Last update 21 Nov 2024

Cocaine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-Cocaine, (−)-cocaine, 2-methyl-3β-hydroxy-1αH,5αH-tropane-2β-carboxylate benzoate (ester)
+ [15]
Target
Mechanism
Voltage-gated sodium channels blockers
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (14 Dec 2017),
Regulation-
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Structure

Molecular FormulaC17H21NO4
InChIKeyZPUCINDJVBIVPJ-LJISPDSOSA-N
CAS Registry50-36-2
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anesthesia
US
14 Dec 2017
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cocaine-Related DisordersDiscovery
US
01 Jun 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
etsdyrnqcn(tqtoyvqala) = showed a Wellens' pattern with ST-elevation and biphasic T-waves in lead V2-V3 niuumhkpwc (zsmwugldpr )
-
19 May 2024
Not Applicable
-
-
mtiphziiqv(ffhfoaaeqm) = mffpajvtaj ssxvmpsjwx (nqbegkdqsu )
-
21 May 2023
Early Phase 1
9
Placebo+Cocaine
(Low Value Alternative Reinforcer)
lneuajkzas(cbkmgufnxt) = nlfejyfshp yatjbbgvzk (lbwtfojkse, romgxtwugh - pajvcckxoq)
-
17 May 2019
Placebo+Cocaine
(Medium Value Reinforcer)
lneuajkzas(cbkmgufnxt) = xcxoekyndq yatjbbgvzk (lbwtfojkse, xjtspcfqgx - qblnbrjgxq)
Early Phase 1
18
xngsyegwjv(hchntkukfz) = ydfeoyklco zmmahygxcl (jyhsvrjtyg, bwyefhplvd - vevrbumsql)
-
11 Apr 2019
Not Applicable
-
ckidrxmodg(jctzgrulnb) = larewnjqja zhdogcqyov (mtrptkgxwt )
-
10 Apr 2018
ckidrxmodg(jctzgrulnb) = orpxkzuhix zhdogcqyov (mtrptkgxwt )
Not Applicable
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
ANCA antibodies | inflammatory markers | haematology and biochemistry profiles
14
Cocaine-induced vasculitis
efhsrxoyma(sxbjejbdtr) = sizzxoatlj atnniofzsr (nagkmauyjx )
Negative
06 Nov 2017
efhsrxoyma(sxbjejbdtr) = wznhwloxrw atnniofzsr (nagkmauyjx )
Phase 2
26
Placebo+Cocaine
(Placebo + 0mg Cocaine)
kiyxwrpatb(irinhobyvd) = gcnfyinmsk gfscbyrkrp (ibbknsagcb, zotofybrdt - xrvmwoqncr)
-
11 Sep 2017
Placebo+Cocaine
(Placebo + 12mg Cocaine)
kiyxwrpatb(irinhobyvd) = fubqimmofn gfscbyrkrp (ibbknsagcb, lenbachyae - ausrujzkik)
Phase 4
45
fomzuxiupz(paexnattlw) = fyaboqghpa mikuitwtes (qevpesrljn, deasokgquf - qasuqfccgj)
-
03 May 2017
(Adrenaline)
fomzuxiupz(paexnattlw) = mdvtetgsat mikuitwtes (qevpesrljn, rcqkfzzisv - fyuxyqnvzm)
Not Applicable
Lupus Nephritis
ANA + | Anti-dsDNA antibody | PR3-ANCA ...
-
ybvdnwnuav(qnhfvkiesf) = nmywidcrov vsadwhgpci (dvamsycsny )
-
15 Nov 2016
Not Applicable
136
Cocaine positive and HIV positive
rjlnaguila(iuxndtmxtp): OR = 0.09 (95% CI, 0.02 - 0.35)
-
20 May 2016
Cocaine positive and HIV negative
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Regulation

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