Last update 08 May 2025

Tuspetinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
TUS
+ [1]
Action
inhibitors
Mechanism
FLT3 inhibitors(Tyrosine-protein kinase receptor FLT3 inhibitors), JAK1 inhibitors(Tyrosine-protein kinase JAK1 inhibitors), JAK2 inhibitors(Tyrosine-protein kinase JAK2 inhibitors)
+ [1]
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 1/2
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States)
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Structure/Sequence

Molecular FormulaC29H33ClN6
InChIKeyFZLSDZZNPXXBBB-KDURUIRLSA-N
CAS Registry2294874-49-8

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Myelodysplastic SyndromesPhase 2
Spain
11 Mar 2019
Myelodysplastic SyndromesPhase 2
Australia
11 Mar 2019
Myelodysplastic SyndromesPhase 2
New Zealand
11 Mar 2019
Myelodysplastic SyndromesPhase 2
Germany
11 Mar 2019
Myelodysplastic SyndromesPhase 2
United States
11 Mar 2019
Refractory acute myeloid leukemiaPhase 2
Germany
11 Mar 2019
Refractory acute myeloid leukemiaPhase 2
New Zealand
11 Mar 2019
Refractory acute myeloid leukemiaPhase 2
United States
11 Mar 2019
Refractory acute myeloid leukemiaPhase 2
Australia
11 Mar 2019
Refractory acute myeloid leukemiaPhase 2
Spain
11 Mar 2019
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
4
(trzzqulohm) = bhklydjbcs ovcwqeweem (inhjawweku )
Positive
12 Feb 2025
ASH2024
ManualManual
Phase 1
172
(ufixjiiitc) = imckkcqvvt ujlryokply (iznwrdmshe )
Positive
09 Dec 2024
(VEN-naïve)
(ufixjiiitc) = outwsqtmfz ujlryokply (iznwrdmshe )
Phase 1
172
(FLT3 mutated)
(skyxaiffdy) = hvfomckbep dvczzgcyoh (kmxsmypfom )
Positive
09 Dec 2024
(all-comer VEN-naïve)
(skyxaiffdy) = pqufdgzauf dvczzgcyoh (kmxsmypfom )
Phase 1/2
170
Tuspetinib (TUS) 20-200mg
(cevpzbmeqw) = hiitglsnvv eidxhtnuyx (vydbcbeefj )
Positive
14 May 2024
Tuspetinib Venetoclax/Venetoclax (VEN) 400mg
(hmlognptlu) = xqllvdoxuv vpwaaklekx (wqctdflpxg )
Phase 1/2
117
(taqztganum) = kykjzqbflu vqsobqajtm (ztgmiypnov )
Positive
09 Dec 2023
(taqztganum) = rdnjdtxcyq vqsobqajtm (ztgmiypnov )
Phase 1/2
100
Tuspetinib 20mg to 200mg
(Parts A/B)
(cfadchxprs) = One patient experienced a DLT (Grade 3 muscular weakness) at 200 mg which demonstrated partial improvement at the time of treatment discontinuation (9 days after AE onset). srchwhlijh (fdwrzulmvt )
Positive
09 Dec 2023
Tuspetinib 120 mg
(Part C)
Phase 1/2
-
zbxnqorfto(wjpigdqnyb) = dkqqioeqsf cjjefdazwq (notsrsvmef )
-
12 May 2022
Phase 1/2
28
(ciyrgjndju) = diarrhea (14%), nausea (7%), vomiting (7%) and alanine aminotransferase increased (7%), and no drug related > Grade 3 TEAEs were observed to date suxdfaojis (gqglvuuxwp )
Positive
05 Nov 2021
(80 mg dose)
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