recovery percentage was evaluated.RESULTSThirty patients in each group were analyzed. There was no significant difference in age and number of pregnancies between groups (p = 0.85 and 0.09, respectively). Comparing before and after treatment, cheese like discharge (p < 0.001), itching (p < 0.001), burning (p < 0.001) had significantly improved in both groups. Further, the recovery percentage was not significantly different between groups (88.9% vs 75% in the chamomile vs clotrimazole groups, respectively).CONCLUSIONChamomile is as effective as clotrimazole in VVC treatment; a higher percentage of women who used this medication recovered, although this did not reach significance. In addition, no complications were reported in either group.

01 Nov 2021·Iranian Journal of Nursing and Midwifery Research

Comparison of the Effects of Nika Vaginal Cream with Clotrimazole Cream on Vaginal Candidiasis Symptoms

Article

Author: Masoumi, Seyedeh Zahra ; Shayan, Arezoo ; Moradkhani, Shirin ; Rashidi, Mohammad Kazem ; Parsapour, Hamideh ; Ghiasian, Seyed Amir

Background:The prevalence of vaginal candidiasis is high in women and proper treatment is essential in this regard.Materials and Methods:This single-blind randomized controlled clinical trial was conducted on 120 women who were referred to Hamadan health centers in 2019. The patients were randomly divided into Clotrimazole cream and Nika vaginal cream groups each including 60 cases. The intervention group received Nika vaginal cream once a day for a week and those in the control group were given Clotrimazole vaginal cream in the same way. The clinical symptoms were studied by clinical examinations and the culture of vaginal discharge before and 7 days after the treatment to confirm the diagnosis of Candida albicans. The results were analyzed by SPSS 21.0 using an independent t test, Mann–Whitney U test, and Chi-square, Fisher's exact, and McNemar's tests, the significance level was set at 0.05.Results:Most patients in both groups reported no clinical symptoms after the intervention, and no significant difference was observed between the two groups in this regard (χ2 = 2.23, p = 0.566). Conversely, a significant difference was found in Nika and Clotrimazole groups before and after the intervention regarding improving Vulvovaginal Candidiasis (VVC) symptoms χ2 = 86.01, χ2 = 99.41, respectively (p < 0.001). Finally, 84.48% and 75.86% of women in the Nika χ2 = 45.02 (p < 0.001) and Clotrimazole cream χ2 = 40.02 (p < 0.001) groups had negative culture results after the intervention.Conclusions:In general, the Nika and Clotrimazole vaginal creams have the same effects concerning improving the symptoms of vaginal candidiasis and thus can be used to treat VVC.

100 Deals associated with Betamethasone Dipropionate/Clotrimazole

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	S01CA05 D07CC01 S03CA06 D07BC01	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Paronychia	China	Tianjin Jinyao Pharmaceutical Co., Ltd.	-
Tinea	China	Tianjin Jinyao Pharmaceutical Co., Ltd.	-
Tinea Capitis	China	Tianjin Jinyao Pharmaceutical Co., Ltd.	-
Tinea Pedis	China	Tianjin Jinyao Pharmaceutical Co., Ltd.	-
Tinea Versicolor	China	Tianjin Jinyao Pharmaceutical Co., Ltd.	-
Vulvovaginitis	China	Tianjin Jinyao Pharmaceutical Co., Ltd.	-