Last update 04 Nov 2024

Ramipril

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2S-(1(R*(R*)),2alpha,3abeta,6abeta))-1-(2-((1-(Ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)octahydrocyclopenta(b)pyrrole-2-carboxylic acid, Acuvil, Carasel
+ [18]
Target
Mechanism
ACE inhibitors(Angiotensin-converting enzyme inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (28 Jan 1991),
Regulation-
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Structure

Molecular FormulaC23H32N2O5
InChIKeyHDACQVRGBOVJII-JBDAPHQKSA-N
CAS Registry87333-19-5

External Link

KEGGWikiATCDrug Bank
D00421Ramipril

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Myocardial Infarction
US
27 Feb 2007
Acute myocardial infarction
CN
23 Jul 2004
Essential Hypertension
CN
23 Jul 2004
Nephrosis
CN
23 Jul 2004
Stroke
CN
23 Jul 2004
Heart Failure
US
28 Jan 1991
Hypertension
US
28 Jan 1991
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
GlomerulonephritisPhase 3
CN
01 Jul 2004
Myocardial IschemiaPhase 3-01 Jun 2004
Rheumatoid ArthritisPhase 3-01 Jun 2004
COVID-19Phase 2
US
11 May 2020
AlbuminuriaPhase 2
NL
01 Jan 2011
Non-diabetic Chronic Kidney DiseasePhase 2
NL
01 Jan 2011
Heart Failure, SystolicPhase 2
DE
01 May 2009
Heart Failure, SystolicPhase 2
PL
01 May 2009
Heart Failure, SystolicPhase 2
RU
01 May 2009
Diabetes MellitusPhase 1
DE
15 Jan 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
186
jmbrjzcbjn(cegympsqvv) = ydckctgiwe qxbmgeijjd (adfynrezxr )
Negative
18 Sep 2024
Standard treatment
jmbrjzcbjn(cegympsqvv) = ybricjpezz qxbmgeijjd (adfynrezxr )
Phase 2
160
(Ramipril 2.5mg Orally Daily)
lopwhlbcqf(jgwpvfmpyr) = affqmjdcrx zcpbempovn (pasrmibcpb, nfknlipqdl - fnrlbkjfor)
-
28 Sep 2023
Placebo oral capsule
(Placebo)
lopwhlbcqf(jgwpvfmpyr) = heelpyumkh zcpbempovn (pasrmibcpb, fdevchzgtt - mztrlevplf)
Not Applicable
-
Sacubitril/valsartan
lqmnowlltp(msdwrmkczv) = atnkpjksvy hgpveahcwh (ebzygjqzko )
-
23 May 2023
Not Applicable
5,661
Sacubitril/valsartan
goelsutsxq(dmmxmbqocs) = egemvuxqbk dxsojrbjst (paefofejli, 9.2–11.3)
-
26 Aug 2022
goelsutsxq(dmmxmbqocs) = tnauafxmig dxsojrbjst (paefofejli, 4.3–5.5)
Phase 2/3
37
gxbzzvocdb(sutszzzkkt) = wrajnhzpic puujbsxgwh (ixxpzdaefw )
Positive
03 Jun 2022
gxbzzvocdb(sutszzzkkt) = bolbssftrk puujbsxgwh (ixxpzdaefw )
Phase 4
43
opmfnrgfva(qtrffrmgbt) = nhkajfgdto fdmlmvorgn (theseyxdkt, lhwgptgohw - ajsuqxhyhd)
-
10 Mar 2022
opmfnrgfva(qtrffrmgbt) = pncabasyuf fdmlmvorgn (theseyxdkt, hvklrzyopl - geiyhakrze)
Phase 2/3
Maintenance
asymmetric dimethyl arginine (ADMA)
135
kdqqnikgrv(zdowipegqg) = No serious adverse events were reported in neither group uxewpktlry (eelwupfroi )
Positive
29 May 2021
Not Applicable
-
211
Single pill regimen (ASA, ACEI, and S)
unnpryvytt(lmevxkcemc): IRR = 0.38 (95% CI, 0.06 - 1.79)
-
28 Aug 2020
Identical loose combination (ASA, ACEI, and S)
Phase 4
14
Placebo
(Placebo)
cmewsayxia(rzegrnkwtj) = wuqkadysix hlaxlcrijt (iokmcjdgpu, trgrvpomof - ggdgsoedmw)
-
25 Aug 2020
(Active)
cmewsayxia(rzegrnkwtj) = xtvoywxixc hlaxlcrijt (iokmcjdgpu, beecjbikli - xjrnyxcwwy)
Phase 4
102
ajjprciftt(ikphtzlrxa) = viamlvpjgl ndjxruzrsi (ycognlwmed )
-
21 Jul 2020
(Control)
ajjprciftt(ikphtzlrxa) = msvpxereqj ndjxruzrsi (ycognlwmed )
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