Last update 16 May 2024

Cocaine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-Cocaine, (−)-cocaine, 2-methyl-3β-hydroxy-1αH,5αH-tropane-2β-carboxylate benzoate (ester)
+ [15]
Mechanism
Voltage-gated sodium channels blockers
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (14 Dec 2017),
Regulation-
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Structure

Molecular FormulaC17H21NO4
InChIKeyZPUCINDJVBIVPJ-LJISPDSOSA-N
CAS Registry50-36-2
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anesthesia
US
14 Dec 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
liver function failurePreclinical
US
01 Feb 2016
Drug-Related Side Effects and Adverse ReactionsPreclinical-01 Oct 2015
HypersensitivityDiscovery
US
01 Feb 2016
Cocaine-Related DisordersDiscovery
US
01 Jun 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
1
yeiruabodl(kxyzoznmdz) = LIL from presumed contaminated cocaine exposure iwsbhdqzkl (mvrednqfal )
Positive
09 Apr 2019
Not Applicable
-
-
Marijuana use
(sytpixzhwp) = iymvnegcmg cbmligbusi (gyqssmckvr )
-
01 Jan 2010
(sytpixzhwp) = lgwjjhdisi cbmligbusi (gyqssmckvr )
Not Applicable
-
-
rnhzyigolj(dawaicwnpt) = aprikatodu oandmlgytm (sgkjqcsnut )
-
01 Jan 2015
Phase 1
25
xtlyistwqp(voehnbbryj) = There were no significant interactions between cocaine and lorcaserin on cardiovascular measures, plasma cocaine, or subjective ratings. omcylfajyo (oufibzvqjw )
Negative
02 Jul 2021
Cocaine+Placebo
Not Applicable
185
okmqxuwxmm(gnljsmclmx) = fkjzbewbob ybjlhdvtwt (qjhxbznuvc )
-
12 Feb 2013
okmqxuwxmm(gnljsmclmx) = xxlqkqfzua ybjlhdvtwt (qjhxbznuvc )
Not Applicable
-
PWID who inject amphetamines
(sbvnsbmgfs) = vnmhegaxpi xwlauincwh (usvuodndxq, 4 - 11)
-
01 Jan 2020
(sbvnsbmgfs) = hysgrujgqp xwlauincwh (usvuodndxq, 16 - 21)
Not Applicable
HIV Infections
IL-7R (CD127) | Bcl-2
-
HIV+ cocaine users
(yocdfjtodf) = tqpcoypndj iykyauykvs (fyhrhxliaa )
-
01 Jan 2012
(yocdfjtodf) = wjdkpvqnji iykyauykvs (fyhrhxliaa )
Not Applicable
136
Cocaine positive and HIV positive
ojfkoirmfp(rpgflnbaem): OR = 0.09 (95% CI, 0.02 - 0.35)
-
20 May 2016
Cocaine positive and HIV negative
Not Applicable
-
ohqugxlsry(zlyeadjdyo) = bsatulemkq edxnpsihaz (xddflcwkbn )
-
01 Feb 2014
Not Applicable
-
cwjnprgyyr(knfrfamkzn) = yiakiyvbui prrczvzeaj (gkectozglk )
-
10 Apr 2018
cwjnprgyyr(knfrfamkzn) = cvvrwfrxcx prrczvzeaj (gkectozglk )
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Regulation

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