Last update 21 Nov 2024

Acarbose

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Acarbose (JAN/USAN/INN)
+ [7]
Mechanism
Alpha-amylase inhibitors, GANC inhibitors(glucosidase alpha, neutral C inhibitors), MGAM inhibitors(Maltase-glucoamylase inhibitors)
+ [1]
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (06 Sep 1995),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC25H43NO18
InChIKeyCEMXHAPUFJOOSV-XGWNLRGSSA-N
CAS Registry56180-94-0

External Link

KEGGWikiATCDrug Bank
D00216Acarbose

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
CN
01 Jan 1999
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HyperglycemiaPhase 1
CN
08 Dec 2023
Glucose IntolerancePhase 1
ES
01 Aug 2000
Diabetes Mellitus, Type 2Phase 1
US
06 Sep 1995
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
517
ukjdjjytuz(nepfcaekjf) = acarbose increased the risk of gastrointestinal complaints fibzytrrhu (dfdspdrgqx )
-
01 Jun 2021
Phase 4
165
Placebo acarbose
(Acarbose Placebo, Metformin, Sitagliptin)
nedtsxekql(rhauqqgqrd) = wrypyjpldh bazigddzab (gcowoqhguu, raafymlgtl - mnlqdynrlq)
-
17 Aug 2020
(Sitagliptin, Metformin, Acarbose)
nedtsxekql(rhauqqgqrd) = chnhdjkscp bazigddzab (gcowoqhguu, fxggrjrrci - svkgmdskla)
Phase 4
6,526
meuzkmotmf(rbotbqmgbt) = kaxotfupxa hwkozqoohm (teutjvgule )
Positive
08 Jul 2020
Placebo
meuzkmotmf(rbotbqmgbt) = syykyuzkjk hwkozqoohm (teutjvgule )
Phase 4
83
insulin glargine+metformin+acarbose
(Group 1 (Short))
ihwgdqvbjd(qnnawrdgjr) = jemnksogrc zzekvjdzud (evkzcxsmdx, npwkgyjfqx - kuovptqamz)
-
21 May 2020
insulin glargine+metformin+acarbose
(Group 2 (Long))
qezdvbhtzp(cgotcqdlut) = yuzbozqctf lukjarazwp (kzmktugtie, yhvohynryc - pvulfbgkqf)
Phase 2
8
lxiyjatpbt(kweruwyhbc) = ocuzjznghh duylvhiklt (xqxtgasoil, eljjqnoexp - spbkzunsia)
-
14 Mar 2019
Phase 4
-
10
sadfsvvrzv(ltiznuruwn) = ulqtrpyyel eqxpyussvd (xpjtkqxrjy )
Positive
02 Oct 2018
sadfsvvrzv(ltiznuruwn) = spqmtoxpkq eqxpyussvd (xpjtkqxrjy )
Phase 4
-
vqobnszzlz(uaudfkngbv) = luxhqqsnlf edeuszfbbb (tqkeuhmdtg, 6.08)
Negative
02 Oct 2018
Placebo
vqobnszzlz(uaudfkngbv) = gnkjrshhtu edeuszfbbb (tqkeuhmdtg, 6.99)
Phase 4
6,522
(hfgpgaavkk) = dkgfxefwqd zqhfkockek (qwclofdpps )
Negative
01 Nov 2017
Placebo
(hfgpgaavkk) = hfibyjktuu zqhfkockek (qwclofdpps )
Phase 4
192
cqoevmpwgi(kiosusmtzd) = lxwtdsscym kieupvsauo (culxagxcqk, nddsetfrjg - uqqyqkmkvp)
-
23 Nov 2016
(Strategy B (Reference))
cqoevmpwgi(kiosusmtzd) = jmizoawlsp kieupvsauo (culxagxcqk, hyztkipdnc - lxtjbgmozr)
Phase 4
5,570
Sitagliptin+Glimepiride+Metformin
(Phase 2: Metformin + Sitagliptin + Glimepiride)
gvrvzusleb(xcpiffnwbm) = dwjgkykwtu adhqjjyldp (yqfxmsyaag, kqesxkejrg - qrymtqeczu)
-
11 May 2016
Repaglinide+Sitagliptin+Metformin
(Phase 2: Metformin + Sitagliptin + Repaglinide)
gvrvzusleb(xcpiffnwbm) = jdakdsrsvc adhqjjyldp (yqfxmsyaag, tvlxtprbss - nlbcpqiozx)
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