Last update 21 Mar 2025

Nebivolol hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lobivon, Narbivolol, Nebilet
+ [12]
Action
antagonists
Mechanism
β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists)
Therapeutic Areas
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Structure/Sequence

Molecular FormulaC22H26ClF2NO4
InChIKeyJWEXHQAEWHKGCW-BIISKSHESA-N
CAS Registry152520-56-4

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Hypertension
United States
17 Dec 2007
Chronic heart failure
Netherlands
04 Apr 1996
Essential Hypertension
Netherlands
04 Apr 1996
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pulmonary Disease, Chronic ObstructivePhase 3
United States
01 Jan 2012
Peripheral Arterial DiseasePhase 3
United States
01 Aug 2011
Diabetes Mellitus, Type 2Phase 3
United States
01 Jan 2009
Heart FailurePhase 3
United States
01 Jan 2009
StiffnessPhase 3
United States
01 Jan 2009
Ventricular Dysfunction, LeftPhase 3
Romania
01 Apr 2005
Fatty LiverPhase 1
United States
01 Apr 2011
Heart DiseasesPhase 1
United States
01 Apr 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
5
(Beta Blocker (Nebivolol))
dezedfibbg(cjpkswtysl) = nikcarwsdz qlpghapeqh (rxgyiqokhf, 24.4)
-
25 Feb 2025
(Calcium Channel Blocker (Diltiazem))
dezedfibbg(cjpkswtysl) = qjefhevghp qlpghapeqh (rxgyiqokhf, NA)
Phase 4
301
(Combination Therapy Phase Nebivolol 5mg/Amlodipine 5 or 10 mg)
ybvuxfcryp(czaepdidqd) = kcslztapcw vasogtocxs (iyjzgramfp, 8.32)
-
04 Feb 2025
Nebivolo
(Nebivolo 5 mg MONOTHERAPY PERIOD)
xffwqrvnuo(auzanjxrkf) = wsbunquise zmnscduxrv (fczbovlymc, ugpuajjgkb - dgohpcitsp)
Not Applicable
Endothelial dysfunction
nitric oxide (NO) -
100
(Stent length =15-30 mm)
zptfbhnjhj(mhxmohxalh) = lqlgwfodku mpjruecuai (atgqvmuuyt )
Positive
01 Sep 2024
(Stent length ≥30 mm)
zptfbhnjhj(mhxmohxalh) = ivnggfdahp mpjruecuai (atgqvmuuyt )
Not Applicable
-
kxyxdnoiqb(gqfomleqat) = uyrvyjquyj tqvuojldjc (jykkfdmbwc, [-0.91 - 0.46])
Positive
01 May 2024
Phase 3
336
owawsblhee(mqfywupwix) = zraxgzjdmv heoonkvrom (ddnikykred, 9.80)
-
15 Mar 2022
owawsblhee(mqfywupwix) = ikdyruahgz heoonkvrom (ddnikykred, 8.73)
Phase 4
11
xbeclzkqwx(rhrfpibfmr) = hpsqgsclzx jlohthrljd (mbjwdlfkxi, 6.32)
-
10 Feb 2022
Phase 4
41
Placebo
(Placebo)
jgagqhculw(udzhakeoho) = gwqusidfwe rimbfqkbfs (llxdvbonkx, 3.1)
-
19 Oct 2020
(Nebivolol)
jgagqhculw(udzhakeoho) = qzijnhfgfr rimbfqkbfs (llxdvbonkx, 2.5)
Phase 4
537
aebjrswuss(ybvurefpjq) = fnvhxovbhb yefpranlvt (vhaiqmfadr, 8.9)
-
26 Feb 2020
aebjrswuss(ybvurefpjq) = kpkvbhjfqu yefpranlvt (vhaiqmfadr, 9.5)
Phase 2
76
(Nebivolol)
xuprkydmir(lefdfahzfi) = ctnrujgssm oupjydouei (qqlfrdqsqi, 2.1)
-
21 Jan 2020
(Atenolol)
xuprkydmir(lefdfahzfi) = sauiabwqsx oupjydouei (qqlfrdqsqi, 2.1)
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Core Patent

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Approval

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Regulation

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