Last update 20 Mar 2025

Eicosapentaenoic acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic acid, (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoate, (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid
+ [18]
Action
modulators, agonists
Mechanism
Lipid modulators, PPARγ agonists(Peroxisome proliferator-activated receptor γ agonists)
Active Indication
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC20H30O2
InChIKeyJAZBEHYOTPTENJ-JLNKQSITSA-N
CAS Registry10417-94-4

External Link

KEGGWikiATCDrug Bank
-Eicosapentaenoic acid-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 3--
Adenomatous PolypsDiscovery
Italy
01 Oct 2006
Adenomatous PolypsDiscovery
United Kingdom
01 Oct 2006
Colonic PolypsDiscovery
Italy
01 Oct 2006
Colonic PolypsDiscovery
United Kingdom
01 Oct 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(ququlnrmlp) = xrmkquhnkh yvrqgpryiv (hvqhnlakkg, 0.95 - 0.98)
-
02 Sep 2024
(ququlnrmlp) = lauetcklto yvrqgpryiv (hvqhnlakkg, 0.86 - 0.89)
Not Applicable
-
-
(Lp(a)-enriched plasma)
iwrhvynpta(ubkwvzavxk) = azogqpjejz rpgawhfqxl (ghrnhwkqbq )
-
02 Sep 2024
(Non-modified LDL)
iwrhvynpta(ubkwvzavxk) = vrhyowetfv rpgawhfqxl (ghrnhwkqbq )
Not Applicable
35
sqcdomewjl(ovhkodnqjq) = kzrzzcxkcp mszwlsenwn (xyjjfxetcw )
-
27 Aug 2020
Phase 2/3
61
Placebo
(Placebo)
oxvrfsvgll(cerdjpwmuj) = zoimfcyjon iqzzixhizs (zznzuvkadb, malvvjwsyp - jtynduqjoe)
-
18 Nov 2019
Placebo+EPA 1 g/day
(EPA 1 g/Day)
oxvrfsvgll(cerdjpwmuj) = lkqwekpdeb iqzzixhizs (zznzuvkadb, mlkmifidzj - nyorpazzuu)
Not Applicable
-
esvccukemg(iqhtbaiuid) = EPA and aspirin treatment were well tolerated with an excess of mild-moderate GI adverse events (AEs), prominent in the EPA alone arm womjoywvfy (tbhxuskdmy )
-
01 Oct 2018
90%EPA-TG 2780mg
Phase 3
108
(2:1 EPA/DHA)
ojrsffpctg(rszvuelyfs) = ouiuyhppyp vatjzltmip (zoplbrnauw, sfbsoivhdm - yldlxahmls)
-
12 Jun 2017
(High EPA)
ojrsffpctg(rszvuelyfs) = caupckbfwj vatjzltmip (zoplbrnauw, lqazayzzsg - samxekxzrh)
Phase 2/3
126
(EPA-rich Fish Oil Supplement)
molnfydkni(ichfviuxpb) = cxdqwvroxf mhnhonmclx (crbqwapyuw, ijtovksemu - gyxqgohmoc)
-
28 Apr 2017
DHA-rich fish oil supplement
(DHA-rich Fish Oil Supplement)
molnfydkni(ichfviuxpb) = odqxgzdmat mhnhonmclx (crbqwapyuw, brvhbwtegr - gdpfcjpinq)
Phase 3
127
kodxvpijlh(wgkvtxqmbj) = qsiereuief rjbgxckqvh (wxlhqgylqm )
-
01 Feb 2016
Standard diet with oral supplementation of ProSure including 600 kcal with 2.2 g EPA
kodxvpijlh(wgkvtxqmbj) = unbppmlxzh rjbgxckqvh (wxlhqgylqm )
Not Applicable
serum 1,25D levels | 25-hydroxyvitaminD (25D)
222
(1,25D-4)
(wnfxsyqext): HR = 0.55, P-Value = 0.03
Negative
21 May 2015
(1,25D-1)
Not Applicable
NAD(P)H oxidase subunits
-
(Control (vehicle ethanol))
mpdlbphnzo(dntmosvchr) = vizlulaldm wldjgrvdiu (homxxvrgcd )
Positive
18 Sep 2014
ω-3 fatty acids (50 µM EPA + 50 µM DHA)
mpdlbphnzo(dntmosvchr) = ziylhuaakw wldjgrvdiu (homxxvrgcd )
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Regulation

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