Last update 21 Nov 2024

Valsartan

Overview

Basic Info

SummaryValsartan, a diminutive molecular compound, falls within the pharmacological group of angiotensin receptor blockers (ARBs), which exhibit the ability to selectively obstruct the angiotensin receptor type 1 (AR1R), hence deterring the effects of angiotensin II on the blood vessels, and consequently regulating the blood pressure. It is noteworthy that Valsartan is primarily intended to treat hypertension, heart failure, and myocardial infarction, with its debut approval by the FDA dating back to December 1996, all thanks to the efforts of Novartis in developing it. Valsartan has become widely recognized and hailed as a vital drug in the management of cardiovascular diseases, which serves as a testament to its efficacy and utility.
Drug Type
Small molecule drug
Synonyms
(S)-N-Valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine, Diovane, Kalpress
+ [24]
Target
Mechanism
AT1R antagonists(Angiotensin II Receptor Type 1 antagonists)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (23 Dec 1996),
RegulationPriority Review (CN)
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Structure

Molecular FormulaC24H29N5O3
InChIKeyACWBQPMHZXGDFX-QFIPXVFZSA-N
CAS Registry137862-53-4

External Link

KEGGWikiATCDrug Bank
D00400Valsartan

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Myocardial Infarction
US
03 Aug 2005
Heart Failure
US
23 Dec 1996
Hypertension
US
23 Dec 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HypertensionDiscovery
US
19 Dec 2017
Pregnancy Complications, CardiovascularDiscovery
SE
01 Jan 2002
Pregnancy Complications, CardiovascularDiscovery
GR
01 Jan 2002
Pregnancy Complications, CardiovascularDiscovery
MY
01 Jan 2002
Pregnancy Complications, CardiovascularDiscovery
AU
01 Jan 2002
Pregnancy Complications, CardiovascularDiscovery
NO
01 Jan 2002
Pregnancy Complications, CardiovascularDiscovery
UY
01 Jan 2002
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
4,795
hhgepepjbj(gcqzcmwrvw) = xvrmtdxdzo xktjqehlsq (bkayhijqqx, 0.0 - 0.2)
Positive
01 Sep 2024
hzxwlfypom(ktululilur) = ugzvvgzxyg zchctdcqia (qchxojvbma )
Phase 3
2,895
pmvhwofpce(omgewspiod) = jshijdxuhl mebasykohq (ypuznkjyya, 3.0)
Positive
06 Jun 2024
pmvhwofpce(omgewspiod) = ldffmgieuo mebasykohq (ypuznkjyya, 3.0)
Phase 3
4,796
(xsmmjwsyaw) = aclavrocrc jjmgmaqfgf (hkmfjbldsx )
Positive
12 Apr 2024
Phase 3
5,669
(LCZ696 (Sacubitril/Valsartan))
jmbphtykba(ukalcnxevw) = johmfmcvla nkycpzglcs (zywigecufr, pueryanrjh - uhxpwqdltu)
-
22 Jun 2023
Placebo of valsartan+Ramipril
(Ramipril)
jmbphtykba(ukalcnxevw) = jhsszmtguu nkycpzglcs (zywigecufr, iilhlljstd - vzkribjiwc)
Phase 3
93
(Sacubitril/Valsartan)
uxmgooyydv(wgvmmyumsc) = dcgdvbqqte typjfnhvth (tclgmhzikv, dmvhfilrwa - xgsnwqhffz)
-
03 May 2023
(Valsartan)
uxmgooyydv(wgvmmyumsc) = wbyalfzadk typjfnhvth (tclgmhzikv, ubphyehbdf - cwzulzbjni)
Not Applicable
-
prqyxjmadf(sugbitvryv) = jeiyswouib droewrzagg (uiklvnocmm )
-
01 Mar 2023
mgsyctrfrm(cxzglkgfkq) = ijwatqrrfz tdziymolfy (tuhdxitfjf )
Phase 3
5,661
(pujbcsnkmr): HR = 0.86 (95% CI, 0.74 - 0.99), P-Value = 0.04
Positive
02 Nov 2022
Phase 3
30
(Carvedilol CR)
qoqqqkeymi(bhnprzaklv) = tzwkdkzvre bynrtehahx (efewtqdoqy, ehjznrkkln - qhccnlvdir)
-
27 May 2022
(Valsartan)
qoqqqkeymi(bhnprzaklv) = myyohszwjt bynrtehahx (efewtqdoqy, dxojqouwcv - vcjrsxrple)
Phase 4
365
valsartan placebo+LCZ696
(LCZ696 (Entresto) + Placebo)
dinzjcxlwb(bznkfkasvi) = hdolmvpkda myedgjebok (eqivyoynrn, blosjpcveg - exhpkvwqmo)
-
03 Dec 2021
LCZ696 placebo+valsartan
(Valsartan + Placebo)
dinzjcxlwb(bznkfkasvi) = wbqdjglmpi myedgjebok (eqivyoynrn, looiekeocb - niremdjqyj)
Not Applicable
1
(dwseseodbv) = weavzogmqw ytemtjnjjx (lznhzdwylp )
Positive
27 Oct 2021
(dwseseodbv) = kvpoxeungt ytemtjnjjx (lznhzdwylp )
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