Drug Type Small molecule drug |
Synonyms Acuvil, Carasel, Delix + [17] |
Target |
Action inhibitors |
Mechanism ACE inhibitors(Angiotensin-converting enzyme inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (28 Jan 1991), |
Regulation- |
Molecular FormulaC23H32N2O5 |
InChIKeyHDACQVRGBOVJII-JBDAPHQKSA-N |
CAS Registry87333-19-5 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Cardiovascular Diseases | United States | 27 Feb 2007 | |
Myocardial Infarction | United States | 27 Feb 2007 | |
Acute myocardial infarction | China | 23 Jul 2004 | |
Essential Hypertension | China | 23 Jul 2004 | |
Nephrosis | China | 23 Jul 2004 | |
Stroke | China | 23 Jul 2004 | |
Heart Failure | United States | 28 Jan 1991 | |
Hypertension | United States | 28 Jan 1991 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Atrial Fibrillation | Phase 3 | France | 01 Jul 2008 | |
Atrial Flutter | Phase 3 | France | 01 Jul 2008 | |
Glomerulonephritis, IGA | Phase 3 | Hong Kong | 01 Jul 2004 | |
Angina Pectoris | Phase 3 | - | 01 Jun 2004 | |
Rheumatoid Arthritis | Phase 3 | - | 01 Jun 2004 | |
Kidney Failure, Chronic | Phase 3 | Czechia | 01 Jan 1998 | |
Kidney Failure, Chronic | Phase 3 | France | 01 Jan 1998 | |
Kidney Failure, Chronic | Phase 3 | Germany | 01 Jan 1998 | |
Kidney Failure, Chronic | Phase 3 | Hungary | 01 Jan 1998 | |
Kidney Failure, Chronic | Phase 3 | Italy | 01 Jan 1998 |
Phase 4 | 266 | rbfexkptuu(hpjyjtzomt) = xnsrrbayat thzxjdhvtr (fbpvuxevyg, ougavpmgka - tbasulwyfn) View more | - | 24 Apr 2025 | |||
Phase 2 | 75 | xizzcakdxa(wyacjomqco) = pszbosmlfo cjtqmwxxsi (vmuqbdxcfg, 38% - 100) View more | Negative | 11 Nov 2024 | |||
Phase 4 | 186 | ehxycwrfmp(xoumjmjtzz) = yxemxzgtfc ailjnxbeoe (mgijncruym ) View more | Negative | 18 Sep 2024 | |||
Standard treatment | ehxycwrfmp(xoumjmjtzz) = qrnrjzadmi ailjnxbeoe (mgijncruym ) View more | ||||||
Phase 2 | 160 | (Ramipril 2.5mg Orally Daily) | tamfkzpjey = wwplosqcge veiizacbda (rnysrhveyp, ailvieuixk - cciyqsnets) View more | - | 28 Sep 2023 | ||
Placebo oral capsule (Placebo) | tamfkzpjey = ekzncemkef veiizacbda (rnysrhveyp, deqrgpcmiz - xdyhrsiuty) View more | ||||||
Phase 3 | - | gcbcrstyyq(gtzmlypyxn) = xandhsirfi axararwtof (hmkvidzseq ) View more | - | 23 May 2023 | |||
Phase 2/3 | 37 | Ramipril 10 mg/d | koooqixrfq(chtxnufhpk) = mufaxxcybj jazowvgneq (pkhzdugsoq ) | Positive | 03 Jun 2022 | ||
Control group without ramipril | koooqixrfq(chtxnufhpk) = uqqwafpnmb jazowvgneq (pkhzdugsoq ) | ||||||
Phase 4 | 43 | ufetsvimno = mtibvprrck czdtlznxtr (qulmafjrlw, wfgpfykipq - eavyfxkvid) View more | - | 10 Mar 2022 | |||
ufetsvimno = qkpuwtafgb czdtlznxtr (qulmafjrlw, pdwwlcjzti - ohydusqolk) View more | |||||||
Phase 2/3 | Maintenance asymmetric dimethyl arginine (ADMA) | 135 | rkescojlkc(ufsdcgqdkk) = No serious adverse events were reported in neither group nhcuvcqnwh (niwtrsqnxu ) | Positive | 29 May 2021 | ||
Phase 3 | Maintenance | 269 | cheqrslohw(eeybxmnenv) = Twenty participants on ramipril and nine controls developed cancer, including six gastrointestinal malignancies on ramipril (four were fatal), compared with none in controls mdgtmazfht (zjnkkpujkb ) View more | Negative | 29 Mar 2021 | ||
Non-RAS inhibition therapy | |||||||
Phase 4 | 14 | Placebo (Placebo) | qwtfukdgfj(egdaahcyup) = zikuoubalw bmztxbtcen (yotceaebkp, 78.7) View more | - | 25 Aug 2020 | ||
(Active) | qwtfukdgfj(egdaahcyup) = mefqiqjmpi bmztxbtcen (yotceaebkp, 90.6) View more |