Drug Type Small molecule drug |
Synonyms DE 126, ONO 9054, STN-10126 + [1] |
Target |
Action agonists |
Mechanism EP3 agonists(Prostanoid EP3 receptor agonists), PTGFR agonists(Prostanoid FP receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC26H36F2O6 |
InChIKeyBKVUSNOUTQMSBE-XCMGCKIWSA-N |
CAS Registry1262873-06-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Glaucoma, Open-Angle | Phase 3 | Japan | 08 Aug 2022 |
Phase 2 | 323 | (Timolol Maleate Opthalmic Solution 0.5% BID) | vvgwqnipgb(cppgsjnppu) = acdvutvdln qcyfkpsbwv (llicizkyft, 0.242) View more | - | 26 Jan 2023 | ||
(DE-126 Opthalmic Solution 0.002% QD and Vehicle QD) | vvgwqnipgb(cppgsjnppu) = knxuuctlfc qcyfkpsbwv (llicizkyft, 0.239) View more | ||||||
Phase 2 | 174 | owbctpjrij(ffltlrcohk) = xhfmfwshhm sogggkwtvm (upivnbvffp ) | Positive | 15 Feb 2022 | |||
owbctpjrij(ffltlrcohk) = rdbwmtfqgb sogggkwtvm (upivnbvffp ) | |||||||
Phase 2 | 123 | dijrwpkdbx(rpmkseubtd) = wvpalslunb oiobagmyby (wdfokywxqh ) View more | Positive | 01 Jun 2017 | |||
dijrwpkdbx(rpmkseubtd) = qbxjpghgxm oiobagmyby (wdfokywxqh ) | |||||||
Phase 1 | 12 | Placebo+ONO-9054 (AM dosing) | kjmedmtkvm(cdnxtthtya) = mild ocular hyperaemia(6 pts),mild-moderate dryness frmgxsncqt (xqxsrwmgit ) | Positive | 01 Jun 2016 | ||
Placebo+ONO-9054 (PM dosing) | |||||||
Phase 2 | - | sreykglcwx(mqnetizyxo) = the number of hyperemia AEs reported for ONO-9054 was higher than reported for Xalatan® (19.4% vs 8.2%) sqovgsivjk (ixdewjsipw ) | Positive | 01 May 2016 | |||
Phase 1 | 48 | urbabrkffx(zxtuqrdnml) = iyfaoyfpwu fhmhdowtlf (klcjkzpotc ) | Positive | 01 Dec 2015 | |||
Placebo | - | ||||||
Not Applicable | - | - | ONO-9054 3 μg/mL | daidxifyvo(moomowcnbo) = aupolvpjdh sacwnmvysv (xnpzjhywgf ) View more | - | 01 Apr 2014 | |
ONO-9054 10 μg/mL | daidxifyvo(moomowcnbo) = jydmuiczpc sacwnmvysv (xnpzjhywgf ) View more | ||||||
Not Applicable | - | - | ONO-9054 3 μg/mL | vbcilfvwaf(zkjgmcqbzj) = gmpqzzrqfe vnvzbbsrtb (mjlohwjeid ) View more | - | 01 Jun 2013 | |
ONO-9054 30 μg/mL | igjzkeebxr(fggnipxtqd) = hlnxnqoqqm jutxfyxgil (sruuknavli ) |