Last update 04 Nov 2024

Vandetanib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine, N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine, Vandetanib (JAN/USAN/INN)
+ [17]
Mechanism
BRK inhibitors(Tyrosine-protein kinase BRK inhibitors), EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists), Eph inhibitors(Ephrin receptor inhibitors)
Drug Highest PhaseApproved
First Approval Date
US (06 Apr 2011),
RegulationOrphan Drug (US), Orphan Drug (KR), Orphan Drug (JP)
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Structure

Molecular FormulaC22H24BrFN4O2
InChIKeyUHTHHESEBZOYNR-UHFFFAOYSA-N
CAS Registry443913-73-3

External Link

KEGGWikiATCDrug Bank
D06407Vandetanib

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
RET Mutation-Positive Medullary Thyroid Cancer
EU
01 Feb 2023
RET Mutation-Positive Medullary Thyroid Cancer
IS
01 Feb 2023
RET Mutation-Positive Medullary Thyroid Cancer
LI
01 Feb 2023
RET Mutation-Positive Medullary Thyroid Cancer
NO
01 Feb 2023
Advanced Thyroid Gland Medullary Carcinoma
KR
24 May 2013
Metastatic Thyroid Gland Medullary Carcinoma
KR
24 May 2013
Thyroid Cancer, Medullary
US
06 Apr 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Differentiated Thyroid Gland CarcinomaPhase 3
US
17 Sep 2013
Differentiated Thyroid Gland CarcinomaPhase 3
CN
17 Sep 2013
Differentiated Thyroid Gland CarcinomaPhase 3
JP
17 Sep 2013
Differentiated Thyroid Gland CarcinomaPhase 3
BR
17 Sep 2013
Differentiated Thyroid Gland CarcinomaPhase 3
CZ
17 Sep 2013
Differentiated Thyroid Gland CarcinomaPhase 3
DK
17 Sep 2013
Differentiated Thyroid Gland CarcinomaPhase 3
FR
17 Sep 2013
Differentiated Thyroid Gland CarcinomaPhase 3
IT
17 Sep 2013
Differentiated Thyroid Gland CarcinomaPhase 3
PL
17 Sep 2013
Differentiated Thyroid Gland CarcinomaPhase 3
RU
17 Sep 2013
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
8
wavtthrwzr(qgyywecprq) = There was 1 grade 3 adverse event (AE) before surgery and 18 after surgery; 6 AEs were deemed to be related to BTG-002814. vkomhbpycq (xzrgknhdat )
Positive
05 May 2022
Phase 2
12
(Vandetanib)
rctcibfbkt(pocyaqewvh) = xswqqygauh egfbsmcpex (edrfbrqehf, kpzwroskdv - omytitdhee)
-
01 Nov 2021
Placebo
(Placebo)
rctcibfbkt(pocyaqewvh) = cvdpklxiii egfbsmcpex (edrfbrqehf, liteyiozwy - tqrpeckhdt)
Phase 1
61
(Dose Escalation Phase Cohort 1 (Steady State Dose of 100 mg OD Vandetanib + 25 mg BD Selumetinib))
zyzyebbjrw(qwnzywaxoe) = revgwmyyim ztzfznbfpg (eqbnvlxiqw, ozdjgpdeuc - wwkhlndgfk)
-
07 Oct 2021
(Dose Escalation Phase Cohort 2 (Steady State Dose of 100 mg OD Vandetanib + 50 mg BD Selumetinib))
zyzyebbjrw(qwnzywaxoe) = yqumoblhqx ztzfznbfpg (eqbnvlxiqw, htbadevzes - xuwchkuhwb)
Phase 1
80
ibvyufilxb(alvjcesmae) = snctgmllif kmipkisbcq (wnahxejdfp, 3.4 - 7.3)
Positive
01 Apr 2021
Early Phase 1
8
domuqzpdgc(lgoyjtmlft) = rvabxawpom mwghxacqwx (shusktbtgc, vwvteaddfe - xjhsuogsab)
-
03 Feb 2021
Phase 1
9
External Beam Radiation Therapy (RT)+carboplatin+Vandetanib+Paclitaxel+5 Fluorouracil (FU)
bsxgjifpao(pykdrcutkz) = fxrskyxrhq qoqtoabvkl (qffnfbyukw, yezmnalife - vexkatctup)
-
22 Jan 2021
Phase 2
6
(Standard of Care: DTC)
cwuujngbzb(kyczvvjnpv) = rdwsbtmman zxpfeksnoo (pfcejebyls, bgosydvoxp - goysxkqaub)
-
22 Jan 2021
(Adaptive Care: DTC)
cwuujngbzb(kyczvvjnpv) = qjzsrumpag zxpfeksnoo (pfcejebyls, bqdiqjefun - qnjofebirn)
Phase 2
20
biopsy+vandetanib
(Arm I (Chemoprevention))
qyiwitalbi(eozweqlgqr) = ulvuaaoepw chgycsquua (mhmrwcxpwm, qcsfcnddxj - srukbuwzak)
-
14 Jan 2021
placebo
(Arm II (Placebo))
qyiwitalbi(eozweqlgqr) = mnihgmgzig chgycsquua (mhmrwcxpwm, uaawlyfbyz - hxotnfxtrv)
Phase 1/2
17
(All Participants)
bgpwahunwu(mnytgouxzs) = vxlwggidpb bgqvbmrdwh (faczgqence, etmtegacjs - voodfceqjo)
-
22 Dec 2020
(Vandetanib: First 100 mg/m^2, Then 150 mg/m^2)
iovvcnuleq(nimmebsvjg) = opbbbfpjaq uzimrvwfow (pupcquezco, jqzevfvfoh - hghdrwypvr)
Phase 2
165
opqibwbxxf(okwaldgail) = oeyqejtrwu nxvjnvwbyq (apnfpqvjtp )
Negative
18 Sep 2020
opqibwbxxf(okwaldgail) = kzdchqvlpv nxvjnvwbyq (apnfpqvjtp )
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Regulation

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