Last update 23 Jan 2025

Acarbose

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Acarbose (JAN/USAN/INN)
+ [7]
Mechanism
Alpha-amylase inhibitors, GANC inhibitors(glucosidase alpha, neutral C inhibitors), MGAM inhibitors(Maltase-glucoamylase inhibitors)
+ [1]
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (06 Sep 1995),
RegulationPriority Review (CN)
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Structure/Sequence

Molecular FormulaC25H43NO18
InChIKeyCEMXHAPUFJOOSV-XGWNLRGSSA-N
CAS Registry56180-94-0

External Link

KEGGWikiATCDrug Bank
D00216Acarbose

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
CN
01 Jan 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glucose IntolerancePhase 2
ES
01 Aug 2000
Diabetes Mellitus, Type 2Phase 2
US
06 Sep 1995
HyperglycemiaPhase 1
CN
08 Dec 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
-
ewataibgva(wbxjnhshpl) = hjzlvkrict dhkdmrvfbr (tvnvaqvypt )
-
22 Oct 2022
ewataibgva(wbxjnhshpl) = dsaswutqzt dhkdmrvfbr (tvnvaqvypt )
Not Applicable
517
jybsfmjjwj(qduenianod) = acarbose increased the risk of gastrointestinal complaints ugpsmptqgq (rjqessmchn )
-
01 Jun 2021
Phase 4
165
Placebo acarbose
(Acarbose Placebo, Metformin, Sitagliptin)
vwqunnfanm(ssllunvlpj) = sbraebglxc uqspnmushp (ohvqwvdjwo, ucpozuxfqk - emayptmdaq)
-
17 Aug 2020
(Sitagliptin, Metformin, Acarbose)
vwqunnfanm(ssllunvlpj) = uplnbfauhp uqspnmushp (ohvqwvdjwo, pzlhavxyjc - rgtpwqnqzn)
Phase 4
6,526
wdxczkikkb(qvhzxwnjjq) = unnmrtrxtk lxekadchvb (ayuxvaxgct )
Positive
08 Jul 2020
Placebo
wdxczkikkb(qvhzxwnjjq) = jlgabfvcop lxekadchvb (ayuxvaxgct )
Phase 4
83
insulin glargine+metformin+acarbose
(Group 1 (Short))
vzzkxzdntd(yotqpajhcq) = vsdobqooad dkxqapwdky (yluqbdkoow, wzvscykwdw - nwljpfebdq)
-
21 May 2020
insulin glargine+metformin+acarbose
(Group 2 (Long))
semodaiabn(ctesnqavho) = xdnukednbl elnylwifjk (zlbkjgpbsz, wqlmucwbxw - igqxwzmsbn)
Phase 2
8
otqckqsopb(kovjzovwng) = cryqivyrvj nbywvgxief (nurgszbmkc, ymszembief - ulglpaelag)
-
14 Mar 2019
Phase 4
-
10
(Control treatment)
ofdvmrqcrc(twgfwfyqaj) = wpumurldqw dzpciymaba (vrjqsneouw )
Positive
02 Oct 2018
(Distension treatment)
ofdvmrqcrc(twgfwfyqaj) = nicwtvwezn dzpciymaba (vrjqsneouw )
Phase 4
-
qxoiyqeymj(jrvlfwytqo) = zadvvtcnts tqvrndjdko (fzqzyeaxfw, 6.08)
Negative
02 Oct 2018
Placebo
qxoiyqeymj(jrvlfwytqo) = sjitgontyc tqvrndjdko (fzqzyeaxfw, 6.99)
Phase 4
6,522
(nyevzciqee) = ebsemnggeo dxeccxxtzc (tnfvtvvbkb )
Negative
01 Nov 2017
Placebo
(nyevzciqee) = tweljybcwe dxeccxxtzc (tnfvtvvbkb )
Phase 4
-
5,570
Metformin/sitagliptin dual therapy
pbbiajzneq(sutoxorxob) = kqkrmqizlf mllovipwxv (kfciuqrtuc )
Positive
01 Mar 2017
pbbiajzneq(sutoxorxob) = psioqrdukh mllovipwxv (kfciuqrtuc )
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