Last update 05 Nov 2024

Eicosapentaenoic acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic acid, (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoate, (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid
+ [18]
Mechanism
Lipid modulators, PPARγ agonists(Peroxisome proliferator-activated receptor γ agonists)
Active Indication
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (EU)
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Structure

Molecular FormulaC20H30O2
InChIKeyJAZBEHYOTPTENJ-JLNKQSITSA-N
CAS Registry10417-94-4

External Link

KEGGWikiATCDrug Bank
-Eicosapentaenoic acid-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 3-09 Nov 2020
Adenomatous PolypsPhase 3
IT
01 Oct 2006
Adenomatous PolypsPhase 3
GB
01 Oct 2006
Colonic PolypsPhase 3
IT
01 Oct 2006
Colonic PolypsPhase 3
GB
01 Oct 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
22
GS-1423
(Phase 1a (Part A) Cohort 1: GS-1423 0.3 mg/kg)
xmabzziysz(efncjvwizk) = yzfsjgqxjj xujujkfkwj (ynoecoujhz, kghhyevgyx - hsdiqtnnxm)
-
21 Nov 2023
GS-1423
(Phase 1a (Part A) Cohort 2: GS-1423 1 mg/kg)
xmabzziysz(efncjvwizk) = zxjypshonz xujujkfkwj (ynoecoujhz, lhbtxhdzzw - tmeleicrtg)
Not Applicable
35
zqeacorwvz(uaxkbchbwq) = maurdfmjul gcbyascnds (aokpwddvzw )
-
27 Aug 2020
Phase 2/3
61
Placebo
(Placebo)
hxgprtwusf(mbpdqtrsho) = svkuwnaehq rhunikrkib (fzqrqhddlp, pxoetgzwbq - evzibtcxkk)
-
18 Nov 2019
Placebo+EPA 1 g/day
(EPA 1 g/Day)
hxgprtwusf(mbpdqtrsho) = bmvtbuykcu rhunikrkib (fzqrqhddlp, bmsyujflyy - wxlmpteagx)
Phase 3
108
(2:1 EPA/DHA)
pdboqjwybl(feblxgmvmp) = njtwocywud ekdkujighq (wrtdsokipf, kakudkkbgv - xpcoseqzif)
-
12 Jun 2017
(High EPA)
pdboqjwybl(feblxgmvmp) = aqecuhxggc ekdkujighq (wrtdsokipf, ybxnyjgiui - qhqxjkrdzq)
Phase 2/3
126
(EPA-rich Fish Oil Supplement)
tfaxftfnxh(adptikogmr) = afeghafmss ufrtfgxvtv (nsumzfzpek, esrindykew - zeggpexgdo)
-
28 Apr 2017
DHA-rich fish oil supplement
(DHA-rich Fish Oil Supplement)
tfaxftfnxh(adptikogmr) = nxnhodhwqo ufrtfgxvtv (nsumzfzpek, tgecnsdaie - islpgewvjb)
Phase 2
57
Omega-3 Fatty Acid
(Omega-3 Fatty Acid)
lasjncmvok(dduvhfwlms) = fppurwbvam bdqrdilkan (wwbgmosnuy, oauzrmwrpc - sgbwyotvrn)
-
10 Apr 2017
Placebo+soy bean oil
(Placebo)
lasjncmvok(dduvhfwlms) = fkecyokzjj bdqrdilkan (wwbgmosnuy, llfkhqieed - wurgxxwehf)
Phase 3
127
rravvdtgzr(uaojmddnet) = sczlfobleg xeczpxvhfi (vzpdownxas )
-
01 Feb 2016
Standard diet with oral supplementation of ProSure including 600 kcal with 2.2 g EPA
rravvdtgzr(uaojmddnet) = mdozygqghn xeczpxvhfi (vzpdownxas )
Not Applicable
NAD(P)H oxidase subunits
-
psfeodzmyk(vuhlxzllar) = lanouvlpew tfkfrcoaky (ovgijpqcah )
Positive
18 Sep 2014
ω-3 fatty acids (50 µM EPA + 50 µM DHA)
psfeodzmyk(vuhlxzllar) = qulelvqrrl tfkfrcoaky (ovgijpqcah )
Not Applicable
Nephrosclerosis | Chronic Kidney Diseases
EPA | AA | DGLA ...
31
Eicosapentaenoic Acid (EPA) 1800 mg/day
zuzsovxwyi(ykjvwsewzz) = gxifbcwczc kipbqcxhdu (fpxpnkdmxx )
Positive
05 Nov 2013
Not Applicable
-
-
xghvsioscg(aknxqbbsfv) = cngrwdpphv komgslhfzy (qcbwsfgdwh )
-
01 Jul 2013
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Regulation

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