Vitamin supplementation in cystic fibrosis in the era of modulators: the impact of vitamin K2 on cardio-metabolic health – a randomised double-blind placebo-controlled trial

Start Date29 Oct 2024

Sponsor / Collaborator-

ChiCTR2400081931 / SuspendedNot ApplicableIIT

The effect of vitamin K2 fortified nutritional intervention on muscle condition and clinical outcomes in elderly patients with muscle wasting syndrome

Start Date19 Mar 2024

Sponsor / Collaborator-

ChiCTR2400081953 / RecruitingPhase 1IIT

A single-arm clinical trial study of the efficacy and safety of vitamin k2 in combination with a second-line standard regimen for the treatment of advanced hepatocellular carcinoma

Start Date18 Mar 2024

Sponsor / Collaborator

The Affiliated Hospital of Qingdao University

100 Clinical Results associated with Menatetrenone

100 Translational Medicine associated with Menatetrenone

100 Patents (Medical) associated with Menatetrenone

1,336

Literatures (Medical) associated with Menatetrenone

01 Feb 2025·FOOD CHEMISTRY

Vitamin K - content in food and dietary intake among the Danes

Article

Author: Jakobsen, Jette ; Christensen, Tue ; Langwagen, Marija ; Jensen, Marie Bagge ; Poulsen, Anders

Insufficient information on the content of vitamin K2 in our foods hinder estimation of the dietary intake. We aimed to establish content of eight vitamin K vitamers, vitamin K1 (phylloquinone; PK) and vitamin K2 (menaquinones; MK-4 to MK-10) in 88 composite food samples representing dairy, eggs, meat, fish, cereals, and plant-based alternatives to dairy. Combined with PK data for other foods, the dietary intake among Danes was estimated. The unit'PKeq' is used to compensate for the difference in molecular weight for MK-4 at 445 g/mol up to MK-10 at 853 g/mol. The highest content was found in chicken thigh with skin at 53 μg PKeq/100 g followed by 49 μg PKeq/100 g in Danablue (blue cheese). The daily intake of vitamin K is 139 μg to 160 μg PKeq for adults. The highest percentage comes from PK (64 %), 27 % from MK-4, 4.6 % from MK-9, and 2.4 % from MK-8.

01 Dec 2024·WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Bioremediation by Brevibacterium sediminis: a prospective pyrene degrading agent to eliminate environmental polycyclic aromatic hydrocarbons

Article

Author: Roy, Suchismita ; Guchhait, Kartik Chandra ; Jana, Debarati ; Dey, Subhamoy ; Panda, Amiya Kumar ; Ghosh, Chandradipa ; Manna, Tuhin ; Mitra, Maitreyee ; Ghosh, Kuntal ; Raul, Priyanka ; Jana, Sahadeb ; Karmakar, Monalisha ; Baitalik, Anirban

Environmental abuses and subsequent array of health hazards by petroleum products have emerged as a global concern that warrants proper remediation. Pyrene (PYR), a polycyclic aromatic hydrocarbon, is a xenobiotic by-product during crude petroleum processing. Biodegradation potential of two bacterial isolates (MK4 and MK9) of Brevibacterium sediminis from oil contaminated sites was explored. MK4 and MK9 could degrade PYR up to 23 and 59% (1000 mg.L^- 1), respectively. A first-order formalism with the rate constant for MK4 and MK9 were found to be 0.022 ± 0.001 and 0.081 ± 0.005 day^- 1, respectively with the corresponding half life period of 31.4 ± 1.4 and 8.6 ± 0.60 days respectively. Both the isolates produce biosurfactants as established by drop collapse assay, oil spreading and emulsification activity studies. Decrease in pH, change in absorbance (bacterial growth), and catechol formation support adaptation capability of the isolates to degrade PYR by using it as a source of carbon. PYR ring cleavage was induced by the ring hydroxylating dioxogenase enzyme present in the strains, as identified by PCR assay. In silico analyses of the PYR degrading enzyme revealed its higher binding affinity (-7.6 kcal.mol^- 1) and stability (Eigen value:1.655763 × 10^- 04) to PYR, as further supported by other thoeroretical studies. MK9 strain was more efficient than the MK4 strain in PYR degradation. Studies gain its prominence as it reports for the first time on the aptitude of B. sediminis as novel PYR-degrading agent that can efficiently be used in the bioremediation of petroleum product pollution with a greener approach.

