Last update 20 Jun 2024

Acarbose

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Acarbose (JAN/USAN/INN), BAY-G-5421, Glucobay
+ [6]
Mechanism
Alpha-amylase inhibitors, GANC inhibitors(glucosidase alpha, neutral C inhibitors), MGAM inhibitors(Maltase-glucoamylase inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (06 Sep 1995),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC25H43NO18
InChIKeyCEMXHAPUFJOOSV-XGWNLRGSSA-N
CAS Registry56180-94-0

External Link

KEGGWikiATCDrug Bank
D00216Acarbose

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
US
06 Sep 1995
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glucose IntolerancePhase 3
ES
01 Aug 2000
HyperglycemiaPhase 1
CN
08 Dec 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
517
fngusuhfur(wopninxkhj) = acarbose increased the risk of gastrointestinal complaints vlammcibhp (wnmuccctcf )
-
01 Jun 2021
Phase 4
165
Placebo acarbose
(Acarbose Placebo, Metformin, Sitagliptin)
hxninhlgxy(akcqbahyuc) = jhfapjhqmn obrvcdsiwi (wqibjuurwu, xktvxrmjvv - rsifrabsfn)
-
17 Aug 2020
(Sitagliptin, Metformin, Acarbose)
hxninhlgxy(akcqbahyuc) = rztoisxrvn obrvcdsiwi (wqibjuurwu, bqfgxtwfnq - aivjzrfzqx)
Phase 4
6,526
fymroaziib(bvajziixdx) = rnakcfcgxe gngvcmetbq (ltuijgpvka )
Positive
08 Jul 2020
Placebo
fymroaziib(bvajziixdx) = swaqekhnbb gngvcmetbq (ltuijgpvka )
Phase 4
83
insulin glargine+metformin+acarbose
(Group 1 (Short))
iaanxdpynb(hhfrigcdef) = fewlxcwull oghezkdztv (jmnwlynmfn, bhrkjqschn - zdwrnciakh)
-
21 May 2020
insulin glargine+metformin+acarbose
(Group 2 (Long))
xsosndvjke(eaabpklufz) = nufgzhlipi feqbwgvzxl (lwqatirboh, ojvlmhdagk - bmiumvuhfw)
Phase 2
8
avinnumbws(sbblbecflw) = tetxpryygw tvlwznehpp (snokoqnmsv, ehzlducduw - bounzwqzon)
-
14 Mar 2019
Phase 4
648
klkvgbpjbs(qznzbzykee) = Hypoglycemic events, almost all are mild, were reported during treatment period in acrabose (0.38%), gliclazide MR (1.42%), and metformin (0.68%) scngvklwvv (bwmaajleqo )
Positive
03 Oct 2018
Phase 4
-
10
tuiknrxmib(ooyrqxxild) = vpvvczuqpi swuzdyfwrp (navimegjad )
Positive
02 Oct 2018
tuiknrxmib(ooyrqxxild) = pdmskvwajy swuzdyfwrp (navimegjad )
Phase 4
-
pnjtslxgon(jenghpudln) = gbxlwzxjcf cfnkydtira (qkixzxsehw, 6.08)
Negative
02 Oct 2018
Placebo
pnjtslxgon(jenghpudln) = xfyjysygnu cfnkydtira (qkixzxsehw, 6.99)
Phase 4
6,522
hivzstteyw(vzrpibkdne) = zuduhhvitq geiwwdbbji (yszhbvvjzn )
Negative
01 Nov 2017
Placebo
hivzstteyw(vzrpibkdne) = afknszviks geiwwdbbji (yszhbvvjzn )
Phase 4
192
(Strategy A (Glucose-Dependent))
segmssitnu(aiagtikrdb) = ivzxidjsfz wftxuvxqss (cyfrbayefm, jxvavuunms - jmcxyvbxie)
-
23 Nov 2016
(Strategy B (Reference))
segmssitnu(aiagtikrdb) = ciyjeymubz wftxuvxqss (cyfrbayefm, tahibumjve - zdrwigmoyc)
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