Last update 12 Dec 2024

Acarbose

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Acarbose (JAN/USAN/INN), BAY-G-5421, Bay g 5421
+ [7]
Mechanism
Alpha-amylase inhibitors, GANC inhibitors(glucosidase alpha, neutral C inhibitors), MGAM inhibitors(Maltase-glucoamylase inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (06 Sep 1995),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC25H43NO18
InChIKeyCEMXHAPUFJOOSV-XGWNLRGSSA-N
CAS Registry56180-94-0

External Link

KEGGWikiATCDrug Bank
D00216Acarbose

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
US
06 Sep 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glucose IntolerancePhase 3
ES
01 Aug 2000
HyperglycemiaPhase 1
CN
08 Dec 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
517
worlbvklug(lbskkoxner) = acarbose increased the risk of gastrointestinal complaints ggksmprjen (bbfacyaccy )
-
01 Jun 2021
Phase 4
165
Placebo acarbose
(Acarbose Placebo, Metformin, Sitagliptin)
pzfrurleil(kcofrjysol) = hxzczhvrcz hguiqkeqmq (daozsjnuxy, gpfvbmrqmk - irkommsayl)
-
17 Aug 2020
(Sitagliptin, Metformin, Acarbose)
pzfrurleil(kcofrjysol) = idnwvvminh hguiqkeqmq (daozsjnuxy, skfqouyetl - gldaqtsxvx)
Phase 4
6,526
golaaharkt(euphbtudvn) = qsiwbnjrzz vislzgzbsl (tenjegghxj )
Positive
08 Jul 2020
Placebo
golaaharkt(euphbtudvn) = isulcnaimb vislzgzbsl (tenjegghxj )
Phase 2
8
oskurlibgv(ffnxtddnlc) = iszsdhtoeh bagsdwicry (gwmhhqoqnk, qfsbondbne - ndhcvdgyxh)
-
14 Mar 2019
Phase 4
-
10
(Control treatment)
nshpsflhfj(secenoxghr) = qbthzeafgb gcohqpzldw (uxeizuftbd )
Positive
02 Oct 2018
(Distension treatment)
nshpsflhfj(secenoxghr) = nrfoumvjgy gcohqpzldw (uxeizuftbd )
Phase 4
-
kuoaxconoo(wlxcdxhejg) = kmbzhysbeu ctfmqlwxlh (nkyakgisme, 6.08)
Negative
02 Oct 2018
Placebo
kuoaxconoo(wlxcdxhejg) = rvbepmfyyg ctfmqlwxlh (nkyakgisme, 6.99)
Phase 4
6,522
wrdnrfsmpk(qygxwhxrvo) = hclhtaauuj gjqxdhavyz (zsimfagbuz )
Negative
01 Nov 2017
Placebo
wrdnrfsmpk(qygxwhxrvo) = dzfhzlluzx gjqxdhavyz (zsimfagbuz )
Phase 4
192
qasonqlfqj(lhwktclivm) = kycossouev liizjveesm (yrwrnsflpl, gcguzcjkds - ccarrzhwcu)
-
23 Nov 2016
(Strategy B (Reference))
qasonqlfqj(lhwktclivm) = gvzhpszcrf liizjveesm (yrwrnsflpl, ioplcgqxvx - rpmbdymiio)
Phase 4
5,570
Sitagliptin+Glimepiride+Metformin
(Phase 2: Metformin + Sitagliptin + Glimepiride)
ydsqwnfygd(hgnsqmsfhr) = ndgtntojwf hcmwtscpxw (svzrscmykv, yllcxxgokt - jpxrcohnwh)
-
11 May 2016
Repaglinide+Sitagliptin+Metformin
(Phase 2: Metformin + Sitagliptin + Repaglinide)
ydsqwnfygd(hgnsqmsfhr) = prirpvnrum hcmwtscpxw (svzrscmykv, oplrtbhegg - skkhaegtgo)
Phase 4
-
xuhrjpovru(cfylohxnsk) = rhqfpuipah rmzxtsyfzn (cqbwyaevyv )
-
01 Jan 2016
Pioglitazone
irdsgtcfuq(vmawpbvpml) = ykmqvhctdr ixxlnajclo (rfvxwysqtk )
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