01 Dec 2024·FOOD MICROBIOLOGY

Soy protein hydrolysates induce menaquinone-7 biosynthesis by enhancing the biofilm formation of Bacillus subtilis natto

Article

Author: Yi, Yunxin ; Coldea, Teodora Emilia ; Chen, Moutong ; Zhao, Haifeng ; Yang, Huirong

Menaquinone-7 (MK-7) is a form of vitamin K₂ with health-beneficial effects. A novel fermentation strategy based on combining soy protein hydrolysates (SPHs) with biofilm-based fermentation was investigated to enhance menaquinone-7 (MK-7) biosynthesis by Bacillus subtilis natto. Results showed the SPHs increased MK-7 yield by 199.4% in two-stage aeration fermentation as compared to the SP-based medium in submerged fermentation, which was related to the formation of robust biofilm with wrinkles and the enhancement of cell viability. Moreover, there was a significant correlation between key genes related to MK-7 and biofilm synthesis, and the quorum sensing (QS) related genes, Spo0A and SinR, were downregulated by 0.64-fold and 0.39-fold respectively, which promoted biofilm matrix synthesis. Meanwhile, SPHs also enhanced the MK-7 precursor, isoprene side chain, supply, and MK-7 assembly efficiency. Improved fermentation performances of bacterial cells during fermentation were attributed to abundant oligopeptides (Mw < 1 kDa) and moderate amino acids, particularly Arg, Asp, and Phe in SPHs. All these results revealed that SPHs were a potential and superior nitrogen source for MK-7 production by Bacillus subtilis natto.

News (Medical) associated with Menatetrenone

04 Jan 2024

·www.globenewswire.com

Healthy Extracts Launches First Anti-Aging Formulation, LONGEVITY

LAS VEGAS, Jan. 04, 2024 (GLOBE NEWSWIRE) -- Healthy Extracts Inc. (OTCQB: HYEX), a platform for acquiring, developing, patenting, marketing, and distributing plant-based nutraceuticals that target select high-growth categories within the multibillion-dollar nutraceuticals market, has launched LONGEVITY Anti-Aging™, a new proprietary formulation designed to support skin vitality, arterial flexibility, and cellular and joint health. LONGEVITY Anti-Aging is available to order today on BergametNA.com. In celebration of the launch, for a limited time you can buy two and get one free. You can also subscribe and save 15% on every order. The formulation is a special blend of the most powerful anti-aging warriors that include trans-resveratrol, quercetin, vitamin D, and vitamin K2. These substances are known to boost blood flow and circulation, reduce the deleterious effects of misplaced calcium in the body, and slow the effects of aging with powerful antioxidants. “LONGEVITY Anti-Aging complements our growing heart health product portfolio which supports a holistic approach to anti-aging like healthy skin,” noted Healthy Extracts president, Duke Pitts. “We anticipate this new product, along with the others we’re planning to launch early this year, will continue drive our growth and market expansion, as they leverage our multiple sales and distribution channels and existing customer base.” LONGEVITY Anti-Aging represents a holistic approach to aging, with a proprietary blend focused on providing the nutrition the body needs for optimal health. It is formulated to help sustain vitality, support heart health, ensure robust bone strength, and contribute to a healthier aging process. The formulation is vegan friendly, non-GMO, gluten-free, and produced and tested by certified U.S. facilities. Key substances and benefits: Trans-resveratrol and quercetin are powerful antioxidants that shield cells from aging and oxidative stress for more youthful function.Vitamin D and K2 are vital for proper calcium absorption and distribution, bolstering bone health and reducing osteoporosis risk.For heart health, ingredients like vitamin K2 and trans-resveratrol are key in maintaining cardiovascular wellness, helping to lower the risk of heart ailments.Vitamin D and quercetin also strengthens immune defense, enhancing protection against infection and disease. LONGEVITY Anti-Aging is your ally for overall longevity, blending ingredients renowned for their anti-aging benefits that support a longer, healthier life. LONGEVITY Anti-Aging introduction follows the recent official launch of BERGAMET SLEEP BREATHING SUPPORT™ , a natural supplement designed to support respiratory function for deeper, more restorative sleep. Given the better than anticipated initial sales of this new product, it is on track to become one of the company’s best sellers in 2024. Healthy Extracts’ full line of natural heart health formulations address the fast-growing, multi-billion dollar heart-health supplement market which is projected to grow at 5.9% CAGR to reach $24.8 billion by 2027, according to ResearchAndMarkets. To learn more about Healthy Extracts’ full line of clinically-backed, natural brain and hearth health products, go to bergametna.com or tryubn.com. About Healthy Extracts “Live Life Young Again” Healthy Extracts Inc. is a platform for acquiring, developing, researching, patenting, marketing, and distributing plant-based nutraceuticals. The company’s subsidiaries, BergametNA™ and Ultimate Brain Nutrients™ (UBN), offer nutraceutical natural heart and brain health supplements. This includes the only heart health supplement distributed in North America containing Citrus Bergamot SuperFruit™. This superfruit has the highest known concentration of polyphenols and flavonoids. UBN’s KETONOMICS® proprietary formulations, which have been designed to enhance brain activity, focus, headache and cognitive behavior, provide many sales and intellectual property licensing opportunities. For more information visit: healthyextractsinc.com, bergametna.com or tryubn.com. Forward-Looking Statements and Safe Harbor Notice All statements other than statements of historical facts included in this press release are "forward-looking statements" (as defined in the Private Securities Litigation Reform Act of 1995). Such forward-looking statements include our expectations and those statements that use forward-looking words such as "projected," "expect," "possibility" and "anticipate." The achievement or success of the matters covered by such forward-looking statements involve significant risks, uncertainties and assumptions. Actual results could differ materially from current projections or implied results. Investors should read the risk factors set forth in the Company's Annual Report on Form 10-K filed with the SEC on March 31, 2023, and future periodic reports filed with the SEC. All of the Company's forward-looking statements are expressly qualified by all such risk factors and other cautionary statements. The Company cautions that statements and assumptions made in this news release constitute forward-looking statements and make no guarantee of future performance. Forward-looking statements are based on estimates and opinions of management at the time statements are made. The information set forth herein speaks only as of the date hereof. The Company and its management undertake no obligation to revise these statements following the date of this news release. Food & Drug Administration Disclosure The product and formulation featured in this release is not for use by or sale to persons under the age of 12. This product should be used only as directed on the label. Consult with a physician before use if you have a serious medical condition or use prescription medications. A doctor’s advice should be sought before using this and any supplemental dietary product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. BergametNA™, Ultimate Brain Nutrients™, UBN™, Citrus Bergamot SuperFruit™ and F4T® are registered trademarks of Healthy Extracts Inc.™ Company ContactDuke Pitts, PresidentHealthy Extracts Inc.Tel (720) 463-1004Email contact Investor ContactRonald Both CMA Investor RelationsTel (949) 432-7566Email contactMedia Contact:Tim RandallCMA Media RelationsTel (949) 432-7572Email Contact A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/200b922a-c04a-45ab-b819-dba1b9750c42

