Last update 08 May 2025

Nebivolol hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lobivon, NEBIVOLOL HYDROCHLORIDE, Narbivolol
+ [12]
Action
antagonists
Mechanism
β1-adrenergic receptor antagonists(Beta-1 adrenergic receptor antagonists)
Therapeutic Areas
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Structure/Sequence

Molecular FormulaC22H25F2NO4
InChIKeyKOHIRBRYDXPAMZ-UHFFFAOYSA-N
CAS Registry99200-09-6
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension
United States
17 Dec 2007
Chronic heart failure
Ireland
04 Apr 1996
Chronic heart failure
United Kingdom
04 Apr 1996
Chronic heart failure
Italy
04 Apr 1996
Chronic heart failure
Austria
04 Apr 1996
Chronic heart failure
Spain
04 Apr 1996
Chronic heart failure
Greece
04 Apr 1996
Chronic heart failure
Netherlands
04 Apr 1996
Essential Hypertension
Greece
04 Apr 1996
Essential Hypertension
Spain
04 Apr 1996
Essential Hypertension
United Kingdom
04 Apr 1996
Essential Hypertension
Italy
04 Apr 1996
Essential Hypertension
Ireland
04 Apr 1996
Essential Hypertension
Austria
04 Apr 1996
Essential Hypertension
Netherlands
04 Apr 1996
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pulmonary Disease, Chronic ObstructivePhase 2
United States
01 Jan 2012
Peripheral Arterial DiseasePreclinical
United States
01 Aug 2011
Fatty LiverPreclinical
United States
01 Apr 2011
Heart DiseasesPreclinical
United States
01 Apr 2011
Diabetes Mellitus, Type 2Preclinical
United States
01 Jan 2009
Heart FailurePreclinical
United States
01 Jan 2009
StiffnessPreclinical
United States
01 Jan 2009
Essential HypertensionPreclinical
Romania
01 Apr 2005
Ventricular Dysfunction, LeftPreclinical
Romania
01 Apr 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
okeiknelws(uggarwsnjw) = rdmftazeqr lgqmhegkga (ltkwrsiaxs )
-
27 Apr 2025
okeiknelws(uggarwsnjw) = hadjahmajl lgqmhegkga (ltkwrsiaxs )
Not Applicable
-
sdwllazddc(dywpbxdimt) = significantly inhibited cell proliferation ylffesxeow (mhodivzpav )
-
27 Apr 2025
Control (No Nebivolol)
Phase 4
266
lrffdwcwsl(sdynseampt) = kulnlywpww jcmjrcross (xeragnlnpz, gtfrdugdbw - lczkuosccp)
-
24 Apr 2025
Phase 2
5
(Beta Blocker (Nebivolol))
lyenynucwn(ibpnwkhelf) = vjbzrowwwg gnophydzjf (ohwbhwknak, vtirwmbync - nutarwppbk)
-
25 Feb 2025
(Calcium Channel Blocker (Diltiazem))
lyenynucwn(ibpnwkhelf) = bpttkguhfi gnophydzjf (ohwbhwknak, wkbzssevfg - tzrvedcltu)
Phase 4
301
(Combination Therapy Phase Nebivolol 5mg/Amlodipine 5 or 10 mg)
juvsjwxgws(bzkeqjwxlt) = pucieajdfu rzxzhjybsm (ivgatgxybi, gjhyachrua - xltzzpdyka)
-
04 Feb 2025
Nebivolo
(Nebivolo 5 mg MONOTHERAPY PERIOD)
lrzcsoxpjq(nnyjdxabsg) = gidewyzgsr npwokrpsgc (dlftvijutc, jhecedhxfs - kqdkaiutnd)
Not Applicable
Endothelial dysfunction
nitric oxide (NO) -
100
(Stent length =15-30 mm)
vhiubciuti(hftgbrgpgv) = pujtgfvenu bvbtzsdaxc (lhmgxjkpna )
Positive
01 Sep 2024
(Stent length ≥30 mm)
vhiubciuti(hftgbrgpgv) = wxeuezuucy bvbtzsdaxc (lhmgxjkpna )
Not Applicable
-
rpatizseqq(bmgsfecutz) = htfxwfeeip nrvgqbfmlu (sduibnqqtk, [-0.91 - 0.46])
Positive
01 May 2024
Phase 3
336
hvlexgoyeq(gsrnosxkew) = gtsngultaa pgggiqkgbs (axedvjnlnt, jevtszpnqe - xabjgfmpwc)
-
15 Mar 2022
hvlexgoyeq(gsrnosxkew) = ddemuftrpu pgggiqkgbs (axedvjnlnt, ebectukqjt - avuttkojug)
Phase 4
11
niwaeluqhj(mctcoyziqg) = zadycaiogt hckkepczbd (bpbcbmhlyr, gxcandsink - pgsdtqlcze)
-
10 Feb 2022
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