Drug Approval

07 Mar 2023

·www.prnewswire.com

NUTRISHOP® Launches Comprehensive Heart Formula To Support Cardiovascular Health

Heart Formula by Nu-Tek Nutrition® is now available exclusively at Nutrishop HENDERSON, Nev., March 7, 2023 /PRNewswire/ -- Nutrishop, a leading national retail nutrition franchise specializing in dietary and nutritional supplements, vitamins and wellness, is proud to announce the launch of Heart Formula by Nu-Tek Nutrition®. This product's comprehensive approach to cardiovascular health contains some of the most sought-after, heart-healthy ingredients on the market. And, it is now available exclusively through Nutrishop. Continue Reading "We all have only one heart, and it is never too early to start caring for it." Tweet this Let’s face it, wellness is the new fitness. Introducing Heart Formula by Nu-Tek Nutrition. It’s loaded with heart-healthy ingredients like Olive Leaf Extract, Garlic, Organic Beet Root, Turmeric, CoEnzymeQ10, and more. Let’s be as healthy on the inside as we look on the outside. "We all know the importance of a healthy heart, yet some of us may overlook it in pursuit of a fit physique. However, the importance of a healthy heart cannot be overstated," said Nutrishop Founder and CEO Bryon McLendon. "If the interior of our bodies is not functioning properly, nothing on the exterior matters. Nu-Tek Nutrition's Heart Formula is the perfect solution to support our body's most important muscle." Loaded with heart-healthy ingredients such as Olive Leaf Extract, Garlic Extract, Turmeric Root, Hawthorn Berry, Organic Beet Root, CoEnzymeQ10, Grape Seed Extract, and Vitamin K2, Heart Formula is easy to incorporate into any wellness routine. In addition to maintaining a healthy body weight, regularly engaging in cardio exercise (brisk walking counts!), reducing stress and consuming good-for-your-heart foods, such as salmon, vegetables, whole grains, nuts and seeds, simply take three capsules daily or as directed by your healthcare professional. "We all have only one heart, and it is never too early to start caring for it," McLendon said. "With Heart Formula by Nu-Tek Nutrition combined with a healthy lifestyle, you're definitely stepping in the right direction." To learn more or purchase Heart Formula, visit NutrishopUSA.com or stop by any Nutrishop location nationwide. About Nu-Tek Nutrition ®: For nearly 20 years, Nu-Tek Nutrition has dedicated itself to building the foundation of health and wellness with innovative, complex powders like Supergreens, Superfruits, and Daily Detox and supplements like Gut Formula and Super Multi+. The brand's products are backed by over 25 years of formulating experience to offer the best wellness supplementation and help people live their best lives. About NUTRISHOP ® Since 2003, NUTRISHOP® has helped countless individuals live a fit, healthy, happy lifestyle. Nutrishop stores offer customers a low-price guarantee on a wide array of cutting-edge dietary supplements along with exceptional, individualized customer service, easy-to-follow meal plans, body composition assessment tools, and sound nutritional guidance. The Nutrishop business model focuses primarily on franchisee-owned and operated stores that provide consumers with the tools required to achieve their health and fitness goals. For more information, visit NutrishopUSA.com and follow on Instagram @NutrishopUSA. To learn more about becoming a Nutrishop franchisee, visit NutrishopFranchise.com. SOURCE Nutrishop

21 Jul 2022

·www.prnewswire.com

Ortek to Launch Oral Care Prebiotic Soft Chew with Added Nutrients for Enamel, Bone, Immune and Cardiovascular Support

Multi-Action BasicBites Synergy Plus™ Poised to Capitalize on the Multibillion Dollar Oral Care, Supplement and Prebiotic Markets ROSLYN HEIGHTS, N.Y., July 21, 2022 /PRNewswire/ -- Ortek Therapeutics, Inc., a leader in developing and commercializing novel oral care technologies, has announced its plans to extend its successful BasicBites® product line later this year with the introduction of BasicBites Synergy Plus™ soft chew. This revolutionary patent pending product combines Ortek's breakthrough microbiome oral care technology with vital nutrients to help support tooth enamel and maintain healthy bones and immune and cardiovascular systems. BasicBites Synergy Plus Soft Chews BasicBites Synergy Plus will further strengthen Ortek's ability to capitalize on opportunities in the global oral care, supplement, and prebiotic markets which last year were valued at approximately $200 billion. The company is also developing additional BasicBites line extensions that it plans to announce soon. "Our products have been well received by our loyal and growing customer base of thousands of consumers and dental professionals," said Mitchell Goldberg, President of Ortek Therapeutics, Inc. As this new product line extension shows, we continually find new ways to take advantage of our university developed microbiome oral care technology." What makes BasicBites Synergy Plus a one-of-a-kind prebiotic and nutritional supplement is its patent pending formula which includes all of the following ingredients: Arginine Bicarbonate and Calcium Carbonate which work together to create a healthy, balanced oral pH environment that protects teeth from harm caused by dry mouth–which effects 1 in 4 adults–and sugary foods and drinks. Arginine, an amino acid, nourishes the beneficial pH-raising bacteria discovered in dental plaque, resulting in immediate and sustained buffering on tooth surfaces that helps neutralize harmful plaque acids-a prebiotic process. The calcium carbonate also enriches tooth enamel and bones and plays an important role in supporting the health of cardiovascular, muscular and nervous systems. K2VITAL®, a novel K2 MK-7 formula superior to other Vitamin K2 supplements. Vitamin K2 facilitates the transport and integration of calcium into bones and teeth. It helps maintain a normal calcium balance in arteries, which may inhibit their calcification and prevent or slow the progression of arterial stiffness. This novel formulation from Kappa Bioscience maintains Vitamin K2's potency in higher pH products such as BasicBites Synergy Plus. Vitamin D3 which helps the body absorb calcium into the bloodstream and has a vital role in maintaining strong teeth and bones. It also helps support a strong immune system and respiratory and neuromuscular functions and could play a role in maintaining cardiovascular health and metabolizing blood glucose. About Ortek Ortek Therapeutics, Inc. is a global leader in developing and commercializing cutting-edge oral care technologies. For more information on the company, visit ortekinc.com. SOURCE Ortek Therapeutics, Inc.

100 Deals associated with Menatetrenone

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KEGG	Wiki	ATC	Drug Bank
D00100	Menatetrenone	B02BA	DB12148

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Osteoporosis, Postmenopausal	CN	Eisai Co., Ltd.	21 Jul 2013
Vitamin K Deficiency Bleeding	JP	Sannova KK	25 May 2012
Vitamin K Deficiency Bleeding	JP	Alfresa Pharma Corp.	25 May 2012
Pain	CN	Eisai Co., Ltd.	29 Jun 2010
Osteoporosis	JP	Eisai Co., Ltd.	30 Jun 1995
Hemorrhage	JP	Eisai Co., Ltd.	29 Jun 1972
Hypoprothrombinemias	JP	Eisai Co., Ltd.	29 Jun 1972

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Hepatocellular Carcinoma	Phase 3	JP	Eisai Co., Ltd.	01 Mar 2004
Cerebral Hemorrhage	Preclinical	JP	Kumamoto University	10 May 2024
Leukemia	Preclinical	JP	Tokyo Medical University	16 Nov 2007

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


AVADEC (ESC2022)	Not Applicable	Coronary Artery Disease	389	Vitamin K2 (720 μg/day) and Vitamin D (25 μg/day)	aiqoasqfjh(ltusbjwnto) = jfrriqqvwh isbbpanzcf (puowwyjgzz ) View more	-	28 Aug 2022
				vitamin k2	aiqoasqfjh(ltusbjwnto) = eiwagsgeeh isbbpanzcf (puowwyjgzz ) View more
MO789 (ERA2022)	Not Applicable	matrix Gla protein (MGP)	120	Vitamin K1	oawedhbnin(uwmauuqlhk) = herfpcztti iolzdufnrr (fvizgrbcdb )	Positive	03 May 2022
				Vitamin K2	oawedhbnin(uwmauuqlhk) = qmbzhzdecu iolzdufnrr (fvizgrbcdb )
Pubmed \| J Am Coll Cardiol	Not Applicable	Aortic Valve, Calcification Of	365	MK-7 plus vitamin D	dmiugtdeni(fqzkjrxdtw) = rdqjlyuhwr bhwaftgqje (ayqvqaudoa, 225 - 326) View more	-	25 Apr 2022
				Vitamin K2 (Placebo)	dmiugtdeni(fqzkjrxdtw) = cvlhfugihs bhwaftgqje (ayqvqaudoa, 246 - 338) View more
FP608 (ERA2019)	Not Applicable	Vascular Calcification uncarboxylated-MGP	102	Vitamin K2 supplementation (200μg/day)	zxwwsrbopa(rqaieiwext) = kmavktqgjz teexglotap (ujelrlybmk ) View more	Negative	13 Jun 2019
				Vitamin K2	zxwwsrbopa(rqaieiwext) = dujxnvjlml teexglotap (ujelrlybmk ) View more
NCT02876354 (Pubmed \| BMC Nephrol)	Phase 4	Hemodialysis complication	50	Vitamin K2 (menaquinone-7)	qpskykeumt(ippbpztonw) = ebnqxlhpoc shocrtpxyy (xfazxibhfh )	-	07 Jun 2017
NCT02876354 (MO021, ERA2017)	Phase 4	Hemodialysis complication dp-ucMGP \| MGP \| vitamin K2	50	Vitamin K2 (menaquinone-7)	zgmcrzesib(cmyrwzweft) = skyiscvnnx aqltficibt (zberpzsbuj )	Positive	26 May 2017
NCT04247087 \| NCT01101698 (Pubmed)	Phase 4	Chronic Kidney Diseases	42	Vitamin K2 + cholecalciferol (K+D)	hojpoyxdcy(hqaolnfjbw) = mitiggxgrf ihjortdduy (kzflwhpaoj )	-	01 Jan 2015
				Cholecalciferol (D)	hojpoyxdcy(hqaolnfjbw) = hmcpwjvmwl ihjortdduy (kzflwhpaoj )
SP230 (ERA2014)	Not Applicable	Chronic Kidney Diseases dp-ucMGP positive \| MGP positive \| osteocalcin	42	Vitamin K2 (menaquinone-7, MK-7) + cholecalciferol	zelqiaevfz(uagofimeku) = tksqfcecbh areergropb (lrkvttqnnh, 1077.1±507.7) View more	Positive	01 May 2014
				Vitamin D	zelqiaevfz(uagofimeku) = leixpaqcgg areergropb (lrkvttqnnh, 793.9±400.3) View more
Pubmed \| Nutr J	Not Applicable	-	-	Menaquinone-4 (MK-4)	jqpekhjkdl(zwwrnzwlcd) = fepeaqizpy ksrhtiszhk (upqkwwumnb )	-	01 Dec 2012
ASN2012	Not Applicable	dp-uc-MGP	200	Vitamin K2 360 µg	mcwjwkzdba(mudbigryaf) = 13% of patients suffered from gastro-intestinal side effects, unrelated to the dose. Nausea caused by the unpleasant smell of the uncoated tablets was reported most frequent. ouoqfjkemx (xnjocglvew )	Positive	30 Oct 2012
				Vitamin K2 720 µg

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